YMR203W / TOM40

Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR203W / TOM40

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:5.47|P-value:2.53E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:9.38|P-value:1.16E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:7.44|P-value:1.09E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:7.38|P-value:1.32E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:5.31|P-value:3.74E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:5.06|P-value:6.51E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:5.84|P-value:1.03E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.95|P-value:8.27E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:14.90|P-value:7.81E-22 ID:SGTC_188|Compound:3229-0966|FD-Score:5.85|P-value:1.01E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:5.32|P-value:3.66E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:8.22|P-value:8.30E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:4.88|P-value:9.69E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:6.16|P-value:4.55E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.99|P-value:7.68E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:6.62|P-value:1.28E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:10.00|P-value:8.48E-11 ID:SGTC_660|Compound:4031-1742|FD-Score:7.21|P-value:2.22E-6 ID:SGTC_674|Compound:0498-0004|FD-Score:7.19|P-value:2.41E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:8.14|P-value:1.10E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:4.96|P-value:8.16E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:15.00|P-value:5.09E-22 ID:SGTC_743|Compound:1275-0778|FD-Score:19.30|P-value:3.21E-35 ID:SGTC_795|Compound:0685-0265|FD-Score:8.64|P-value:1.91E-8 ID:SGTC_801|Compound:0866-0028|FD-Score:6.29|P-value:3.17E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:6.15|P-value:4.58E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:6.45|P-value:2.02E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:9.09|P-value:3.54E-9 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.27|P-value:4.11E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:8.02|P-value:1.68E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:8.75|P-value:1.28E-8 ID:SGTC_978|Compound:1416-0512|FD-Score:4.87|P-value:9.88E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:5.46|P-value:2.63E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:7.94|P-value:2.14E-7 ID:SGTC_1016|Compound:4226-1401|FD-Score:5.88|P-value:9.25E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:8.64|P-value:1.87E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:5.61|P-value:1.82E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.37|P-value:2.57E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:6.59|P-value:1.38E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:7.57|P-value:7.25E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:7.86|P-value:2.80E-7 ID:SGTC_1238|Compound:0333-0287|FD-Score:6.57|P-value:1.47E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:9.36|P-value:1.25E-9 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.70|P-value:1.48E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.44|P-value:2.10E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.21|P-value:4.71E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:8.73|P-value:1.34E-8 ID:SGTC_1453|Compound:4237-0541|FD-Score:10.60|P-value:7.56E-12 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:6.76|P-value:8.63E-6 ID:SGTC_1629|Compound:st005085|FD-Score:5.90|P-value:8.94E-5 ID:SGTC_1638|Compound:st008370|FD-Score:6.99|P-value:4.35E-6 ID:SGTC_1641|Compound:st009299|FD-Score:9.03|P-value:4.48E-9 ID:SGTC_1658|Compound:st012944|FD-Score:9.34|P-value:1.33E-9 ID:SGTC_1659|Compound:st012954|FD-Score:5.62|P-value:1.80E-4 ID:SGTC_1773|Compound:st048542|FD-Score:8.46|P-value:3.64E-8 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.98|P-value:4.42E-6 ID:SGTC_1797|Compound:st048695|FD-Score:11.50|P-value:1.04E-13 ID:SGTC_1831|Compound:st055328|FD-Score:14.00|P-value:2.64E-19 ID:SGTC_1884|Compound:5633444|FD-Score:8.35|P-value:5.28E-8 ID:SGTC_1921|Compound:5740136|FD-Score:-6.18|P-value:3.53E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:7.32|P-value:1.60E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-5.50|P-value:2.01E-4 ID:SGTC_1935|Compound:st074532|FD-Score:5.45|P-value:2.69E-4 ID:SGTC_1952|Compound:st077036|FD-Score:7.80|P-value:3.40E-7 ID:SGTC_1962|Compound:st076595|FD-Score:10.20|P-value:3.97E-11 ID:SGTC_2002|Compound:4023503|FD-Score:5.35|P-value:3.42E-4 ID:SGTC_2006|Compound:4011487|FD-Score:10.40|P-value:1.45E-11 ID:SGTC_2011|Compound:4012611|FD-Score:8.17|P-value:9.94E-8 ID:SGTC_2050|Compound:5263056|FD-Score:5.96|P-value:7.64E-5 ID:SGTC_2066|Compound:5222451|FD-Score:10.90|P-value:1.81E-12 ID:SGTC_2129|Compound:girgensonine|FD-Score:9.45|P-value:8.87E-10 ID:SGTC_2139|Compound:5578692|FD-Score:6.88|P-value:6.02E-6 ID:SGTC_2149|Compound:5554786|FD-Score:5.98|P-value:7.16E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:6.91|P-value:5.52E-6 ID:SGTC_2177|Compound:5811945|FD-Score:6.19|P-value:4.20E-5 ID:SGTC_2197|Compound:6588183|FD-Score:7.73|P-value:4.30E-7 ID:SGTC_2223|Compound:6903751|FD-Score:4.88|P-value:9.69E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:5.12|P-value:5.74E-4 ID:SGTC_2256|Compound:7954252|FD-Score:6.13|P-value:4.86E-5 ID:SGTC_2275|Compound:7947463|FD-Score:6.02|P-value:6.50E-5 ID:SGTC_2336|Compound:9001819|FD-Score:8.74|P-value:1.28E-8 ID:SGTC_2370|Compound:9071495|FD-Score:4.95|P-value:8.35E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:8.27|P-value:6.89E-8 ID:SGTC_2485|Compound:5633444|FD-Score:5.97|P-value:7.30E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:4.95|P-value:8.44E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:9.08|P-value:3.64E-9 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:17.70|P-value:6.40E-30 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:14.10|P-value:1.50E-19 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:6.90|P-value:5.63E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:7.48|P-value:9.71E-7 ID:SGTC_2586|Compound:curcumin|FD-Score:16.10|P-value:4.24E-25 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:7.91|P-value:2.35E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:6.80|P-value:7.51E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:12.00|P-value:8.21E-15 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.11|P-value:5.92E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:11.10|P-value:6.16E-13 ID:SGTC_2676|Compound:harmalol|FD-Score:5.59|P-value:1.93E-4 ID:SGTC_2696|Compound:st077691|FD-Score:6.88|P-value:5.99E-6 ID:SGTC_2709|Compound:st078560|FD-Score:7.67|P-value:5.31E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.39|P-value:3.07E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:11.40|P-value:1.61E-13 ID:SGTC_2766|Compound:oltipraz|FD-Score:17.80|P-value:2.53E-30 ID:SGTC_2880|Compound:9042983|FD-Score:5.79|P-value:1.18E-4 ID:SGTC_2887|Compound:9044784|FD-Score:8.05|P-value:1.51E-7 ID:SGTC_2928|Compound:9011484|FD-Score:7.76|P-value:3.92E-7 ID:SGTC_2930|Compound:9013230|FD-Score:10.20|P-value:4.82E-11 ID:SGTC_2938|Compound:9059746|FD-Score:5.34|P-value:3.44E-4 ID:SGTC_2980|Compound:9014342|FD-Score:10.50|P-value:1.09E-11 ID:SGTC_2993|Compound:9054257|FD-Score:6.03|P-value:6.38E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.42|P-value:2.88E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.99|P-value:7.62E-4 ID:SGTC_3071|Compound:9117417|FD-Score:5.14|P-value:5.46E-4 ID:SGTC_3081|Compound:9117243|FD-Score:7.56|P-value:7.47E-7 ID:SGTC_3161|Compound:9100388|FD-Score:11.30|P-value:3.55E-13 ID:SGTC_3175|Compound:9106517|FD-Score:11.70|P-value:4.14E-14 ID:SGTC_3181|Compound:9108277|FD-Score:9.49|P-value:7.56E-10 ID:SGTC_3198|Compound:9112019|FD-Score:6.29|P-value:3.21E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:5.47|P-value:2.53E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:9.38|P-value:1.16E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:7.44|P-value:1.09E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:7.38|P-value:1.32E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:5.31|P-value:3.74E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:5.06|P-value:6.51E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:5.84|P-value:1.03E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.95|P-value:8.27E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:14.90|P-value:7.81E-22 ID:SGTC_188|Compound:3229-0966|FD-Score:5.85|P-value:1.01E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:5.32|P-value:3.66E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:8.22|P-value:8.30E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:4.88|P-value:9.69E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:6.16|P-value:4.55E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.99|P-value:7.68E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:6.62|P-value:1.28E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:10.00|P-value:8.48E-11 ID:SGTC_660|Compound:4031-1742|FD-Score:7.21|P-value:2.22E-6 ID:SGTC_674|Compound:0498-0004|FD-Score:7.19|P-value:2.41E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:8.14|P-value:1.10E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:4.96|P-value:8.16E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:15.00|P-value:5.09E-22 ID:SGTC_743|Compound:1275-0778|FD-Score:19.30|P-value:3.21E-35 ID:SGTC_795|Compound:0685-0265|FD-Score:8.64|P-value:1.91E-8 ID:SGTC_801|Compound:0866-0028|FD-Score:6.29|P-value:3.17E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:6.15|P-value:4.58E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:6.45|P-value:2.02E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:9.09|P-value:3.54E-9 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.27|P-value:4.11E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:8.02|P-value:1.68E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:8.75|P-value:1.28E-8 ID:SGTC_978|Compound:1416-0512|FD-Score:4.87|P-value:9.88E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:5.46|P-value:2.63E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:7.94|P-value:2.14E-7 ID:SGTC_1016|Compound:4226-1401|FD-Score:5.88|P-value:9.25E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:8.64|P-value:1.87E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:5.61|P-value:1.82E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.37|P-value:2.57E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:6.59|P-value:1.38E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:7.57|P-value:7.25E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:7.86|P-value:2.80E-7 ID:SGTC_1238|Compound:0333-0287|FD-Score:6.57|P-value:1.47E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:9.36|P-value:1.25E-9 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.70|P-value:1.48E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.44|P-value:2.10E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.21|P-value:4.71E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:8.73|P-value:1.34E-8 ID:SGTC_1453|Compound:4237-0541|FD-Score:10.60|P-value:7.56E-12 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:6.76|P-value:8.63E-6 ID:SGTC_1629|Compound:st005085|FD-Score:5.90|P-value:8.94E-5 ID:SGTC_1638|Compound:st008370|FD-Score:6.99|P-value:4.35E-6 ID:SGTC_1641|Compound:st009299|FD-Score:9.03|P-value:4.48E-9 ID:SGTC_1658|Compound:st012944|FD-Score:9.34|P-value:1.33E-9 ID:SGTC_1659|Compound:st012954|FD-Score:5.62|P-value:1.80E-4 ID:SGTC_1773|Compound:st048542|FD-Score:8.46|P-value:3.64E-8 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.98|P-value:4.42E-6 ID:SGTC_1797|Compound:st048695|FD-Score:11.50|P-value:1.04E-13 ID:SGTC_1831|Compound:st055328|FD-Score:14.00|P-value:2.64E-19 ID:SGTC_1884|Compound:5633444|FD-Score:8.35|P-value:5.28E-8 ID:SGTC_1921|Compound:5740136|FD-Score:-6.18|P-value:3.53E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:7.32|P-value:1.60E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-5.50|P-value:2.01E-4 ID:SGTC_1935|Compound:st074532|FD-Score:5.45|P-value:2.69E-4 ID:SGTC_1952|Compound:st077036|FD-Score:7.80|P-value:3.40E-7 ID:SGTC_1962|Compound:st076595|FD-Score:10.20|P-value:3.97E-11 ID:SGTC_2002|Compound:4023503|FD-Score:5.35|P-value:3.42E-4 ID:SGTC_2006|Compound:4011487|FD-Score:10.40|P-value:1.45E-11 ID:SGTC_2011|Compound:4012611|FD-Score:8.17|P-value:9.94E-8 ID:SGTC_2050|Compound:5263056|FD-Score:5.96|P-value:7.64E-5 ID:SGTC_2066|Compound:5222451|FD-Score:10.90|P-value:1.81E-12 ID:SGTC_2129|Compound:girgensonine|FD-Score:9.45|P-value:8.87E-10 ID:SGTC_2139|Compound:5578692|FD-Score:6.88|P-value:6.02E-6 ID:SGTC_2149|Compound:5554786|FD-Score:5.98|P-value:7.16E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:6.91|P-value:5.52E-6 ID:SGTC_2177|Compound:5811945|FD-Score:6.19|P-value:4.20E-5 ID:SGTC_2197|Compound:6588183|FD-Score:7.73|P-value:4.30E-7 ID:SGTC_2223|Compound:6903751|FD-Score:4.88|P-value:9.69E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:5.12|P-value:5.74E-4 ID:SGTC_2256|Compound:7954252|FD-Score:6.13|P-value:4.86E-5 ID:SGTC_2275|Compound:7947463|FD-Score:6.02|P-value:6.50E-5 ID:SGTC_2336|Compound:9001819|FD-Score:8.74|P-value:1.28E-8 ID:SGTC_2370|Compound:9071495|FD-Score:4.95|P-value:8.35E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:8.27|P-value:6.89E-8 ID:SGTC_2485|Compound:5633444|FD-Score:5.97|P-value:7.30E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:4.95|P-value:8.44E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:9.08|P-value:3.64E-9 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:17.70|P-value:6.40E-30 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:14.10|P-value:1.50E-19 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:6.90|P-value:5.63E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:7.48|P-value:9.71E-7 ID:SGTC_2586|Compound:curcumin|FD-Score:16.10|P-value:4.24E-25 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:7.91|P-value:2.35E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:6.80|P-value:7.51E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:12.00|P-value:8.21E-15 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.11|P-value:5.92E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:11.10|P-value:6.16E-13 ID:SGTC_2676|Compound:harmalol|FD-Score:5.59|P-value:1.93E-4 ID:SGTC_2696|Compound:st077691|FD-Score:6.88|P-value:5.99E-6 ID:SGTC_2709|Compound:st078560|FD-Score:7.67|P-value:5.31E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.39|P-value:3.07E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:11.40|P-value:1.61E-13 ID:SGTC_2766|Compound:oltipraz|FD-Score:17.80|P-value:2.53E-30 ID:SGTC_2880|Compound:9042983|FD-Score:5.79|P-value:1.18E-4 ID:SGTC_2887|Compound:9044784|FD-Score:8.05|P-value:1.51E-7 ID:SGTC_2928|Compound:9011484|FD-Score:7.76|P-value:3.92E-7 ID:SGTC_2930|Compound:9013230|FD-Score:10.20|P-value:4.82E-11 ID:SGTC_2938|Compound:9059746|FD-Score:5.34|P-value:3.44E-4 ID:SGTC_2980|Compound:9014342|FD-Score:10.50|P-value:1.09E-11 ID:SGTC_2993|Compound:9054257|FD-Score:6.03|P-value:6.38E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.42|P-value:2.88E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.99|P-value:7.62E-4 ID:SGTC_3071|Compound:9117417|FD-Score:5.14|P-value:5.46E-4 ID:SGTC_3081|Compound:9117243|FD-Score:7.56|P-value:7.47E-7 ID:SGTC_3161|Compound:9100388|FD-Score:11.30|P-value:3.55E-13 ID:SGTC_3175|Compound:9106517|FD-Score:11.70|P-value:4.14E-14 ID:SGTC_3181|Compound:9108277|FD-Score:9.49|P-value:7.56E-10 ID:SGTC_3198|Compound:9112019|FD-Score:6.29|P-value:3.21E-5

Top fitness defect scores for YMR203W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_743 1275-0778 19.30 158.0 µM 3.21E-35 excess fatty acid 1 1.87E-83 11.00
2 SGTC_2766 oltipraz 17.80 83.9 µM 2.53E-30 heme requiring 1 1.70E-71 6.85
3 SGTC_2519 cryptotanshinone 17.70 88.0 µM 6.40E-30 heme biosynthesis & mitochondrial translocase 1 1.63E-70 4.55
4 SGTC_2586 curcumin 16.10 80.0 µM 4.24E-25 iron homeostasis 1 9.49E-59 9.56
5 SGTC_733 4069-0007 15.00 56.1 µM 5.09E-22 ERAD & cell cycle 2 3.05E-51 5.88
6 SGTC_177 1327-0068 14.90 8.4 µM 7.81E-22 3 8.67E-51 3.95
7 SGTC_2541 muurolladie-3-one 14.10 83.1 µM 1.50E-19 excess fatty acid 1 3.20E-45 6.17
8 SGTC_1831 st055328 14.00 12.0 µM 2.64E-19 heme biosynthesis & mitochondrial translocase 1 1.26E-44 2.94
9 SGTC_2630 antimycin a 12.00 100.0 µM 8.21E-15 mitochondrial processes 1 1.08E-33 5.66
10 SGTC_3175 9106517 11.70 49.5 µM 4.14E-14 iron homeostasis 1 5.50E-32 3.65
11 SGTC_1797 st048695 11.50 56.8 µM 1.04E-13 NEO1 2 5.11E-31 4.28
12 SGTC_2727 riluzole 11.40 51.8 µM 1.61E-13 mitochondrial processes 1 1.48E-30 3.63
13 SGTC_3161 9100388 11.30 49.5 µM 3.55E-13 iron homeostasis 1 1.02E-29 3.71
14 SGTC_2666 tannic acid 11.10 100.0 µM 6.16E-13 iron homeostasis 2 3.87E-29 4.63
15 SGTC_2066 5222451 10.90 176.0 µM 1.81E-12 heme biosynthesis & mitochondrial translocase 5 5.32E-28 2.45
16 SGTC_1453 4237-0541 10.60 195.0 µM 7.56E-12 heme biosynthesis & mitochondrial translocase 2 1.70E-26 2.26
17 SGTC_2980 9014342 10.50 25.3 µM 1.09E-11 2 4.09E-26 1.57
18 SGTC_2006 4011487 10.40 200.0 µM 1.45E-11 endomembrane recycling 4 8.23E-26 0.93
19 SGTC_1962 st076595 10.20 64.5 µM 3.97E-11 redox potentiating 1 9.51E-25 4.29
20 SGTC_2930 9013230 10.20 14.9 µM 4.82E-11 heme biosynthesis & mitochondrial translocase 5 1.51E-24 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.314 1.81E-77 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.264 2.93E-54 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.261 2.68E-53 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.257 1.03E-51 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.249 1.03E-48 YMR290W-A_d YMR290W-A_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
0.249 2.31E-48 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.248 5.27E-48 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.235 4.09E-43 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.225 1.12E-39 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.220 6.80E-38 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.211 4.16E-35 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.209 2.35E-34 YCR052W RSC6 het Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
0.192 4.52E-29 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.189 2.09E-28 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.189 3.68E-28 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria