YMR206W_p

Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR206W / YMR206W

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.19|P-value:4.25E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.04|P-value:5.98E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.19|P-value:3.46E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.97|P-value:1.18E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.16|P-value:3.88E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-4.05|P-value:8.75E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.38|P-value:1.72E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.18|P-value:4.43E-6 ID:SGTC_1094|Compound:duloxetine|FD-Score:-4.67|P-value:3.64E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.78|P-value:2.90E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.01|P-value:7.09E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:2.98|P-value:7.66E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.06|P-value:5.59E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.03|P-value:6.40E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.18|P-value:4.34E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.79|P-value:2.81E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.00|P-value:7.09E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.16|P-value:3.91E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.16|P-value:3.88E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:-2.93|P-value:9.60E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.38|P-value:1.72E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.84|P-value:1.34E-7 ID:SGTC_1529|Compound:apigenin|FD-Score:6.16|P-value:3.01E-11 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.64|P-value:4.04E-7 ID:SGTC_1655|Compound:st012546|FD-Score:3.02|P-value:6.44E-4 ID:SGTC_1750|Compound:st081859|FD-Score:2.91|P-value:9.77E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.06|P-value:5.56E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.65|P-value:5.41E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.55|P-value:7.89E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-2.93|P-value:9.67E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-5.74|P-value:5.91E-10 ID:SGTC_2303|Compound:7774051|FD-Score:2.92|P-value:9.47E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.11|P-value:4.97E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.14|P-value:4.46E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.65|P-value:5.62E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-3.63|P-value:6.01E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.16|P-value:4.77E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.37|P-value:1.65E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.41|P-value:1.36E-6 ID:SGTC_3033|Compound:9090887|FD-Score:4.57|P-value:5.88E-7 ID:SGTC_3058|Compound:9093861|FD-Score:2.97|P-value:7.92E-4 ID:SGTC_3139|Compound:9095020|FD-Score:2.94|P-value:8.74E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.48|P-value:1.08E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-4.13|P-value:6.02E-6 ID:SGTC_3286|Compound:9117135|FD-Score:3.11|P-value:4.63E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.43|P-value:1.24E-6 ID:SGTC_3300|Compound:9124615|FD-Score:8.09|P-value:4.15E-18 ID:SGTC_3302|Compound:9125395|FD-Score:-2.92|P-value:9.99E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.19|P-value:4.25E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.04|P-value:5.98E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.19|P-value:3.46E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.97|P-value:1.18E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.16|P-value:3.88E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-4.05|P-value:8.75E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.38|P-value:1.72E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.18|P-value:4.43E-6 ID:SGTC_1094|Compound:duloxetine|FD-Score:-4.67|P-value:3.64E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.78|P-value:2.90E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.01|P-value:7.09E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:2.98|P-value:7.66E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.06|P-value:5.59E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.03|P-value:6.40E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.18|P-value:4.34E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.79|P-value:2.81E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.00|P-value:7.09E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.16|P-value:3.91E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.16|P-value:3.88E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:-2.93|P-value:9.60E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.38|P-value:1.72E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.84|P-value:1.34E-7 ID:SGTC_1529|Compound:apigenin|FD-Score:6.16|P-value:3.01E-11 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.64|P-value:4.04E-7 ID:SGTC_1655|Compound:st012546|FD-Score:3.02|P-value:6.44E-4 ID:SGTC_1750|Compound:st081859|FD-Score:2.91|P-value:9.77E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.06|P-value:5.56E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.65|P-value:5.41E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.55|P-value:7.89E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-2.93|P-value:9.67E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-5.74|P-value:5.91E-10 ID:SGTC_2303|Compound:7774051|FD-Score:2.92|P-value:9.47E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.11|P-value:4.97E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.14|P-value:4.46E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.65|P-value:5.62E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-3.63|P-value:6.01E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.16|P-value:4.77E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.37|P-value:1.65E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.41|P-value:1.36E-6 ID:SGTC_3033|Compound:9090887|FD-Score:4.57|P-value:5.88E-7 ID:SGTC_3058|Compound:9093861|FD-Score:2.97|P-value:7.92E-4 ID:SGTC_3139|Compound:9095020|FD-Score:2.94|P-value:8.74E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.48|P-value:1.08E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-4.13|P-value:6.02E-6 ID:SGTC_3286|Compound:9117135|FD-Score:3.11|P-value:4.63E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.43|P-value:1.24E-6 ID:SGTC_3300|Compound:9124615|FD-Score:8.09|P-value:4.15E-18 ID:SGTC_3302|Compound:9125395|FD-Score:-2.92|P-value:9.99E-4

Top fitness defect scores for YMR206W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3300 9124615 8.09 50.5 µM 4.15E-18 1 3.02E-16
2 SGTC_1529 apigenin 6.16 74.0 µM 3.01E-11 4 3.75E-10
3 SGTC_1515 3460-0031 4.84 42.1 µM 1.34E-7 DNA intercalators 8 6.55E-7
4 SGTC_1539 benzyladenosine 4.64 56.0 µM 4.04E-7 5 1.75E-6
5 SGTC_3033 9090887 4.57 49.5 µM 5.88E-7 fatty acid desaturase (OLE1) 12 2.44E-6
6 SGTC_3299 9121982 4.43 43.1 µM 1.24E-6 15 4.76E-6
7 SGTC_2993 9054257 4.41 71.4 µM 1.36E-6 fatty acid desaturase (OLE1) 31 5.16E-6
8 SGTC_65 0798-0905 4.19 35.0 µM 4.25E-6 calcium & mitochondrial duress 80 1.42E-5
9 SGTC_1266 0828-0227 4.18 32.9 µM 4.34E-6 17 1.45E-5
10 SGTC_960 1222-0186 4.18 7.7 µM 4.43E-6 27 1.48E-5
11 SGTC_2921 7974240 4.16 10.7 µM 4.77E-6 44 1.58E-5
12 SGTC_705 1124-0212 3.97 310.0 µM 1.18E-5 11 3.54E-5
13 SGTC_1312 1218-2183 3.79 165.0 µM 2.81E-5 13 7.65E-5
14 SGTC_1098 clofazimine 3.78 15.1 µM 2.90E-5 heme biosynthesis & mitochondrial translocase 29 7.87E-5
15 SGTC_1985 st071382 3.55 65.5 µM 7.89E-5 30 1.92E-4
16 SGTC_3149 9097855 3.48 49.5 µM 1.08E-4 Golgi 39 2.55E-4
17 SGTC_2953 9074162 3.37 66.5 µM 1.65E-4 48 3.71E-4
18 SGTC_569 4130-2812 3.19 160.0 µM 3.46E-4 amide catabolism 28 7.17E-4
19 SGTC_891 0929-0073 3.16 133.0 µM 3.88E-4 55 7.94E-4
20 SGTC_1508 1080-0625 3.16 72.9 µM 3.88E-4 42 7.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 4.26E-17 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.115 2.48E-11 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.114 3.39E-11 YLR049C_p YLR049C_p hom Putative protein of unknown function
0.090 1.90E-7 YIL102C_p YIL102C_p hom Putative protein of unknown function
0.089 2.68E-7 YGL067W NPY1 hom NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member
0.086 6.63E-7 YNR002C ATO2 hom Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication
0.085 7.90E-7 YNR049C MSO1 hom Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress
0.085 8.92E-7 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.13E-6 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.081 2.43E-6 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.66E-6 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.080 3.23E-6 YIL159W BNR1 hom Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
0.080 3.68E-6 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.075 1.23E-5 YLR335W NUP2 hom Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
0.074 1.57E-5 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase