Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
![]() ![]() Click on Significant Values for Screen Details |
Top fitness defect scores for YMR158C-A deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.104 | 1.59E-9 | YBR169C | SSE2 | hom | Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication |
0.091 | 1.23E-7 | YAL062W | GDH3 | hom | NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication |
0.088 | 3.77E-7 | YGR234W | YHB1 | hom | Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
0.086 | 6.44E-7 | YLR456W_p | YLR456W_p | hom | Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication |
0.081 | 2.59E-6 | YIL010W | DOT5 | hom | Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth |
0.077 | 8.97E-6 | YBL032W | HEK2 | hom | RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K |
0.076 | 1.11E-5 | YER175C | TMT1 | hom | Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle |
0.075 | 1.32E-5 | YML070W | DAK1 | hom | Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation |
0.073 | 2.34E-5 | YHR188C | GPI16 | het | Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog |
0.072 | 2.78E-5 | YBR139W | YBR139W | hom | Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner |
0.072 | 2.87E-5 | YGR217W | CCH1 | hom | Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together |
0.072 | 2.97E-5 | YBR301W | PAU24 | hom | Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth |
0.071 | 4.22E-5 | YCL026C-B | HBN1 | hom | Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress |
0.070 | 5.54E-5 | YPL141C | FRK1 | hom | Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication |
0.069 | 6.51E-5 | YDL161W | ENT1 | hom | Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress |