YMR190C / SGS1

Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR190C / SGS1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.55|P-value:2.44E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.30|P-value:1.30E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:-5.47|P-value:1.14E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:3.76|P-value:1.10E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:5.09|P-value:3.30E-7 ID:SGTC_268|Compound:camptothecin|FD-Score:3.56|P-value:2.31E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.38|P-value:4.44E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.84|P-value:8.36E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:5.45|P-value:5.38E-8 ID:SGTC_540|Compound:1187-0821|FD-Score:4.83|P-value:1.21E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:4.22|P-value:1.78E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.83|P-value:1.57E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.31|P-value:5.69E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.14|P-value:9.90E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:5.11|P-value:3.06E-7 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.23|P-value:1.71E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.33|P-value:5.20E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.64|P-value:1.73E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.84|P-value:8.16E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:5.87|P-value:5.51E-9 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.60|P-value:2.01E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.75|P-value:1.18E-4 ID:SGTC_1521|Compound:st012942|FD-Score:5.03|P-value:4.46E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-3.34|P-value:8.73E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.16|P-value:2.27E-5 ID:SGTC_1822|Compound:st052468|FD-Score:3.93|P-value:5.87E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.55|P-value:2.41E-4 ID:SGTC_2043|Compound:5101342|FD-Score:4.31|P-value:1.22E-5 ID:SGTC_2044|Compound:5102272|FD-Score:-3.36|P-value:8.10E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-4.04|P-value:7.10E-5 ID:SGTC_2134|Compound:5324836|FD-Score:10.90|P-value:2.74E-26 ID:SGTC_2265|Compound:7929201|FD-Score:4.76|P-value:1.68E-6 ID:SGTC_2307|Compound:7538926|FD-Score:3.95|P-value:5.34E-5 ID:SGTC_2380|Compound:9035439|FD-Score:4.10|P-value:2.99E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.23|P-value:1.72E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.65|P-value:1.68E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.26|P-value:6.53E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.52|P-value:2.72E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.61|P-value:3.49E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.46|P-value:5.87E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.83|P-value:8.49E-5 ID:SGTC_3049|Compound:9092223|FD-Score:4.62|P-value:3.10E-6 ID:SGTC_3133|Compound:9127736|FD-Score:3.33|P-value:5.26E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.23|P-value:7.39E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.90|P-value:1.21E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.44|P-value:3.55E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.55|P-value:2.44E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.30|P-value:1.30E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:-5.47|P-value:1.14E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:3.76|P-value:1.10E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:5.09|P-value:3.30E-7 ID:SGTC_268|Compound:camptothecin|FD-Score:3.56|P-value:2.31E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.38|P-value:4.44E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.84|P-value:8.36E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:5.45|P-value:5.38E-8 ID:SGTC_540|Compound:1187-0821|FD-Score:4.83|P-value:1.21E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:4.22|P-value:1.78E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.83|P-value:1.57E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.31|P-value:5.69E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.14|P-value:9.90E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:5.11|P-value:3.06E-7 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.23|P-value:1.71E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.33|P-value:5.20E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.64|P-value:1.73E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.84|P-value:8.16E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:5.87|P-value:5.51E-9 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.60|P-value:2.01E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.75|P-value:1.18E-4 ID:SGTC_1521|Compound:st012942|FD-Score:5.03|P-value:4.46E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-3.34|P-value:8.73E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.16|P-value:2.27E-5 ID:SGTC_1822|Compound:st052468|FD-Score:3.93|P-value:5.87E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.55|P-value:2.41E-4 ID:SGTC_2043|Compound:5101342|FD-Score:4.31|P-value:1.22E-5 ID:SGTC_2044|Compound:5102272|FD-Score:-3.36|P-value:8.10E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-4.04|P-value:7.10E-5 ID:SGTC_2134|Compound:5324836|FD-Score:10.90|P-value:2.74E-26 ID:SGTC_2265|Compound:7929201|FD-Score:4.76|P-value:1.68E-6 ID:SGTC_2307|Compound:7538926|FD-Score:3.95|P-value:5.34E-5 ID:SGTC_2380|Compound:9035439|FD-Score:4.10|P-value:2.99E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.23|P-value:1.72E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.65|P-value:1.68E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.26|P-value:6.53E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.52|P-value:2.72E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.61|P-value:3.49E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.46|P-value:5.87E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.83|P-value:8.49E-5 ID:SGTC_3049|Compound:9092223|FD-Score:4.62|P-value:3.10E-6 ID:SGTC_3133|Compound:9127736|FD-Score:3.33|P-value:5.26E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.23|P-value:7.39E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.90|P-value:1.21E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.44|P-value:3.55E-4

Top fitness defect scores for YMR190C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2134 5324836 10.90 1.5 µM 2.74E-26 1 6.39E-28
2 SGTC_1395 3486-0190 5.87 4.3 µM 5.51E-9 1 2.24E-9
3 SGTC_536 3852-0578 5.45 10.6 µM 5.38E-8 3 2.54E-8
4 SGTC_1223 0764-0573 5.11 147.0 µM 3.06E-7 3 1.62E-7
5 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 5.09 44.4 nM 3.30E-7 DNA damage response 22 1.75E-7
6 SGTC_1521 st012942 5.03 49.4 µM 4.46E-7 11 2.42E-7
7 SGTC_540 1187-0821 4.83 17.3 µM 1.21E-6 6 6.96E-7
8 SGTC_2265 7929201 4.76 200.0 µM 1.68E-6 14 9.91E-7
9 SGTC_3049 9092223 4.62 49.5 µM 3.10E-6 10 1.90E-6
10 SGTC_2043 5101342 4.31 149.0 µM 1.22E-5 SWF1 & branched chain AA biosynthesis 10 8.13E-6
11 SGTC_86 0417-1630 4.30 471.9 µM 1.30E-5 ubiquinone biosynthesis & proteasome 133 8.71E-6
12 SGTC_1243 0416-0003 4.23 5.7 µM 1.71E-5 PDR1 21 1.17E-5
13 SGTC_2535 4',4'-dimethoxydalbergione 4.23 51.2 µM 1.72E-5 DNA damage response 13 1.17E-5
14 SGTC_754 3474-0146 4.22 171.0 µM 1.78E-5 copper-dependent oxidative stress 21 1.22E-5
15 SGTC_1772 st048439 4.16 82.2 µM 2.27E-5 31 1.57E-5
16 SGTC_2380 9035439 4.10 200.0 µM 2.99E-5 endomembrane recycling 16 2.10E-5
17 SGTC_2307 7538926 3.95 6.3 µM 5.34E-5 44 3.89E-5
18 SGTC_1822 st052468 3.93 42.0 µM 5.87E-5 12 4.30E-5
19 SGTC_1389 3405-0187 3.84 19.0 µM 8.16E-5 17 6.09E-5
20 SGTC_475 α-linolenic acid 3.84 10.0 µM 8.36E-5 excess fatty acid 21 6.25E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.34E-16 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.135 3.73E-15 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.134 5.78E-15 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.127 1.28E-13 YOR352W TFB6 hom Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.126 2.58E-13 YER162C RAD4 hom Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.110 1.55E-10 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.103 2.33E-9 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.096 2.31E-8 YJR043C POL32 hom Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
0.091 1.47E-7 YGL087C MMS2 hom Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
0.088 2.99E-7 YDR092W UBC13 hom Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
0.087 4.50E-7 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.087 4.87E-7 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.086 6.43E-7 YOL007C CSI2 hom Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
0.086 7.02E-7 YEL037C RAD23 hom Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover
0.084 1.07E-6 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication