HIPHOP chemogenomics database
YMR193W / MRPL24 
Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YMR193W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.599 | 0 | YMR228W | MTF1 | hom | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |
| 0.510 | 5.96E-222 | YNL177C | MRPL22 | hom | Mitochondrial ribosomal protein of the large subunit |
| 0.501 | 1.60E-212 | YPL040C | ISM1 | hom | Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth |
| 0.486 | 5.78E-199 | YKL170W | MRPL38 | hom | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress |
| 0.484 | 2.18E-196 | YLR069C | MEF1 | hom | Mitochondrial elongation factor involved in translational elongation |
| 0.482 | 5.05E-194 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
| 0.480 | 4.88E-193 | YML061C | PIF1 | hom | DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells |
| 0.479 | 4.63E-192 | YHR168W | MTG2 | hom | Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly |
| 0.474 | 3.17E-187 | YER050C | RSM18 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein |
| 0.474 | 3.33E-187 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
| 0.469 | 3.68E-183 | YER087W | AIM10 | hom | Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss |
| 0.467 | 1.55E-181 | YLR149C | YLR149C | hom | Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress |
| 0.463 | 8.78E-178 | YDR194C | MSS116 | hom | DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing |
| 0.462 | 3.36E-177 | YPL183W-A | RTC6 | hom | Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress |
| 0.457 | 1.89E-172 | YCR046C | IMG1 | hom | Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome |