YMR211W / DML1

Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR211W / DML1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.09|P-value:5.66E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.95|P-value:8.36E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:8.46|P-value:8.53E-12 ID:SGTC_108|Compound:0509-0257|FD-Score:7.14|P-value:6.54E-9 ID:SGTC_119|Compound:0121-0043|FD-Score:4.12|P-value:5.22E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:6.83|P-value:2.69E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:5.10|P-value:2.43E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:8.88|P-value:8.12E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.00|P-value:7.47E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.60|P-value:1.27E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:6.22|P-value:3.75E-7 ID:SGTC_184|Compound:1494-0393|FD-Score:13.60|P-value:1.13E-27 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:4.65|P-value:1.07E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:12.60|P-value:5.63E-24 ID:SGTC_256|Compound:clotrimazole|FD-Score:6.57|P-value:8.50E-8 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-4.00|P-value:7.58E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:23.40|P-value:2.35E-77 ID:SGTC_268|Compound:camptothecin|FD-Score:10.10|P-value:6.38E-16 ID:SGTC_288|Compound:1315-0019|FD-Score:4.17|P-value:4.47E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:5.96|P-value:1.07E-6 ID:SGTC_329|Compound:k048-0121|FD-Score:6.10|P-value:6.04E-7 ID:SGTC_331|Compound:k048-0133|FD-Score:4.80|P-value:6.72E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:4.51|P-value:1.67E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:7.81|P-value:2.60E-10 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.78|P-value:7.10E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:6.17|P-value:4.51E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.69|P-value:9.28E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.11|P-value:5.50E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-5.78|P-value:2.21E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:12.00|P-value:8.54E-22 ID:SGTC_576|Compound:1073-0113|FD-Score:12.10|P-value:3.35E-22 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.12|P-value:5.44E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-4.13|P-value:5.24E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.65|P-value:1.08E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:4.90|P-value:4.87E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:5.38|P-value:9.27E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:5.16|P-value:2.03E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:7.63|P-value:6.25E-10 ID:SGTC_730|Compound:1436-0052|FD-Score:5.15|P-value:2.04E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:7.27|P-value:3.67E-9 ID:SGTC_746|Compound:1095-0025|FD-Score:4.11|P-value:5.34E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:4.43|P-value:2.13E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:8.31|P-value:1.89E-11 ID:SGTC_922|Compound:1866-0035|FD-Score:9.70|P-value:6.06E-15 ID:SGTC_924|Compound:2046-0044|FD-Score:4.50|P-value:1.69E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.45|P-value:7.17E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:6.64|P-value:6.23E-8 ID:SGTC_1067|Compound:clotrimazole|FD-Score:14.00|P-value:6.57E-29 ID:SGTC_1084|Compound:voriconazole|FD-Score:5.75|P-value:2.40E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.96|P-value:8.49E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.80|P-value:6.73E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.96|P-value:8.14E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.75|P-value:8.12E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.94|P-value:8.55E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:5.52|P-value:5.56E-6 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.43|P-value:2.08E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.96|P-value:8.51E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.03|P-value:6.65E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.11|P-value:5.40E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.24|P-value:3.63E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.68|P-value:9.78E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:14.20|P-value:9.06E-30 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-6.69|P-value:5.51E-8 ID:SGTC_1696|Compound:st025591|FD-Score:4.44|P-value:2.03E-4 ID:SGTC_1707|Compound:st032323|FD-Score:23.50|P-value:4.34E-78 ID:SGTC_1712|Compound:st032288|FD-Score:4.52|P-value:1.60E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.16|P-value:4.66E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.50|P-value:9.23E-24 ID:SGTC_1872|Compound:amphotericin b|FD-Score:11.10|P-value:3.88E-19 ID:SGTC_1873|Compound:rapamycin|FD-Score:25.40|P-value:1.12E-90 ID:SGTC_1884|Compound:5633444|FD-Score:8.18|P-value:3.81E-11 ID:SGTC_1885|Compound:st057546|FD-Score:-3.96|P-value:8.29E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.91|P-value:9.29E-4 ID:SGTC_1930|Compound:st074634|FD-Score:7.01|P-value:1.24E-8 ID:SGTC_1968|Compound:st069590|FD-Score:11.00|P-value:8.77E-19 ID:SGTC_2027|Compound:5150920|FD-Score:4.54|P-value:1.50E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.85|P-value:5.73E-5 ID:SGTC_2038|Compound:4100038|FD-Score:5.51|P-value:5.89E-6 ID:SGTC_2041|Compound:5107442|FD-Score:-5.92|P-value:1.30E-6 ID:SGTC_2096|Compound:5468907|FD-Score:6.31|P-value:2.59E-7 ID:SGTC_2111|Compound:5486399|FD-Score:-4.66|P-value:1.10E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.10|P-value:5.45E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.42|P-value:2.16E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.96|P-value:8.40E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.36|P-value:2.56E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:10.60|P-value:1.98E-17 ID:SGTC_2443|Compound:5493264|FD-Score:-5.06|P-value:3.00E-5 ID:SGTC_2449|Compound:5812982|FD-Score:5.43|P-value:7.67E-6 ID:SGTC_2459|Compound:5811157|FD-Score:10.20|P-value:2.35E-16 ID:SGTC_2471|Compound:5466956|FD-Score:6.75|P-value:3.84E-8 ID:SGTC_2475|Compound:5812728|FD-Score:4.64|P-value:1.09E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.40|P-value:8.65E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.53|P-value:1.56E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:36.00|P-value:9.38E-181 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.88|P-value:2.20E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:10.30|P-value:9.27E-17 ID:SGTC_2601|Compound:securinine|FD-Score:-5.27|P-value:1.44E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:5.16|P-value:1.98E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.21|P-value:1.69E-5 ID:SGTC_2732|Compound:terfenadine|FD-Score:4.35|P-value:2.68E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-6.09|P-value:6.54E-7 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.40|P-value:2.40E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.28|P-value:1.30E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.90|P-value:9.56E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.01|P-value:7.01E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.96|P-value:8.01E-4 ID:SGTC_3074|Compound:9116018|FD-Score:5.73|P-value:2.59E-6 ID:SGTC_3081|Compound:9117243|FD-Score:5.47|P-value:6.73E-6 ID:SGTC_3085|Compound:9117376|FD-Score:7.42|P-value:1.80E-9 ID:SGTC_3091|Compound:9116372|FD-Score:9.67|P-value:7.11E-15 ID:SGTC_3098|Compound:9119039|FD-Score:4.78|P-value:7.01E-5 ID:SGTC_3126|Compound:9127922|FD-Score:4.79|P-value:6.94E-5 ID:SGTC_3141|Compound:9094609|FD-Score:4.06|P-value:6.15E-4 ID:SGTC_3181|Compound:9108277|FD-Score:5.38|P-value:9.10E-6 ID:SGTC_3247|Compound:9135149|FD-Score:11.00|P-value:1.01E-18 ID:SGTC_3296|Compound:9122258|FD-Score:4.25|P-value:3.57E-4 ID:SGTC_3303|Compound:9125618|FD-Score:5.55|P-value:4.96E-6 ID:SGTC_3311|Compound:9131146|FD-Score:15.20|P-value:9.82E-34 ID:SGTC_3321|Compound:9137793|FD-Score:10.10|P-value:5.66E-16 ID:SGTC_3322|Compound:9139058|FD-Score:4.18|P-value:4.40E-4 ID:SGTC_3334|Compound:9142812|FD-Score:5.10|P-value:2.46E-5 ID:SGTC_3350|Compound:9150499|FD-Score:10.60|P-value:2.35E-17 ID:SGTC_3351|Compound:9150312|FD-Score:10.70|P-value:7.18E-18 ID:SGTC_8|Compound:0354-0001|FD-Score:4.09|P-value:5.66E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.95|P-value:8.36E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:8.46|P-value:8.53E-12 ID:SGTC_108|Compound:0509-0257|FD-Score:7.14|P-value:6.54E-9 ID:SGTC_119|Compound:0121-0043|FD-Score:4.12|P-value:5.22E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:6.83|P-value:2.69E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:5.10|P-value:2.43E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:8.88|P-value:8.12E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.00|P-value:7.47E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.60|P-value:1.27E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:6.22|P-value:3.75E-7 ID:SGTC_184|Compound:1494-0393|FD-Score:13.60|P-value:1.13E-27 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:4.65|P-value:1.07E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:12.60|P-value:5.63E-24 ID:SGTC_256|Compound:clotrimazole|FD-Score:6.57|P-value:8.50E-8 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-4.00|P-value:7.58E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:23.40|P-value:2.35E-77 ID:SGTC_268|Compound:camptothecin|FD-Score:10.10|P-value:6.38E-16 ID:SGTC_288|Compound:1315-0019|FD-Score:4.17|P-value:4.47E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:5.96|P-value:1.07E-6 ID:SGTC_329|Compound:k048-0121|FD-Score:6.10|P-value:6.04E-7 ID:SGTC_331|Compound:k048-0133|FD-Score:4.80|P-value:6.72E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:4.51|P-value:1.67E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:7.81|P-value:2.60E-10 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.78|P-value:7.10E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:6.17|P-value:4.51E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.69|P-value:9.28E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.11|P-value:5.50E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-5.78|P-value:2.21E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:12.00|P-value:8.54E-22 ID:SGTC_576|Compound:1073-0113|FD-Score:12.10|P-value:3.35E-22 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.12|P-value:5.44E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-4.13|P-value:5.24E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.65|P-value:1.08E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:4.90|P-value:4.87E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:5.38|P-value:9.27E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:5.16|P-value:2.03E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:7.63|P-value:6.25E-10 ID:SGTC_730|Compound:1436-0052|FD-Score:5.15|P-value:2.04E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:7.27|P-value:3.67E-9 ID:SGTC_746|Compound:1095-0025|FD-Score:4.11|P-value:5.34E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:4.43|P-value:2.13E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:8.31|P-value:1.89E-11 ID:SGTC_922|Compound:1866-0035|FD-Score:9.70|P-value:6.06E-15 ID:SGTC_924|Compound:2046-0044|FD-Score:4.50|P-value:1.69E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.45|P-value:7.17E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:6.64|P-value:6.23E-8 ID:SGTC_1067|Compound:clotrimazole|FD-Score:14.00|P-value:6.57E-29 ID:SGTC_1084|Compound:voriconazole|FD-Score:5.75|P-value:2.40E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.96|P-value:8.49E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.80|P-value:6.73E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.96|P-value:8.14E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.75|P-value:8.12E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.94|P-value:8.55E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:5.52|P-value:5.56E-6 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.43|P-value:2.08E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.96|P-value:8.51E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.03|P-value:6.65E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.11|P-value:5.40E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.24|P-value:3.63E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.68|P-value:9.78E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:14.20|P-value:9.06E-30 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-6.69|P-value:5.51E-8 ID:SGTC_1696|Compound:st025591|FD-Score:4.44|P-value:2.03E-4 ID:SGTC_1707|Compound:st032323|FD-Score:23.50|P-value:4.34E-78 ID:SGTC_1712|Compound:st032288|FD-Score:4.52|P-value:1.60E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.16|P-value:4.66E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.50|P-value:9.23E-24 ID:SGTC_1872|Compound:amphotericin b|FD-Score:11.10|P-value:3.88E-19 ID:SGTC_1873|Compound:rapamycin|FD-Score:25.40|P-value:1.12E-90 ID:SGTC_1884|Compound:5633444|FD-Score:8.18|P-value:3.81E-11 ID:SGTC_1885|Compound:st057546|FD-Score:-3.96|P-value:8.29E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.91|P-value:9.29E-4 ID:SGTC_1930|Compound:st074634|FD-Score:7.01|P-value:1.24E-8 ID:SGTC_1968|Compound:st069590|FD-Score:11.00|P-value:8.77E-19 ID:SGTC_2027|Compound:5150920|FD-Score:4.54|P-value:1.50E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.85|P-value:5.73E-5 ID:SGTC_2038|Compound:4100038|FD-Score:5.51|P-value:5.89E-6 ID:SGTC_2041|Compound:5107442|FD-Score:-5.92|P-value:1.30E-6 ID:SGTC_2096|Compound:5468907|FD-Score:6.31|P-value:2.59E-7 ID:SGTC_2111|Compound:5486399|FD-Score:-4.66|P-value:1.10E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.10|P-value:5.45E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.42|P-value:2.16E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.96|P-value:8.40E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.36|P-value:2.56E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:10.60|P-value:1.98E-17 ID:SGTC_2443|Compound:5493264|FD-Score:-5.06|P-value:3.00E-5 ID:SGTC_2449|Compound:5812982|FD-Score:5.43|P-value:7.67E-6 ID:SGTC_2459|Compound:5811157|FD-Score:10.20|P-value:2.35E-16 ID:SGTC_2471|Compound:5466956|FD-Score:6.75|P-value:3.84E-8 ID:SGTC_2475|Compound:5812728|FD-Score:4.64|P-value:1.09E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.40|P-value:8.65E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.53|P-value:1.56E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:36.00|P-value:9.38E-181 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.88|P-value:2.20E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:10.30|P-value:9.27E-17 ID:SGTC_2601|Compound:securinine|FD-Score:-5.27|P-value:1.44E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:5.16|P-value:1.98E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.21|P-value:1.69E-5 ID:SGTC_2732|Compound:terfenadine|FD-Score:4.35|P-value:2.68E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-6.09|P-value:6.54E-7 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.40|P-value:2.40E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.28|P-value:1.30E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.90|P-value:9.56E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.01|P-value:7.01E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.96|P-value:8.01E-4 ID:SGTC_3074|Compound:9116018|FD-Score:5.73|P-value:2.59E-6 ID:SGTC_3081|Compound:9117243|FD-Score:5.47|P-value:6.73E-6 ID:SGTC_3085|Compound:9117376|FD-Score:7.42|P-value:1.80E-9 ID:SGTC_3091|Compound:9116372|FD-Score:9.67|P-value:7.11E-15 ID:SGTC_3098|Compound:9119039|FD-Score:4.78|P-value:7.01E-5 ID:SGTC_3126|Compound:9127922|FD-Score:4.79|P-value:6.94E-5 ID:SGTC_3141|Compound:9094609|FD-Score:4.06|P-value:6.15E-4 ID:SGTC_3181|Compound:9108277|FD-Score:5.38|P-value:9.10E-6 ID:SGTC_3247|Compound:9135149|FD-Score:11.00|P-value:1.01E-18 ID:SGTC_3296|Compound:9122258|FD-Score:4.25|P-value:3.57E-4 ID:SGTC_3303|Compound:9125618|FD-Score:5.55|P-value:4.96E-6 ID:SGTC_3311|Compound:9131146|FD-Score:15.20|P-value:9.82E-34 ID:SGTC_3321|Compound:9137793|FD-Score:10.10|P-value:5.66E-16 ID:SGTC_3322|Compound:9139058|FD-Score:4.18|P-value:4.40E-4 ID:SGTC_3334|Compound:9142812|FD-Score:5.10|P-value:2.46E-5 ID:SGTC_3350|Compound:9150499|FD-Score:10.60|P-value:2.35E-17 ID:SGTC_3351|Compound:9150312|FD-Score:10.70|P-value:7.18E-18

Top fitness defect scores for YMR211W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2567 aureobasidin a 36.00 60.0 nM 9.38E-181 3 1.44E-284 10.60
2 SGTC_1873 rapamycin 25.40 2.0 nM 1.12E-90 1 4.02E-142 6.77
3 SGTC_1707 st032323 23.50 6.3 µM 4.34E-78 DNA damage response 1 3.20E-122 11.70
4 SGTC_266 formosanin C 23.40 406.0 nM 2.35E-77 sphingolipid biosynthesis & PDR1 1 4.62E-121 11.20
5 SGTC_3311 9131146 15.20 2.9 µM 9.82E-34 cell wall 2 3.73E-52 5.73
6 SGTC_1568 digitonin 14.20 820.0 nM 9.06E-30 sphingolipid biosynthesis & PDR1 1 6.73E-46 7.39
7 SGTC_1067 clotrimazole 14.00 1.4 µM 6.57E-29 azole & statin 2 1.53E-44 2.40
8 SGTC_184 1494-0393 13.60 24.7 µM 1.13E-27 1 1.36E-42 3.26
9 SGTC_227 fluconazole 12.60 33.5 µM 5.63E-24 azole & statin 10 9.19E-37 1.84
10 SGTC_1844 rapamycin 12.50 4.0 nM 9.23E-24 5 2.00E-36 0.26
11 SGTC_576 1073-0113 12.10 22.7 µM 3.35E-22 redox potentiating 2 5.75E-34 0.03
12 SGTC_525 k781-2675 12.00 26.7 µM 8.54E-22 redox potentiating 5 2.51E-33 3.42
13 SGTC_1872 amphotericin b 11.10 148.0 nM 3.88E-19 RNA pol III & RNase P/MRP 6 3.86E-29 2.44
14 SGTC_1968 st069590 11.00 43.6 µM 8.77E-19 4 1.39E-28 1.20
15 SGTC_3247 9135149 11.00 49.5 µM 1.01E-18 DNA damage response 2 1.75E-28 2.13
16 SGTC_3351 9150312 10.70 21.6 µM 7.18E-18 cell wall 1 3.82E-27 1.90
17 SGTC_2420 aureobasidin a 10.60 50.0 nM 1.98E-17 3 1.88E-26 6.25
18 SGTC_3350 9150499 10.60 3.6 µM 2.35E-17 cell wall 2 2.46E-26 2.82
19 SGTC_2584 androsterone 10.30 48.7 µM 9.27E-17 cell wall 2 2.14E-25 1.57
20 SGTC_2459 5811157 10.20 9.2 µM 2.35E-16 mitochondrial processes 4 9.23E-25 2.51

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.336 1.91E-89 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.307 5.53E-74 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.291 2.66E-66 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.262 7.55E-54 YKL182W FAS1 het Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
0.262 1.22E-53 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.225 6.60E-40 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.222 9.85E-39 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.216 7.18E-37 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.212 1.52E-35 YHR007C ERG11 het Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
0.212 2.36E-35 YER112W LSM4 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
0.207 5.66E-34 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.206 1.34E-33 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.188 3.82E-28 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.179 1.13E-25 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.176 8.59E-25 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching