YMR158C-A_p

Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR158C-A / YMR158C-A

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-3.22|P-value:5.27E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-3.59|P-value:1.29E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.32|P-value:2.50E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.71|P-value:5.19E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.14|P-value:7.13E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:4.68|P-value:5.32E-7 ID:SGTC_277|Compound:nystatin|FD-Score:3.61|P-value:8.15E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:3.20|P-value:4.02E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.04|P-value:7.26E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.08|P-value:8.83E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:4.05|P-value:1.17E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.51|P-value:1.74E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.16|P-value:4.69E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.87|P-value:2.62E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:2.96|P-value:9.42E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.46|P-value:1.49E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.14|P-value:7.03E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.64|P-value:1.06E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.91|P-value:2.21E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.41|P-value:2.13E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.32|P-value:5.32E-6 ID:SGTC_1241|Compound:0364-0022|FD-Score:6.55|P-value:5.09E-12 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.12|P-value:7.70E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.92|P-value:2.10E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:5.46|P-value:6.47E-9 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.14|P-value:7.09E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.03|P-value:7.56E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.53|P-value:1.11E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.16|P-value:6.53E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.00|P-value:8.26E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.43|P-value:2.43E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-3.32|P-value:3.73E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.15|P-value:4.84E-4 ID:SGTC_2069|Compound:5228469|FD-Score:4.15|P-value:7.40E-6 ID:SGTC_2289|Compound:7946404|FD-Score:3.10|P-value:5.83E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.18|P-value:4.35E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.98|P-value:1.62E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:2.98|P-value:9.04E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.56|P-value:9.65E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.22|P-value:2.75E-8 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.71|P-value:5.21E-5 ID:SGTC_2781|Compound:5567276|FD-Score:-4.18|P-value:9.94E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.52|P-value:1.15E-4 ID:SGTC_2803|Compound:7707263|FD-Score:5.42|P-value:8.24E-9 ID:SGTC_2836|Compound:9010338|FD-Score:3.15|P-value:4.83E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.90|P-value:3.52E-5 ID:SGTC_3038|Compound:9091290|FD-Score:2.98|P-value:8.94E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.51|P-value:1.26E-6 ID:SGTC_3174|Compound:9107204|FD-Score:5.06|P-value:6.97E-8 ID:SGTC_3327|Compound:9140648|FD-Score:3.00|P-value:8.40E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.27|P-value:3.06E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-3.22|P-value:5.27E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-3.59|P-value:1.29E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.32|P-value:2.50E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.71|P-value:5.19E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.14|P-value:7.13E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:4.68|P-value:5.32E-7 ID:SGTC_277|Compound:nystatin|FD-Score:3.61|P-value:8.15E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:3.20|P-value:4.02E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.04|P-value:7.26E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.08|P-value:8.83E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:4.05|P-value:1.17E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.51|P-value:1.74E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.16|P-value:4.69E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.87|P-value:2.62E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:2.96|P-value:9.42E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.46|P-value:1.49E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.14|P-value:7.03E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.64|P-value:1.06E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.91|P-value:2.21E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.41|P-value:2.13E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.32|P-value:5.32E-6 ID:SGTC_1241|Compound:0364-0022|FD-Score:6.55|P-value:5.09E-12 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.12|P-value:7.70E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.92|P-value:2.10E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:5.46|P-value:6.47E-9 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.14|P-value:7.09E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.03|P-value:7.56E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.53|P-value:1.11E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.16|P-value:6.53E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.00|P-value:8.26E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.43|P-value:2.43E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-3.32|P-value:3.73E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.15|P-value:4.84E-4 ID:SGTC_2069|Compound:5228469|FD-Score:4.15|P-value:7.40E-6 ID:SGTC_2289|Compound:7946404|FD-Score:3.10|P-value:5.83E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.18|P-value:4.35E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.98|P-value:1.62E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:2.98|P-value:9.04E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.56|P-value:9.65E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.22|P-value:2.75E-8 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.71|P-value:5.21E-5 ID:SGTC_2781|Compound:5567276|FD-Score:-4.18|P-value:9.94E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.52|P-value:1.15E-4 ID:SGTC_2803|Compound:7707263|FD-Score:5.42|P-value:8.24E-9 ID:SGTC_2836|Compound:9010338|FD-Score:3.15|P-value:4.83E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.90|P-value:3.52E-5 ID:SGTC_3038|Compound:9091290|FD-Score:2.98|P-value:8.94E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.51|P-value:1.26E-6 ID:SGTC_3174|Compound:9107204|FD-Score:5.06|P-value:6.97E-8 ID:SGTC_3327|Compound:9140648|FD-Score:3.00|P-value:8.40E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.27|P-value:3.06E-4

Top fitness defect scores for YMR158C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1241 0364-0022 6.55 50.8 µM 5.09E-12 ERG2 4 2.96E-11
2 SGTC_1296 1068-0102 5.46 11.9 µM 6.47E-9 2 2.34E-8
3 SGTC_2803 7707263 5.42 71.4 µM 8.24E-9 11 2.93E-8
4 SGTC_2689 tacrolimus 5.22 100.0 µM 2.75E-8 19 9.04E-8
5 SGTC_3174 9107204 5.06 49.5 µM 6.97E-8 ERG2 10 2.15E-7
6 SGTC_259 usnic acid 4.68 108.9 µM 5.32E-7 6 1.43E-6
7 SGTC_3071 9117417 4.51 49.5 µM 1.26E-6 fatty acid desaturase (OLE1) 12 3.20E-6
8 SGTC_1170 0310-0127 4.41 64.8 µM 2.13E-6 12 5.22E-6
9 SGTC_2069 5228469 4.15 200.0 µM 7.40E-6 9 1.67E-5
10 SGTC_466 geldanamycin 4.05 89.2 µM 1.17E-5 RPP1 & pyrimidine depletion 7 2.56E-5
11 SGTC_2524 avocatin b 3.98 10.6 µM 1.62E-5 24 3.45E-5
12 SGTC_1295 1013-0063 3.92 9.8 µM 2.10E-5 13 4.40E-5
13 SGTC_1075 aripiprazole 3.91 15.2 µM 2.21E-5 33 4.63E-5
14 SGTC_779 1360-0071 3.87 233.0 µM 2.62E-5 fatty acid desaturase (OLE1) 27 5.42E-5
15 SGTC_65 0798-0905 3.71 35.0 µM 5.19E-5 calcium & mitochondrial duress 100 1.02E-4
16 SGTC_2751 anetholtrithion 3.71 17.2 µM 5.21E-5 31 1.03E-4
17 SGTC_277 nystatin 3.61 15.5 µM 8.15E-5 19 1.56E-4
18 SGTC_2626 ethyl orsellinate 3.56 100.0 µM 9.65E-5 46 1.82E-4
19 SGTC_1732 st034308 3.53 51.8 µM 1.11E-4 36 2.08E-4
20 SGTC_2789 5281112 3.52 71.4 µM 1.15E-4 57 2.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.59E-9 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.091 1.23E-7 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.088 3.77E-7 YGR234W YHB1 hom Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.086 6.44E-7 YLR456W_p YLR456W_p hom Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication
0.081 2.59E-6 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.077 8.97E-6 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.076 1.11E-5 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.075 1.32E-5 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.073 2.34E-5 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.072 2.78E-5 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.072 2.87E-5 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.072 2.97E-5 YBR301W PAU24 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.071 4.22E-5 YCL026C-B HBN1 hom Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.070 5.54E-5 YPL141C FRK1 hom Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication
0.069 6.51E-5 YDL161W ENT1 hom Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress