YMR172C-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR172C-A / YMR172C-A

Click on Significant Values for Screen Details ID:SGTC_166|Compound:k072-0058|FD-Score:3.34|P-value:4.10E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.89|P-value:4.89E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.78|P-value:7.67E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-4.29|P-value:9.29E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:4.97|P-value:3.19E-7 ID:SGTC_389|Compound:tpck|FD-Score:3.41|P-value:3.10E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.14|P-value:1.71E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.17|P-value:7.53E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.39|P-value:3.42E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.93|P-value:3.92E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:3.33|P-value:4.18E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:5.98|P-value:1.06E-9 ID:SGTC_778|Compound:3456-2434|FD-Score:3.36|P-value:3.83E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.28|P-value:9.11E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.14|P-value:8.76E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.17|P-value:7.37E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.68|P-value:1.38E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.21|P-value:6.33E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.82|P-value:6.51E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.50|P-value:2.27E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.98|P-value:3.33E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.12|P-value:8.73E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.22|P-value:6.31E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.38|P-value:3.86E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-4.78|P-value:9.53E-7 ID:SGTC_1735|Compound:st034310|FD-Score:5.68|P-value:6.35E-9 ID:SGTC_1740|Compound:st038286|FD-Score:3.18|P-value:7.19E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.02|P-value:2.79E-5 ID:SGTC_1848|Compound:st056003|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-4.23|P-value:1.23E-5 ID:SGTC_1952|Compound:st077036|FD-Score:4.43|P-value:4.50E-6 ID:SGTC_1953|Compound:st076800|FD-Score:-3.40|P-value:3.51E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.42|P-value:4.75E-6 ID:SGTC_2057|Compound:5236571|FD-Score:3.13|P-value:8.46E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.36|P-value:4.10E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.26|P-value:9.67E-6 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.12|P-value:8.70E-4 ID:SGTC_2166|Compound:5933061|FD-Score:6.24|P-value:2.05E-10 ID:SGTC_2264|Compound:7948757|FD-Score:3.79|P-value:7.29E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.90|P-value:4.67E-7 ID:SGTC_2463|Compound:5473429|FD-Score:3.29|P-value:4.91E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.62|P-value:1.45E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.40|P-value:3.22E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.10|P-value:2.00E-5 ID:SGTC_2585|Compound:alliin|FD-Score:-3.37|P-value:3.87E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.36|P-value:4.07E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.16|P-value:7.60E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.40|P-value:3.26E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.72|P-value:9.53E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.22|P-value:6.14E-4 ID:SGTC_3135|Compound:9127742|FD-Score:5.33|P-value:4.81E-8 ID:SGTC_3147|Compound:9097027|FD-Score:4.07|P-value:2.26E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-3.55|P-value:2.03E-4 ID:SGTC_3160|Compound:9100216|FD-Score:-4.25|P-value:1.12E-5 ID:SGTC_3162|Compound:9099653|FD-Score:-3.30|P-value:5.07E-4 ID:SGTC_3175|Compound:9106517|FD-Score:5.65|P-value:7.91E-9 ID:SGTC_3214|Compound:9129694|FD-Score:-3.52|P-value:2.30E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.20|P-value:6.72E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.31|P-value:7.90E-6 ID:SGTC_3232|Compound:9132874|FD-Score:-3.82|P-value:7.08E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-3.28|P-value:5.50E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.44|P-value:2.81E-4 ID:SGTC_3319|Compound:9138450|FD-Score:7.37|P-value:8.35E-14 ID:SGTC_3322|Compound:9139058|FD-Score:3.21|P-value:6.48E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-4.22|P-value:1.31E-5 ID:SGTC_3349|Compound:9149703|FD-Score:3.26|P-value:5.44E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.34|P-value:4.10E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.89|P-value:4.89E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.78|P-value:7.67E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-4.29|P-value:9.29E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:4.97|P-value:3.19E-7 ID:SGTC_389|Compound:tpck|FD-Score:3.41|P-value:3.10E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.14|P-value:1.71E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.17|P-value:7.53E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.39|P-value:3.42E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.93|P-value:3.92E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:3.33|P-value:4.18E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:5.98|P-value:1.06E-9 ID:SGTC_778|Compound:3456-2434|FD-Score:3.36|P-value:3.83E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.28|P-value:9.11E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.14|P-value:8.76E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.17|P-value:7.37E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.68|P-value:1.38E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.21|P-value:6.33E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.82|P-value:6.51E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.50|P-value:2.27E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.98|P-value:3.33E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.12|P-value:8.73E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.22|P-value:6.31E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.38|P-value:3.86E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-4.78|P-value:9.53E-7 ID:SGTC_1735|Compound:st034310|FD-Score:5.68|P-value:6.35E-9 ID:SGTC_1740|Compound:st038286|FD-Score:3.18|P-value:7.19E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.02|P-value:2.79E-5 ID:SGTC_1848|Compound:st056003|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-4.23|P-value:1.23E-5 ID:SGTC_1952|Compound:st077036|FD-Score:4.43|P-value:4.50E-6 ID:SGTC_1953|Compound:st076800|FD-Score:-3.40|P-value:3.51E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.42|P-value:4.75E-6 ID:SGTC_2057|Compound:5236571|FD-Score:3.13|P-value:8.46E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.36|P-value:4.10E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.26|P-value:9.67E-6 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.12|P-value:8.70E-4 ID:SGTC_2166|Compound:5933061|FD-Score:6.24|P-value:2.05E-10 ID:SGTC_2264|Compound:7948757|FD-Score:3.79|P-value:7.29E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.90|P-value:4.67E-7 ID:SGTC_2463|Compound:5473429|FD-Score:3.29|P-value:4.91E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.62|P-value:1.45E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.40|P-value:3.22E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.10|P-value:2.00E-5 ID:SGTC_2585|Compound:alliin|FD-Score:-3.37|P-value:3.87E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.36|P-value:4.07E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.16|P-value:7.60E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.40|P-value:3.26E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.72|P-value:9.53E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.22|P-value:6.14E-4 ID:SGTC_3135|Compound:9127742|FD-Score:5.33|P-value:4.81E-8 ID:SGTC_3147|Compound:9097027|FD-Score:4.07|P-value:2.26E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-3.55|P-value:2.03E-4 ID:SGTC_3160|Compound:9100216|FD-Score:-4.25|P-value:1.12E-5 ID:SGTC_3162|Compound:9099653|FD-Score:-3.30|P-value:5.07E-4 ID:SGTC_3175|Compound:9106517|FD-Score:5.65|P-value:7.91E-9 ID:SGTC_3214|Compound:9129694|FD-Score:-3.52|P-value:2.30E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.20|P-value:6.72E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.31|P-value:7.90E-6 ID:SGTC_3232|Compound:9132874|FD-Score:-3.82|P-value:7.08E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-3.28|P-value:5.50E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.44|P-value:2.81E-4 ID:SGTC_3319|Compound:9138450|FD-Score:7.37|P-value:8.35E-14 ID:SGTC_3322|Compound:9139058|FD-Score:3.21|P-value:6.48E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-4.22|P-value:1.31E-5 ID:SGTC_3349|Compound:9149703|FD-Score:3.26|P-value:5.44E-4

Top fitness defect scores for YMR172C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3319 9138450 7.37 16.8 µM 8.35E-14 1 8.73E-14
2 SGTC_2166 5933061 6.24 31.5 µM 2.05E-10 tubulin folding & SWR complex 13 2.14E-10
3 SGTC_776 4476-4378 5.98 112.0 µM 1.06E-9 ERG2 7 1.10E-9
4 SGTC_1735 st034310 5.68 56.8 µM 6.35E-9 Golgi 5 6.62E-9
5 SGTC_3175 9106517 5.65 49.5 µM 7.91E-9 iron homeostasis 5 8.24E-9
6 SGTC_3135 9127742 5.33 49.5 µM 4.81E-8 6 5.00E-8
7 SGTC_386 1509-0011 4.97 3.1 µM 3.19E-7 109 3.32E-7
8 SGTC_670 4204-0025 4.93 119.0 µM 3.92E-7 copper-dependent oxidative stress 15 4.08E-7
9 SGTC_2417 cerulenin 4.90 830.0 nM 4.67E-7 11 4.85E-7
10 SGTC_1177 0983-0204 4.68 23.6 µM 1.38E-6 8 1.43E-6
11 SGTC_1952 st077036 4.43 64.1 µM 4.50E-6 21 4.67E-6
12 SGTC_1978 st071761 4.42 42.0 µM 4.75E-6 TSC3-RPN4 8 4.92E-6
13 SGTC_3222 9128301 4.31 49.5 µM 7.90E-6 60S ribosome export 19 8.19E-6
14 SGTC_792 4534-1957 4.28 155.0 µM 9.11E-6 24 9.44E-6
15 SGTC_2085 5307070 4.26 144.1 µM 9.67E-6 superoxide 21 1.00E-5
16 SGTC_391 gliotoxin 4.14 8.3 µM 1.71E-5 53 1.77E-5
17 SGTC_2562 3',7'-dimethoxyflavone 4.10 64.9 µM 2.00E-5 27 2.07E-5
18 SGTC_3147 9097027 4.07 49.5 µM 2.26E-5 20 2.33E-5
19 SGTC_1838 st055369 4.02 84.5 µM 2.79E-5 17 2.89E-5
20 SGTC_1409 3909-8004 3.98 61.9 µM 3.33E-5 18 3.44E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.05E-9 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.094 4.41E-8 YGR283C YGR283C hom Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus
0.094 5.60E-8 YLR427W MAG2 hom Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
0.091 1.40E-7 YPR128C ANT1 hom Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation
0.091 1.46E-7 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.087 5.07E-7 YNR034W SOL1 hom Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.085 8.00E-7 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.083 1.44E-6 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.082 1.82E-6 YBR194W AIM4 hom Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress
0.076 1.02E-5 YKR040C_d YKR040C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
0.076 1.21E-5 YMR150C IMP1 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.075 1.29E-5 YLR341W SPO77 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.075 1.31E-5 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.073 2.59E-5 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.072 3.15E-5 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20