YMR189W / GCV2

P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR189W / GCV2

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:2.88|P-value:6.36E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:2.81|P-value:8.33E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-2.91|P-value:6.67E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.40|P-value:7.02E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.64|P-value:2.85E-5 ID:SGTC_472|Compound:calcifediol|FD-Score:3.04|P-value:3.32E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.25|P-value:1.39E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.64|P-value:1.11E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:3.04|P-value:3.31E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.14|P-value:1.82E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:5.19|P-value:3.53E-9 ID:SGTC_914|Compound:3820-6779|FD-Score:3.83|P-value:9.22E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.71|P-value:2.06E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.66|P-value:9.69E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.21|P-value:1.66E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.20|P-value:1.70E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.06|P-value:3.05E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.06|P-value:3.09E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.95|P-value:5.77E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.13|P-value:2.31E-4 ID:SGTC_1647|Compound:st011722|FD-Score:-3.38|P-value:9.40E-5 ID:SGTC_1651|Compound:st011928|FD-Score:-2.99|P-value:4.93E-4 ID:SGTC_1671|Compound:st016596|FD-Score:-3.28|P-value:1.48E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.68|P-value:8.68E-8 ID:SGTC_1774|Compound:st048371|FD-Score:3.05|P-value:3.16E-4 ID:SGTC_1826|Compound:st055655|FD-Score:2.86|P-value:6.87E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.01|P-value:3.69E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.34|P-value:6.22E-7 ID:SGTC_1882|Compound:5615643|FD-Score:2.85|P-value:7.10E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-2.94|P-value:5.83E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.80|P-value:1.36E-5 ID:SGTC_2127|Compound:5253358|FD-Score:2.92|P-value:5.36E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.83|P-value:9.22E-6 ID:SGTC_2242|Compound:6630449|FD-Score:-3.04|P-value:4.01E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.16|P-value:1.69E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.66|P-value:9.92E-8 ID:SGTC_2431|Compound:5490079|FD-Score:4.45|P-value:3.31E-7 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.00|P-value:4.69E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.18|P-value:2.29E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.27|P-value:1.25E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.41|P-value:6.94E-5 ID:SGTC_2625|Compound:euphol|FD-Score:-2.87|P-value:7.72E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.14|P-value:2.63E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.28|P-value:1.20E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.28|P-value:8.88E-7 ID:SGTC_2928|Compound:9011484|FD-Score:3.34|P-value:9.24E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.29|P-value:1.19E-4 ID:SGTC_3015|Compound:9080845|FD-Score:2.82|P-value:7.94E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.34|P-value:9.38E-5 ID:SGTC_3198|Compound:9112019|FD-Score:-2.96|P-value:5.53E-4 ID:SGTC_3228|Compound:9131799|FD-Score:-3.19|P-value:2.14E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.18|P-value:1.84E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.24|P-value:1.46E-4 ID:SGTC_3261|Compound:9137475|FD-Score:3.10|P-value:2.64E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:2.88|P-value:6.36E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:2.81|P-value:8.33E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-2.91|P-value:6.67E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.40|P-value:7.02E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.64|P-value:2.85E-5 ID:SGTC_472|Compound:calcifediol|FD-Score:3.04|P-value:3.32E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.25|P-value:1.39E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.64|P-value:1.11E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:3.04|P-value:3.31E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.14|P-value:1.82E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:5.19|P-value:3.53E-9 ID:SGTC_914|Compound:3820-6779|FD-Score:3.83|P-value:9.22E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.71|P-value:2.06E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.66|P-value:9.69E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.21|P-value:1.66E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.20|P-value:1.70E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.06|P-value:3.05E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.06|P-value:3.09E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.95|P-value:5.77E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.13|P-value:2.31E-4 ID:SGTC_1647|Compound:st011722|FD-Score:-3.38|P-value:9.40E-5 ID:SGTC_1651|Compound:st011928|FD-Score:-2.99|P-value:4.93E-4 ID:SGTC_1671|Compound:st016596|FD-Score:-3.28|P-value:1.48E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.68|P-value:8.68E-8 ID:SGTC_1774|Compound:st048371|FD-Score:3.05|P-value:3.16E-4 ID:SGTC_1826|Compound:st055655|FD-Score:2.86|P-value:6.87E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.01|P-value:3.69E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.34|P-value:6.22E-7 ID:SGTC_1882|Compound:5615643|FD-Score:2.85|P-value:7.10E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-2.94|P-value:5.83E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.80|P-value:1.36E-5 ID:SGTC_2127|Compound:5253358|FD-Score:2.92|P-value:5.36E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.83|P-value:9.22E-6 ID:SGTC_2242|Compound:6630449|FD-Score:-3.04|P-value:4.01E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.16|P-value:1.69E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.66|P-value:9.92E-8 ID:SGTC_2431|Compound:5490079|FD-Score:4.45|P-value:3.31E-7 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.00|P-value:4.69E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.18|P-value:2.29E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.27|P-value:1.25E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.41|P-value:6.94E-5 ID:SGTC_2625|Compound:euphol|FD-Score:-2.87|P-value:7.72E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.14|P-value:2.63E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.28|P-value:1.20E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.28|P-value:8.88E-7 ID:SGTC_2928|Compound:9011484|FD-Score:3.34|P-value:9.24E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.29|P-value:1.19E-4 ID:SGTC_3015|Compound:9080845|FD-Score:2.82|P-value:7.94E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.34|P-value:9.38E-5 ID:SGTC_3198|Compound:9112019|FD-Score:-2.96|P-value:5.53E-4 ID:SGTC_3228|Compound:9131799|FD-Score:-3.19|P-value:2.14E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.18|P-value:1.84E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.24|P-value:1.46E-4 ID:SGTC_3261|Compound:9137475|FD-Score:3.10|P-value:2.64E-4

Top fitness defect scores for YMR189W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_913 3487-1245 5.19 167.0 µM 3.53E-9 6 1.07E-7
2 SGTC_1738 st035555 4.68 74.0 µM 8.68E-8 TSC3-RPN4 18 1.43E-6
3 SGTC_945 3381-0768 4.66 11.3 µM 9.69E-8 endomembrane recycling 19 1.57E-6
4 SGTC_2422 chlorphenesin carbamate 4.66 384.2 µM 9.92E-8 14 1.60E-6
5 SGTC_669 0108-0021 4.64 26.2 µM 1.11E-7 fatty acid desaturase (OLE1) 52 1.75E-6
6 SGTC_2431 5490079 4.45 200.0 µM 3.31E-7 20 4.25E-6
7 SGTC_1877 wortmannin 4.34 25.0 µM 6.22E-7 84 7.10E-6
8 SGTC_2805 7950783 4.28 58.4 µM 8.88E-7 22 9.48E-6
9 SGTC_2342 7990637 4.16 118.9 µM 1.69E-6 RNA processing & uracil transport 27 1.60E-5
10 SGTC_907 3448-6986 4.14 75.5 µM 1.82E-6 22 1.70E-5
11 SGTC_914 3820-6779 3.83 408.0 µM 9.22E-6 28 6.36E-5
12 SGTC_2167 5876490 3.83 200.0 µM 9.22E-6 35 6.36E-5
13 SGTC_2621 lithochol-11-enic acid 3.41 100.0 µM 6.94E-5 47 3.29E-4
14 SGTC_266 formosanin C 3.40 406.0 nM 7.02E-5 sphingolipid biosynthesis & PDR1 84 3.32E-4
15 SGTC_2928 9011484 3.34 9.8 µM 9.24E-5 heme biosynthesis & mitochondrial translocase 57 4.16E-4
16 SGTC_3089 9117425 3.34 49.5 µM 9.38E-5 55 4.21E-4
17 SGTC_2955 9076254 3.29 12.2 µM 1.19E-4 37 5.09E-4
18 SGTC_2804 7954240 3.28 19.5 µM 1.20E-4 62 5.13E-4
19 SGTC_2617 dihydrotanshinone i 3.27 20.8 µM 1.25E-4 copper-dependent oxidative stress 77 5.30E-4
20 SGTC_518 1021-0119 3.25 62.6 µM 1.39E-4 ERG2 76 5.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.43E-9 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.101 5.25E-9 YIR042C_p YIR042C_p hom Putative protein of unknown function; YIR042C is a non-essential gene
0.100 6.47E-9 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.093 6.42E-8 YDR370C DXO1 hom Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p
0.093 7.95E-8 YOR343C_d YOR343C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.24E-7 YMR085W_p YMR085W_p hom Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
0.089 2.38E-7 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.086 5.83E-7 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.086 6.38E-7 YER149C PEA2 hom Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
0.086 6.49E-7 YOR189W IES4 hom Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses
0.086 6.64E-7 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.085 7.29E-7 YMR095C SNO1 hom Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.085 8.70E-7 YLR344W RPL26A hom Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication
0.084 1.10E-6 YBR214W SDS24 hom Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication
0.082 2.21E-6 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication