YMR170C / ALD2

Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR170C / ALD2

Click on Significant Values for Screen Details ID:SGTC_80|Compound:0159-0065|FD-Score:3.35|P-value:2.74E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.59|P-value:1.10E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:8.72|P-value:1.54E-19 ID:SGTC_173|Compound:1273-0061|FD-Score:-5.17|P-value:5.86E-8 ID:SGTC_334|Compound:1502-1024|FD-Score:3.11|P-value:6.63E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.40|P-value:2.88E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.90|P-value:3.14E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.07|P-value:8.17E-4 ID:SGTC_456|Compound:gingerol|FD-Score:5.20|P-value:4.32E-8 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.14|P-value:6.00E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.08|P-value:7.36E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.95|P-value:2.41E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.19|P-value:5.39E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:4.48|P-value:1.97E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:3.65|P-value:8.48E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.56|P-value:5.07E-9 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.78|P-value:4.96E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.14|P-value:6.56E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.73|P-value:5.96E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.73|P-value:5.97E-5 ID:SGTC_1646|Compound:st011709|FD-Score:3.06|P-value:7.90E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-4.31|P-value:4.90E-6 ID:SGTC_1676|Compound:st018489|FD-Score:-3.38|P-value:2.68E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-3.10|P-value:7.43E-4 ID:SGTC_1702|Compound:st027038|FD-Score:-3.15|P-value:6.17E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.14|P-value:9.87E-6 ID:SGTC_1724|Compound:st037281|FD-Score:-4.44|P-value:2.60E-6 ID:SGTC_1765|Compound:st044815|FD-Score:-4.68|P-value:7.84E-7 ID:SGTC_1767|Compound:st044992|FD-Score:-3.79|P-value:5.09E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.20|P-value:4.92E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.72|P-value:5.78E-7 ID:SGTC_2302|Compound:7771753|FD-Score:3.66|P-value:8.10E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.39|P-value:3.09E-6 ID:SGTC_2340|Compound:7987427|FD-Score:3.96|P-value:2.24E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.07|P-value:7.69E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.91|P-value:3.13E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.93|P-value:2.78E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.24|P-value:4.26E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.39|P-value:3.04E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.31|P-value:3.21E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.10|P-value:7.60E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.25|P-value:4.02E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.03|P-value:8.94E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.30|P-value:3.32E-4 ID:SGTC_3332|Compound:9141069|FD-Score:4.03|P-value:1.67E-5 ID:SGTC_3347|Compound:9188721|FD-Score:-3.10|P-value:7.58E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.82|P-value:4.20E-5 ID:SGTC_80|Compound:0159-0065|FD-Score:3.35|P-value:2.74E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.59|P-value:1.10E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:8.72|P-value:1.54E-19 ID:SGTC_173|Compound:1273-0061|FD-Score:-5.17|P-value:5.86E-8 ID:SGTC_334|Compound:1502-1024|FD-Score:3.11|P-value:6.63E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.40|P-value:2.88E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.90|P-value:3.14E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.07|P-value:8.17E-4 ID:SGTC_456|Compound:gingerol|FD-Score:5.20|P-value:4.32E-8 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.14|P-value:6.00E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.08|P-value:7.36E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.95|P-value:2.41E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.19|P-value:5.39E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:4.48|P-value:1.97E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:3.65|P-value:8.48E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.56|P-value:5.07E-9 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.78|P-value:4.96E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.14|P-value:6.56E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.73|P-value:5.96E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.73|P-value:5.97E-5 ID:SGTC_1646|Compound:st011709|FD-Score:3.06|P-value:7.90E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-4.31|P-value:4.90E-6 ID:SGTC_1676|Compound:st018489|FD-Score:-3.38|P-value:2.68E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-3.10|P-value:7.43E-4 ID:SGTC_1702|Compound:st027038|FD-Score:-3.15|P-value:6.17E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.14|P-value:9.87E-6 ID:SGTC_1724|Compound:st037281|FD-Score:-4.44|P-value:2.60E-6 ID:SGTC_1765|Compound:st044815|FD-Score:-4.68|P-value:7.84E-7 ID:SGTC_1767|Compound:st044992|FD-Score:-3.79|P-value:5.09E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.20|P-value:4.92E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.72|P-value:5.78E-7 ID:SGTC_2302|Compound:7771753|FD-Score:3.66|P-value:8.10E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.39|P-value:3.09E-6 ID:SGTC_2340|Compound:7987427|FD-Score:3.96|P-value:2.24E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.07|P-value:7.69E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.91|P-value:3.13E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.93|P-value:2.78E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.24|P-value:4.26E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.39|P-value:3.04E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.31|P-value:3.21E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.10|P-value:7.60E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.25|P-value:4.02E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.03|P-value:8.94E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.30|P-value:3.32E-4 ID:SGTC_3332|Compound:9141069|FD-Score:4.03|P-value:1.67E-5 ID:SGTC_3347|Compound:9188721|FD-Score:-3.10|P-value:7.58E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.82|P-value:4.20E-5

Top fitness defect scores for YMR170C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 8.72 51.8 µM 1.54E-19 ERAD & cell cycle 42 1.45E-18
2 SGTC_1161 k007-0610 5.56 110.0 µM 5.07E-9 ERAD & cell cycle 64 1.31E-8
3 SGTC_456 gingerol 5.20 170.0 µM 4.32E-8 6 9.99E-8
4 SGTC_2021 4019055 4.72 173.0 µM 5.78E-7 endomembrane recycling 74 1.16E-6
5 SGTC_848 0368-0089 4.48 85.6 µM 1.97E-6 iron homeostasis 4 3.72E-6
6 SGTC_359 0081-0058 4.40 15.9 µM 2.88E-6 60S ribosome export 30 5.33E-6
7 SGTC_2467 5474540 4.39 200.0 µM 3.04E-6 9 5.60E-6
8 SGTC_2322 7413319 4.39 38.2 µM 3.09E-6 ERAD & cell cycle 132 5.69E-6
9 SGTC_1718 roemerine 4.14 11.9 µM 9.87E-6 redox potentiating 49 1.71E-5
10 SGTC_3332 9141069 4.03 11.2 µM 1.67E-5 14 2.81E-5
11 SGTC_2340 7987427 3.96 183.4 µM 2.24E-5 33 3.72E-5
12 SGTC_568 1193-0097 3.95 7.5 µM 2.41E-5 ERAD & cell cycle 152 3.98E-5
13 SGTC_3354 9151612 3.82 71.4 µM 4.20E-5 13 6.74E-5
14 SGTC_1192 1488-0095 3.78 21.4 µM 4.96E-5 17 7.90E-5
15 SGTC_1285 0929-0069 3.73 65.5 µM 5.96E-5 24 9.40E-5
16 SGTC_1369 1866-0067 3.73 208.0 µM 5.97E-5 RPP1 & pyrimidine depletion 46 9.42E-5
17 SGTC_2302 7771753 3.66 200.0 µM 8.10E-5 53 1.26E-4
18 SGTC_988 1497-1057 3.65 103.0 µM 8.48E-5 17 1.31E-4
19 SGTC_85 0868-0259 3.59 160.1 µM 1.10E-4 60S ribosome export 18 1.68E-4
20 SGTC_813 k007-0158 3.44 173.0 µM 1.97E-4 fatty acid desaturase (OLE1) 67 2.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.314 7.60E-78 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.269 1.08E-56 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.216 1.08E-36 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.210 7.63E-35 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.209 1.80E-34 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.206 1.27E-33 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.199 2.77E-31 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.193 1.88E-29 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.180 1.03E-25 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.177 6.59E-25 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.176 1.21E-24 YDL122W UBP1 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
0.174 2.87E-24 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.173 6.99E-24 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.163 2.02E-21 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.161 5.82E-21 YNL127W FAR11 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2