YMR158W / MRPS8

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR158W / MRPS8

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.56|P-value:1.54E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.31|P-value:3.91E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.21|P-value:5.62E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.24|P-value:4.87E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:5.15|P-value:8.72E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:5.93|P-value:8.77E-10 ID:SGTC_174|Compound:3553-0389|FD-Score:4.11|P-value:1.50E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:4.18|P-value:1.10E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.53|P-value:1.71E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.71|P-value:8.54E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:3.52|P-value:1.77E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.60|P-value:1.54E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:5.49|P-value:1.22E-8 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.45|P-value:2.34E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.31|P-value:3.80E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.28|P-value:7.17E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.24|P-value:8.04E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:4.37|P-value:4.55E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:3.46|P-value:2.22E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.41|P-value:2.72E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.02|P-value:2.23E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.37|P-value:3.01E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-8.15|P-value:5.68E-17 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.95|P-value:2.89E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.31|P-value:6.02E-6 ID:SGTC_1157|Compound:4092-0394|FD-Score:6.14|P-value:2.31E-10 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.36|P-value:3.07E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.35|P-value:5.12E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.57|P-value:1.49E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.07|P-value:1.85E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.93|P-value:3.14E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.28|P-value:4.46E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.06|P-value:9.01E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.51|P-value:2.14E-6 ID:SGTC_1891|Compound:st059073|FD-Score:4.87|P-value:3.79E-7 ID:SGTC_1911|Compound:st060208|FD-Score:3.44|P-value:2.40E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.76|P-value:6.94E-5 ID:SGTC_1952|Compound:st077036|FD-Score:3.40|P-value:2.84E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.75|P-value:6.71E-5 ID:SGTC_2010|Compound:4012422|FD-Score:5.14|P-value:9.35E-8 ID:SGTC_2144|Compound:5628481|FD-Score:4.97|P-value:2.29E-7 ID:SGTC_2161|Compound:5662504|FD-Score:3.33|P-value:3.70E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-4.39|P-value:3.90E-6 ID:SGTC_2172|Compound:5754775|FD-Score:3.38|P-value:3.08E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.05|P-value:9.41E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.04|P-value:9.85E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.14|P-value:1.31E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.82|P-value:5.37E-5 ID:SGTC_2393|Compound:9031399|FD-Score:3.43|P-value:2.54E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.44|P-value:2.39E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.26|P-value:7.61E-6 ID:SGTC_2426|Compound:5582046|FD-Score:4.37|P-value:4.71E-6 ID:SGTC_2444|Compound:5485484|FD-Score:-3.46|P-value:2.15E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.21|P-value:5.72E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.36|P-value:3.24E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-3.29|P-value:4.07E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.11|P-value:7.96E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.18|P-value:7.25E-8 ID:SGTC_2937|Compound:9044753|FD-Score:3.49|P-value:1.97E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.68|P-value:9.66E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.44|P-value:2.39E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.10|P-value:8.48E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.14|P-value:7.27E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-4.22|P-value:8.75E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.56|P-value:1.54E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.31|P-value:3.91E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.21|P-value:5.62E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.24|P-value:4.87E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:5.15|P-value:8.72E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:5.93|P-value:8.77E-10 ID:SGTC_174|Compound:3553-0389|FD-Score:4.11|P-value:1.50E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:4.18|P-value:1.10E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.53|P-value:1.71E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.71|P-value:8.54E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:3.52|P-value:1.77E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.60|P-value:1.54E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:5.49|P-value:1.22E-8 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.45|P-value:2.34E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.31|P-value:3.80E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.28|P-value:7.17E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.24|P-value:8.04E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:4.37|P-value:4.55E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:3.46|P-value:2.22E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.41|P-value:2.72E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.02|P-value:2.23E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.37|P-value:3.01E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-8.15|P-value:5.68E-17 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.95|P-value:2.89E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.31|P-value:6.02E-6 ID:SGTC_1157|Compound:4092-0394|FD-Score:6.14|P-value:2.31E-10 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.36|P-value:3.07E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.35|P-value:5.12E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.57|P-value:1.49E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.07|P-value:1.85E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.93|P-value:3.14E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.28|P-value:4.46E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.06|P-value:9.01E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.51|P-value:2.14E-6 ID:SGTC_1891|Compound:st059073|FD-Score:4.87|P-value:3.79E-7 ID:SGTC_1911|Compound:st060208|FD-Score:3.44|P-value:2.40E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.76|P-value:6.94E-5 ID:SGTC_1952|Compound:st077036|FD-Score:3.40|P-value:2.84E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.75|P-value:6.71E-5 ID:SGTC_2010|Compound:4012422|FD-Score:5.14|P-value:9.35E-8 ID:SGTC_2144|Compound:5628481|FD-Score:4.97|P-value:2.29E-7 ID:SGTC_2161|Compound:5662504|FD-Score:3.33|P-value:3.70E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-4.39|P-value:3.90E-6 ID:SGTC_2172|Compound:5754775|FD-Score:3.38|P-value:3.08E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.05|P-value:9.41E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.04|P-value:9.85E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.14|P-value:1.31E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.82|P-value:5.37E-5 ID:SGTC_2393|Compound:9031399|FD-Score:3.43|P-value:2.54E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.44|P-value:2.39E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.26|P-value:7.61E-6 ID:SGTC_2426|Compound:5582046|FD-Score:4.37|P-value:4.71E-6 ID:SGTC_2444|Compound:5485484|FD-Score:-3.46|P-value:2.15E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.21|P-value:5.72E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.36|P-value:3.24E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-3.29|P-value:4.07E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.11|P-value:7.96E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.18|P-value:7.25E-8 ID:SGTC_2937|Compound:9044753|FD-Score:3.49|P-value:1.97E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.68|P-value:9.66E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.44|P-value:2.39E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.10|P-value:8.48E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.14|P-value:7.27E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-4.22|P-value:8.75E-6

Top fitness defect scores for YMR158W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1157 4092-0394 6.14 27.6 µM 2.31E-10 3 4.16E-10
2 SGTC_173 1273-0061 5.93 2.7 µM 8.77E-10 mitochondrial stress 111 1.52E-9
3 SGTC_310 1273-0058 5.49 1.1 µM 1.22E-8 mitochondrial stress 163 1.96E-8
4 SGTC_2932 9016711 5.18 44.5 µM 7.25E-8 22 1.10E-7
5 SGTC_141 0443-0274 5.15 32.3 µM 8.72E-8 mitochondrial response to ROS 20 1.31E-7
6 SGTC_2010 4012422 5.14 159.0 µM 9.35E-8 5 1.41E-7
7 SGTC_2144 5628481 4.97 200.0 µM 2.29E-7 ERG2 11 3.35E-7
8 SGTC_1891 st059073 4.87 26.2 µM 3.79E-7 TSC3-RPN4 9 5.47E-7
9 SGTC_236 1509-0011 4.60 5.3 µM 1.54E-6 353 2.13E-6
10 SGTC_771 0250-0039 4.37 27.3 µM 4.55E-6 10 6.11E-6
11 SGTC_2426 5582046 4.37 32.2 µM 4.71E-6 18 6.31E-6
12 SGTC_1176 0848-0131 4.35 83.3 µM 5.12E-6 Golgi 16 6.84E-6
13 SGTC_1134 3477-0009 4.31 42.5 µM 6.02E-6 37 8.01E-6
14 SGTC_451 chloral hydrate 4.28 100.0 µM 7.17E-6 41 9.49E-6
15 SGTC_2407 paclitaxel 4.26 400.0 µM 7.61E-6 25 1.01E-5
16 SGTC_175 3793-3120 4.18 23.7 µM 1.10E-5 9 1.44E-5
17 SGTC_2274 7947094 4.14 46.1 µM 1.31E-5 29 1.70E-5
18 SGTC_174 3553-0389 4.11 74.3 µM 1.50E-5 19 1.95E-5
19 SGTC_1255 0566-0045 4.07 221.0 µM 1.85E-5 excess fatty acid 27 2.38E-5
20 SGTC_908 3448-7491 4.02 47.7 µM 2.23E-5 mitochondrial stress 121 2.86E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 1.09E-40 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.223 6.41E-39 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.221 3.11E-38 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.218 1.72E-37 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.205 2.97E-33 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.201 8.87E-32 YHR120W MSH1 hom DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
0.199 3.25E-31 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.198 3.79E-31 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.196 2.39E-30 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.194 7.11E-30 YGR222W PET54 hom Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
0.190 1.24E-28 YPR099C_d YPR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W
0.189 2.81E-28 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.187 6.60E-28 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.187 9.48E-28 YDR405W MRP20 hom Mitochondrial ribosomal protein of the large subunit
0.186 1.49E-27 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth