YMR168C / CEP3

Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR168C / CEP3

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.22|P-value:2.35E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.57|P-value:5.14E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:5.29|P-value:4.84E-9 ID:SGTC_126|Compound:0417-1624|FD-Score:5.48|P-value:1.36E-9 ID:SGTC_143|Compound:4032-1194|FD-Score:5.61|P-value:5.82E-10 ID:SGTC_144|Compound:4161-2749|FD-Score:14.60|P-value:8.76E-57 ID:SGTC_145|Compound:3737-0113|FD-Score:18.50|P-value:3.69E-89 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:21.90|P-value:3.62E-124 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.28|P-value:1.81E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.90|P-value:5.25E-8 ID:SGTC_257|Compound:daunorubicin|FD-Score:6.19|P-value:9.59E-12 ID:SGTC_264|Compound:promethazine|FD-Score:23.50|P-value:2.15E-143 ID:SGTC_341|Compound:1486-1430|FD-Score:2.98|P-value:6.07E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.53|P-value:6.28E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.36|P-value:3.89E-9 ID:SGTC_470|Compound:aa-861|FD-Score:4.55|P-value:3.98E-7 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.98|P-value:7.82E-6 ID:SGTC_512|Compound:prima-1|FD-Score:2.90|P-value:7.98E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:2.92|P-value:7.52E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.68|P-value:3.19E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:4.83|P-value:7.91E-8 ID:SGTC_794|Compound:k038-0031|FD-Score:3.75|P-value:2.30E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.07|P-value:4.14E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.22|P-value:2.37E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:2.99|P-value:5.66E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.97|P-value:8.21E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.10|P-value:4.29E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.15|P-value:3.12E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.67|P-value:3.34E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.62|P-value:4.28E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.75|P-value:1.26E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:11.40|P-value:1.67E-35 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.40|P-value:1.12E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.82|P-value:8.48E-8 ID:SGTC_1494|Compound:4358-1428|FD-Score:5.04|P-value:2.35E-8 ID:SGTC_1515|Compound:3460-0031|FD-Score:7.48|P-value:2.65E-16 ID:SGTC_1519|Compound:esterone|FD-Score:6.63|P-value:3.33E-13 ID:SGTC_1526|Compound:st051518|FD-Score:-3.81|P-value:2.04E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:5.12|P-value:1.40E-8 ID:SGTC_1578|Compound:josamycin|FD-Score:3.87|P-value:1.35E-5 ID:SGTC_1701|Compound:st028638|FD-Score:2.90|P-value:7.90E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.43|P-value:1.12E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.04|P-value:5.89E-6 ID:SGTC_1776|Compound:st049249|FD-Score:4.05|P-value:5.39E-6 ID:SGTC_1780|Compound:st038448|FD-Score:-3.93|P-value:1.16E-5 ID:SGTC_1822|Compound:st052468|FD-Score:2.95|P-value:6.64E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.34|P-value:1.67E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.85|P-value:1.72E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:12.40|P-value:1.40E-41 ID:SGTC_1956|Compound:st077085|FD-Score:3.02|P-value:5.17E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.27|P-value:1.89E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.51|P-value:4.89E-7 ID:SGTC_2296|Compound:7971656|FD-Score:3.87|P-value:1.29E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-2.96|P-value:7.43E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-2.91|P-value:8.71E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.13|P-value:3.91E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-6.28|P-value:6.34E-12 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.45|P-value:8.91E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:6.48|P-value:1.04E-12 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.06|P-value:4.38E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.71|P-value:1.62E-7 ID:SGTC_2684|Compound:capsaicin|FD-Score:-2.88|P-value:9.74E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.73|P-value:2.59E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.76|P-value:2.21E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-2.96|P-value:7.28E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.28|P-value:2.07E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.38|P-value:1.22E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-4.60|P-value:3.71E-7 ID:SGTC_2782|Compound:7736369|FD-Score:-3.65|P-value:4.33E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-8.22|P-value:3.62E-19 ID:SGTC_2786|Compound:7743617|FD-Score:-5.98|P-value:5.62E-11 ID:SGTC_2805|Compound:7950783|FD-Score:3.26|P-value:1.95E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.14|P-value:3.22E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.47|P-value:8.10E-5 ID:SGTC_3040|Compound:9091894|FD-Score:3.26|P-value:1.96E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.13|P-value:3.36E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.17|P-value:3.04E-6 ID:SGTC_3294|Compound:9122953|FD-Score:3.23|P-value:2.26E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.30|P-value:1.95E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.22|P-value:2.35E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.57|P-value:5.14E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:5.29|P-value:4.84E-9 ID:SGTC_126|Compound:0417-1624|FD-Score:5.48|P-value:1.36E-9 ID:SGTC_143|Compound:4032-1194|FD-Score:5.61|P-value:5.82E-10 ID:SGTC_144|Compound:4161-2749|FD-Score:14.60|P-value:8.76E-57 ID:SGTC_145|Compound:3737-0113|FD-Score:18.50|P-value:3.69E-89 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:21.90|P-value:3.62E-124 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.28|P-value:1.81E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.90|P-value:5.25E-8 ID:SGTC_257|Compound:daunorubicin|FD-Score:6.19|P-value:9.59E-12 ID:SGTC_264|Compound:promethazine|FD-Score:23.50|P-value:2.15E-143 ID:SGTC_341|Compound:1486-1430|FD-Score:2.98|P-value:6.07E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.53|P-value:6.28E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.36|P-value:3.89E-9 ID:SGTC_470|Compound:aa-861|FD-Score:4.55|P-value:3.98E-7 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.98|P-value:7.82E-6 ID:SGTC_512|Compound:prima-1|FD-Score:2.90|P-value:7.98E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:2.92|P-value:7.52E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.68|P-value:3.19E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:4.83|P-value:7.91E-8 ID:SGTC_794|Compound:k038-0031|FD-Score:3.75|P-value:2.30E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.07|P-value:4.14E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.22|P-value:2.37E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:2.99|P-value:5.66E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.97|P-value:8.21E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.10|P-value:4.29E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.15|P-value:3.12E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.67|P-value:3.34E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.62|P-value:4.28E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.75|P-value:1.26E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:11.40|P-value:1.67E-35 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.40|P-value:1.12E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.82|P-value:8.48E-8 ID:SGTC_1494|Compound:4358-1428|FD-Score:5.04|P-value:2.35E-8 ID:SGTC_1515|Compound:3460-0031|FD-Score:7.48|P-value:2.65E-16 ID:SGTC_1519|Compound:esterone|FD-Score:6.63|P-value:3.33E-13 ID:SGTC_1526|Compound:st051518|FD-Score:-3.81|P-value:2.04E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:5.12|P-value:1.40E-8 ID:SGTC_1578|Compound:josamycin|FD-Score:3.87|P-value:1.35E-5 ID:SGTC_1701|Compound:st028638|FD-Score:2.90|P-value:7.90E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.43|P-value:1.12E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.04|P-value:5.89E-6 ID:SGTC_1776|Compound:st049249|FD-Score:4.05|P-value:5.39E-6 ID:SGTC_1780|Compound:st038448|FD-Score:-3.93|P-value:1.16E-5 ID:SGTC_1822|Compound:st052468|FD-Score:2.95|P-value:6.64E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.34|P-value:1.67E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.85|P-value:1.72E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:12.40|P-value:1.40E-41 ID:SGTC_1956|Compound:st077085|FD-Score:3.02|P-value:5.17E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.27|P-value:1.89E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.51|P-value:4.89E-7 ID:SGTC_2296|Compound:7971656|FD-Score:3.87|P-value:1.29E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-2.96|P-value:7.43E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-2.91|P-value:8.71E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.13|P-value:3.91E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-6.28|P-value:6.34E-12 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.45|P-value:8.91E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:6.48|P-value:1.04E-12 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.06|P-value:4.38E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.71|P-value:1.62E-7 ID:SGTC_2684|Compound:capsaicin|FD-Score:-2.88|P-value:9.74E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.73|P-value:2.59E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.76|P-value:2.21E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-2.96|P-value:7.28E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.28|P-value:2.07E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.38|P-value:1.22E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-4.60|P-value:3.71E-7 ID:SGTC_2782|Compound:7736369|FD-Score:-3.65|P-value:4.33E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-8.22|P-value:3.62E-19 ID:SGTC_2786|Compound:7743617|FD-Score:-5.98|P-value:5.62E-11 ID:SGTC_2805|Compound:7950783|FD-Score:3.26|P-value:1.95E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.14|P-value:3.22E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.47|P-value:8.10E-5 ID:SGTC_3040|Compound:9091894|FD-Score:3.26|P-value:1.96E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.13|P-value:3.36E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.17|P-value:3.04E-6 ID:SGTC_3294|Compound:9122953|FD-Score:3.23|P-value:2.26E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.30|P-value:1.95E-4

Top fitness defect scores for YMR168C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_264 promethazine 23.50 12.5 mM 2.15E-143 DNA intercalators 1 7.35E-123 9.82
2 SGTC_219 mitoxanthrone 21.90 164.4 µM 3.62E-124 DNA intercalators 1 2.05E-106 11.00
3 SGTC_145 3737-0113 18.50 38.4 µM 3.69E-89 DNA intercalators 1 1.80E-76 4.52
4 SGTC_144 4161-2749 14.60 112.4 µM 8.76E-57 DNA intercalators 1 8.81E-49 6.09
5 SGTC_1926 methyl fluorone black 12.40 53.6 µM 1.40E-41 DNA intercalators 1 8.86E-36 1.91
6 SGTC_1468 k284-1086 11.40 134.0 µM 1.67E-35 DNA intercalators 1 1.40E-30 3.56
7 SGTC_1515 3460-0031 7.48 42.1 µM 2.65E-16 DNA intercalators 1 3.74E-14 1.57
8 SGTC_1519 esterone 6.63 74.0 µM 3.33E-13 DNA intercalators 1 1.68E-11 1.36
9 SGTC_2597 laccaic acid a 6.48 100.0 µM 1.04E-12 2 4.45E-11 1.62
10 SGTC_257 daunorubicin 6.19 18.5 µM 9.59E-12 anthracycline transcription coupled DNA repair 7 2.98E-10 0.21
11 SGTC_143 4032-1194 5.61 15.7 µM 5.82E-10 4 1.00E-8 0.40
12 SGTC_126 0417-1624 5.48 672.5 µM 1.36E-9 DNA intercalators 5 2.07E-8 0.16
13 SGTC_125 0133-0007 5.29 11.8 µM 4.84E-9 DNA intercalators 2 6.16E-8 0.37
14 SGTC_1529 apigenin 5.12 74.0 µM 1.40E-8 1 1.53E-7 0.80
15 SGTC_1494 4358-1428 5.04 177.0 µM 2.35E-8 3 2.39E-7 0.36
16 SGTC_255 tunicamycin 4.90 200.5 nM 5.25E-8 unfolded protein response 12 4.75E-7 0.51
17 SGTC_711 k292-0785 4.83 179.0 µM 7.91E-8 DNA intercalators 3 6.76E-7 0.04
18 SGTC_1487 3970-0795 4.82 2.8 µM 8.48E-8 DNA intercalators 3 7.17E-7 0.69
19 SGTC_1461 k072-0203 4.75 53.8 µM 1.26E-7 4 1.01E-6 0.04
20 SGTC_2625 euphol 4.71 100.0 µM 1.62E-7 5 1.25E-6 0.28

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.719 0 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.700 0 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.579 1.81E-299 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.570 2.24E-287 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.480 7.07E-193 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.474 6.72E-188 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.434 5.15E-154 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.430 7.14E-151 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.419 1.13E-142 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.407 5.17E-134 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.385 1.18E-118 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.360 3.22E-103 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.341 2.19E-92 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.340 1.91E-91 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.323 1.83E-82 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition