YMR174C / PAI3

Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR174C / PAI3

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:-3.41|P-value:1.92E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.34|P-value:2.43E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.70|P-value:5.46E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:3.45|P-value:1.57E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.50|P-value:1.27E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.75|P-value:4.61E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.56|P-value:9.76E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.74|P-value:4.65E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.95|P-value:1.79E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:3.32|P-value:2.64E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.15|P-value:5.00E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.75|P-value:4.50E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.13|P-value:5.56E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.43|P-value:1.66E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.48|P-value:1.38E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:5.22|P-value:2.43E-8 ID:SGTC_998|Compound:3996-0085|FD-Score:3.81|P-value:3.38E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.88|P-value:2.46E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.19|P-value:5.86E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:-2.97|P-value:9.66E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-4.31|P-value:3.45E-6 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.79|P-value:3.76E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.91|P-value:2.14E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:4.06|P-value:1.09E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.16|P-value:4.71E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:6.14|P-value:7.20E-11 ID:SGTC_1843|Compound:st055809|FD-Score:3.37|P-value:2.10E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.09|P-value:6.08E-4 ID:SGTC_1984|Compound:st072354|FD-Score:4.26|P-value:4.30E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.75|P-value:4.34E-5 ID:SGTC_1998|Compound:st075797|FD-Score:3.00|P-value:8.56E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.13|P-value:5.57E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.02|P-value:7.86E-4 ID:SGTC_2150|Compound:5556613|FD-Score:4.05|P-value:1.13E-5 ID:SGTC_2151|Compound:5563267|FD-Score:7.64|P-value:7.35E-16 ID:SGTC_2153|Compound:5569715|FD-Score:3.51|P-value:1.19E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.90|P-value:2.31E-5 ID:SGTC_2200|Compound:6600604|FD-Score:2.96|P-value:9.76E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.34|P-value:2.92E-6 ID:SGTC_2309|Compound:7664088|FD-Score:3.63|P-value:7.37E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.07|P-value:6.70E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.36|P-value:2.62E-6 ID:SGTC_2401|Compound:5128683|FD-Score:-2.97|P-value:9.62E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.92|P-value:2.12E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.63|P-value:7.77E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.58|P-value:9.48E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.20|P-value:4.09E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.21|P-value:3.89E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.47|P-value:1.43E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.08|P-value:6.46E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.14|P-value:5.27E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.26|P-value:3.27E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.76|P-value:4.40E-5 ID:SGTC_3295|Compound:9122362|FD-Score:-3.42|P-value:1.84E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.41|P-value:1.92E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.34|P-value:2.43E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.70|P-value:5.46E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:3.45|P-value:1.57E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.50|P-value:1.27E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.75|P-value:4.61E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.56|P-value:9.76E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.74|P-value:4.65E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.95|P-value:1.79E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:3.32|P-value:2.64E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.15|P-value:5.00E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.75|P-value:4.50E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.13|P-value:5.56E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.43|P-value:1.66E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.48|P-value:1.38E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:5.22|P-value:2.43E-8 ID:SGTC_998|Compound:3996-0085|FD-Score:3.81|P-value:3.38E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.88|P-value:2.46E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.19|P-value:5.86E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:-2.97|P-value:9.66E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-4.31|P-value:3.45E-6 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.79|P-value:3.76E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.91|P-value:2.14E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:4.06|P-value:1.09E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.16|P-value:4.71E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:6.14|P-value:7.20E-11 ID:SGTC_1843|Compound:st055809|FD-Score:3.37|P-value:2.10E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.09|P-value:6.08E-4 ID:SGTC_1984|Compound:st072354|FD-Score:4.26|P-value:4.30E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.75|P-value:4.34E-5 ID:SGTC_1998|Compound:st075797|FD-Score:3.00|P-value:8.56E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.13|P-value:5.57E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.02|P-value:7.86E-4 ID:SGTC_2150|Compound:5556613|FD-Score:4.05|P-value:1.13E-5 ID:SGTC_2151|Compound:5563267|FD-Score:7.64|P-value:7.35E-16 ID:SGTC_2153|Compound:5569715|FD-Score:3.51|P-value:1.19E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.90|P-value:2.31E-5 ID:SGTC_2200|Compound:6600604|FD-Score:2.96|P-value:9.76E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.34|P-value:2.92E-6 ID:SGTC_2309|Compound:7664088|FD-Score:3.63|P-value:7.37E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.07|P-value:6.70E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.36|P-value:2.62E-6 ID:SGTC_2401|Compound:5128683|FD-Score:-2.97|P-value:9.62E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.92|P-value:2.12E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.63|P-value:7.77E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.58|P-value:9.48E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.20|P-value:4.09E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.21|P-value:3.89E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.47|P-value:1.43E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.08|P-value:6.46E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.14|P-value:5.27E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.26|P-value:3.27E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.76|P-value:4.40E-5 ID:SGTC_3295|Compound:9122362|FD-Score:-3.42|P-value:1.84E-4

Top fitness defect scores for YMR174C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2151 5563267 7.64 85.4 µM 7.35E-16 4 1.11E-14
2 SGTC_1449 4112-4002 6.14 201.0 µM 7.20E-11 RPP1 & pyrimidine depletion 5 4.25E-10
3 SGTC_938 3126-1755 5.22 342.0 µM 2.43E-8 4 8.92E-8
4 SGTC_2348 9022543 4.36 33.4 µM 2.62E-6 mitochondrial processes 18 6.59E-6
5 SGTC_2268 7933382 4.34 153.8 µM 2.92E-6 29 7.28E-6
6 SGTC_1984 st072354 4.26 53.1 µM 4.30E-6 10 1.04E-5
7 SGTC_1311 1190-0148 4.19 100.0 µM 5.86E-6 azole & statin 24 1.38E-5
8 SGTC_1372 2752-0194 4.06 270.0 µM 1.09E-5 15 2.45E-5
9 SGTC_2150 5556613 4.05 200.0 µM 1.13E-5 19 2.53E-5
10 SGTC_548 1436-0017 3.95 110.0 µM 1.79E-5 TSC3-RPN4 36 3.86E-5
11 SGTC_2408 sulbentine 3.92 18.4 µM 2.12E-5 51 4.51E-5
12 SGTC_1344 1488-0097 3.91 29.1 µM 2.14E-5 17 4.53E-5
13 SGTC_2160 5660466 3.90 132.9 µM 2.31E-5 60S ribosome export 16 4.86E-5
14 SGTC_1132 3456-3614 3.88 2.5 µM 2.46E-5 tubulin folding & SWR complex 50 5.15E-5
15 SGTC_998 3996-0085 3.81 177.0 µM 3.38E-5 25 6.91E-5
16 SGTC_1325 1431-0015 3.79 227.0 µM 3.76E-5 Golgi 22 7.63E-5
17 SGTC_1987 st072290 3.75 61.9 µM 4.34E-5 18 8.70E-5
18 SGTC_848 0368-0089 3.75 85.6 µM 4.50E-5 iron homeostasis 17 8.99E-5
19 SGTC_531 3788-1495 3.74 174.0 µM 4.65E-5 unfolded protein response 24 9.27E-5
20 SGTC_132 0417-1715 3.70 25.8 µM 5.46E-5 RPP1 & pyrimidine depletion 30 1.08E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.36E-17 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.146 1.78E-17 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.124 6.02E-13 YPR086W SUA7 het Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
0.101 4.94E-9 YBL091C MAP2 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p
0.100 7.19E-9 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.091 1.33E-7 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.091 1.42E-7 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.089 2.34E-7 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.089 2.72E-7 YOR257W CDC31 het Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
0.087 3.88E-7 YBR270C_p BIT2_p hom Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication
0.087 4.42E-7 YML122C_d YML122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.084 1.08E-6 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.084 1.23E-6 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.084 1.26E-6 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.082 2.14E-6 YEL015W EDC3 hom Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress