YMR195W / ICY1

Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR195W / ICY1

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.34|P-value:2.51E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.01|P-value:8.63E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:3.26|P-value:3.37E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.16|P-value:4.92E-4 ID:SGTC_251|Compound:melphalan|FD-Score:6.38|P-value:1.86E-11 ID:SGTC_282|Compound:k297-0036|FD-Score:3.26|P-value:3.45E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.11|P-value:1.29E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.40|P-value:2.57E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:4.30|P-value:3.91E-6 ID:SGTC_394|Compound:menadione|FD-Score:3.95|P-value:2.02E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.03|P-value:8.04E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.09|P-value:6.48E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.32|P-value:2.68E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.62|P-value:1.06E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.82|P-value:3.48E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-4.67|P-value:8.70E-7 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.17|P-value:6.10E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-3.24|P-value:4.68E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.51|P-value:1.69E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:4.01|P-value:1.52E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.44|P-value:2.19E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.54|P-value:1.51E-4 ID:SGTC_1717|Compound:st033143|FD-Score:11.40|P-value:2.32E-32 ID:SGTC_1720|Compound:st037298|FD-Score:-3.50|P-value:1.75E-4 ID:SGTC_1723|Compound:st034307|FD-Score:5.80|P-value:8.93E-10 ID:SGTC_1746|Compound:st038117|FD-Score:3.75|P-value:4.83E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.31|P-value:2.83E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.55|P-value:1.45E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.44|P-value:1.72E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.07|P-value:8.72E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.48|P-value:1.47E-4 ID:SGTC_2353|Compound:9059630|FD-Score:-3.20|P-value:5.37E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.43|P-value:1.74E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.51|P-value:1.91E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.06|P-value:9.04E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.53|P-value:1.54E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-4.37|P-value:3.93E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.33|P-value:3.37E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.34|P-value:2.51E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.01|P-value:8.63E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:3.26|P-value:3.37E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.16|P-value:4.92E-4 ID:SGTC_251|Compound:melphalan|FD-Score:6.38|P-value:1.86E-11 ID:SGTC_282|Compound:k297-0036|FD-Score:3.26|P-value:3.45E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.11|P-value:1.29E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.40|P-value:2.57E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:4.30|P-value:3.91E-6 ID:SGTC_394|Compound:menadione|FD-Score:3.95|P-value:2.02E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.03|P-value:8.04E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.09|P-value:6.48E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.32|P-value:2.68E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.62|P-value:1.06E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.82|P-value:3.48E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-4.67|P-value:8.70E-7 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.17|P-value:6.10E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-3.24|P-value:4.68E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.51|P-value:1.69E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:4.01|P-value:1.52E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.44|P-value:2.19E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.54|P-value:1.51E-4 ID:SGTC_1717|Compound:st033143|FD-Score:11.40|P-value:2.32E-32 ID:SGTC_1720|Compound:st037298|FD-Score:-3.50|P-value:1.75E-4 ID:SGTC_1723|Compound:st034307|FD-Score:5.80|P-value:8.93E-10 ID:SGTC_1746|Compound:st038117|FD-Score:3.75|P-value:4.83E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.31|P-value:2.83E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.55|P-value:1.45E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.44|P-value:1.72E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.07|P-value:8.72E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.48|P-value:1.47E-4 ID:SGTC_2353|Compound:9059630|FD-Score:-3.20|P-value:5.37E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.43|P-value:1.74E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.51|P-value:1.91E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.06|P-value:9.04E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.53|P-value:1.54E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-4.37|P-value:3.93E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.33|P-value:3.37E-4

Top fitness defect scores for YMR195W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1717 st033143 11.40 58.0 µM 2.32E-32 4 2.28E-30
2 SGTC_251 melphalan 6.38 456.5 µM 1.86E-11 DNA damage response 6 8.86E-11
3 SGTC_1723 st034307 5.80 2.5 µM 8.93E-10 mitochondrial processes 6 3.33E-9
4 SGTC_382 3229-0966 4.30 23.2 µM 3.91E-6 12 8.52E-6
5 SGTC_780 0109-0199 4.01 192.0 µM 1.52E-5 10 3.03E-5
6 SGTC_394 menadione 3.95 8.3 µM 2.02E-5 superoxide 32 3.96E-5
7 SGTC_608 k048-0125 3.82 159.0 µM 3.48E-5 34 6.59E-5
8 SGTC_1746 st038117 3.75 42.0 µM 4.83E-5 39 8.95E-5
9 SGTC_2327 6189656 3.48 200.0 µM 1.47E-4 35 2.54E-4
10 SGTC_2176 5809774 3.44 34.0 µM 1.72E-4 mitochondrial processes 28 2.93E-4
11 SGTC_2397 5161689 3.43 200.0 µM 1.74E-4 52 2.97E-4
12 SGTC_24 0417-1663 3.34 219.0 µM 2.51E-4 37 4.18E-4
13 SGTC_570 0987-0065 3.32 62.6 µM 2.68E-4 60S ribosome export 16 4.45E-4
14 SGTC_1919 st067113 3.31 52.3 µM 2.83E-4 TSC3-RPN4 51 4.68E-4
15 SGTC_133 0724-0033 3.26 378.9 µM 3.37E-4 50 5.51E-4
16 SGTC_282 k297-0036 3.26 65.7 µM 3.45E-4 9 5.62E-4
17 SGTC_217 ketoconazole 3.16 989.0 nM 4.92E-4 ergosterol depletion effects on membrane 55 7.84E-4
18 SGTC_529 4076-0302 3.09 30.3 µM 6.48E-4 mitochondrial processes 48 0.00102
19 SGTC_420 mitomycin C 3.03 81.9 mM 8.04E-4 58 0.00124
20 SGTC_110 0850-0284 3.01 111.6 µM 8.63E-4 31 0.00133

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 2.11E-71 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.140 4.05E-16 YER011W TIR1 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
0.135 3.38E-15 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.131 2.27E-14 YNL099C OCA1 hom Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA
0.127 1.38E-13 YBR062C_p YBR062C_p hom Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.
0.117 1.24E-11 YBR237W PRP5 het RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
0.115 2.31E-11 YJL044C GYP6 hom GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport
0.113 5.70E-11 YJR005C-A_p YJR005C-A_p hom Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication
0.112 6.80E-11 YJL060W BNA3 hom Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
0.111 1.13E-10 YDR325W YCG1 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.110 1.87E-10 YJL083W TAX4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication
0.109 2.21E-10 YKL043W PHD1 hom Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication
0.105 9.82E-10 YPL183C RTT10 hom WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6
0.101 5.01E-9 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.101 4.98E-9 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data