YMR157C / AIM36

Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR157C / AIM36

Click on Significant Values for Screen Details ID:SGTC_152|Compound:4469-0003|FD-Score:4.04|P-value:1.02E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.78|P-value:6.02E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:3.76|P-value:2.67E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.62|P-value:1.14E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:6.73|P-value:4.23E-10 ID:SGTC_577|Compound:r071-0003|FD-Score:4.66|P-value:9.82E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.49|P-value:6.43E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.60|P-value:1.24E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:-5.00|P-value:4.96E-6 ID:SGTC_838|Compound:0109-0203|FD-Score:3.62|P-value:4.19E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.50|P-value:1.83E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.81|P-value:2.26E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.46|P-value:7.13E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.51|P-value:6.05E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.49|P-value:1.93E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:-4.06|P-value:1.78E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.00|P-value:1.16E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.68|P-value:6.06E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.78|P-value:5.87E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:8.33|P-value:1.80E-14 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.57|P-value:4.96E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.56|P-value:8.98E-4 ID:SGTC_1531|Compound:st059297|FD-Score:-3.66|P-value:6.54E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:5.69|P-value:1.02E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.58|P-value:2.63E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.77|P-value:2.62E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.58|P-value:8.40E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.65|P-value:3.91E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.06|P-value:9.55E-5 ID:SGTC_2189|Compound:6047310|FD-Score:5.02|P-value:2.19E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-4.64|P-value:2.08E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-4.59|P-value:2.60E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.42|P-value:2.55E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.81|P-value:2.30E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.24|P-value:9.49E-5 ID:SGTC_2954|Compound:9074818|FD-Score:3.42|P-value:8.00E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.35|P-value:9.98E-4 ID:SGTC_2964|Compound:9083345|FD-Score:6.22|P-value:6.87E-9 ID:SGTC_152|Compound:4469-0003|FD-Score:4.04|P-value:1.02E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.78|P-value:6.02E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:3.76|P-value:2.67E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.62|P-value:1.14E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:6.73|P-value:4.23E-10 ID:SGTC_577|Compound:r071-0003|FD-Score:4.66|P-value:9.82E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.49|P-value:6.43E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.60|P-value:1.24E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:-5.00|P-value:4.96E-6 ID:SGTC_838|Compound:0109-0203|FD-Score:3.62|P-value:4.19E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.50|P-value:1.83E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.81|P-value:2.26E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.46|P-value:7.13E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.51|P-value:6.05E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.49|P-value:1.93E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:-4.06|P-value:1.78E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.00|P-value:1.16E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.68|P-value:6.06E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.78|P-value:5.87E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:8.33|P-value:1.80E-14 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.57|P-value:4.96E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.56|P-value:8.98E-4 ID:SGTC_1531|Compound:st059297|FD-Score:-3.66|P-value:6.54E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:5.69|P-value:1.02E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.58|P-value:2.63E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.77|P-value:2.62E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.58|P-value:8.40E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.65|P-value:3.91E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.06|P-value:9.55E-5 ID:SGTC_2189|Compound:6047310|FD-Score:5.02|P-value:2.19E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-4.64|P-value:2.08E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-4.59|P-value:2.60E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.42|P-value:2.55E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.81|P-value:2.30E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.24|P-value:9.49E-5 ID:SGTC_2954|Compound:9074818|FD-Score:3.42|P-value:8.00E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.35|P-value:9.98E-4 ID:SGTC_2964|Compound:9083345|FD-Score:6.22|P-value:6.87E-9

Top fitness defect scores for YMR157C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1281 0884-0031 8.33 11.8 µM 1.80E-14 fatty acid desaturase (OLE1) 3 3.96E-17
2 SGTC_563 tetrahydrosecaminediol 6.73 614.0 µM 4.23E-10 amide catabolism 2 8.30E-12
3 SGTC_2964 9083345 6.22 53.4 µM 6.87E-9 3 2.45E-10
4 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 5.69 61.9 µM 1.02E-7 2 6.46E-9
5 SGTC_2189 6047310 5.02 154.4 µM 2.19E-6 RPP1 & pyrimidine depletion 7 2.61E-7
6 SGTC_1280 0880-0253 4.78 10.1 µM 5.87E-6 5 8.61E-7
7 SGTC_400 oxethazaine 4.78 37.5 µM 6.02E-6 calcium & mitochondrial duress 11 8.86E-7
8 SGTC_577 r071-0003 4.66 38.6 µM 9.82E-6 fatty acid desaturase (OLE1) 34 1.60E-6
9 SGTC_523 1934-0222 4.62 13.7 µM 1.14E-5 19 1.91E-6
10 SGTC_742 0kpi-0133 4.60 140.0 µM 1.24E-5 ERG2 10 2.12E-6
11 SGTC_1006 4099-6547 4.50 255.0 µM 1.83E-5 11 3.37E-6
12 SGTC_1226 3909-7979 4.49 35.4 µM 1.93E-5 29 3.60E-6
13 SGTC_2519 cryptotanshinone 4.42 88.0 µM 2.55E-5 heme biosynthesis & mitochondrial translocase 7 5.05E-6
14 SGTC_2185 6113692 4.06 200.0 µM 9.55E-5 ergosterol biosynthesis 14 2.46E-5
15 SGTC_152 4469-0003 4.04 551.2 µM 1.02E-4 23 2.65E-5
16 SGTC_1273 0849-0096 4.00 14.1 µM 1.16E-4 RPP1 & pyrimidine depletion 17 3.11E-5
17 SGTC_1127 asiatic acid 3.81 681.4 nM 2.26E-4 27 6.91E-5
18 SGTC_2606 farnesol 3.81 9.8 µM 2.30E-4 22 7.04E-5
19 SGTC_1786 berberine 3.77 21.6 µM 2.62E-4 60S ribosome export 36 8.26E-5
20 SGTC_408 cantharidin 3.76 100.0 µM 2.67E-4 cell wall signaling 28 8.43E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.97E-10 YEL011W GLC3 hom Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.090 1.56E-7 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.086 5.91E-7 YLR430W SEN1 het Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS
0.078 5.71E-6 YHR022C_p YHR022C_p hom Putative protein of unknown function; YHR022C is not an essential gene
0.072 3.07E-5 YOL075C_p YOL075C_p hom Putative ABC transporter
0.069 6.05E-5 YIL100W_d YIL100W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
0.069 6.74E-5 YCR047C BUD23 hom Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.066 1.18E-4 YLR043C TRX1 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.066 1.30E-4 YIL037C PRM2 hom Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion
0.064 2.12E-4 YIL119C RPI1 hom Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF
0.064 2.15E-4 YDR066C RTR2 hom Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication
0.063 2.71E-4 YHR135C YCK1 hom Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication
0.062 3.32E-4 YCR076C FUB1 hom Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene
0.060 5.45E-4 YEL005C VAB2 hom Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter
0.059 5.76E-4 YDR437W GPI19 het Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P