YMR169C / ALD3

Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR169C / ALD3

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-3.88|P-value:5.94E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:4.71|P-value:1.38E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:4.34|P-value:7.90E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.29|P-value:5.53E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.94|P-value:4.65E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.42|P-value:3.28E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.33|P-value:7.97E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:-4.91|P-value:5.36E-7 ID:SGTC_659|Compound:k018-0002|FD-Score:4.55|P-value:2.93E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:3.76|P-value:9.15E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:3.50|P-value:2.43E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.85|P-value:6.74E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.84|P-value:6.49E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:3.35|P-value:4.19E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.10|P-value:2.26E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.46|P-value:2.90E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.76|P-value:9.08E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.30|P-value:5.10E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.35|P-value:7.30E-6 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.22|P-value:6.73E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.31|P-value:5.07E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.77|P-value:8.61E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.18|P-value:7.64E-4 ID:SGTC_1602|Compound:st001878|FD-Score:5.69|P-value:7.38E-9 ID:SGTC_1608|Compound:st001473|FD-Score:-3.78|P-value:8.76E-5 ID:SGTC_1612|Compound:st002233|FD-Score:3.12|P-value:9.43E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.69|P-value:1.20E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.40|P-value:5.90E-6 ID:SGTC_1740|Compound:st038286|FD-Score:3.38|P-value:3.84E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.16|P-value:8.20E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.11|P-value:2.18E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.15|P-value:8.51E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-4.19|P-value:1.61E-5 ID:SGTC_2486|Compound:5283202|FD-Score:8.87|P-value:5.52E-19 ID:SGTC_2488|Compound:5268135|FD-Score:5.52|P-value:1.93E-8 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.48|P-value:4.05E-6 ID:SGTC_2804|Compound:7954240|FD-Score:3.42|P-value:3.26E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.42|P-value:5.42E-6 ID:SGTC_2959|Compound:9079155|FD-Score:4.79|P-value:9.20E-7 ID:SGTC_2962|Compound:9082311|FD-Score:-6.45|P-value:7.25E-11 ID:SGTC_2975|Compound:9084847|FD-Score:3.37|P-value:3.95E-4 ID:SGTC_3176|Compound:9106582|FD-Score:4.00|P-value:3.33E-5 ID:SGTC_3178|Compound:9107506|FD-Score:-4.21|P-value:1.44E-5 ID:SGTC_3289|Compound:9119912|FD-Score:3.14|P-value:8.67E-4 ID:SGTC_3294|Compound:9122953|FD-Score:4.20|P-value:1.43E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.88|P-value:5.94E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:4.71|P-value:1.38E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:4.34|P-value:7.90E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.29|P-value:5.53E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.94|P-value:4.65E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.42|P-value:3.28E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.33|P-value:7.97E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:-4.91|P-value:5.36E-7 ID:SGTC_659|Compound:k018-0002|FD-Score:4.55|P-value:2.93E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:3.76|P-value:9.15E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:3.50|P-value:2.43E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.85|P-value:6.74E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.84|P-value:6.49E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:3.35|P-value:4.19E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.10|P-value:2.26E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.46|P-value:2.90E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.76|P-value:9.08E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.30|P-value:5.10E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.35|P-value:7.30E-6 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.22|P-value:6.73E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.31|P-value:5.07E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.77|P-value:8.61E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.18|P-value:7.64E-4 ID:SGTC_1602|Compound:st001878|FD-Score:5.69|P-value:7.38E-9 ID:SGTC_1608|Compound:st001473|FD-Score:-3.78|P-value:8.76E-5 ID:SGTC_1612|Compound:st002233|FD-Score:3.12|P-value:9.43E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.69|P-value:1.20E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.40|P-value:5.90E-6 ID:SGTC_1740|Compound:st038286|FD-Score:3.38|P-value:3.84E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.16|P-value:8.20E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.11|P-value:2.18E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.15|P-value:8.51E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-4.19|P-value:1.61E-5 ID:SGTC_2486|Compound:5283202|FD-Score:8.87|P-value:5.52E-19 ID:SGTC_2488|Compound:5268135|FD-Score:5.52|P-value:1.93E-8 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.48|P-value:4.05E-6 ID:SGTC_2804|Compound:7954240|FD-Score:3.42|P-value:3.26E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.42|P-value:5.42E-6 ID:SGTC_2959|Compound:9079155|FD-Score:4.79|P-value:9.20E-7 ID:SGTC_2962|Compound:9082311|FD-Score:-6.45|P-value:7.25E-11 ID:SGTC_2975|Compound:9084847|FD-Score:3.37|P-value:3.95E-4 ID:SGTC_3176|Compound:9106582|FD-Score:4.00|P-value:3.33E-5 ID:SGTC_3178|Compound:9107506|FD-Score:-4.21|P-value:1.44E-5 ID:SGTC_3289|Compound:9119912|FD-Score:3.14|P-value:8.67E-4 ID:SGTC_3294|Compound:9122953|FD-Score:4.20|P-value:1.43E-5

Top fitness defect scores for YMR169C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2486 5283202 8.87 22.4 µM 5.52E-19 6 3.67E-19
2 SGTC_1602 st001878 5.69 87.6 µM 7.38E-9 5 6.31E-9
3 SGTC_2488 5268135 5.52 45.7 µM 1.93E-8 21 1.66E-8
4 SGTC_2959 9079155 4.79 11.0 µM 9.20E-7 14 8.26E-7
5 SGTC_61 0978-8327 4.71 98.6 µM 1.38E-6 ergosterol biosynthesis 12 1.24E-6
6 SGTC_659 k018-0002 4.55 107.0 µM 2.93E-6 12 2.66E-6
7 SGTC_2562 3',7'-dimethoxyflavone 4.48 64.9 µM 4.05E-6 16 3.69E-6
8 SGTC_2908 7930301 4.42 100.0 µM 5.42E-6 15 4.95E-6
9 SGTC_1683 st010134 4.40 710.0 nM 5.90E-6 16 5.39E-6
10 SGTC_1252 0493-0875 4.35 34.8 µM 7.30E-6 19 6.69E-6
11 SGTC_156 3474-0145 4.34 5.6 µM 7.90E-6 endomembrane recycling 41 7.24E-6
12 SGTC_481 bay k-8644 4.33 50.0 µM 7.97E-6 22 7.31E-6
13 SGTC_3294 9122953 4.20 26.3 µM 1.43E-5 tubulin folding & SWR complex 24 1.32E-5
14 SGTC_1931 st074438 4.11 57.1 µM 2.18E-5 14 2.02E-5
15 SGTC_1024 4507-0395 4.10 26.0 µM 2.26E-5 TSC3-RPN4 23 2.10E-5
16 SGTC_3176 9106582 4.00 49.5 µM 3.33E-5 2 3.10E-5
17 SGTC_767 0929-0023 3.84 86.0 µM 6.49E-5 TRP & mitochondrial translation 80 6.08E-5
18 SGTC_1583 clindamycin 3.77 39.6 µM 8.61E-5 mitochondrial processes 19 8.08E-5
19 SGTC_1121 fusaric acid 3.76 630.5 nM 9.08E-5 39 8.53E-5
20 SGTC_697 0508-1955 3.76 564.0 µM 9.15E-5 45 8.59E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.088 3.53E-7 YMR096W SNZ1 hom Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.088 3.87E-7 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.087 4.56E-7 YMR311C GLC8 hom Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress
0.084 1.14E-6 YGL007W_d BRP1_d hom Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1
0.083 1.38E-6 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.083 1.59E-6 YJL127C SPT10 hom Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
0.079 4.12E-6 YNL088W TOP2 het Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.079 4.55E-6 YJL210W PEX2 hom RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
0.078 5.93E-6 YML009C MRPL39 hom Mitochondrial ribosomal protein of the large subunit
0.075 1.30E-5 YGL050W TYW3 hom tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
0.074 1.61E-5 YCR098C GIT1 hom Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
0.074 1.83E-5 YNL206C RTT106 hom Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition
0.072 2.64E-5 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.071 3.94E-5 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.071 4.20E-5 YNL049C SFB2 hom Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p