YMR193W / MRPL24

Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR193W / MRPL24

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.69|P-value:1.72E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.29|P-value:1.71E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:5.13|P-value:3.93E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:3.69|P-value:1.77E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.50|P-value:3.48E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.45|P-value:4.00E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:12.40|P-value:1.08E-32 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:4.08E-25 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.08|P-value:5.12E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:9.21|P-value:7.49E-19 ID:SGTC_314|Compound:1671-0008|FD-Score:4.57|P-value:5.35E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.96|P-value:2.15E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.90|P-value:2.86E-6 ID:SGTC_433|Compound:pimozide|FD-Score:3.51|P-value:3.34E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.82|P-value:1.05E-10 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.55|P-value:5.40E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.72|P-value:3.10E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.61|P-value:4.46E-6 ID:SGTC_596|Compound:1155-0152|FD-Score:3.51|P-value:3.31E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.23|P-value:8.35E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.14|P-value:3.89E-7 ID:SGTC_782|Compound:0083-0095|FD-Score:3.26|P-value:7.75E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.20|P-value:9.16E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.15|P-value:3.05E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.25|P-value:2.04E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:6.70|P-value:6.69E-11 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.40|P-value:1.07E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.90|P-value:1.19E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.51|P-value:6.84E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.84|P-value:1.02E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.32|P-value:3.30E-5 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.58|P-value:4.94E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.86|P-value:9.24E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.34|P-value:5.88E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-5.28|P-value:4.83E-7 ID:SGTC_1677|Compound:st019204|FD-Score:-3.54|P-value:5.75E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.43|P-value:8.16E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.05|P-value:9.43E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-3.84|P-value:1.98E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.28|P-value:8.85E-10 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.03|P-value:1.01E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.11|P-value:1.71E-11 ID:SGTC_1921|Compound:5740136|FD-Score:4.50|P-value:6.98E-6 ID:SGTC_1962|Compound:st076595|FD-Score:-4.12|P-value:7.06E-5 ID:SGTC_1971|Compound:st069429|FD-Score:4.01|P-value:5.19E-5 ID:SGTC_2004|Compound:4023728|FD-Score:4.02|P-value:5.11E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.02|P-value:5.09E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.77|P-value:1.33E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.03|P-value:4.88E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.22|P-value:8.69E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.59|P-value:2.49E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.51|P-value:6.19E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.94|P-value:7.00E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-6.20|P-value:3.99E-9 ID:SGTC_2526|Compound:patulin|FD-Score:3.95|P-value:6.53E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.62|P-value:9.72E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.92|P-value:1.53E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.47|P-value:7.24E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.94|P-value:1.48E-11 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.84|P-value:2.02E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.69|P-value:1.74E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.38|P-value:5.15E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.64|P-value:3.99E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-8.58|P-value:5.55E-16 ID:SGTC_2778|Compound:tioconazole|FD-Score:-6.10|P-value:6.89E-9 ID:SGTC_2792|Compound:7535235|FD-Score:3.83|P-value:1.06E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-4.07|P-value:8.66E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-4.17|P-value:5.79E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-9.28|P-value:2.02E-18 ID:SGTC_2940|Compound:9060638|FD-Score:4.53|P-value:6.27E-6 ID:SGTC_3110|Compound:9122132|FD-Score:-3.50|P-value:6.38E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.37|P-value:5.40E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.71|P-value:3.15E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.69|P-value:1.72E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.29|P-value:1.71E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:5.13|P-value:3.93E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:3.69|P-value:1.77E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.50|P-value:3.48E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.45|P-value:4.00E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:12.40|P-value:1.08E-32 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:4.08E-25 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.08|P-value:5.12E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:9.21|P-value:7.49E-19 ID:SGTC_314|Compound:1671-0008|FD-Score:4.57|P-value:5.35E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.96|P-value:2.15E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.90|P-value:2.86E-6 ID:SGTC_433|Compound:pimozide|FD-Score:3.51|P-value:3.34E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.82|P-value:1.05E-10 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.55|P-value:5.40E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.72|P-value:3.10E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.61|P-value:4.46E-6 ID:SGTC_596|Compound:1155-0152|FD-Score:3.51|P-value:3.31E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.23|P-value:8.35E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.14|P-value:3.89E-7 ID:SGTC_782|Compound:0083-0095|FD-Score:3.26|P-value:7.75E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.20|P-value:9.16E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.15|P-value:3.05E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.25|P-value:2.04E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:6.70|P-value:6.69E-11 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.40|P-value:1.07E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.90|P-value:1.19E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.51|P-value:6.84E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.84|P-value:1.02E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.32|P-value:3.30E-5 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.58|P-value:4.94E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.86|P-value:9.24E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.34|P-value:5.88E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-5.28|P-value:4.83E-7 ID:SGTC_1677|Compound:st019204|FD-Score:-3.54|P-value:5.75E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.43|P-value:8.16E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.05|P-value:9.43E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-3.84|P-value:1.98E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.28|P-value:8.85E-10 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.03|P-value:1.01E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.11|P-value:1.71E-11 ID:SGTC_1921|Compound:5740136|FD-Score:4.50|P-value:6.98E-6 ID:SGTC_1962|Compound:st076595|FD-Score:-4.12|P-value:7.06E-5 ID:SGTC_1971|Compound:st069429|FD-Score:4.01|P-value:5.19E-5 ID:SGTC_2004|Compound:4023728|FD-Score:4.02|P-value:5.11E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.02|P-value:5.09E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.77|P-value:1.33E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.03|P-value:4.88E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.22|P-value:8.69E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.59|P-value:2.49E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.51|P-value:6.19E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.94|P-value:7.00E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-6.20|P-value:3.99E-9 ID:SGTC_2526|Compound:patulin|FD-Score:3.95|P-value:6.53E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.62|P-value:9.72E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.92|P-value:1.53E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.47|P-value:7.24E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.94|P-value:1.48E-11 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.84|P-value:2.02E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.69|P-value:1.74E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.38|P-value:5.15E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.64|P-value:3.99E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-8.58|P-value:5.55E-16 ID:SGTC_2778|Compound:tioconazole|FD-Score:-6.10|P-value:6.89E-9 ID:SGTC_2792|Compound:7535235|FD-Score:3.83|P-value:1.06E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-4.07|P-value:8.66E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-4.17|P-value:5.79E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-9.28|P-value:2.02E-18 ID:SGTC_2940|Compound:9060638|FD-Score:4.53|P-value:6.27E-6 ID:SGTC_3110|Compound:9122132|FD-Score:-3.50|P-value:6.38E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.37|P-value:5.40E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.71|P-value:3.15E-4

Top fitness defect scores for YMR193W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 12.40 2.7 µM 1.08E-32 mitochondrial stress 21 7.12E-36
2 SGTC_236 1509-0011 10.80 5.3 µM 4.08E-25 177 1.85E-27
3 SGTC_310 1273-0058 9.21 1.1 µM 7.49E-19 mitochondrial stress 60 1.64E-20
4 SGTC_2688 kanamycin b 6.94 96.7 µM 1.48E-11 calcium & mitochondrial duress 109 1.92E-12
5 SGTC_832 4083-0019 6.70 164.0 µM 6.69E-11 translation 12 1.01E-11
6 SGTC_1742 st038235 6.28 28.9 µM 8.85E-10 mitochondrial stress 41 1.74E-10
7 SGTC_778 3456-2434 5.14 196.0 µM 3.89E-7 mitochondrial response to ROS 42 1.41E-7
8 SGTC_63 0099-0242 5.13 26.7 µM 3.93E-7 mitochondrial stress 52 1.42E-7
9 SGTC_275 trichlorophene 5.08 5.7 µM 5.12E-7 mitochondrial stress 164 1.90E-7
10 SGTC_1048 3161-0300 4.90 24.5 µM 1.19E-6 11 4.79E-7
11 SGTC_582 0987-0078 4.61 156.0 µM 4.46E-6 calcium & mitochondrial duress 43 2.04E-6
12 SGTC_314 1671-0008 4.57 2.7 µM 5.35E-6 31 2.49E-6
13 SGTC_2940 9060638 4.53 45.9 µM 6.27E-6 amide catabolism 11 2.96E-6
14 SGTC_1476 4112-3294 4.51 3.3 µM 6.84E-6 60S ribosome export 8 3.25E-6
15 SGTC_1921 5740136 4.50 50.0 µM 6.98E-6 TRP & mitochondrial translation 39 3.33E-6
16 SGTC_1036 k216-0215 4.40 33.5 µM 1.07E-5 mitochondrial response to ROS 39 5.33E-6
17 SGTC_28 pentachloropyridine N-oxide 4.29 1.6 µM 1.71E-5 TSC3-RPN4 57 8.87E-6
18 SGTC_831 k061-1017 4.25 217.0 µM 2.04E-5 translation 45 1.07E-5
19 SGTC_830 4076-0286 4.15 57.8 µM 3.05E-5 translation 52 1.67E-5
20 SGTC_2151 5563267 4.03 85.4 µM 4.88E-5 18 2.79E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.599 0 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.510 5.96E-222 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.501 1.60E-212 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.486 5.78E-199 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.484 2.18E-196 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.482 5.05E-194 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.480 4.88E-193 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.479 4.63E-192 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.474 3.17E-187 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.474 3.33E-187 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.469 3.68E-183 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.467 1.55E-181 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.463 8.78E-178 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.462 3.36E-177 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.457 1.89E-172 YCR046C IMG1 hom Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome