YMR213W / CEF1

Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR213W / CEF1

Click on Significant Values for Screen Details ID:SGTC_249|Compound:wiskostatin|FD-Score:3.34|P-value:6.32E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:2.91|P-value:4.26E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:2.70|P-value:9.79E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:2.85|P-value:5.46E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.73|P-value:8.77E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.92|P-value:3.01E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:-2.92|P-value:3.65E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.67|P-value:9.96E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.41|P-value:4.55E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.74|P-value:8.89E-6 ID:SGTC_1384|Compound:3089-0840|FD-Score:-3.75|P-value:7.54E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.29|P-value:7.03E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:-2.75|P-value:7.33E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.97|P-value:2.95E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.31|P-value:6.61E-5 ID:SGTC_1678|Compound:st019265|FD-Score:-2.68|P-value:9.73E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-2.76|P-value:7.06E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.48|P-value:3.24E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-2.80|P-value:5.93E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.08|P-value:2.06E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.38|P-value:5.32E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.05|P-value:2.38E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-2.76|P-value:7.13E-4 ID:SGTC_2108|Compound:5365811|FD-Score:2.78|P-value:7.33E-4 ID:SGTC_2148|Compound:5546263|FD-Score:2.70|P-value:9.73E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-2.82|P-value:5.64E-4 ID:SGTC_2262|Compound:9014885|FD-Score:3.09|P-value:1.99E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-2.70|P-value:9.04E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:2.84|P-value:5.59E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:8.51|P-value:6.95E-23 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.04|P-value:2.48E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:8.71|P-value:6.54E-24 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.22|P-value:6.50E-7 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.79|P-value:6.29E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.37|P-value:5.46E-5 ID:SGTC_2696|Compound:st077691|FD-Score:2.72|P-value:9.24E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:2.74|P-value:8.44E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.80|P-value:6.70E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.96|P-value:3.45E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.38|P-value:5.40E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.60|P-value:1.80E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.34|P-value:6.32E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:2.91|P-value:4.26E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:2.70|P-value:9.79E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:2.85|P-value:5.46E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.73|P-value:8.77E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.92|P-value:3.01E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:-2.92|P-value:3.65E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.67|P-value:9.96E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.41|P-value:4.55E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.74|P-value:8.89E-6 ID:SGTC_1384|Compound:3089-0840|FD-Score:-3.75|P-value:7.54E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.29|P-value:7.03E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:-2.75|P-value:7.33E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.97|P-value:2.95E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.31|P-value:6.61E-5 ID:SGTC_1678|Compound:st019265|FD-Score:-2.68|P-value:9.73E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-2.76|P-value:7.06E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.48|P-value:3.24E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-2.80|P-value:5.93E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.08|P-value:2.06E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.38|P-value:5.32E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.05|P-value:2.38E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-2.76|P-value:7.13E-4 ID:SGTC_2108|Compound:5365811|FD-Score:2.78|P-value:7.33E-4 ID:SGTC_2148|Compound:5546263|FD-Score:2.70|P-value:9.73E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-2.82|P-value:5.64E-4 ID:SGTC_2262|Compound:9014885|FD-Score:3.09|P-value:1.99E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-2.70|P-value:9.04E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:2.84|P-value:5.59E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:8.51|P-value:6.95E-23 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.04|P-value:2.48E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:8.71|P-value:6.54E-24 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.22|P-value:6.50E-7 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.79|P-value:6.29E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.37|P-value:5.46E-5 ID:SGTC_2696|Compound:st077691|FD-Score:2.72|P-value:9.24E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:2.74|P-value:8.44E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.80|P-value:6.70E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.96|P-value:3.45E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.38|P-value:5.40E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.60|P-value:1.80E-5

Top fitness defect scores for YMR213W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2613 3',4'-dimethoxydalbergione 8.71 24.6 µM 6.54E-24 1 1.49E-18 2.84
2 SGTC_2605 digitonin 8.51 300.0 nM 6.95E-23 2 8.93E-18 3.00
3 SGTC_2616 abietic acid 4.22 100.0 µM 6.50E-7 2 1.24E-5 0.07
4 SGTC_1259 0671-0132 3.74 43.0 µM 8.89E-6 6 9.20E-5 0.03
5 SGTC_3232 9132874 3.60 49.5 µM 1.80E-5 RPP1 & pyrimidine depletion 10 1.58E-4 0.01
6 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.48 14.9 µM 3.24E-5 10 2.48E-4 0.01
7 SGTC_1254 0550-0035 3.41 264.0 µM 4.55E-5 14 3.23E-4 0.05
8 SGTC_2014 4013930 3.38 200.0 µM 5.32E-5 8 3.64E-4 0.07
9 SGTC_3179 9107801 3.38 49.5 µM 5.40E-5 3 3.68E-4 0.28
10 SGTC_2678 equilin 3.37 100.0 µM 5.46E-5 4 3.71E-4 0.31
11 SGTC_249 wiskostatin 3.34 11.2 µM 6.32E-5 5 4.15E-4 0.13
12 SGTC_2262 9014885 3.09 67.5 µM 1.99E-4 3 0.00100 0.43
13 SGTC_1917 st066507 3.08 28.5 µM 2.06E-4 Golgi 21 0.00103 0.08
14 SGTC_2015 5119600 3.05 184.0 µM 2.38E-4 21 0.00115 0.01
15 SGTC_2611 pyromycin 3.04 23.9 µM 2.48E-4 20 0.00119 0.03
16 SGTC_2807 7945238 2.96 52.0 µM 3.45E-4 14 0.00154 0.01
17 SGTC_329 k048-0121 2.91 21.3 µM 4.26E-4 RSC & ERG11 19 0.00181 0.05
18 SGTC_334 1502-1024 2.85 68.5 µM 5.46E-4 14 0.00219 0.06
19 SGTC_2598 perillyl alcohol 2.84 100.0 µM 5.59E-4 26 0.00223 0.02
20 SGTC_2764 methyldopa 2.80 94.7 µM 6.70E-4 18 0.00257 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 1.80E-26 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.177 6.54E-25 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.176 8.73E-25 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.159 2.39E-20 YOR287C RRP36 het Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
0.154 2.42E-19 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.146 2.42E-17 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.141 1.89E-16 YDR330W UBX5 hom UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
0.138 8.84E-16 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.133 8.58E-15 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.133 1.02E-14 YBL019W APN2 hom Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.132 1.78E-14 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.121 2.31E-12 YGL249W ZIP2 hom Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.121 2.36E-12 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.118 6.19E-12 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.117 1.04E-11 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C