YMR173W-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR173W-A / YMR173W-A

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:-3.54|P-value:3.17E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.27|P-value:2.31E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.77|P-value:1.60E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-4.37|P-value:1.28E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:4.58|P-value:6.08E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:5.15|P-value:4.27E-7 ID:SGTC_355|Compound:1311-2252|FD-Score:-6.01|P-value:3.67E-9 ID:SGTC_462|Compound:ag-879|FD-Score:3.72|P-value:1.92E-4 ID:SGTC_469|Compound:w7|FD-Score:-3.67|P-value:1.99E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.09|P-value:4.69E-5 ID:SGTC_480|Compound:am 92016|FD-Score:4.22|P-value:2.83E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.30|P-value:8.34E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.67|P-value:2.28E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.73|P-value:1.60E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:-4.40|P-value:1.14E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.67|P-value:4.00E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.44|P-value:4.44E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.33|P-value:7.55E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:5.13|P-value:4.80E-7 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.60|P-value:2.60E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:6.23|P-value:1.28E-9 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.43|P-value:1.15E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.47|P-value:9.66E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:3.96|P-value:7.86E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.39|P-value:6.09E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.51|P-value:4.05E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.82|P-value:1.35E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.52|P-value:3.38E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.27|P-value:9.15E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-3.96|P-value:6.66E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.58|P-value:3.22E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.31|P-value:8.01E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-4.33|P-value:1.52E-5 ID:SGTC_2002|Compound:4023503|FD-Score:7.62|P-value:1.56E-13 ID:SGTC_2012|Compound:4023501|FD-Score:4.09|P-value:4.66E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.67|P-value:2.30E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-3.28|P-value:7.69E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.34|P-value:7.24E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.49|P-value:4.33E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.87|P-value:1.11E-4 ID:SGTC_2708|Compound:st078559|FD-Score:-3.20|P-value:9.93E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.93|P-value:8.77E-5 ID:SGTC_2828|Compound:7998861|FD-Score:4.30|P-value:1.97E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.41|P-value:5.81E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.77|P-value:1.62E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.69|P-value:2.16E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.96|P-value:6.74E-5 ID:SGTC_3074|Compound:9116018|FD-Score:4.24|P-value:2.57E-5 ID:SGTC_3076|Compound:9116187|FD-Score:-3.29|P-value:7.51E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.41|P-value:5.71E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.34|P-value:7.22E-4 ID:SGTC_3295|Compound:9122362|FD-Score:5.00|P-value:8.70E-7 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.54|P-value:3.17E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.27|P-value:2.31E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.77|P-value:1.60E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-4.37|P-value:1.28E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:4.58|P-value:6.08E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:5.15|P-value:4.27E-7 ID:SGTC_355|Compound:1311-2252|FD-Score:-6.01|P-value:3.67E-9 ID:SGTC_462|Compound:ag-879|FD-Score:3.72|P-value:1.92E-4 ID:SGTC_469|Compound:w7|FD-Score:-3.67|P-value:1.99E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.09|P-value:4.69E-5 ID:SGTC_480|Compound:am 92016|FD-Score:4.22|P-value:2.83E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.30|P-value:8.34E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.67|P-value:2.28E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.73|P-value:1.60E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:-4.40|P-value:1.14E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.67|P-value:4.00E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.44|P-value:4.44E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.33|P-value:7.55E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:5.13|P-value:4.80E-7 