YMR197C / VTI1

Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR197C / VTI1

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:3.70|P-value:4.50E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.46|P-value:9.64E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.73|P-value:4.09E-4 ID:SGTC_397|Compound:arbidol|FD-Score:-3.65|P-value:2.22E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.39|P-value:5.36E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.53|P-value:7.73E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.21|P-value:9.38E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:5.30|P-value:7.53E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.21|P-value:7.41E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:-4.27|P-value:2.09E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:5.10|P-value:1.83E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:-4.57|P-value:6.04E-6 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:5.32|P-value:6.88E-7 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.82|P-value:1.20E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.53|P-value:7.82E-4 ID:SGTC_1863|Compound:st057641|FD-Score:5.04|P-value:2.40E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.59|P-value:6.38E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.73|P-value:1.66E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.68|P-value:1.95E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.12|P-value:3.82E-5 ID:SGTC_1952|Compound:st077036|FD-Score:3.91|P-value:2.20E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.78|P-value:1.39E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.63|P-value:5.59E-4 ID:SGTC_2020|Compound:4017018|FD-Score:7.34|P-value:9.93E-12 ID:SGTC_2231|Compound:micatex|FD-Score:3.94|P-value:1.98E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.64|P-value:5.50E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.11|P-value:1.06E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.69|P-value:1.89E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.83|P-value:2.89E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.58|P-value:6.68E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.70|P-value:4.44E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.83|P-value:2.86E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.50|P-value:8.62E-4 ID:SGTC_2556|Compound:citropten|FD-Score:4.75|P-value:8.61E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.78|P-value:3.41E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.72|P-value:4.12E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.70|P-value:4.50E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.54|P-value:2.05E-5 ID:SGTC_3071|Compound:9117417|FD-Score:3.66|P-value:5.05E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.97|P-value:1.77E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.70|P-value:4.50E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.46|P-value:9.64E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.73|P-value:4.09E-4 ID:SGTC_397|Compound:arbidol|FD-Score:-3.65|P-value:2.22E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.39|P-value:5.36E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.53|P-value:7.73E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.21|P-value:9.38E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:5.30|P-value:7.53E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.21|P-value:7.41E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:-4.27|P-value:2.09E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:5.10|P-value:1.83E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:-4.57|P-value:6.04E-6 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:5.32|P-value:6.88E-7 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.82|P-value:1.20E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.53|P-value:7.82E-4 ID:SGTC_1863|Compound:st057641|FD-Score:5.04|P-value:2.40E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.59|P-value:6.38E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.73|P-value:1.66E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.68|P-value:1.95E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.12|P-value:3.82E-5 ID:SGTC_1952|Compound:st077036|FD-Score:3.91|P-value:2.20E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.78|P-value:1.39E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.63|P-value:5.59E-4 ID:SGTC_2020|Compound:4017018|FD-Score:7.34|P-value:9.93E-12 ID:SGTC_2231|Compound:micatex|FD-Score:3.94|P-value:1.98E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.64|P-value:5.50E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.11|P-value:1.06E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.69|P-value:1.89E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.83|P-value:2.89E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.58|P-value:6.68E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.70|P-value:4.44E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.83|P-value:2.86E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.50|P-value:8.62E-4 ID:SGTC_2556|Compound:citropten|FD-Score:4.75|P-value:8.61E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.78|P-value:3.41E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.72|P-value:4.12E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.70|P-value:4.50E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.54|P-value:2.05E-5 ID:SGTC_3071|Compound:9117417|FD-Score:3.66|P-value:5.05E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.97|P-value:1.77E-4

Top fitness defect scores for YMR197C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2020 4017018 7.34 200.0 µM 9.93E-12 2 1.10E-13 1.75
2 SGTC_1517 deoxycholic acid methyl ester 5.32 49.2 µM 6.88E-7 2 5.26E-8 2.09
3 SGTC_1096 rimcazole 5.30 32.2 µM 7.53E-7 2 5.84E-8 1.81
4 SGTC_1278 0874-0585 5.10 172.0 µM 1.83E-6 1 1.66E-7 0.74
5 SGTC_1863 st057641 5.04 20.1 µM 2.40E-6 1 2.28E-7 0.47
6 SGTC_2556 citropten 4.75 84.6 µM 8.61E-6 3 1.03E-6 0.74
7 SGTC_3058 9093861 4.54 49.5 µM 2.05E-5 3 2.86E-6 0.10
8 SGTC_1098 clofazimine 4.21 15.1 µM 7.41E-5 heme biosynthesis & mitochondrial translocase 26 1.30E-5 0.14
9 SGTC_2241 6772625 4.11 37.8 µM 1.06E-4 7 1.99E-5 0.12
10 SGTC_3329 9141233 3.97 27.6 µM 1.77E-4 3 3.62E-5 0.18
11 SGTC_2231 micatex 3.94 6.8 µM 1.98E-4 6 4.15E-5 0.00
12 SGTC_1952 st077036 3.91 64.1 µM 2.20E-4 14 4.68E-5 0.01
13 SGTC_2506 ethyl hematommate 3.83 54.2 µM 2.86E-4 RPP1 & pyrimidine depletion 4 6.40E-5 0.08
14 SGTC_2336 9001819 3.83 198.7 µM 2.89E-4 heme biosynthesis & mitochondrial translocase 39 6.46E-5 0.05
15 SGTC_2660 2',4'-dihydroxychalcone 3.78 17.1 µM 3.41E-4 4 7.87E-5 0.10
16 SGTC_173 1273-0061 3.73 2.7 µM 4.09E-4 mitochondrial stress 29 9.75E-5 0.08
17 SGTC_2666 tannic acid 3.72 100.0 µM 4.12E-4 iron homeostasis 12 9.84E-5 0.04
18 SGTC_2453 5731132 3.70 22.2 µM 4.44E-4 7 1.07E-4 0.06
19 SGTC_63 0099-0242 3.70 26.7 µM 4.50E-4 mitochondrial stress 25 1.09E-4 0.01
20 SGTC_2852 9023854 3.70 52.0 µM 4.50E-4 7 1.09E-4 0.25

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.56E-10 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.098 1.43E-8 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.090 2.01E-7 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.085 8.21E-7 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.084 1.09E-6 YPL196W OXR1 hom Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes
0.083 1.45E-6 YDR472W TRS31 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.082 2.07E-6 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.077 7.40E-6 YIL014C-A_p YIL014C-A_p hom Putative protein of unknown function
0.077 7.73E-6 YNR069C BSC5 hom Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro
0.075 1.46E-5 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.073 2.06E-5 YPR099C_d YPR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W
0.072 3.37E-5 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.071 4.12E-5 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.070 4.43E-5 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.069 5.72E-5 YML091C RPM2 het Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus