YMR164C / MSS11

Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR164C / MSS11

Click on Significant Values for Screen Details ID:SGTC_364|Compound:0083-0097|FD-Score:-3.63|P-value:5.11E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.32|P-value:9.37E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.81|P-value:1.85E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.70|P-value:5.81E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-3.76|P-value:3.25E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.05|P-value:7.67E-5 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.82|P-value:2.69E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-4.07|P-value:1.12E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.63|P-value:7.89E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:3.74|P-value:2.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.44|P-value:2.75E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.15|P-value:8.32E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.40|P-value:7.22E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.66|P-value:3.09E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.30|P-value:9.83E-4 ID:SGTC_1705|Compound:st027868|FD-Score:4.17|P-value:4.99E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.77|P-value:2.08E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.77|P-value:3.15E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.72|P-value:2.52E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-4.65|P-value:1.19E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-3.57|P-value:6.20E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-4.03|P-value:1.30E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.35|P-value:8.45E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.30|P-value:9.85E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.83|P-value:1.73E-4 ID:SGTC_2791|Compound:5663188|FD-Score:4.01|P-value:8.81E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.64|P-value:7.52E-6 ID:SGTC_2979|Compound:9012552|FD-Score:-6.07|P-value:1.58E-8 ID:SGTC_2983|Compound:9022671|FD-Score:3.63|P-value:3.42E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-7.52|P-value:3.33E-12 ID:SGTC_2987|Compound:9018338|FD-Score:-3.42|P-value:9.79E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.34|P-value:8.77E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.63|P-value:5.11E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.32|P-value:9.37E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.81|P-value:1.85E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.70|P-value:5.81E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-3.76|P-value:3.25E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.05|P-value:7.67E-5 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.82|P-value:2.69E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-4.07|P-value:1.12E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.63|P-value:7.89E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:3.74|P-value:2.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.44|P-value:2.75E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.15|P-value:8.32E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.40|P-value:7.22E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.66|P-value:3.09E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.30|P-value:9.83E-4 ID:SGTC_1705|Compound:st027868|FD-Score:4.17|P-value:4.99E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.77|P-value:2.08E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.77|P-value:3.15E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.72|P-value:2.52E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-4.65|P-value:1.19E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-3.57|P-value:6.20E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-4.03|P-value:1.30E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.35|P-value:8.45E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.30|P-value:9.85E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.83|P-value:1.73E-4 ID:SGTC_2791|Compound:5663188|FD-Score:4.01|P-value:8.81E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.64|P-value:7.52E-6 ID:SGTC_2979|Compound:9012552|FD-Score:-6.07|P-value:1.58E-8 ID:SGTC_2983|Compound:9022671|FD-Score:3.63|P-value:3.42E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-7.52|P-value:3.33E-12 ID:SGTC_2987|Compound:9018338|FD-Score:-3.42|P-value:9.79E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.34|P-value:8.77E-4

Top fitness defect scores for YMR164C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_439 amiodarone 4.70 34.4 µM 5.81E-6 NEO1-PIK1 70 1.29E-6
2 SGTC_2794 7785382 4.64 27.3 µM 7.52E-6 14 1.74E-6
3 SGTC_884 0851-0618 4.63 334.0 µM 7.89E-6 7 1.84E-6
4 SGTC_1705 st027868 4.17 56.3 µM 4.99E-5 6 1.55E-5
5 SGTC_644 1498-1197 4.05 63.3 µM 7.67E-5 18 2.56E-5
6 SGTC_2791 5663188 4.01 71.4 µM 8.81E-5 RPP1 & pyrimidine depletion 19 3.00E-5
7 SGTC_2693 st077581 3.83 40.7 µM 1.73E-4 39 6.53E-5
8 SGTC_435 c-PAF 3.81 6.7 µM 1.85E-4 50 7.05E-5
9 SGTC_1731 st035964 3.77 63.0 µM 2.08E-4 35 8.06E-5
10 SGTC_888 0916-0002 3.74 7.0 µM 2.36E-4 NEO1 50 9.32E-5
11 SGTC_1809 st050081 3.72 57.6 µM 2.52E-4 18 1.01E-4
12 SGTC_1254 0550-0035 3.66 264.0 µM 3.09E-4 31 1.27E-4
13 SGTC_2983 9022671 3.63 13.0 µM 3.42E-4 60S ribosome export 21 1.43E-4
14 SGTC_1169 aniline yellow 3.40 25.8 µM 7.22E-4 24 3.38E-4
15 SGTC_2175 5807670 3.35 165.3 µM 8.45E-4 37 4.05E-4
16 SGTC_3326 9140064 3.34 16.4 µM 8.77E-4 32 4.23E-4
17 SGTC_425 3825-7017 3.32 13.1 µM 9.37E-4 45 4.56E-4
18 SGTC_1570 verbenone 3.30 133.0 µM 9.83E-4 34 4.82E-4
19 SGTC_2608 thymoquinone 3.30 42.7 µM 9.85E-4 35 4.83E-4
20 SGTC_1847 st056231 3.29 15.0 µM 0.00101 62 4.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 8.82E-35 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.178 4.08E-25 YDR193W_d YDR193W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.162 3.01E-21 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.135 3.82E-15 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
0.134 6.41E-15 YAL017W PSK1 hom PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.131 2.27E-14 YNL305C BXI1 hom Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
0.118 7.80E-12 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.116 1.71E-11 YGL086W MAD1 hom Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.116 1.87E-11 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.115 2.32E-11 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.115 2.40E-11 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.113 4.55E-11 YAR019C CDC15 het Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress
0.108 3.10E-10 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.108 3.88E-10 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.104 1.41E-9 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species