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.60|P-value:2.60E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:6.23|P-value:1.28E-9 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.43|P-value:1.15E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.47|P-value:9.66E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:3.96|P-value:7.86E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.39|P-value:6.09E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.51|P-value:4.05E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.82|P-value:1.35E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.52|P-value:3.38E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.27|P-value:9.15E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-3.96|P-value:6.66E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.58|P-value:3.22E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.31|P-value:8.01E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-4.33|P-value:1.52E-5 ID:SGTC_2002|Compound:4023503|FD-Score:7.62|P-value:1.56E-13 ID:SGTC_2012|Compound:4023501|FD-Score:4.09|P-value:4.66E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.67|P-value:2.30E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-3.28|P-value:7.69E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.34|P-value:7.24E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.49|P-value:4.33E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.87|P-value:1.11E-4 ID:SGTC_2708|Compound:st078559|FD-Score:-3.20|P-value:9.93E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.93|P-value:8.77E-5 ID:SGTC_2828|Compound:7998861|FD-Score:4.30|P-value:1.97E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.41|P-value:5.81E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.77|P-value:1.62E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.69|P-value:2.16E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.96|P-value:6.74E-5 ID:SGTC_3074|Compound:9116018|FD-Score:4.24|P-value:2.57E-5 ID:SGTC_3076|Compound:9116187|FD-Score:-3.29|P-value:7.51E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.41|P-value:5.71E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.34|P-value:7.22E-4 ID:SGTC_3295|Compound:9122362|FD-Score:5.00|P-value:8.70E-7

Top fitness defect scores for YMR173W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2002 4023503 7.62 131.0 µM 1.56E-13 mitochondrial processes 3 1.29E-14
2 SGTC_982 1491-0518 6.23 27.5 µM 1.28E-9 1 2.34E-10
3 SGTC_350 k064-0020 5.15 19.8 µM 4.27E-7 heme requiring 10 1.29E-7
4 SGTC_971 1315-0384 5.13 26.7 µM 4.80E-7 cell wall signaling 5 1.47E-7
5 SGTC_3295 9122362 5.00 53.6 µM 8.70E-7 3 2.80E-7
6 SGTC_609 0986-0026 4.67 86.3 µM 4.00E-6 calcium & mitochondrial duress 17 1.47E-6
7 SGTC_346 4513-0042 4.58 7.2 µM 6.08E-6 azole & statin 25 2.32E-6
8 SGTC_1049 3226-0134 4.47 66.0 µM 9.66E-6 19 3.84E-6
9 SGTC_1045 1348-1485 4.43 165.0 µM 1.15E-5 16 4.64E-6
10 SGTC_2828 7998861 4.30 71.4 µM 1.97E-5 10 8.35E-6
11 SGTC_158 k038-0087 4.27 26.4 µM 2.31E-5 ubiquinone biosynthesis & proteasome 121 9.89E-6
12 SGTC_3074 9116018 4.24 49.5 µM 2.57E-5 RNA processing & uracil transport 15 1.11E-5
13 SGTC_480 am 92016 4.22 50.0 µM 2.83E-5 9 1.24E-5
14 SGTC_2012 4023501 4.09 200.0 µM 4.66E-5 26 2.12E-5
15 SGTC_471 1-acyl-paf 4.09 4.0 µM 4.69E-5 DNA intercalators 29 2.14E-5
16 SGTC_1074 carmofur 3.96 3.8 µM 7.86E-5 exosome 20 3.75E-5
17 SGTC_2762 leflunomide 3.93 42.1 µM 8.77E-5 29 4.23E-5
18 SGTC_2698 st077697 3.87 67.5 µM 1.11E-4 18 5.46E-5
19 SGTC_1451 4152-0210 3.82 104.0 µM 1.35E-4 32 6.76E-5
20 SGTC_165 k038-0023 3.77 64.4 µM 1.60E-4 ubiquinone biosynthesis & proteasome 89 8.13E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 5.34E-14 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.115 2.54E-11 YBR211C AME1 het Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress
0.103 2.00E-9 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.090 1.70E-7 YKL218C SRY1 hom 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity
0.090 1.95E-7 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.081 2.52E-6 YNL009W IDP3 hom Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication
0.079 4.21E-6 YJR107W_p YJR107W_p hom Putative lipase
0.075 1.22E-5 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.074 1.63E-5 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.074 2.02E-5 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.073 2.40E-5 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
0.073 2.46E-5 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.072 3.35E-5 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.071 4.36E-5 YJL055W_p YJL055W_p hom Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU
0.069 6.84E-5 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data