YMR196W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR196W / YMR196W

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.77|P-value:2.75E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.42|P-value:8.67E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.52|P-value:1.67E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.39|P-value:9.39E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.58|P-value:5.15E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.75|P-value:2.97E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.07|P-value:9.35E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.52|P-value:6.25E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.67|P-value:9.12E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:4.06|P-value:9.86E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:6.82|P-value:2.01E-10 ID:SGTC_1041|Compound:0206-0046|FD-Score:-5.05|P-value:1.84E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.15|P-value:7.10E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.33|P-value:3.55E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:5.53|P-value:2.03E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.43|P-value:8.30E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.94|P-value:2.54E-8 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.68|P-value:3.65E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:7.73|P-value:7.00E-13 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.96|P-value:1.44E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-4.98|P-value:2.49E-6 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.94|P-value:1.53E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.47|P-value:7.42E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.72|P-value:3.21E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.76|P-value:6.40E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.78|P-value:2.61E-4 ID:SGTC_2208|Compound:7283366|FD-Score:4.38|P-value:2.93E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.46|P-value:7.63E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.56|P-value:5.42E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.38|P-value:9.79E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.76|P-value:2.86E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.68|P-value:3.67E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.56|P-value:5.47E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:6.21|P-value:6.35E-9 ID:SGTC_2593|Compound:nobiletin|FD-Score:15.20|P-value:2.66E-44 ID:SGTC_2602|Compound:kawain|FD-Score:-5.71|P-value:8.06E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-7.57|P-value:1.96E-12 ID:SGTC_2701|Compound:st077767|FD-Score:3.43|P-value:8.19E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.63|P-value:4.42E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-4.37|P-value:3.06E-5 ID:SGTC_2844|Compound:9010103|FD-Score:3.59|P-value:5.00E-4 ID:SGTC_2856|Compound:9022925|FD-Score:5.23|P-value:8.15E-7 ID:SGTC_2909|Compound:7941780|FD-Score:-3.59|P-value:5.02E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.59|P-value:4.93E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.96|P-value:1.41E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.60|P-value:4.89E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-5.14|P-value:1.22E-6 ID:SGTC_3215|Compound:9129942|FD-Score:-3.62|P-value:4.53E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.65|P-value:4.07E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.77|P-value:2.75E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.42|P-value:8.67E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.52|P-value:1.67E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.39|P-value:9.39E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.58|P-value:5.15E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.75|P-value:2.97E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.07|P-value:9.35E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.52|P-value:6.25E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.67|P-value:9.12E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:4.06|P-value:9.86E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:6.82|P-value:2.01E-10 ID:SGTC_1041|Compound:0206-0046|FD-Score:-5.05|P-value:1.84E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.15|P-value:7.10E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.33|P-value:3.55E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:5.53|P-value:2.03E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.43|P-value:8.30E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.94|P-value:2.54E-8 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.68|P-value:3.65E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:7.73|P-value:7.00E-13 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.96|P-value:1.44E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-4.98|P-value:2.49E-6 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.94|P-value:1.53E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.47|P-value:7.42E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.72|P-value:3.21E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.76|P-value:6.40E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.78|P-value:2.61E-4 ID:SGTC_2208|Compound:7283366|FD-Score:4.38|P-value:2.93E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.46|P-value:7.63E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.56|P-value:5.42E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.38|P-value:9.79E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.76|P-value:2.86E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.68|P-value:3.67E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.56|P-value:5.47E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:6.21|P-value:6.35E-9 ID:SGTC_2593|Compound:nobiletin|FD-Score:15.20|P-value:2.66E-44 ID:SGTC_2602|Compound:kawain|FD-Score:-5.71|P-value:8.06E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-7.57|P-value:1.96E-12 ID:SGTC_2701|Compound:st077767|FD-Score:3.43|P-value:8.19E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.63|P-value:4.42E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-4.37|P-value:3.06E-5 ID:SGTC_2844|Compound:9010103|FD-Score:3.59|P-value:5.00E-4 ID:SGTC_2856|Compound:9022925|FD-Score:5.23|P-value:8.15E-7 ID:SGTC_2909|Compound:7941780|FD-Score:-3.59|P-value:5.02E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.59|P-value:4.93E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.96|P-value:1.41E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.60|P-value:4.89E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-5.14|P-value:1.22E-6 ID:SGTC_3215|Compound:9129942|FD-Score:-3.62|P-value:4.53E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.65|P-value:4.07E-4

Top fitness defect scores for YMR196W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2593 nobiletin 15.20 86.2 µM 2.66E-44 1 2.65E-52
2 SGTC_1203 3992-3522 7.73 103.0 µM 7.00E-13 1 5.54E-15
3 SGTC_1038 k292-0204 6.82 154.0 µM 2.01E-10 2 4.56E-12
4 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 6.21 13.2 µM 6.35E-9 3 2.72E-10
5 SGTC_1171 0368-0077 5.94 21.4 µM 2.54E-8 4 1.40E-9
6 SGTC_1105 epirubicin 5.53 18.1 µM 2.03E-7 anthracycline transcription coupled DNA repair 5 1.65E-8
7 SGTC_2856 9022925 5.23 19.5 µM 8.15E-7 7 8.52E-8
8 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.76 90.6 µM 6.40E-6 17 9.72E-7
9 SGTC_646 4092-0839 4.67 27.3 µM 9.12E-6 plasma membrane duress 13 1.48E-6
10 SGTC_95 0471-0001 4.52 561.1 µM 1.67E-5 16 3.02E-6
11 SGTC_2208 7283366 4.38 200.0 µM 2.93E-5 7 5.86E-6
12 SGTC_1075 aripiprazole 4.33 15.2 µM 3.55E-5 19 7.34E-6
13 SGTC_1042 0350-0096 4.15 82.0 µM 7.10E-5 TSC3-RPN4 22 1.66E-5
14 SGTC_454 lyso-paf C-16 4.07 6.7 µM 9.35E-5 14 2.30E-5
15 SGTC_653 0203-0016 4.06 55.2 µM 9.86E-5 11 2.45E-5
16 SGTC_1461 k072-0203 3.96 53.8 µM 1.44E-4 10 3.82E-5
17 SGTC_1637 st007924 3.78 17.4 µM 2.61E-4 25 7.74E-5
18 SGTC_2561 acetosyringone 3.76 100.0 µM 2.86E-4 33 8.60E-5
19 SGTC_450 aminopyrene 3.75 156.0 nM 2.97E-4 36 8.98E-5
20 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.72 19.1 µM 3.21E-4 23 9.87E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 2.48E-23 YCR004C YCP4 hom Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.160 9.01E-21 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.147 1.18E-17 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.120 3.09E-12 YMR182C RGM1 hom Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication
0.114 3.75E-11 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.104 1.67E-9 YOL091W SPO21 hom Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
0.100 7.56E-9 YCL001W-A_p YCL001W-A_p hom Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III
0.098 1.32E-8 YLR435W TSR2 hom Protein with a potential role in pre-rRNA processing
0.095 3.73E-8 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.095 4.11E-8 YJR147W HMS2 hom Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.094 5.05E-8 YOR053W_d YOR053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
0.093 5.87E-8 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.090 1.67E-7 YDR460W TFB3 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
0.083 1.67E-6 YML003W_p YML003W_p hom Putative protein of unknown function
0.080 3.54E-6 YNR002C ATO2 hom Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication