YMR166C_p

Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR166C / YMR166C

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:4.17|P-value:2.98E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:3.25|P-value:8.92E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:6.19|P-value:1.22E-9 ID:SGTC_125|Compound:0133-0007|FD-Score:3.26|P-value:8.55E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:5.20|P-value:2.83E-7 ID:SGTC_144|Compound:4161-2749|FD-Score:10.20|P-value:4.19E-23 ID:SGTC_145|Compound:3737-0113|FD-Score:14.00|P-value:5.58E-42 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:17.00|P-value:1.96E-60 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.18|P-value:2.83E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.25|P-value:2.11E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:9.82|P-value:1.56E-21 ID:SGTC_264|Compound:promethazine|FD-Score:24.00|P-value:2.01E-118 ID:SGTC_291|Compound:4130-1278|FD-Score:3.52|P-value:3.54E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.95|P-value:8.87E-7 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.60|P-value:3.47E-8 ID:SGTC_512|Compound:prima-1|FD-Score:4.40|P-value:1.15E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.80|P-value:1.26E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.32|P-value:6.74E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.26|P-value:8.65E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.26|P-value:2.07E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.67|P-value:2.03E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.96|P-value:6.83E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:4.96|P-value:8.82E-7 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.39|P-value:5.52E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.91|P-value:8.34E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:5.74|P-value:1.61E-8 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.86|P-value:1.02E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.36|P-value:6.13E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.63|P-value:2.40E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:11.60|P-value:2.81E-29 ID:SGTC_1475|Compound:4092-1048|FD-Score:6.65|P-value:7.52E-11 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.93|P-value:7.74E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:9.99|P-value:3.23E-22 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.11|P-value:1.99E-9 ID:SGTC_1494|Compound:4358-1428|FD-Score:6.92|P-value:1.33E-11 ID:SGTC_1515|Compound:3460-0031|FD-Score:5.20|P-value:2.78E-7 ID:SGTC_1519|Compound:esterone|FD-Score:5.77|P-value:1.35E-8 ID:SGTC_1529|Compound:apigenin|FD-Score:3.97|P-value:6.64E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:7.66|P-value:8.11E-14 ID:SGTC_2027|Compound:5150920|FD-Score:4.64|P-value:3.95E-6 ID:SGTC_2128|Compound:5255449|FD-Score:3.51|P-value:3.62E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.42|P-value:4.98E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.80|P-value:1.24E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.27|P-value:8.31E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.58|P-value:2.90E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.35|P-value:6.29E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-4.08|P-value:4.12E-5 ID:SGTC_2296|Compound:7971656|FD-Score:6.54|P-value:1.48E-10 ID:SGTC_2300|Compound:7976697|FD-Score:-5.18|P-value:2.89E-7 ID:SGTC_2303|Compound:7774051|FD-Score:10.40|P-value:3.91E-24 ID:SGTC_2328|Compound:6201408|FD-Score:3.82|P-value:1.19E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.99|P-value:5.82E-5 ID:SGTC_2424|Compound:5537928|FD-Score:3.32|P-value:7.01E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.55|P-value:3.22E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-5.45|P-value:7.35E-8 ID:SGTC_2976|Compound:9009005|FD-Score:6.00|P-value:3.89E-9 ID:SGTC_2981|Compound:9013952|FD-Score:4.06|P-value:4.57E-5 ID:SGTC_3040|Compound:9091894|FD-Score:8.42|P-value:2.52E-16 ID:SGTC_3126|Compound:9127922|FD-Score:-3.35|P-value:6.13E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.75|P-value:1.54E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.23|P-value:2.31E-5 ID:SGTC_3294|Compound:9122953|FD-Score:3.95|P-value:7.07E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.63|P-value:2.36E-4 ID:SGTC_3310|Compound:9130229|FD-Score:8.22|P-value:1.22E-15 ID:SGTC_3324|Compound:9138759|FD-Score:3.82|P-value:1.19E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:4.17|P-value:2.98E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:3.25|P-value:8.92E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:6.19|P-value:1.22E-9 ID:SGTC_125|Compound:0133-0007|FD-Score:3.26|P-value:8.55E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:5.20|P-value:2.83E-7 ID:SGTC_144|Compound:4161-2749|FD-Score:10.20|P-value:4.19E-23 ID:SGTC_145|Compound:3737-0113|FD-Score:14.00|P-value:5.58E-42 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:17.00|P-value:1.96E-60 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.18|P-value:2.83E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.25|P-value:2.11E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:9.82|P-value:1.56E-21 ID:SGTC_264|Compound:promethazine|FD-Score:24.00|P-value:2.01E-118 ID:SGTC_291|Compound:4130-1278|FD-Score:3.52|P-value:3.54E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.95|P-value:8.87E-7 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.60|P-value:3.47E-8 ID:SGTC_512|Compound:prima-1|FD-Score:4.40|P-value:1.15E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.80|P-value:1.26E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.32|P-value:6.74E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.26|P-value:8.65E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.26|P-value:2.07E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.67|P-value:2.03E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.96|P-value:6.83E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:4.96|P-value:8.82E-7 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.39|P-value:5.52E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.91|P-value:8.34E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:5.74|P-value:1.61E-8 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.86|P-value:1.02E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.36|P-value:6.13E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.63|P-value:2.40E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:11.60|P-value:2.81E-29 ID:SGTC_1475|Compound:4092-1048|FD-Score:6.65|P-value:7.52E-11 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.93|P-value:7.74E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:9.99|P-value:3.23E-22 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.11|P-value:1.99E-9 ID:SGTC_1494|Compound:4358-1428|FD-Score:6.92|P-value:1.33E-11 ID:SGTC_1515|Compound:3460-0031|FD-Score:5.20|P-value:2.78E-7 ID:SGTC_1519|Compound:esterone|FD-Score:5.77|P-value:1.35E-8 ID:SGTC_1529|Compound:apigenin|FD-Score:3.97|P-value:6.64E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:7.66|P-value:8.11E-14 ID:SGTC_2027|Compound:5150920|FD-Score:4.64|P-value:3.95E-6 ID:SGTC_2128|Compound:5255449|FD-Score:3.51|P-value:3.62E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.42|P-value:4.98E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.80|P-value:1.24E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.27|P-value:8.31E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.58|P-value:2.90E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.35|P-value:6.29E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-4.08|P-value:4.12E-5 ID:SGTC_2296|Compound:7971656|FD-Score:6.54|P-value:1.48E-10 ID:SGTC_2300|Compound:7976697|FD-Score:-5.18|P-value:2.89E-7 ID:SGTC_2303|Compound:7774051|FD-Score:10.40|P-value:3.91E-24 ID:SGTC_2328|Compound:6201408|FD-Score:3.82|P-value:1.19E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.99|P-value:5.82E-5 ID:SGTC_2424|Compound:5537928|FD-Score:3.32|P-value:7.01E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.55|P-value:3.22E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-5.45|P-value:7.35E-8 ID:SGTC_2976|Compound:9009005|FD-Score:6.00|P-value:3.89E-9 ID:SGTC_2981|Compound:9013952|FD-Score:4.06|P-value:4.57E-5 ID:SGTC_3040|Compound:9091894|FD-Score:8.42|P-value:2.52E-16 ID:SGTC_3126|Compound:9127922|FD-Score:-3.35|P-value:6.13E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.75|P-value:1.54E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.23|P-value:2.31E-5 ID:SGTC_3294|Compound:9122953|FD-Score:3.95|P-value:7.07E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.63|P-value:2.36E-4 ID:SGTC_3310|Compound:9130229|FD-Score:8.22|P-value:1.22E-15 ID:SGTC_3324|Compound:9138759|FD-Score:3.82|P-value:1.19E-4

Top fitness defect scores for YMR166C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_264 promethazine 24.00 12.5 mM 2.01E-118 DNA intercalators 2 2.52E-127
2 SGTC_219 mitoxanthrone 17.00 164.4 µM 1.96E-60 DNA intercalators 2 6.43E-65
3 SGTC_145 3737-0113 14.00 38.4 µM 5.58E-42 DNA intercalators 3 4.67E-45
4 SGTC_1468 k284-1086 11.60 134.0 µM 2.81E-29 DNA intercalators 1 2.18E-31
5 SGTC_2303 7774051 10.40 200.0 µM 3.91E-24 1 7.46E-26
6 SGTC_144 4161-2749 10.20 112.4 µM 4.19E-23 DNA intercalators 2 9.59E-25
7 SGTC_1487 3970-0795 9.99 2.8 µM 3.23E-22 DNA intercalators 1 8.62E-24
8 SGTC_257 daunorubicin 9.82 18.5 µM 1.56E-21 anthracycline transcription coupled DNA repair 4 4.69E-23
9 SGTC_3040 9091894 8.42 49.5 µM 2.52E-16 DNA intercalators 2 1.89E-17
10 SGTC_3310 9130229 8.22 44.1 µM 1.22E-15 Golgi 1 1.03E-16
11 SGTC_1926 methyl fluorone black 7.66 53.6 µM 8.11E-14 DNA intercalators 9 9.39E-15
12 SGTC_1494 4358-1428 6.92 177.0 µM 1.33E-11 4 2.27E-12
13 SGTC_1475 4092-1048 6.65 11.7 µM 7.52E-11 plasma membrane duress 7 1.46E-11
14 SGTC_2296 7971656 6.54 126.5 µM 1.48E-10 9 3.01E-11
15 SGTC_77 0828-0286 6.19 12.5 µM 1.22E-9 TSC3-RPN4 3 2.92E-10
16 SGTC_1493 4348-0038 6.11 111.0 µM 1.99E-9 RSC complex & mRNA processing 1 4.93E-10
17 SGTC_2976 9009005 6.00 19.5 µM 3.89E-9 11 1.02E-9
18 SGTC_1519 esterone 5.77 74.0 µM 1.35E-8 DNA intercalators 6 3.86E-9
19 SGTC_1290 0986-0249 5.74 10.2 µM 1.61E-8 DNA intercalators 6 4.67E-9
20 SGTC_471 1-acyl-paf 5.60 4.0 µM 3.47E-8 DNA intercalators 9 1.07E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.709 0 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.700 0 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.620 0 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.540 2.89E-252 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.529 1.79E-241 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.507 5.72E-219 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.440 5.08E-159 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.410 1.26E-135 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.393 3.86E-124 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.392 4.86E-123 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.390 6.76E-122 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.383 1.06E-117 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.365 6.25E-106 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.325 4.03E-83 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.294 9.48E-68 YLR133W CKI1 hom Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication