HIPHOP chemogenomics database

YMR158C-A_p

Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR158C-A / YMR158C-A

Click on Significant Values for Screen Details

Top fitness defect scores for YMR158C-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1241	0364-0022	6.55	50.8 µM	5.09E-12	ERG2	4	2.96E-11
2	SGTC_1296	1068-0102	5.46	11.9 µM	6.47E-9		2	2.34E-8
3	SGTC_2803	7707263	5.42	71.4 µM	8.24E-9		11	2.93E-8
4	SGTC_2689	tacrolimus	5.22	100.0 µM	2.75E-8		19	9.04E-8
5	SGTC_3174	9107204	5.06	49.5 µM	6.97E-8	ERG2	10	2.15E-7
6	SGTC_259	usnic acid	4.68	108.9 µM	5.32E-7		6	1.43E-6
7	SGTC_3071	9117417	4.51	49.5 µM	1.26E-6	fatty acid desaturase (OLE1)	12	3.20E-6
8	SGTC_1170	0310-0127	4.41	64.8 µM	2.13E-6		12	5.22E-6
9	SGTC_2069	5228469	4.15	200.0 µM	7.40E-6		9	1.67E-5
10	SGTC_466	geldanamycin	4.05	89.2 µM	1.17E-5	RPP1 & pyrimidine depletion	7	2.56E-5
11	SGTC_2524	avocatin b	3.98	10.6 µM	1.62E-5		24	3.45E-5
12	SGTC_1295	1013-0063	3.92	9.8 µM	2.10E-5		13	4.40E-5
13	SGTC_1075	aripiprazole	3.91	15.2 µM	2.21E-5		33	4.63E-5
14	SGTC_779	1360-0071	3.87	233.0 µM	2.62E-5	fatty acid desaturase (OLE1)	27	5.42E-5
15	SGTC_65	0798-0905	3.71	35.0 µM	5.19E-5	calcium & mitochondrial duress	100	1.02E-4
16	SGTC_2751	anetholtrithion	3.71	17.2 µM	5.21E-5		31	1.03E-4
17	SGTC_277	nystatin	3.61	15.5 µM	8.15E-5		19	1.56E-4
18	SGTC_2626	ethyl orsellinate	3.56	100.0 µM	9.65E-5		46	1.82E-4
19	SGTC_1732	st034308	3.53	51.8 µM	1.11E-4		36	2.08E-4
20	SGTC_2789	5281112	3.52	71.4 µM	1.15E-4		57	2.14E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.104	1.59E-9	YBR169C	SSE2	hom	Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.091	1.23E-7	YAL062W	GDH3	hom	NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.088	3.77E-7	YGR234W	YHB1	hom	Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.086	6.44E-7	YLR456W_p	YLR456W_p	hom	Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication
0.081	2.59E-6	YIL010W	DOT5	hom	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.077	8.97E-6	YBL032W	HEK2	hom	RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.076	1.11E-5	YER175C	TMT1	hom	Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.075	1.32E-5	YML070W	DAK1	hom	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.073	2.34E-5	YHR188C	GPI16	het	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.072	2.78E-5	YBR139W	YBR139W	hom	Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.072	2.87E-5	YGR217W	CCH1	hom	Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.072	2.97E-5	YBR301W	PAU24	hom	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.071	4.22E-5	YCL026C-B	HBN1	hom	Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.070	5.54E-5	YPL141C	FRK1	hom	Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication
0.069	6.51E-5	YDL161W	ENT1	hom	Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress