YMR163C / INP2

Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR163C / INP2

Click on Significant Values for Screen Details ID:SGTC_264|Compound:promethazine|FD-Score:-3.33|P-value:3.25E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.15|P-value:8.80E-6 ID:SGTC_389|Compound:tpck|FD-Score:3.33|P-value:2.80E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.20|P-value:4.53E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:-4.26|P-value:6.20E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:3.14|P-value:5.70E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:6.41|P-value:1.75E-11 ID:SGTC_966|Compound:1300-0360|FD-Score:6.26|P-value:4.86E-11 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.31|P-value:3.51E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.05|P-value:1.37E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.02|P-value:8.73E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.09|P-value:1.12E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.27|P-value:3.53E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.41|P-value:2.01E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.03|P-value:8.37E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:5.67|P-value:2.32E-9 ID:SGTC_1607|Compound:st000305|FD-Score:3.50|P-value:1.43E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-4.36|P-value:3.87E-6 ID:SGTC_1724|Compound:st037281|FD-Score:4.98|P-value:1.28E-7 ID:SGTC_1755|Compound:st041960|FD-Score:-3.38|P-value:2.69E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.62|P-value:8.72E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.06|P-value:7.64E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.12|P-value:7.00E-4 ID:SGTC_1901|Compound:st060216|FD-Score:4.59|P-value:1.01E-6 ID:SGTC_1942|Compound:st076330|FD-Score:3.24|P-value:3.86E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.76|P-value:4.21E-7 ID:SGTC_2020|Compound:4017018|FD-Score:3.88|P-value:2.93E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.41|P-value:2.01E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.22|P-value:4.24E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.47|P-value:1.62E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.26|P-value:4.12E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.58|P-value:1.26E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.51|P-value:1.62E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.29|P-value:3.23E-4 ID:SGTC_2691|Compound:st077356|FD-Score:6.13|P-value:1.14E-10 ID:SGTC_2713|Compound:st079149|FD-Score:3.23|P-value:4.01E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-4.34|P-value:4.11E-6 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.22|P-value:4.20E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.63|P-value:8.41E-5 ID:SGTC_2908|Compound:7930301|FD-Score:5.90|P-value:5.39E-10 ID:SGTC_2929|Compound:9013348|FD-Score:3.10|P-value:6.53E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.85|P-value:3.32E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-3.39|P-value:2.52E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.70|P-value:6.23E-5 ID:SGTC_3175|Compound:9106517|FD-Score:-3.62|P-value:1.03E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.86|P-value:3.19E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.52|P-value:1.34E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.33|P-value:3.25E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.15|P-value:8.80E-6 ID:SGTC_389|Compound:tpck|FD-Score:3.33|P-value:2.80E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.20|P-value:4.53E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:-4.26|P-value:6.20E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:3.14|P-value:5.70E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:6.41|P-value:1.75E-11 ID:SGTC_966|Compound:1300-0360|FD-Score:6.26|P-value:4.86E-11 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.31|P-value:3.51E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.05|P-value:1.37E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.02|P-value:8.73E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.09|P-value:1.12E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.27|P-value:3.53E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.41|P-value:2.01E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.03|P-value:8.37E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:5.67|P-value:2.32E-9 ID:SGTC_1607|Compound:st000305|FD-Score:3.50|P-value:1.43E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-4.36|P-value:3.87E-6 ID:SGTC_1724|Compound:st037281|FD-Score:4.98|P-value:1.28E-7 ID:SGTC_1755|Compound:st041960|FD-Score:-3.38|P-value:2.69E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.62|P-value:8.72E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.06|P-value:7.64E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.12|P-value:7.00E-4 ID:SGTC_1901|Compound:st060216|FD-Score:4.59|P-value:1.01E-6 ID:SGTC_1942|Compound:st076330|FD-Score:3.24|P-value:3.86E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.76|P-value:4.21E-7 ID:SGTC_2020|Compound:4017018|FD-Score:3.88|P-value:2.93E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.41|P-value:2.01E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.22|P-value:4.24E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.47|P-value:1.62E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.26|P-value:4.12E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.58|P-value:1.26E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.51|P-value:1.62E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.29|P-value:3.23E-4 ID:SGTC_2691|Compound:st077356|FD-Score:6.13|P-value:1.14E-10 ID:SGTC_2713|Compound:st079149|FD-Score:3.23|P-value:4.01E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-4.34|P-value:4.11E-6 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.22|P-value:4.20E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.63|P-value:8.41E-5 ID:SGTC_2908|Compound:7930301|FD-Score:5.90|P-value:5.39E-10 ID:SGTC_2929|Compound:9013348|FD-Score:3.10|P-value:6.53E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.85|P-value:3.32E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-3.39|P-value:2.52E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.70|P-value:6.23E-5 ID:SGTC_3175|Compound:9106517|FD-Score:-3.62|P-value:1.03E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.86|P-value:3.19E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.52|P-value:1.34E-4

Top fitness defect scores for YMR163C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_782 0083-0095 6.41 30.5 µM 1.75E-11 2 7.40E-11
2 SGTC_966 1300-0360 6.26 30.2 µM 4.86E-11 heme requiring 4 1.94E-10
3 SGTC_2691 st077356 6.13 60.2 µM 1.14E-10 6 4.32E-10
4 SGTC_2908 7930301 5.90 100.0 µM 5.39E-10 3 1.86E-9
5 SGTC_1532 4',5'-dihydroxyflavone 5.67 78.7 µM 2.32E-9 Golgi 11 7.31E-9
6 SGTC_1724 st037281 4.98 8.3 µM 1.28E-7 19 3.18E-7
7 SGTC_1954 st077032 4.76 68.9 µM 4.21E-7 7 9.70E-7
8 SGTC_1901 st060216 4.59 58.6 µM 1.01E-6 15 2.21E-6
9 SGTC_287 k060-0039 4.15 29.6 µM 8.80E-6 9 1.69E-5
10 SGTC_1212 0520-0165 4.09 585.0 µM 1.12E-5 26 2.12E-5
11 SGTC_1123 mangostin 4.05 811.3 nM 1.37E-5 mitochondrial response to ROS 34 2.56E-5
12 SGTC_2020 4017018 3.88 200.0 µM 2.93E-5 20 5.22E-5
13 SGTC_3263 9137018 3.86 49.5 µM 3.19E-5 18 5.66E-5
14 SGTC_2930 9013230 3.85 14.9 µM 3.32E-5 heme biosynthesis & mitochondrial translocase 44 5.89E-5
15 SGTC_3026 9090633 3.70 49.5 µM 6.23E-5 29 1.06E-4
16 SGTC_2804 7954240 3.63 19.5 µM 8.41E-5 46 1.41E-4
17 SGTC_1775 st081588 3.62 35.2 µM 8.72E-5 60S ribosome export 31 1.46E-4
18 SGTC_3281 9140613 3.52 49.5 µM 1.34E-4 RPP1 & pyrimidine depletion 35 2.19E-4
19 SGTC_1607 st000305 3.50 50.6 µM 1.43E-4 27 2.32E-4
20 SGTC_2253 7938677 3.47 135.8 µM 1.62E-4 22 2.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.64E-11 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.102 3.41E-9 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.098 1.31E-8 YLR045C STU2 het Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
0.096 2.24E-8 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.094 4.25E-8 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.093 7.91E-8 YLR019W PSR2 hom Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
0.092 8.48E-8 YNL228W_d YNL228W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1
0.091 1.16E-7 YOL029C_p YOL029C_p hom Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens
0.085 7.29E-7 YBL089W AVT5 hom Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication
0.081 2.31E-6 YAR035C-A_p YAR035C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis
0.078 5.45E-6 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.077 9.12E-6 YIL088C AVT7 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.076 1.02E-5 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.076 1.04E-5 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.075 1.35E-5 YPL104W MSD1 hom Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene