HIPHOP chemogenomics database

YMR196W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR196W / YMR196W

Click on Significant Values for Screen Details

Top fitness defect scores for YMR196W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2593	nobiletin	15.20	86.2 µM	2.66E-44		1	2.65E-52
2	SGTC_1203	3992-3522	7.73	103.0 µM	7.00E-13		1	5.54E-15
3	SGTC_1038	k292-0204	6.82	154.0 µM	2.01E-10		2	4.56E-12
4	SGTC_2579	2',5'-dihydroxy-4-methoxychalcone	6.21	13.2 µM	6.35E-9		3	2.72E-10
5	SGTC_1171	0368-0077	5.94	21.4 µM	2.54E-8		4	1.40E-9
6	SGTC_1105	epirubicin	5.53	18.1 µM	2.03E-7	anthracycline transcription coupled DNA repair	5	1.65E-8
7	SGTC_2856	9022925	5.23	19.5 µM	8.15E-7		7	8.52E-8
8	SGTC_1599	8-chlro-1-tetrahydronorharmanone	4.76	90.6 µM	6.40E-6		17	9.72E-7
9	SGTC_646	4092-0839	4.67	27.3 µM	9.12E-6	plasma membrane duress	13	1.48E-6
10	SGTC_95	0471-0001	4.52	561.1 µM	1.67E-5		16	3.02E-6
11	SGTC_2208	7283366	4.38	200.0 µM	2.93E-5		7	5.86E-6
12	SGTC_1075	aripiprazole	4.33	15.2 µM	3.55E-5		19	7.34E-6
13	SGTC_1042	0350-0096	4.15	82.0 µM	7.10E-5	TSC3-RPN4	22	1.66E-5
14	SGTC_454	lyso-paf C-16	4.07	6.7 µM	9.35E-5		14	2.30E-5
15	SGTC_653	0203-0016	4.06	55.2 µM	9.86E-5		11	2.45E-5
16	SGTC_1461	k072-0203	3.96	53.8 µM	1.44E-4		10	3.82E-5
17	SGTC_1637	st007924	3.78	17.4 µM	2.61E-4		25	7.74E-5
18	SGTC_2561	acetosyringone	3.76	100.0 µM	2.86E-4		33	8.60E-5
19	SGTC_450	aminopyrene	3.75	156.0 nM	2.97E-4		36	8.98E-5
20	SGTC_1598	3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin	3.72	19.1 µM	3.21E-4		23	9.87E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.171	2.48E-23	YCR004C	YCP4	hom	Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.160	9.01E-21	YFR012W	DCV1	hom	Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.147	1.18E-17	YGL110C	CUE3	hom	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.120	3.09E-12	YMR182C	RGM1	hom	Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication
0.114	3.75E-11	YJL125C	GCD14	het	Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.104	1.67E-9	YOL091W	SPO21	hom	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
0.100	7.56E-9	YCL001W-A_p	YCL001W-A_p	hom	Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III
0.098	1.32E-8	YLR435W	TSR2	hom	Protein with a potential role in pre-rRNA processing
0.095	3.73E-8	YER046W	SPO73	hom	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.095	4.11E-8	YJR147W	HMS2	hom	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.094	5.05E-8	YOR053W_d	YOR053W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
0.093	5.87E-8	YOR376W_d	YOR376W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.090	1.67E-7	YDR460W	TFB3	het	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
0.083	1.67E-6	YML003W_p	YML003W_p	hom	Putative protein of unknown function
0.080	3.54E-6	YNR002C	ATO2	hom	Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication