YMR193C-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR193C-A / YMR193C-A

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.30|P-value:2.42E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.61|P-value:4.71E-5 ID:SGTC_80|Compound:0159-0065|FD-Score:2.86|P-value:9.65E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.58|P-value:7.67E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.12|P-value:5.01E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.35|P-value:1.41E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.11|P-value:4.42E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:3.15|P-value:3.20E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.20|P-value:2.67E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.26|P-value:2.06E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.08|P-value:5.75E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.62|P-value:4.45E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.60|P-value:3.50E-7 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.10|P-value:5.38E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.72|P-value:2.93E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.26|P-value:2.11E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.06|P-value:4.58E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.09|P-value:4.98E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.11|P-value:3.72E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.17|P-value:3.31E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.26|P-value:2.06E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.05|P-value:6.04E-6 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.15|P-value:3.21E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.88|P-value:9.00E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:2.94|P-value:7.06E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.27|P-value:1.98E-4 ID:SGTC_1563|Compound:conessine|FD-Score:-3.24|P-value:3.08E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.68|P-value:4.84E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.17|P-value:4.07E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.94|P-value:7.20E-4 ID:SGTC_1727|Compound:st034309|FD-Score:2.98|P-value:6.24E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-4.47|P-value:1.08E-6 ID:SGTC_1803|Compound:st050068|FD-Score:-3.33|P-value:2.19E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.45|P-value:1.32E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-6.07|P-value:5.54E-11 ID:SGTC_1841|Compound:st054148|FD-Score:3.05|P-value:4.81E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.58|P-value:5.35E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.18|P-value:2.87E-4 ID:SGTC_1967|Compound:st070177|FD-Score:4.70|P-value:1.91E-7 ID:SGTC_2143|Compound:5623677|FD-Score:2.99|P-value:5.87E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.35|P-value:1.33E-6 ID:SGTC_2404|Compound:5161160|FD-Score:-3.47|P-value:1.19E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.75|P-value:2.45E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-3.56|P-value:8.46E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-7.35|P-value:2.60E-15 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.86|P-value:2.20E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:5.24|P-value:7.95E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.85|P-value:1.59E-5 ID:SGTC_2993|Compound:9054257|FD-Score:4.16|P-value:3.57E-6 ID:SGTC_3052|Compound:9092717|FD-Score:2.96|P-value:6.65E-4 ID:SGTC_3336|Compound:9143619|FD-Score:5.76|P-value:2.73E-10 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.30|P-value:2.42E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.61|P-value:4.71E-5 ID:SGTC_80|Compound:0159-0065|FD-Score:2.86|P-value:9.65E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.58|P-value:7.67E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.12|P-value:5.01E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.35|P-value:1.41E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.11|P-value:4.42E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:3.15|P-value:3.20E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.20|P-value:2.67E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.26|P-value:2.06E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.08|P-value:5.75E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.62|P-value:4.45E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.60|P-value:3.50E-7 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.10|P-value:5.38E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.72|P-value:2.93E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.26|P-value:2.11E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.06|P-value:4.58E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.09|P-value:4.98E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.11|P-value:3.72E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.17|P-value:3.31E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.26|P-value:2.06E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.05|P-value:6.04E-6 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.15|P-value:3.21E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.88|P-value:9.00E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:2.94|P-value:7.06E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.27|P-value:1.98E-4 ID:SGTC_1563|Compound:conessine|FD-Score:-3.24|P-value:3.08E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.68|P-value:4.84E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.17|P-value:4.07E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.94|P-value:7.20E-4 ID:SGTC_1727|Compound:st034309|FD-Score:2.98|P-value:6.24E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-4.47|P-value:1.08E-6 ID:SGTC_1803|Compound:st050068|FD-Score:-3.33|P-value:2.19E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.45|P-value:1.32E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-6.07|P-value:5.54E-11 ID:SGTC_1841|Compound:st054148|FD-Score:3.05|P-value:4.81E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.58|P-value:5.35E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.18|P-value:2.87E-4 ID:SGTC_1967|Compound:st070177|FD-Score:4.70|P-value:1.91E-7 ID:SGTC_2143|Compound:5623677|FD-Score:2.99|P-value:5.87E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.35|P-value:1.33E-6 ID:SGTC_2404|Compound:5161160|FD-Score:-3.47|P-value:1.19E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.75|P-value:2.45E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-3.56|P-value:8.46E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-7.35|P-value:2.60E-15 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.86|P-value:2.20E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:5.24|P-value:7.95E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.85|P-value:1.59E-5 ID:SGTC_2993|Compound:9054257|FD-Score:4.16|P-value:3.57E-6 ID:SGTC_3052|Compound:9092717|FD-Score:2.96|P-value:6.65E-4 ID:SGTC_3336|Compound:9143619|FD-Score:5.76|P-value:2.73E-10

Top fitness defect scores for YMR193C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3336 9143619 5.76 71.4 µM 2.73E-10 3 4.23E-9
2 SGTC_2638 epoxomicin 5.24 18.0 µM 7.95E-9 8 7.96E-8
3 SGTC_1967 st070177 4.70 51.4 µM 1.91E-7 9 1.27E-6
4 SGTC_832 4083-0019 4.60 164.0 µM 3.50E-7 translation 59 2.15E-6
5 SGTC_2295 7971645 4.35 200.0 µM 1.33E-6 15 6.86E-6
6 SGTC_1017 4239-0030 4.26 168.0 µM 2.11E-6 18 1.03E-5
7 SGTC_1206 3978-0017 4.17 132.0 µM 3.31E-6 ERG2 28 1.52E-5
8 SGTC_2993 9054257 4.16 71.4 µM 3.57E-6 fatty acid desaturase (OLE1) 39 1.62E-5
9 SGTC_152 4469-0003 4.11 551.2 µM 4.42E-6 21 1.96E-5
10 SGTC_1148 3909-7663 4.09 27.7 µM 4.98E-6 14 2.17E-5
11 SGTC_1351 1496-0003 4.05 46.5 µM 6.04E-6 20 2.57E-5
12 SGTC_2688 kanamycin b 3.85 96.7 µM 1.59E-5 calcium & mitochondrial duress 389 5.97E-5
13 SGTC_2423 st077119 3.75 87.2 µM 2.45E-5 17 8.67E-5
14 SGTC_1004 4084-0029 3.72 199.0 µM 2.93E-5 22 1.01E-4
15 SGTC_625 k213-0058 3.62 121.0 µM 4.45E-5 translation 132 1.46E-4
16 SGTC_39 0986-0283 3.61 58.4 µM 4.71E-5 calcium & mitochondrial duress 48 1.53E-4
17 SGTC_1862 st057513 3.58 3.8 µM 5.35E-5 20 1.71E-4
18 SGTC_118 0083-0097 3.35 135.3 µM 1.41E-4 translation 212 4.00E-4
19 SGTC_1551 6-bromo-3'-methylflavone 3.27 63.5 µM 1.98E-4 46 5.36E-4
20 SGTC_1216 1165-0504 3.26 9.7 µM 2.06E-4 36 5.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 5.17E-24 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.148 7.19E-18 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.140 3.83E-16 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.132 1.86E-14 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.123 8.63E-13 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.122 1.49E-12 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.120 3.88E-12 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.119 4.16E-12 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.117 1.19E-11 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.115 2.84E-11 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.114 4.25E-11 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.113 4.77E-11 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.112 6.62E-11 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.109 2.34E-10 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.109 2.48E-10 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2