YMR175W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR175W-A / YMR175W-A

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.15|P-value:6.38E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.73|P-value:7.24E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.14|P-value:6.66E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.33|P-value:5.32E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:3.89|P-value:3.63E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.32|P-value:3.48E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.77|P-value:6.00E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.55|P-value:1.46E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.17|P-value:5.90E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.62|P-value:1.29E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:3.04|P-value:9.48E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-5.74|P-value:5.54E-9 ID:SGTC_892|Compound:0929-0076|FD-Score:6.35|P-value:6.03E-11 ID:SGTC_896|Compound:0964-0007|FD-Score:-4.88|P-value:6.31E-7 ID:SGTC_904|Compound:1141-0088|FD-Score:6.87|P-value:1.70E-12 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.31|P-value:5.43E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.33|P-value:3.38E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.06|P-value:2.90E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.78|P-value:5.87E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.59|P-value:1.52E-6 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.58|P-value:1.32E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.40|P-value:2.62E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.05|P-value:9.05E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.64|P-value:1.56E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.49|P-value:1.87E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.89|P-value:3.66E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.21|P-value:5.12E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.81|P-value:5.17E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.07|P-value:8.40E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.88|P-value:6.06E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.05|P-value:8.91E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.54|P-value:2.27E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.79|P-value:8.60E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-5.83|P-value:3.28E-9 ID:SGTC_1849|Compound:st056239|FD-Score:4.80|P-value:5.26E-7 ID:SGTC_1910|Compound:st062352|FD-Score:4.74|P-value:7.08E-7 ID:SGTC_2288|Compound:7946289|FD-Score:3.49|P-value:1.84E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.45|P-value:2.18E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.03|P-value:9.61E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.25|P-value:6.61E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.47|P-value:1.96E-4 ID:SGTC_2886|Compound:9058944|FD-Score:3.26|P-value:4.38E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.71|P-value:7.73E-5 ID:SGTC_2899|Compound:9053889|FD-Score:3.86|P-value:4.13E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:3.15|P-value:6.38E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.73|P-value:7.24E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.14|P-value:6.66E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.33|P-value:5.32E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:3.89|P-value:3.63E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.32|P-value:3.48E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.77|P-value:6.00E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.55|P-value:1.46E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.17|P-value:5.90E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.62|P-value:1.29E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:3.04|P-value:9.48E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-5.74|P-value:5.54E-9 ID:SGTC_892|Compound:0929-0076|FD-Score:6.35|P-value:6.03E-11 ID:SGTC_896|Compound:0964-0007|FD-Score:-4.88|P-value:6.31E-7 ID:SGTC_904|Compound:1141-0088|FD-Score:6.87|P-value:1.70E-12 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.31|P-value:5.43E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.33|P-value:3.38E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.06|P-value:2.90E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.78|P-value:5.87E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.59|P-value:1.52E-6 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.58|P-value:1.32E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.40|P-value:2.62E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.05|P-value:9.05E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.64|P-value:1.56E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.49|P-value:1.87E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.89|P-value:3.66E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.21|P-value:5.12E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.81|P-value:5.17E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.07|P-value:8.40E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.88|P-value:6.06E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.05|P-value:8.91E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.54|P-value:2.27E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.79|P-value:8.60E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-5.83|P-value:3.28E-9 ID:SGTC_1849|Compound:st056239|FD-Score:4.80|P-value:5.26E-7 ID:SGTC_1910|Compound:st062352|FD-Score:4.74|P-value:7.08E-7 ID:SGTC_2288|Compound:7946289|FD-Score:3.49|P-value:1.84E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.45|P-value:2.18E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.03|P-value:9.61E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.25|P-value:6.61E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.47|P-value:1.96E-4 ID:SGTC_2886|Compound:9058944|FD-Score:3.26|P-value:4.38E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.71|P-value:7.73E-5 ID:SGTC_2899|Compound:9053889|FD-Score:3.86|P-value:4.13E-5

Top fitness defect scores for YMR175W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_904 1141-0088 6.87 396.0 µM 1.70E-12 1 3.16E-12
2 SGTC_892 0929-0076 6.35 29.0 µM 6.03E-11 TRP & mitochondrial translation 6 1.06E-10
3 SGTC_1849 st056239 4.80 19.2 µM 5.26E-7 RPP1 & pyrimidine depletion 9 7.80E-7
4 SGTC_1910 st062352 4.74 60.4 µM 7.08E-7 15 1.04E-6
5 SGTC_744 1594-0068 4.62 283.0 µM 1.29E-6 amide catabolism 15 1.88E-6
6 SGTC_1012 4112-3522 4.59 18.0 µM 1.52E-6 14 2.20E-6
7 SGTC_135 0933-0004 4.33 26.4 µM 5.32E-6 60S ribosome export 14 7.53E-6
8 SGTC_236 1509-0011 3.89 5.3 µM 3.63E-5 387 4.94E-5
9 SGTC_1339 1486-1321 3.89 22.7 µM 3.66E-5 ERG2 25 4.97E-5
10 SGTC_2899 9053889 3.86 58.4 µM 4.13E-5 12 5.60E-5
11 SGTC_1446 4239-0190 3.81 62.0 µM 5.17E-5 43 6.98E-5
12 SGTC_968 1309-0633 3.78 340.0 µM 5.87E-5 17 7.90E-5
13 SGTC_440 fluspirilene 3.77 35.1 µM 6.00E-5 17 8.07E-5
14 SGTC_122 0236-0016 3.73 402.4 µM 7.24E-5 RNA processing & uracil transport 38 9.70E-5
15 SGTC_2894 9048625 3.71 32.5 µM 7.73E-5 16 1.03E-4
16 SGTC_1041 0206-0046 3.58 107.0 µM 1.32E-4 43 1.74E-4
17 SGTC_446 go6976 3.55 132.0 µM 1.46E-4 19 1.93E-4
18 SGTC_2288 7946289 3.49 167.3 µM 1.84E-4 43 2.41E-4
19 SGTC_1281 0884-0031 3.49 11.8 µM 1.87E-4 fatty acid desaturase (OLE1) 35 2.45E-4
20 SGTC_2884 9058502 3.47 52.0 µM 1.96E-4 41 2.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 8.16E-15 YGR174C CBP4 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex
0.133 1.14E-14 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.129 6.00E-14 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.114 3.42E-11 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.113 4.45E-11 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.112 7.05E-11 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.111 1.30E-10 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.110 1.66E-10 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.107 5.32E-10 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.106 8.22E-10 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.105 9.78E-10 YDR529C QCR7 hom Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
0.105 1.11E-9 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.105 1.16E-9 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.102 3.39E-9 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.102 3.52E-9 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p