YMR214W / SCJ1

One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR214W / SCJ1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:6.76|P-value:1.19E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:7.12|P-value:1.27E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:6.48|P-value:6.37E-10 ID:SGTC_103|Compound:0844-0104|FD-Score:4.49|P-value:1.30E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.42|P-value:6.98E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.58|P-value:8.48E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:4.10|P-value:6.03E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:6.18|P-value:3.51E-9 ID:SGTC_178|Compound:4092-0806|FD-Score:5.89|P-value:1.71E-8 ID:SGTC_207|Compound:4185-0010|FD-Score:4.89|P-value:2.34E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-8.94|P-value:3.06E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:3.42|P-value:6.70E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:-4.41|P-value:1.89E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-4.95|P-value:1.79E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.84|P-value:1.64E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.08|P-value:9.87E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.65|P-value:3.12E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.44|P-value:6.47E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.34|P-value:8.96E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.73|P-value:2.37E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.59|P-value:3.94E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.87|P-value:1.49E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:16.20|P-value:5.66E-52 ID:SGTC_455|Compound:paf C-16|FD-Score:4.44|P-value:1.62E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:8.16|P-value:1.04E-14 ID:SGTC_673|Compound:1082-0474|FD-Score:3.76|P-value:2.14E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.98|P-value:9.87E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.03|P-value:7.94E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.54|P-value:4.67E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.74|P-value:2.29E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.41|P-value:7.02E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.50|P-value:5.24E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.57|P-value:9.10E-8 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.80|P-value:1.85E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-5.51|P-value:1.30E-7 ID:SGTC_1558|Compound:st069300|FD-Score:-4.57|P-value:9.77E-6 ID:SGTC_1614|Compound:st002383|FD-Score:4.14|P-value:5.29E-5 ID:SGTC_1658|Compound:st012944|FD-Score:5.18|P-value:6.08E-7 ID:SGTC_1737|Compound:st035557|FD-Score:4.39|P-value:1.95E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.17|P-value:6.40E-7 ID:SGTC_1786|Compound:berberine|FD-Score:-4.20|P-value:4.31E-5 ID:SGTC_1903|Compound:st060211|FD-Score:4.24|P-value:3.52E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.47|P-value:5.86E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.78|P-value:3.79E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.33|P-value:9.04E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.61|P-value:3.69E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.41|P-value:7.03E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-5.16|P-value:6.77E-7 ID:SGTC_2127|Compound:5253358|FD-Score:3.56|P-value:4.24E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.10|P-value:6.22E-5 ID:SGTC_2396|Compound:5342950|FD-Score:5.83|P-value:2.35E-8 ID:SGTC_2488|Compound:5268135|FD-Score:3.53|P-value:4.72E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.00|P-value:1.34E-34 ID:SGTC_2585|Compound:alliin|FD-Score:4.34|P-value:2.38E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:6.27|P-value:2.09E-9 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.71|P-value:5.01E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.70|P-value:2.71E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.16|P-value:1.11E-14 ID:SGTC_3016|Compound:9080866|FD-Score:3.35|P-value:8.49E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.75|P-value:2.24E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.78|P-value:1.99E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.90|P-value:2.20E-6 ID:SGTC_3196|Compound:9111891|FD-Score:-5.76|P-value:3.46E-8 ID:SGTC_3200|Compound:9114385|FD-Score:5.05|P-value:1.11E-6 ID:SGTC_3225|Compound:9130819|FD-Score:4.73|P-value:4.62E-6 ID:SGTC_3318|Compound:9139014|FD-Score:4.24|P-value:3.62E-5 ID:SGTC_3324|Compound:9138759|FD-Score:4.14|P-value:5.16E-5 ID:SGTC_3334|Compound:9142812|FD-Score:5.00|P-value:1.41E-6 ID:SGTC_8|Compound:0354-0001|FD-Score:6.76|P-value:1.19E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:7.12|P-value:1.27E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:6.48|P-value:6.37E-10 ID:SGTC_103|Compound:0844-0104|FD-Score:4.49|P-value:1.30E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.42|P-value:6.98E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.58|P-value:8.48E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:4.10|P-value:6.03E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:6.18|P-value:3.51E-9 ID:SGTC_178|Compound:4092-0806|FD-Score:5.89|P-value:1.71E-8 ID:SGTC_207|Compound:4185-0010|FD-Score:4.89|P-value:2.34E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-8.94|P-value:3.06E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:3.42|P-value:6.70E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:-4.41|P-value:1.89E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-4.95|P-value:1.79E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.84|P-value:1.64E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.08|P-value:9.87E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.65|P-value:3.12E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.44|P-value:6.47E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.34|P-value:8.96E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.73|P-value:2.37E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.59|P-value:3.94E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.87|P-value:1.49E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:16.20|P-value:5.66E-52 ID:SGTC_455|Compound:paf C-16|FD-Score:4.44|P-value:1.62E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:8.16|P-value:1.04E-14 ID:SGTC_673|Compound:1082-0474|FD-Score:3.76|P-value:2.14E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.98|P-value:9.87E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.03|P-value:7.94E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.54|P-value:4.67E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.74|P-value:2.29E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.41|P-value:7.02E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.50|P-value:5.24E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.57|P-value:9.10E-8 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.80|P-value:1.85E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-5.51|P-value:1.30E-7 ID:SGTC_1558|Compound:st069300|FD-Score:-4.57|P-value:9.77E-6 ID:SGTC_1614|Compound:st002383|FD-Score:4.14|P-value:5.29E-5 ID:SGTC_1658|Compound:st012944|FD-Score:5.18|P-value:6.08E-7 ID:SGTC_1737|Compound:st035557|FD-Score:4.39|P-value:1.95E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.17|P-value:6.40E-7 ID:SGTC_1786|Compound:berberine|FD-Score:-4.20|P-value:4.31E-5 ID:SGTC_1903|Compound:st060211|FD-Score:4.24|P-value:3.52E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.47|P-value:5.86E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.78|P-value:3.79E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.33|P-value:9.04E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.61|P-value:3.69E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.41|P-value:7.03E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-5.16|P-value:6.77E-7 ID:SGTC_2127|Compound:5253358|FD-Score:3.56|P-value:4.24E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.10|P-value:6.22E-5 ID:SGTC_2396|Compound:5342950|FD-Score:5.83|P-value:2.35E-8 ID:SGTC_2488|Compound:5268135|FD-Score:3.53|P-value:4.72E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.00|P-value:1.34E-34 ID:SGTC_2585|Compound:alliin|FD-Score:4.34|P-value:2.38E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:6.27|P-value:2.09E-9 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.71|P-value:5.01E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.70|P-value:2.71E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.16|P-value:1.11E-14 ID:SGTC_3016|Compound:9080866|FD-Score:3.35|P-value:8.49E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.75|P-value:2.24E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.78|P-value:1.99E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.90|P-value:2.20E-6 ID:SGTC_3196|Compound:9111891|FD-Score:-5.76|P-value:3.46E-8 ID:SGTC_3200|Compound:9114385|FD-Score:5.05|P-value:1.11E-6 ID:SGTC_3225|Compound:9130819|FD-Score:4.73|P-value:4.62E-6 ID:SGTC_3318|Compound:9139014|FD-Score:4.24|P-value:3.62E-5 ID:SGTC_3324|Compound:9138759|FD-Score:4.14|P-value:5.16E-5 ID:SGTC_3334|Compound:9142812|FD-Score:5.00|P-value:1.41E-6

Top fitness defect scores for YMR214W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_453 enantio-paf c16 16.20 10.0 µM 5.66E-52 1 5.41E-59
2 SGTC_2582 agaric acid 13.00 100.0 µM 1.34E-34 redox potentiating 28 3.50E-39
3 SGTC_568 1193-0097 8.16 7.5 µM 1.04E-14 ERAD & cell cycle 33 1.62E-16
4 SGTC_2896 9052656 8.16 71.4 µM 1.11E-14 endomembrane recycling 16 1.73E-16
5 SGTC_58 0957-0393 7.12 9.0 µM 1.27E-11 cell wall 160 5.26E-13
6 SGTC_8 0354-0001 6.76 70.0 µM 1.19E-10 20 6.74E-12
7 SGTC_59 0330-0160 6.48 1.3 µM 6.37E-10 29 4.53E-11
8 SGTC_2586 curcumin 6.27 80.0 µM 2.09E-9 iron homeostasis 12 1.75E-10
9 SGTC_124 0136-0217 6.18 7.1 µM 3.51E-9 mitochondrial stress 23 3.15E-10
10 SGTC_178 4092-0806 5.89 87.5 µM 1.71E-8 ergosterol depletion effects on membrane 42 1.90E-9
11 SGTC_2396 5342950 5.83 42.8 µM 2.35E-8 RSC complex & mRNA processing 15 2.74E-9
12 SGTC_116 0155-0182 5.58 31.8 µM 8.48E-8 mitochondrial response to ROS 31 1.18E-8
13 SGTC_1425 4048-4433 5.57 7.3 µM 9.10E-8 copper-dependent oxidative stress 13 1.28E-8
14 SGTC_1658 st012944 5.18 20.0 µM 6.08E-7 iron homeostasis 43 1.10E-7
15 SGTC_1750 st081859 5.17 2.4 µM 6.40E-7 endomembrane recycling 133 1.17E-7
16 SGTC_268 camptothecin 5.08 39.6 µM 9.87E-7 DNA damage response 46 1.91E-7
17 SGTC_3200 9114385 5.05 49.5 µM 1.11E-6 13 2.19E-7
18 SGTC_3334 9142812 5.00 21.9 µM 1.41E-6 13 2.87E-7
19 SGTC_3142 9086498 4.90 49.5 µM 2.20E-6 iron homeostasis 20 4.74E-7
20 SGTC_207 4185-0010 4.89 4.5 µM 2.34E-6 endomembrane recycling 56 5.09E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.331 1.65E-86 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.304 6.26E-73 YOR034C-A_p YOR034C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.260 4.31E-53 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.258 2.87E-52 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.248 4.12E-48 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.246 2.72E-47 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.241 1.62E-45 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.234 6.66E-43 YKL121W_p DGR2_p hom Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds
0.228 6.11E-41 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.215 2.49E-36 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.198 4.62E-31 YDL173W PAR32 hom Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
0.193 1.38E-29 YER072W VTC1 hom Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.190 1.09E-28 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.190 1.32E-28 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.189 1.89E-28 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels