YMR182C / RGM1

Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR182C / RGM1

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.35|P-value:3.12E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.54|P-value:1.54E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.15|P-value:6.52E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.07|P-value:1.68E-5 ID:SGTC_237|Compound:nikkomycin|FD-Score:-3.05|P-value:9.39E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-3.64|P-value:1.00E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.24|P-value:4.84E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.71|P-value:7.61E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.40|P-value:2.62E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.28|P-value:4.16E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.36|P-value:3.12E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.69|P-value:8.48E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:3.84|P-value:4.52E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:3.05|P-value:9.41E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:4.39|P-value:3.73E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:3.06|P-value:8.95E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.92|P-value:7.60E-10 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.07|P-value:8.76E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.66|P-value:9.66E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.36|P-value:3.02E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.20|P-value:5.40E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.19|P-value:5.71E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.39|P-value:2.73E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-8.51|P-value:1.90E-18 ID:SGTC_1729|Compound:st035615|FD-Score:3.50|P-value:1.80E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.47|P-value:2.58E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-3.41|P-value:2.48E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.41|P-value:3.40E-6 ID:SGTC_1776|Compound:st049249|FD-Score:3.15|P-value:6.63E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.59|P-value:1.28E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.16|P-value:6.25E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-4.54|P-value:1.84E-6 ID:SGTC_2186|Compound:6124449|FD-Score:3.04|P-value:9.61E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.20|P-value:5.44E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.06|P-value:8.93E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.53|P-value:1.60E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.24|P-value:7.68E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:6.00|P-value:4.84E-10 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.36|P-value:3.04E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.17|P-value:1.04E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.74|P-value:6.91E-5 ID:SGTC_2826|Compound:7992541|FD-Score:-3.05|P-value:9.36E-4 ID:SGTC_3071|Compound:9117417|FD-Score:5.28|P-value:3.57E-8 ID:SGTC_24|Compound:0417-1663|FD-Score:3.35|P-value:3.12E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.54|P-value:1.54E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.15|P-value:6.52E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.07|P-value:1.68E-5 ID:SGTC_237|Compound:nikkomycin|FD-Score:-3.05|P-value:9.39E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-3.64|P-value:1.00E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.24|P-value:4.84E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.71|P-value:7.61E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.40|P-value:2.62E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.28|P-value:4.16E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.36|P-value:3.12E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.69|P-value:8.48E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:3.84|P-value:4.52E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:3.05|P-value:9.41E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:4.39|P-value:3.73E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:3.06|P-value:8.95E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.92|P-value:7.60E-10 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.07|P-value:8.76E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.66|P-value:9.66E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.36|P-value:3.02E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.20|P-value:5.40E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.19|P-value:5.71E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.39|P-value:2.73E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-8.51|P-value:1.90E-18 ID:SGTC_1729|Compound:st035615|FD-Score:3.50|P-value:1.80E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.47|P-value:2.58E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-3.41|P-value:2.48E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.41|P-value:3.40E-6 ID:SGTC_1776|Compound:st049249|FD-Score:3.15|P-value:6.63E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.59|P-value:1.28E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.16|P-value:6.25E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-4.54|P-value:1.84E-6 ID:SGTC_2186|Compound:6124449|FD-Score:3.04|P-value:9.61E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.20|P-value:5.44E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.06|P-value:8.93E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.53|P-value:1.60E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.24|P-value:7.68E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:6.00|P-value:4.84E-10 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.36|P-value:3.04E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.17|P-value:1.04E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.74|P-value:6.91E-5 ID:SGTC_2826|Compound:7992541|FD-Score:-3.05|P-value:9.36E-4 ID:SGTC_3071|Compound:9117417|FD-Score:5.28|P-value:3.57E-8

Top fitness defect scores for YMR182C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2557 derrustone 6.00 83.8 µM 4.84E-10 6 1.02E-9
2 SGTC_1203 3992-3522 5.92 103.0 µM 7.60E-10 6 1.57E-9
3 SGTC_3071 9117417 5.28 49.5 µM 3.57E-8 fatty acid desaturase (OLE1) 7 6.37E-8
4 SGTC_1730 st033808 4.47 45.1 µM 2.58E-6 21 3.91E-6
5 SGTC_1755 st041960 4.41 45.2 µM 3.40E-6 15 5.11E-6
6 SGTC_728 3030-5151 4.39 22.5 µM 3.73E-6 10 5.59E-6
7 SGTC_2550 chrysin dimethyl ether 4.24 71.9 µM 7.68E-6 7 1.12E-5
8 SGTC_2601 securinine 4.17 100.0 µM 1.04E-5 26 1.50E-5
9 SGTC_142 0335-0849 4.07 62.7 µM 1.68E-5 ubiquinone biosynthesis & proteasome 120 2.38E-5
10 SGTC_590 k048-0076 3.84 22.4 µM 4.52E-5 RSC & ERG11 13 6.17E-5
11 SGTC_2766 oltipraz 3.74 83.9 µM 6.91E-5 heme requiring 32 9.29E-5
12 SGTC_454 lyso-paf C-16 3.69 6.7 µM 8.48E-5 25 1.13E-4
13 SGTC_1296 1068-0102 3.66 11.9 µM 9.66E-5 13 1.28E-4
14 SGTC_1970 st070122 3.59 35.8 µM 1.28E-4 TSC3-RPN4 36 1.68E-4
15 SGTC_55 0767-0285 3.54 6.6 µM 1.54E-4 55 2.01E-4
16 SGTC_2518 prenyletin 3.53 46.3 µM 1.60E-4 16 2.08E-4
17 SGTC_1729 st035615 3.50 46.0 µM 1.80E-4 50 2.33E-4
18 SGTC_1538 2',3',6-trimethoxyflavanone 3.39 63.6 µM 2.73E-4 27 3.49E-4
19 SGTC_2593 nobiletin 3.36 86.2 µM 3.04E-4 49 3.87E-4
20 SGTC_419 nsc-638432 3.36 893.0 µM 3.12E-4 DNA damage response 28 3.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.46E-20 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.143 9.52E-17 YOL064C MET22 hom Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway
0.120 3.09E-12 YMR196W_p YMR196W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
0.107 4.90E-10 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.107 5.27E-10 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.105 1.03E-9 YBR175W SWD3 hom Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
0.097 1.92E-8 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.096 2.36E-8 YHR077C NMD2 hom Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
0.095 4.10E-8 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.094 4.64E-8 YHR106W TRR2 hom Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication
0.094 5.01E-8 YOR052C YOR052C hom Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress
0.093 7.53E-8 YJR140C HIR3 hom Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein
0.092 9.41E-8 YKL032C IXR1 hom Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
0.090 2.00E-7 YNL175C NOP13 hom Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress
0.089 2.10E-7 YKR041W YKR041W hom Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking