YMR175W / SIP18

Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR175W / SIP18

Click on Significant Values for Screen Details ID:SGTC_342|Compound:k048-0088|FD-Score:3.20|P-value:2.24E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.89|P-value:7.60E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.41|P-value:9.17E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.82|P-value:1.44E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.64|P-value:3.30E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:2.94|P-value:6.37E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.22|P-value:2.11E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.44|P-value:8.04E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.01|P-value:4.86E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.54|P-value:5.76E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.00|P-value:5.08E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.51|P-value:6.07E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.24|P-value:1.96E-4 ID:SGTC_1608|Compound:st001473|FD-Score:2.96|P-value:5.95E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.67|P-value:3.23E-5 ID:SGTC_1704|Compound:st028805|FD-Score:-2.91|P-value:7.63E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.41|P-value:9.18E-5 ID:SGTC_1895|Compound:st058434|FD-Score:2.89|P-value:7.60E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.33|P-value:1.35E-4 ID:SGTC_2299|Compound:7976368|FD-Score:2.97|P-value:5.58E-4 ID:SGTC_2307|Compound:7538926|FD-Score:2.85|P-value:8.88E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.55|P-value:5.62E-5 ID:SGTC_2413|Compound:inermin|FD-Score:-5.43|P-value:1.67E-9 ID:SGTC_2416|Compound:tofa|FD-Score:-4.39|P-value:8.82E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.06|P-value:4.40E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.99|P-value:2.75E-8 ID:SGTC_2465|Compound:5809242|FD-Score:2.91|P-value:7.21E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.15|P-value:3.04E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:2.99|P-value:5.26E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.25|P-value:1.63E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.23|P-value:2.16E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.73|P-value:1.14E-7 ID:SGTC_2823|Compound:7987624|FD-Score:3.06|P-value:4.02E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.16|P-value:2.91E-6 ID:SGTC_2832|Compound:7992762|FD-Score:3.83|P-value:1.36E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.42|P-value:8.99E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-3.07|P-value:4.17E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.50|P-value:6.31E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.02|P-value:4.67E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.53|P-value:5.44E-5 ID:SGTC_3100|Compound:9120536|FD-Score:3.91|P-value:9.40E-6 ID:SGTC_3113|Compound:9123498|FD-Score:-3.44|P-value:8.84E-5 ID:SGTC_3165|Compound:9101544|FD-Score:2.98|P-value:5.55E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.51|P-value:6.70E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.20|P-value:2.24E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.89|P-value:7.60E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.41|P-value:9.17E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.82|P-value:1.44E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.64|P-value:3.30E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:2.94|P-value:6.37E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.22|P-value:2.11E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.44|P-value:8.04E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.01|P-value:4.86E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.54|P-value:5.76E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.00|P-value:5.08E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.51|P-value:6.07E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.24|P-value:1.96E-4 ID:SGTC_1608|Compound:st001473|FD-Score:2.96|P-value:5.95E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.67|P-value:3.23E-5 ID:SGTC_1704|Compound:st028805|FD-Score:-2.91|P-value:7.63E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.41|P-value:9.18E-5 ID:SGTC_1895|Compound:st058434|FD-Score:2.89|P-value:7.60E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.33|P-value:1.35E-4 ID:SGTC_2299|Compound:7976368|FD-Score:2.97|P-value:5.58E-4 ID:SGTC_2307|Compound:7538926|FD-Score:2.85|P-value:8.88E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.55|P-value:5.62E-5 ID:SGTC_2413|Compound:inermin|FD-Score:-5.43|P-value:1.67E-9 ID:SGTC_2416|Compound:tofa|FD-Score:-4.39|P-value:8.82E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.06|P-value:4.40E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.99|P-value:2.75E-8 ID:SGTC_2465|Compound:5809242|FD-Score:2.91|P-value:7.21E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.15|P-value:3.04E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:2.99|P-value:5.26E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.25|P-value:1.63E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.23|P-value:2.16E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.73|P-value:1.14E-7 ID:SGTC_2823|Compound:7987624|FD-Score:3.06|P-value:4.02E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.16|P-value:2.91E-6 ID:SGTC_2832|Compound:7992762|FD-Score:3.83|P-value:1.36E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.42|P-value:8.99E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-3.07|P-value:4.17E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.50|P-value:6.31E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.02|P-value:4.67E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.53|P-value:5.44E-5 ID:SGTC_3100|Compound:9120536|FD-Score:3.91|P-value:9.40E-6 ID:SGTC_3113|Compound:9123498|FD-Score:-3.44|P-value:8.84E-5 ID:SGTC_3165|Compound:9101544|FD-Score:2.98|P-value:5.55E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.51|P-value:6.70E-5

Top fitness defect scores for YMR175W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2804 7954240 4.73 19.5 µM 1.14E-7 15 1.14E-6
2 SGTC_2767 sibutramine 4.25 71.5 µM 1.63E-6 16 1.06E-5
3 SGTC_2418 pentamidine 4.06 31.7 µM 4.40E-6 mitochondrial processes 38 2.46E-5
4 SGTC_3100 9120536 3.91 49.5 µM 9.40E-6 16 4.67E-5
5 SGTC_2832 7992762 3.83 52.0 µM 1.36E-5 34 6.39E-5
6 SGTC_1013 4112-3890 3.82 241.0 µM 1.44E-5 TSC3-RPN4 35 6.68E-5
7 SGTC_1153 4055-0057 3.64 267.0 µM 3.30E-5 36 1.35E-4
8 SGTC_3045 9092950 3.53 49.5 µM 5.44E-5 27 2.05E-4
9 SGTC_1557 sumaresinolic acid 3.51 42.3 µM 6.07E-5 30 2.25E-4
10 SGTC_2963 9082507 3.50 9.0 µM 6.31E-5 40 2.33E-4
11 SGTC_1357 1503-1303 3.44 39.5 µM 8.04E-5 53 2.86E-4
12 SGTC_2857 9024691 3.42 58.4 µM 8.99E-5 39 3.14E-4
13 SGTC_737 1950-0117 3.41 57.9 µM 9.17E-5 37 3.19E-4
14 SGTC_1712 st032288 3.41 53.4 µM 9.18E-5 calcium & mitochondrial duress 223 3.19E-4
15 SGTC_2001 4023502 3.33 57.7 µM 1.35E-4 mitochondrial processes 39 4.42E-4
16 SGTC_1592 4',5'-dihydroxyflavone 3.24 8.8 µM 1.96E-4 60S ribosome export 37 6.05E-4
17 SGTC_1211 1056-0033 3.22 32.3 µM 2.11E-4 24 6.45E-4
18 SGTC_342 k048-0088 3.20 23.3 µM 2.24E-4 RSC & ERG11 42 6.79E-4
19 SGTC_2823 7987624 3.06 58.4 µM 4.02E-4 86 0.00111
20 SGTC_2964 9083345 3.02 53.4 µM 4.67E-4 60 0.00126

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 2.69E-28 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.125 4.35E-13 YGL247W BRR6 het Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism
0.097 1.78E-8 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.094 5.16E-8 YDL127W PCL2 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth
0.091 1.27E-7 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.090 1.77E-7 YMR086C-A_d YMR086C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 2.01E-7 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.089 2.37E-7 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.087 5.22E-7 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
0.084 9.76E-7 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.083 1.57E-6 YLR005W SSL1 het Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
0.081 2.86E-6 YNL203C_d YNL203C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 6.37E-6 YMR065W KAR5 hom Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone
0.078 6.99E-6 YDL046W NPC2 hom Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
0.077 8.88E-6 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p