YMR209C_p

Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR209C / YMR209C

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:4.28|P-value:9.07E-6 ID:SGTC_113|Compound:0099-0221|FD-Score:3.40|P-value:3.23E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.12|P-value:8.89E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.39|P-value:3.37E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.23|P-value:6.17E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.21|P-value:1.21E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.87|P-value:5.22E-5 ID:SGTC_433|Compound:pimozide|FD-Score:3.78|P-value:7.44E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.18|P-value:7.28E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.33|P-value:4.27E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.29|P-value:4.85E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.38|P-value:3.57E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.16|P-value:1.55E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.04|P-value:8.12E-13 ID:SGTC_818|Compound:4072-2707|FD-Score:3.70|P-value:1.05E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.12|P-value:8.95E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:6.13|P-value:3.90E-10 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.56|P-value:1.71E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.13|P-value:8.70E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:6.38|P-value:7.57E-11 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.21|P-value:6.51E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.28|P-value:5.09E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.65|P-value:1.29E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.24|P-value:5.78E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.14|P-value:8.38E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.93|P-value:4.17E-5 ID:SGTC_1758|Compound:st042942|FD-Score:3.24|P-value:5.94E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.09|P-value:9.91E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.25|P-value:5.73E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.26|P-value:5.54E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.81|P-value:6.33E-5 ID:SGTC_2161|Compound:5662504|FD-Score:3.39|P-value:3.41E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.95|P-value:3.69E-5 ID:SGTC_2208|Compound:7283366|FD-Score:3.54|P-value:1.96E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.85|P-value:5.42E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.86|P-value:5.40E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.86|P-value:5.54E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.26|P-value:5.09E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.47|P-value:2.54E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.71|P-value:9.93E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.33|P-value:4.27E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.80|P-value:7.12E-5 ID:SGTC_2824|Compound:7998404|FD-Score:4.48|P-value:3.55E-6 ID:SGTC_2853|Compound:9015042|FD-Score:3.32|P-value:4.46E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.49|P-value:2.33E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.17|P-value:7.60E-4 ID:SGTC_3161|Compound:9100388|FD-Score:4.34|P-value:6.65E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-3.65|P-value:1.17E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.31|P-value:4.31E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:4.28|P-value:9.07E-6 ID:SGTC_113|Compound:0099-0221|FD-Score:3.40|P-value:3.23E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.12|P-value:8.89E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.39|P-value:3.37E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.23|P-value:6.17E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.21|P-value:1.21E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.87|P-value:5.22E-5 ID:SGTC_433|Compound:pimozide|FD-Score:3.78|P-value:7.44E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.18|P-value:7.28E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.33|P-value:4.27E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.29|P-value:4.85E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.38|P-value:3.57E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.16|P-value:1.55E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.04|P-value:8.12E-13 ID:SGTC_818|Compound:4072-2707|FD-Score:3.70|P-value:1.05E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.12|P-value:8.95E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:6.13|P-value:3.90E-10 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.56|P-value:1.71E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.13|P-value:8.70E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:6.38|P-value:7.57E-11 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.21|P-value:6.51E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.28|P-value:5.09E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.65|P-value:1.29E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.24|P-value:5.78E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.14|P-value:8.38E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.93|P-value:4.17E-5 ID:SGTC_1758|Compound:st042942|FD-Score:3.24|P-value:5.94E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.09|P-value:9.91E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.25|P-value:5.73E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.26|P-value:5.54E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.81|P-value:6.33E-5 ID:SGTC_2161|Compound:5662504|FD-Score:3.39|P-value:3.41E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.95|P-value:3.69E-5 ID:SGTC_2208|Compound:7283366|FD-Score:3.54|P-value:1.96E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.85|P-value:5.42E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.86|P-value:5.40E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.86|P-value:5.54E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.26|P-value:5.09E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.47|P-value:2.54E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.71|P-value:9.93E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.33|P-value:4.27E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.80|P-value:7.12E-5 ID:SGTC_2824|Compound:7998404|FD-Score:4.48|P-value:3.55E-6 ID:SGTC_2853|Compound:9015042|FD-Score:3.32|P-value:4.46E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.49|P-value:2.33E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.17|P-value:7.60E-4 ID:SGTC_3161|Compound:9100388|FD-Score:4.34|P-value:6.65E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-3.65|P-value:1.17E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.31|P-value:4.31E-4

Top fitness defect scores for YMR209C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_682 0kpi-0099 7.04 17.0 µM 8.12E-13 15 9.58E-13
2 SGTC_1055 3448-0672 6.38 86.0 µM 7.57E-11 8 8.63E-11
3 SGTC_962 1254-0300 6.13 21.5 µM 3.90E-10 5 4.39E-10
4 SGTC_2399 5884133 4.86 200.0 µM 5.54E-7 cell wall signaling 45 5.93E-7
5 SGTC_2824 7998404 4.48 52.0 µM 3.55E-6 24 3.75E-6
6 SGTC_3161 9100388 4.34 49.5 µM 6.65E-6 iron homeostasis 6 7.00E-6
7 SGTC_1 0258-0098 4.28 57.4 µM 9.07E-6 heme biosynthesis & mitochondrial translocase 7 9.52E-6
8 SGTC_204 1543-0184 4.21 62.4 µM 1.21E-5 TRP & mitochondrial translation 26 1.26E-5
9 SGTC_672 1441-0018 4.16 53.7 µM 1.55E-5 15 1.62E-5
10 SGTC_2163 5671233 3.95 125.0 µM 3.69E-5 23 3.84E-5
11 SGTC_1460 k062-0059 3.93 9.2 µM 4.17E-5 Golgi 15 4.33E-5
12 SGTC_391 gliotoxin 3.87 8.3 µM 5.22E-5 66 5.42E-5
13 SGTC_2344 7990960 3.86 77.0 µM 5.40E-5 28 5.60E-5
14 SGTC_2806 7952793 3.80 58.4 µM 7.12E-5 28 7.37E-5
15 SGTC_433 pimozide 3.78 108.0 µM 7.44E-5 20 7.70E-5
16 SGTC_2721 ifenprodil 3.71 61.4 µM 9.93E-5 plasma membrane duress 25 1.03E-4
17 SGTC_818 4072-2707 3.70 53.5 µM 1.05E-4 20 1.09E-4
18 SGTC_1299 1079-1439 3.65 3.7 µM 1.29E-4 TSC3-RPN4 15 1.34E-4
19 SGTC_2208 7283366 3.54 200.0 µM 1.96E-4 15 2.02E-4
20 SGTC_2912 7964298 3.49 10.9 µM 2.33E-4 cell wall 110 2.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 9.26E-34 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.101 4.64E-9 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.101 4.91E-9 YBR194W AIM4 hom Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress
0.090 1.65E-7 YGR040W KSS1 hom Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
0.089 2.23E-7 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.087 4.71E-7 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
0.086 6.01E-7 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.086 6.40E-7 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.084 1.08E-6 YPL217C BMS1 het GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p
0.083 1.50E-6 YFL013W-A_d YFL013W-A_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
0.083 1.50E-6 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.083 1.53E-6 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.083 1.54E-6 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.083 1.70E-6 YGR270W YTA7 hom Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p
0.081 2.83E-6 YDL170W UGA3 hom Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus