YMR194C-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR194C-A / YMR194C-A

Click on Significant Values for Screen Details ID:SGTC_147|Compound:4466-0538|FD-Score:-3.25|P-value:2.95E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.70|P-value:4.65E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-4.14|P-value:6.16E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:2.99|P-value:8.28E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:-3.13|P-value:4.78E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.95|P-value:1.62E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:4.21|P-value:4.70E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.29|P-value:2.66E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.30|P-value:2.54E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.73|P-value:4.31E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.31|P-value:2.36E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:6.35|P-value:1.08E-11 ID:SGTC_996|Compound:3970-0799|FD-Score:3.08|P-value:5.99E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.07|P-value:6.25E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.41|P-value:1.66E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.22|P-value:3.54E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.90|P-value:1.96E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.36|P-value:2.01E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.72|P-value:3.41E-7 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.72|P-value:3.26E-7 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.35|P-value:2.14E-4 ID:SGTC_1591|Compound:genipin|FD-Score:4.21|P-value:4.71E-6 ID:SGTC_1630|Compound:st005209|FD-Score:3.24|P-value:3.23E-4 ID:SGTC_1702|Compound:st027038|FD-Score:4.04|P-value:1.04E-5 ID:SGTC_1726|Compound:st035556|FD-Score:4.66|P-value:4.49E-7 ID:SGTC_1727|Compound:st034309|FD-Score:3.05|P-value:6.56E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.68|P-value:5.26E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.04|P-value:6.47E-4 ID:SGTC_1813|Compound:st051246|FD-Score:4.22|P-value:4.31E-6 ID:SGTC_1835|Compound:st008666|FD-Score:5.74|P-value:7.38E-10 ID:SGTC_1852|Compound:st056254|FD-Score:3.49|P-value:1.18E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.85|P-value:2.37E-5 ID:SGTC_1925|Compound:st057770|FD-Score:4.57|P-value:7.26E-7 ID:SGTC_1934|Compound:st074720|FD-Score:4.01|P-value:1.22E-5 ID:SGTC_2040|Compound:5100729|FD-Score:4.45|P-value:1.39E-6 ID:SGTC_2142|Compound:5622915|FD-Score:3.86|P-value:2.36E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-3.37|P-value:1.88E-4 ID:SGTC_2237|Compound:6667747|FD-Score:4.23|P-value:4.10E-6 ID:SGTC_2242|Compound:6630449|FD-Score:3.08|P-value:5.97E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.42|P-value:1.50E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.45|P-value:1.39E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.32|P-value:2.65E-6 ID:SGTC_2704|Compound:st078022|FD-Score:3.32|P-value:2.36E-4 ID:SGTC_2705|Compound:st078069|FD-Score:4.17|P-value:5.59E-6 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.08|P-value:5.92E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.11|P-value:5.14E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.12|P-value:5.16E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.31|P-value:2.86E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.41|P-value:1.68E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.00|P-value:7.58E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.96|P-value:1.54E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.09|P-value:5.78E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.04|P-value:6.82E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.15|P-value:4.50E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-4.26|P-value:3.35E-6 ID:SGTC_3306|Compound:9127676|FD-Score:-4.14|P-value:6.26E-6 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.25|P-value:2.95E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.70|P-value:4.65E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-4.14|P-value:6.16E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:2.99|P-value:8.28E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:-3.13|P-value:4.78E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.95|P-value:1.62E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:4.21|P-value:4.70E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.29|P-value:2.66E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.30|P-value:2.54E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.73|P-value:4.31E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.31|P-value:2.36E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:6.35|P-value:1.08E-11 ID:SGTC_996|Compound:3970-0799|FD-Score:3.08|P-value:5.99E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.07|P-value:6.25E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.41|P-value:1.66E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.22|P-value:3.54E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.90|P-value:1.96E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.36|P-value:2.01E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.72|P-value:3.41E-7 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.72|P-value:3.26E-7 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.35|P-value:2.14E-4 ID:SGTC_1591|Compound:genipin|FD-Score:4.21|P-value:4.71E-6 ID:SGTC_1630|Compound:st005209|FD-Score:3.24|P-value:3.23E-4 ID:SGTC_1702|Compound:st027038|FD-Score:4.04|P-value:1.04E-5 ID:SGTC_1726|Compound:st035556|FD-Score:4.66|P-value:4.49E-7 ID:SGTC_1727|Compound:st034309|FD-Score:3.05|P-value:6.56E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.68|P-value:5.26E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.04|P-value:6.47E-4 ID:SGTC_1813|Compound:st051246|FD-Score:4.22|P-value:4.31E-6 ID:SGTC_1835|Compound:st008666|FD-Score:5.74|P-value:7.38E-10 ID:SGTC_1852|Compound:st056254|FD-Score:3.49|P-value:1.18E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.85|P-value:2.37E-5 ID:SGTC_1925|Compound:st057770|FD-Score:4.57|P-value:7.26E-7 ID:SGTC_1934|Compound:st074720|FD-Score:4.01|P-value:1.22E-5 ID:SGTC_2040|Compound:5100729|FD-Score:4.45|P-value:1.39E-6 ID:SGTC_2142|Compound:5622915|FD-Score:3.86|P-value:2.36E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-3.37|P-value:1.88E-4 ID:SGTC_2237|Compound:6667747|FD-Score:4.23|P-value:4.10E-6 ID:SGTC_2242|Compound:6630449|FD-Score:3.08|P-value:5.97E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.42|P-value:1.50E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.45|P-value:1.39E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.32|P-value:2.65E-6 ID:SGTC_2704|Compound:st078022|FD-Score:3.32|P-value:2.36E-4 ID:SGTC_2705|Compound:st078069|FD-Score:4.17|P-value:5.59E-6 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.08|P-value:5.92E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.11|P-value:5.14E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.12|P-value:5.16E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.31|P-value:2.86E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.41|P-value:1.68E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.00|P-value:7.58E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.96|P-value:1.54E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.09|P-value:5.78E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.04|P-value:6.82E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.15|P-value:4.50E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-4.26|P-value:3.35E-6 ID:SGTC_3306|Compound:9127676|FD-Score:-4.14|P-value:6.26E-6

Top fitness defect scores for YMR194C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_993 3909-8757 6.35 62.7 µM 1.08E-11 3 1.05E-10
2 SGTC_1835 st008666 5.74 49.2 µM 7.38E-10 8 4.75E-9
3 SGTC_1521 st012942 4.72 49.4 µM 3.26E-7 18 1.16E-6
4 SGTC_1227 3909-8010 4.72 46.6 µM 3.41E-7 6 1.21E-6
5 SGTC_1726 st035556 4.66 14.6 µM 4.49E-7 23 1.55E-6
6 SGTC_1925 st057770 4.57 10.1 µM 7.26E-7 TSC3-RPN4 12 2.39E-6
7 SGTC_2578 7,8-dihydroxyflavone 4.45 64.4 µM 1.39E-6 24 4.30E-6
8 SGTC_2040 5100729 4.45 123.0 µM 1.39E-6 33 4.31E-6
9 SGTC_2617 dihydrotanshinone i 4.32 20.8 µM 2.65E-6 copper-dependent oxidative stress 30 7.71E-6
10 SGTC_2823 7987624 4.31 58.4 µM 2.86E-6 21 8.27E-6
11 SGTC_2237 6667747 4.23 47.2 µM 4.10E-6 12 1.14E-5
12 SGTC_1813 st051246 4.22 8.6 µM 4.31E-6 TSC3-RPN4 9 1.20E-5
13 SGTC_652 0437-0092 4.21 114.0 µM 4.70E-6 9 1.29E-5
14 SGTC_1591 genipin 4.21 88.4 µM 4.71E-6 mitochondrial processes 8 1.30E-5
15 SGTC_2705 st078069 4.17 42.8 µM 5.59E-6 3 1.51E-5
16 SGTC_1702 st027038 4.04 51.0 µM 1.04E-5 8 2.65E-5
17 SGTC_1934 st074720 4.01 32.6 µM 1.22E-5 54 3.07E-5
18 SGTC_3085 9117376 3.96 49.5 µM 1.54E-5 9 3.79E-5
19 SGTC_605 1315-0399 3.95 119.0 µM 1.62E-5 Golgi 24 3.97E-5
20 SGTC_1140 3229-1848 3.90 3.0 µM 1.96E-5 10 4.71E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.04E-9 YLR392C ART10 hom Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene
0.088 2.98E-7 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.081 2.29E-6 YOL150C_d YOL150C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.57E-6 YJL200C ACO2 hom Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
0.080 3.15E-6 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.079 4.86E-6 YIL013C PDR11 hom ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth
0.079 5.29E-6 YGR243W FMP43 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress
0.077 8.49E-6 YBL078C ATG8 hom Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis
0.074 1.84E-5 YPL261C_d YPL261C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W
0.074 1.86E-5 YNL318C HXT14 hom Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.074 2.01E-5 YPL111W CAR1 hom Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
0.073 2.61E-5 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.070 5.10E-5 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.069 6.18E-5 YJL145W SFH5 hom Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress
0.068 8.77E-5 YGR143W SKN1 hom Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p