YMR156C / TPP1

DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR156C / TPP1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.09|P-value:1.78E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.87|P-value:4.53E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.83|P-value:5.15E-7 ID:SGTC_539|Compound:4859-0462|FD-Score:3.07|P-value:9.65E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:6.05|P-value:4.84E-10 ID:SGTC_686|Compound:1319-0111|FD-Score:4.80|P-value:6.24E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.85|P-value:4.77E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:5.25|P-value:5.44E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:3.84|P-value:5.29E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.90|P-value:4.03E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.45|P-value:2.44E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:6.20|P-value:1.85E-10 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.44|P-value:2.49E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:7.61|P-value:7.35E-15 ID:SGTC_947|Compound:3447-0010|FD-Score:4.11|P-value:1.66E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.36|P-value:3.39E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.67|P-value:1.02E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.11|P-value:8.26E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:7.79|P-value:1.66E-15 ID:SGTC_1254|Compound:0550-0035|FD-Score:5.49|P-value:1.42E-8 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.95|P-value:8.98E-10 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.77|P-value:7.06E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:6.25|P-value:1.29E-10 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.33|P-value:3.78E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.60|P-value:1.40E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.46|P-value:2.26E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:5.35|P-value:3.20E-8 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.13|P-value:7.67E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.56|P-value:1.58E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.57|P-value:1.54E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.32|P-value:4.02E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.11|P-value:8.45E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.79|P-value:6.55E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.84|P-value:5.15E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.87|P-value:4.66E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.13|P-value:7.94E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.07|P-value:1.97E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.38|P-value:3.20E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.67|P-value:1.06E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.51|P-value:1.95E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.09|P-value:1.76E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-3.38|P-value:3.14E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.10|P-value:8.57E-4 ID:SGTC_2307|Compound:7538926|FD-Score:7.79|P-value:1.76E-15 ID:SGTC_2315|Compound:7733312|FD-Score:6.27|P-value:1.18E-10 ID:SGTC_2338|Compound:7999974|FD-Score:-3.66|P-value:1.06E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.12|P-value:8.07E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.62|P-value:1.28E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-3.33|P-value:3.72E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.01|P-value:2.55E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.75|P-value:7.63E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.52|P-value:1.80E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.42|P-value:2.80E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.12|P-value:7.88E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.33|P-value:5.95E-6 ID:SGTC_2702|Compound:st077768|FD-Score:4.64|P-value:1.36E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.92|P-value:3.70E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.76|P-value:7.24E-5 ID:SGTC_2818|Compound:7996756|FD-Score:6.03|P-value:5.30E-10 ID:SGTC_2873|Compound:9040596|FD-Score:3.57|P-value:1.57E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.94|P-value:3.38E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-3.29|P-value:4.26E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.61|P-value:1.33E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.27|P-value:4.70E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.88|P-value:4.32E-5 ID:SGTC_2981|Compound:9013952|FD-Score:-3.26|P-value:4.83E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.16|P-value:6.89E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.94|P-value:3.46E-5 ID:SGTC_3077|Compound:9117319|FD-Score:3.34|P-value:3.64E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.62|P-value:1.29E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.53|P-value:1.73E-4 ID:SGTC_3327|Compound:9140648|FD-Score:5.83|P-value:1.88E-9 ID:SGTC_3329|Compound:9141233|FD-Score:-3.07|P-value:9.24E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.09|P-value:1.78E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.87|P-value:4.53E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.83|P-value:5.15E-7 ID:SGTC_539|Compound:4859-0462|FD-Score:3.07|P-value:9.65E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:6.05|P-value:4.84E-10 ID:SGTC_686|Compound:1319-0111|FD-Score:4.80|P-value:6.24E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.85|P-value:4.77E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:5.25|P-value:5.44E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:3.84|P-value:5.29E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.90|P-value:4.03E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.45|P-value:2.44E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:6.20|P-value:1.85E-10 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.44|P-value:2.49E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:7.61|P-value:7.35E-15 ID:SGTC_947|Compound:3447-0010|FD-Score:4.11|P-value:1.66E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.36|P-value:3.39E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.67|P-value:1.02E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.11|P-value:8.26E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:7.79|P-value:1.66E-15 ID:SGTC_1254|Compound:0550-0035|FD-Score:5.49|P-value:1.42E-8 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.95|P-value:8.98E-10 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.77|P-value:7.06E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:6.25|P-value:1.29E-10 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.33|P-value:3.78E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.60|P-value:1.40E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.46|P-value:2.26E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:5.35|P-value:3.20E-8 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.13|P-value:7.67E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.56|P-value:1.58E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.57|P-value:1.54E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.32|P-value:4.02E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.11|P-value:8.45E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.79|P-value:6.55E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.84|P-value:5.15E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.87|P-value:4.66E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.13|P-value:7.94E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.07|P-value:1.97E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.38|P-value:3.20E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.67|P-value:1.06E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.51|P-value:1.95E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.09|P-value:1.76E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-3.38|P-value:3.14E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.10|P-value:8.57E-4 ID:SGTC_2307|Compound:7538926|FD-Score:7.79|P-value:1.76E-15 ID:SGTC_2315|Compound:7733312|FD-Score:6.27|P-value:1.18E-10 ID:SGTC_2338|Compound:7999974|FD-Score:-3.66|P-value:1.06E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.12|P-value:8.07E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.62|P-value:1.28E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-3.33|P-value:3.72E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.01|P-value:2.55E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.75|P-value:7.63E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.52|P-value:1.80E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.42|P-value:2.80E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.12|P-value:7.88E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.33|P-value:5.95E-6 ID:SGTC_2702|Compound:st077768|FD-Score:4.64|P-value:1.36E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.92|P-value:3.70E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.76|P-value:7.24E-5 ID:SGTC_2818|Compound:7996756|FD-Score:6.03|P-value:5.30E-10 ID:SGTC_2873|Compound:9040596|FD-Score:3.57|P-value:1.57E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.94|P-value:3.38E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-3.29|P-value:4.26E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.61|P-value:1.33E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.27|P-value:4.70E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.88|P-value:4.32E-5 ID:SGTC_2981|Compound:9013952|FD-Score:-3.26|P-value:4.83E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.16|P-value:6.89E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.94|P-value:3.46E-5 ID:SGTC_3077|Compound:9117319|FD-Score:3.34|P-value:3.64E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.62|P-value:1.29E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.53|P-value:1.73E-4 ID:SGTC_3327|Compound:9140648|FD-Score:5.83|P-value:1.88E-9 ID:SGTC_3329|Compound:9141233|FD-Score:-3.07|P-value:9.24E-4

Top fitness defect scores for YMR156C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1136 pergolide 7.79 1.1 µM 1.66E-15 2 3.27E-15
2 SGTC_2307 7538926 7.79 6.3 µM 1.76E-15 4 3.46E-15
3 SGTC_878 0828-0289 7.61 13.7 µM 7.35E-15 8 1.40E-14
4 SGTC_2315 7733312 6.27 200.0 µM 1.18E-10 5 1.83E-10
5 SGTC_1291 0993-0025 6.25 5.8 µM 1.29E-10 1 1.99E-10
6 SGTC_874 0599-0792 6.20 117.0 µM 1.85E-10 5 2.83E-10
7 SGTC_671 0560-0003 6.05 407.0 µM 4.84E-10 1 7.28E-10
8 SGTC_2818 7996756 6.03 13.0 µM 5.30E-10 2 7.95E-10
9 SGTC_1266 0828-0227 5.95 32.9 µM 8.98E-10 2 1.33E-9
10 SGTC_3327 9140648 5.83 26.9 µM 1.88E-9 3 2.74E-9
11 SGTC_1254 0550-0035 5.49 264.0 µM 1.42E-8 5 1.99E-8
12 SGTC_1445 4239-0156 5.35 97.7 µM 3.20E-8 4 4.40E-8
13 SGTC_702 1488-0190 5.25 94.0 µM 5.44E-8 amide catabolism 2 7.41E-8
14 SGTC_530 4358-1714 4.83 28.0 µM 5.15E-7 20 6.68E-7
15 SGTC_686 1319-0111 4.80 510.0 µM 6.24E-7 60S ribosome export 14 8.06E-7
16 SGTC_2702 st077768 4.64 96.8 µM 1.36E-6 8 1.72E-6
17 SGTC_2679 rapamycin 4.33 1.0 nM 5.95E-6 125 7.34E-6
18 SGTC_947 3447-0010 4.11 211.0 µM 1.66E-5 10 2.01E-5
19 SGTC_2059 5238311 4.09 157.0 µM 1.76E-5 20 2.12E-5
20 SGTC_18 0111-0177 4.09 500.0 nM 1.78E-5 69 2.15E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 4.73E-23 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.155 1.38E-19 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.138 8.97E-16 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.133 1.09E-14 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.123 1.02E-12 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.113 4.40E-11 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.110 2.03E-10 YIR009W MSL1 hom U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members
0.105 9.70E-10 YNR005C_d YNR005C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104 1.67E-9 YDL160C DHH1 hom Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress
0.102 3.58E-9 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.099 8.80E-9 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.099 9.16E-9 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.097 2.10E-8 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.094 5.04E-8 YPL192C PRM3 hom Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body
0.092 8.45E-8 YOL100W PKH2 hom Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p