YMR201C / RAD14

Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR201C / RAD14

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.50|P-value:3.38E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.47|P-value:3.74E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:4.03|P-value:4.61E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:5.29|P-value:1.39E-7 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:37.10|P-value:2.41E-284 ID:SGTC_368|Compound:fentichlor|FD-Score:4.60|P-value:3.98E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:6.10|P-value:1.62E-9 ID:SGTC_408|Compound:cantharidin|FD-Score:3.56|P-value:2.78E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.75|P-value:1.36E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.28|P-value:7.28E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.58|P-value:2.45E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.91|P-value:7.25E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:3.27|P-value:7.58E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.98|P-value:6.74E-7 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.24|P-value:8.43E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.39|P-value:1.03E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.81|P-value:1.54E-6 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.62|P-value:3.68E-6 ID:SGTC_1158|Compound:4092-0494|FD-Score:-3.27|P-value:7.42E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.44|P-value:4.14E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.36|P-value:5.44E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.57|P-value:4.55E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.50|P-value:3.37E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.22|P-value:8.85E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.72|P-value:1.53E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-3.57|P-value:2.53E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.93|P-value:6.94E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:4.80|P-value:1.62E-6 ID:SGTC_1893|Compound:st059353|FD-Score:3.45|P-value:4.02E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.56|P-value:2.66E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.27|P-value:7.58E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.34|P-value:5.88E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.96|P-value:5.94E-5 ID:SGTC_2792|Compound:7535235|FD-Score:3.73|P-value:1.47E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.31|P-value:6.46E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.59|P-value:2.44E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.50|P-value:3.38E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.47|P-value:3.74E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:4.03|P-value:4.61E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:5.29|P-value:1.39E-7 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:37.10|P-value:2.41E-284 ID:SGTC_368|Compound:fentichlor|FD-Score:4.60|P-value:3.98E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:6.10|P-value:1.62E-9 ID:SGTC_408|Compound:cantharidin|FD-Score:3.56|P-value:2.78E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.75|P-value:1.36E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.28|P-value:7.28E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.58|P-value:2.45E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.91|P-value:7.25E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:3.27|P-value:7.58E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.98|P-value:6.74E-7 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.24|P-value:8.43E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.39|P-value:1.03E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.81|P-value:1.54E-6 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.62|P-value:3.68E-6 ID:SGTC_1158|Compound:4092-0494|FD-Score:-3.27|P-value:7.42E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.44|P-value:4.14E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.36|P-value:5.44E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.57|P-value:4.55E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.50|P-value:3.37E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.22|P-value:8.85E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.72|P-value:1.53E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-3.57|P-value:2.53E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.93|P-value:6.94E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:4.80|P-value:1.62E-6 ID:SGTC_1893|Compound:st059353|FD-Score:3.45|P-value:4.02E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.56|P-value:2.66E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.27|P-value:7.58E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.34|P-value:5.88E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.96|P-value:5.94E-5 ID:SGTC_2792|Compound:7535235|FD-Score:3.73|P-value:1.47E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.31|P-value:6.46E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.59|P-value:2.44E-4

Top fitness defect scores for YMR201C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 37.10 44.4 nM 2.41E-284 DNA damage response 1 4.12E-301
2 SGTC_372 0155-0182 6.10 15.9 µM 1.62E-9 mitochondrial response to ROS 4 5.43E-10
3 SGTC_247 mechlorethamine 5.29 29.7 µM 1.39E-7 DNA damage response 7 6.03E-8
4 SGTC_927 2425-1185 4.98 123.0 µM 6.74E-7 7 3.22E-7
5 SGTC_1076 itraconazole 4.81 331.0 nM 1.54E-6 18 7.72E-7
6 SGTC_1880 MG-132 4.80 525.0 µM 1.62E-6 9 8.13E-7
7 SGTC_1080 nisoldipine 4.62 24.4 µM 3.68E-6 TSC3-RPN4 13 1.93E-6
8 SGTC_368 fentichlor 4.60 4.6 µM 3.98E-6 16 2.10E-6
9 SGTC_1217 1183-1422 4.57 255.0 µM 4.55E-6 3 2.42E-6
10 SGTC_1070 indatraline 4.39 8.8 µM 1.03E-5 60S ribosome export 16 5.72E-6
11 SGTC_111 0083-0039 4.03 52.5 µM 4.61E-5 3 2.80E-5
12 SGTC_1868 st057644 3.93 42.7 µM 6.94E-5 39 4.32E-5
13 SGTC_420 mitomycin C 3.75 81.9 mM 1.36E-4 23 8.82E-5
14 SGTC_2792 7535235 3.73 81.8 µM 1.47E-4 fatty acid desaturase (OLE1) 39 9.58E-5
15 SGTC_1467 k284-1082 3.72 293.0 µM 1.53E-4 24 9.96E-5
16 SGTC_3288 9119690 3.59 36.2 µM 2.44E-4 25 1.64E-4
17 SGTC_408 cantharidin 3.56 100.0 µM 2.78E-4 cell wall signaling 32 1.87E-4
18 SGTC_1229 0139-0193 3.50 12.2 µM 3.37E-4 RSC complex & mRNA processing 21 2.30E-4
19 SGTC_47 0149-0135 3.50 24.2 µM 3.38E-4 TSC3-RPN4 31 2.31E-4
20 SGTC_1893 st059353 3.45 36.1 µM 4.02E-4 42 2.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.736 0 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.692 0 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.601 0 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.553 6.32E-268 YER162C RAD4 hom Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.435 2.21E-155 YDR092W UBC13 hom Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
0.434 1.46E-154 YEL037C RAD23 hom Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover
0.332 6.58E-87 YGL087C MMS2 hom Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
0.273 2.88E-58 YLR032W RAD5 hom DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress
0.245 5.67E-47 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.236 9.63E-44 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.233 1.19E-42 YCR066W RAD18 hom E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA
0.185 3.82E-27 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.184 5.16E-27 YIR002C MPH1 hom 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases
0.181 4.35E-26 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.168 1.20E-22 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex