YMR215W / GAS3

Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR215W / GAS3

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.10|P-value:7.10E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.05|P-value:8.64E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-4.06|P-value:1.95E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-4.50|P-value:2.55E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.35|P-value:3.56E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:8.18|P-value:3.05E-17 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.73|P-value:8.11E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-5.50|P-value:1.23E-8 ID:SGTC_493|Compound:zm226600|FD-Score:3.20|P-value:4.92E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.57|P-value:1.37E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.04|P-value:8.76E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.75|P-value:5.89E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.27|P-value:3.91E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.82|P-value:4.38E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.99|P-value:2.66E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:5.12|P-value:7.87E-8 ID:SGTC_874|Compound:0599-0792|FD-Score:3.49|P-value:1.69E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.17|P-value:5.57E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:5.38|P-value:1.78E-8 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.12|P-value:8.05E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.37|P-value:2.64E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:5.95|P-value:5.46E-10 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.21|P-value:4.84E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.84|P-value:5.14E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.59|P-value:1.43E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.61|P-value:1.32E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-4.08|P-value:1.79E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.69|P-value:7.65E-5 ID:SGTC_2331|Compound:7980721|FD-Score:4.61|P-value:1.11E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.86|P-value:4.77E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.99|P-value:2.13E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.42|P-value:2.69E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-4.23|P-value:9.18E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.40|P-value:3.17E-6 ID:SGTC_2795|Compound:7780010|FD-Score:4.15|P-value:1.03E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-4.05|P-value:2.08E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-3.75|P-value:7.55E-5 ID:SGTC_2867|Compound:9039098|FD-Score:-5.22|P-value:5.95E-8 ID:SGTC_2873|Compound:9040596|FD-Score:-3.98|P-value:2.83E-5 ID:SGTC_2878|Compound:9043973|FD-Score:3.75|P-value:5.90E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.09|P-value:1.34E-5 ID:SGTC_3055|Compound:9094636|FD-Score:-3.12|P-value:8.21E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.76|P-value:5.37E-7 ID:SGTC_3211|Compound:9128781|FD-Score:-3.68|P-value:9.99E-5 ID:SGTC_3254|Compound:9136651|FD-Score:3.65|P-value:8.84E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.88|P-value:4.36E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:3.10|P-value:7.10E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.05|P-value:8.64E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-4.06|P-value:1.95E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-4.50|P-value:2.55E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.35|P-value:3.56E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:8.18|P-value:3.05E-17 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.73|P-value:8.11E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-5.50|P-value:1.23E-8 ID:SGTC_493|Compound:zm226600|FD-Score:3.20|P-value:4.92E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.57|P-value:1.37E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.04|P-value:8.76E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.75|P-value:5.89E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.27|P-value:3.91E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.82|P-value:4.38E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.99|P-value:2.66E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:5.12|P-value:7.87E-8 ID:SGTC_874|Compound:0599-0792|FD-Score:3.49|P-value:1.69E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.17|P-value:5.57E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:5.38|P-value:1.78E-8 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.12|P-value:8.05E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.37|P-value:2.64E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:5.95|P-value:5.46E-10 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.21|P-value:4.84E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.84|P-value:5.14E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.59|P-value:1.43E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.61|P-value:1.32E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-4.08|P-value:1.79E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.69|P-value:7.65E-5 ID:SGTC_2331|Compound:7980721|FD-Score:4.61|P-value:1.11E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.86|P-value:4.77E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.99|P-value:2.13E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.42|P-value:2.69E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-4.23|P-value:9.18E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.40|P-value:3.17E-6 ID:SGTC_2795|Compound:7780010|FD-Score:4.15|P-value:1.03E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-4.05|P-value:2.08E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-3.75|P-value:7.55E-5 ID:SGTC_2867|Compound:9039098|FD-Score:-5.22|P-value:5.95E-8 ID:SGTC_2873|Compound:9040596|FD-Score:-3.98|P-value:2.83E-5 ID:SGTC_2878|Compound:9043973|FD-Score:3.75|P-value:5.90E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.09|P-value:1.34E-5 ID:SGTC_3055|Compound:9094636|FD-Score:-3.12|P-value:8.21E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.76|P-value:5.37E-7 ID:SGTC_3211|Compound:9128781|FD-Score:-3.68|P-value:9.99E-5 ID:SGTC_3254|Compound:9136651|FD-Score:3.65|P-value:8.84E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.88|P-value:4.36E-5

Top fitness defect scores for YMR215W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_353 1988-1175 8.18 58.3 µM 3.05E-17 unfolded protein response 5 1.48E-16
2 SGTC_1059 3448-6867 5.95 171.0 µM 5.46E-10 1 1.34E-9
3 SGTC_946 3434-1334 5.38 87.4 µM 1.78E-8 8 3.76E-8
4 SGTC_763 3453-1109 5.12 128.0 µM 7.87E-8 4 1.57E-7
5 SGTC_3202 9113761 4.76 49.5 µM 5.37E-7 25 9.87E-7
6 SGTC_2331 7980721 4.61 200.0 µM 1.11E-6 10 1.98E-6
7 SGTC_501 nsc-95397 4.57 161.0 µM 1.37E-6 6 2.41E-6
8 SGTC_2635 hydroquinidine 4.40 100.0 µM 3.17E-6 14 5.40E-6
9 SGTC_2795 7780010 4.15 54.5 µM 1.03E-5 24 1.67E-5
10 SGTC_2924 9010168 4.09 62.8 µM 1.34E-5 cell wall signaling 34 2.15E-5
11 SGTC_2568 diosmetin 3.99 100.0 µM 2.13E-5 24 3.35E-5
12 SGTC_702 1488-0190 3.82 94.0 µM 4.38E-5 amide catabolism 18 6.69E-5
13 SGTC_531 3788-1495 3.75 174.0 µM 5.89E-5 unfolded protein response 23 8.88E-5
14 SGTC_2878 9043973 3.75 26.0 µM 5.90E-5 26 8.90E-5
15 SGTC_2056 5235370 3.69 200.0 µM 7.65E-5 54 1.14E-4
16 SGTC_3254 9136651 3.65 49.5 µM 8.84E-5 DNA damage response 32 1.31E-4
17 SGTC_1942 st076330 3.59 65.2 µM 1.15E-4 37 1.68E-4
18 SGTC_874 0599-0792 3.49 117.0 µM 1.69E-4 41 2.44E-4
19 SGTC_1058 3448-5425 3.37 97.3 µM 2.64E-4 46 3.73E-4
20 SGTC_609 0986-0026 3.27 86.3 µM 3.91E-4 calcium & mitochondrial duress 57 5.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 6.04E-23 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.162 3.41E-21 YHR079C IRE1 hom Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.130 4.02E-14 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.127 1.64E-13 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.118 5.95E-12 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.117 8.97E-12 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.106 7.85E-10 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.103 2.16E-9 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.099 9.59E-9 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.097 1.55E-8 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.096 2.96E-8 YER085C_p YER085C_p hom Putative protein of unknown function
0.093 6.92E-8 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.091 1.15E-7 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.089 2.10E-7 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.089 2.63E-7 YPR185W ATG13 hom Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling