YMR216C / SKY1

SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR216C / SKY1

Click on Significant Values for Screen Details ID:SGTC_130|Compound:0136-0219|FD-Score:5.35|P-value:1.73E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:5.00|P-value:5.51E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:6.92|P-value:3.83E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.91|P-value:8.72E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.78|P-value:3.83E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:6.49|P-value:2.40E-7 ID:SGTC_204|Compound:1543-0184|FD-Score:5.63|P-value:6.64E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:4.87|P-value:8.45E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:10.80|P-value:1.68E-17 ID:SGTC_455|Compound:paf C-16|FD-Score:6.21|P-value:7.39E-7 ID:SGTC_462|Compound:ag-879|FD-Score:4.63|P-value:1.75E-4 ID:SGTC_470|Compound:aa-861|FD-Score:5.51|P-value:1.01E-5 ID:SGTC_490|Compound:phenamil|FD-Score:4.34|P-value:4.14E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:7.96|P-value:3.06E-10 ID:SGTC_612|Compound:0302-0167|FD-Score:4.37|P-value:3.74E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.12|P-value:7.47E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-6.62|P-value:7.39E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:4.05|P-value:9.06E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.09|P-value:8.19E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.00|P-value:6.87E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.15|P-value:6.98E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:4.48|P-value:2.78E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:5.31|P-value:1.99E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:6.11|P-value:1.11E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:4.11|P-value:7.83E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:9.20|P-value:3.94E-13 ID:SGTC_1013|Compound:4112-3890|FD-Score:7.66|P-value:1.33E-9 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.20|P-value:6.14E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.59|P-value:2.00E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:6.12|P-value:1.05E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:-4.24|P-value:3.51E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.18|P-value:6.44E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.12|P-value:7.47E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.85|P-value:8.99E-5 ID:SGTC_1669|Compound:st015249|FD-Score:5.04|P-value:4.84E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.84|P-value:1.72E-6 ID:SGTC_1759|Compound:st043059|FD-Score:4.51|P-value:2.53E-4 ID:SGTC_1854|Compound:st056233|FD-Score:5.56|P-value:8.46E-6 ID:SGTC_1972|Compound:st070201|FD-Score:4.54|P-value:2.32E-4 ID:SGTC_2013|Compound:4024628|FD-Score:6.52|P-value:2.09E-7 ID:SGTC_2033|Compound:5192550|FD-Score:4.27|P-value:4.97E-4 ID:SGTC_2041|Compound:5107442|FD-Score:8.02|P-value:2.26E-10 ID:SGTC_2052|Compound:5265182|FD-Score:4.18|P-value:6.39E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-4.05|P-value:5.91E-4 ID:SGTC_2192|Compound:5915882|FD-Score:4.90|P-value:7.62E-5 ID:SGTC_2241|Compound:6772625|FD-Score:5.11|P-value:3.86E-5 ID:SGTC_2248|Compound:tofa|FD-Score:7.10|P-value:1.78E-8 ID:SGTC_2300|Compound:7976697|FD-Score:-6.54|P-value:1.04E-7 ID:SGTC_2302|Compound:7771753|FD-Score:5.55|P-value:8.63E-6 ID:SGTC_2391|Compound:6285546|FD-Score:4.14|P-value:7.09E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.10|P-value:4.01E-5 ID:SGTC_2416|Compound:tofa|FD-Score:5.67|P-value:5.66E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.20|P-value:6.11E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.89|P-value:9.26E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.28|P-value:4.87E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.05|P-value:9.15E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.03|P-value:9.53E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:5.99|P-value:1.73E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.83|P-value:3.10E-6 ID:SGTC_2740|Compound:felodipine|FD-Score:4.71|P-value:1.37E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:9.41|P-value:1.15E-13 ID:SGTC_2747|Compound:doxorubicin|FD-Score:4.74|P-value:1.24E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:6.72|P-value:9.34E-8 ID:SGTC_2790|Compound:5423970|FD-Score:4.59|P-value:1.96E-4 ID:SGTC_2845|Compound:9003024|FD-Score:7.30|P-value:7.30E-9 ID:SGTC_2858|Compound:9025781|FD-Score:5.20|P-value:2.86E-5 ID:SGTC_2907|Compound:7721985|FD-Score:4.54|P-value:2.30E-4 ID:SGTC_2932|Compound:9016711|FD-Score:8.23|P-value:7.88E-11 ID:SGTC_2940|Compound:9060638|FD-Score:4.13|P-value:7.41E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.24|P-value:3.52E-4 ID:SGTC_2997|Compound:9067075|FD-Score:5.74|P-value:4.35E-6 ID:SGTC_3038|Compound:9091290|FD-Score:4.26|P-value:5.08E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.47|P-value:2.86E-4 ID:SGTC_3211|Compound:9128781|FD-Score:6.06|P-value:1.35E-6 ID:SGTC_3231|Compound:9132313|FD-Score:4.04|P-value:9.23E-4 ID:SGTC_3253|Compound:9135987|FD-Score:5.44|P-value:1.29E-5 ID:SGTC_3294|Compound:9122953|FD-Score:-4.48|P-value:1.74E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.10|P-value:7.95E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:5.35|P-value:1.73E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:5.00|P-value:5.51E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:6.92|P-value:3.83E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.91|P-value:8.72E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.78|P-value:3.83E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:6.49|P-value:2.40E-7 ID:SGTC_204|Compound:1543-0184|FD-Score:5.63|P-value:6.64E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:4.87|P-value:8.45E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:10.80|P-value:1.68E-17 ID:SGTC_455|Compound:paf C-16|FD-Score:6.21|P-value:7.39E-7 ID:SGTC_462|Compound:ag-879|FD-Score:4.63|P-value:1.75E-4 ID:SGTC_470|Compound:aa-861|FD-Score:5.51|P-value:1.01E-5 ID:SGTC_490|Compound:phenamil|FD-Score:4.34|P-value:4.14E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:7.96|P-value:3.06E-10 ID:SGTC_612|Compound:0302-0167|FD-Score:4.37|P-value:3.74E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.12|P-value:7.47E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-6.62|P-value:7.39E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:4.05|P-value:9.06E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.09|P-value:8.19E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.00|P-value:6.87E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.15|P-value:6.98E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:4.48|P-value:2.78E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:5.31|P-value:1.99E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:6.11|P-value:1.11E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:4.11|P-value:7.83E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:9.20|P-value:3.94E-13 ID:SGTC_1013|Compound:4112-3890|FD-Score:7.66|P-value:1.33E-9 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.20|P-value:6.14E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.59|P-value:2.00E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:6.12|P-value:1.05E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:-4.24|P-value:3.51E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.18|P-value:6.44E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.12|P-value:7.47E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.85|P-value:8.99E-5 ID:SGTC_1669|Compound:st015249|FD-Score:5.04|P-value:4.84E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.84|P-value:1.72E-6 ID:SGTC_1759|Compound:st043059|FD-Score:4.51|P-value:2.53E-4 ID:SGTC_1854|Compound:st056233|FD-Score:5.56|P-value:8.46E-6 ID:SGTC_1972|Compound:st070201|FD-Score:4.54|P-value:2.32E-4 ID:SGTC_2013|Compound:4024628|FD-Score:6.52|P-value:2.09E-7 ID:SGTC_2033|Compound:5192550|FD-Score:4.27|P-value:4.97E-4 ID:SGTC_2041|Compound:5107442|FD-Score:8.02|P-value:2.26E-10 ID:SGTC_2052|Compound:5265182|FD-Score:4.18|P-value:6.39E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-4.05|P-value:5.91E-4 ID:SGTC_2192|Compound:5915882|FD-Score:4.90|P-value:7.62E-5 ID:SGTC_2241|Compound:6772625|FD-Score:5.11|P-value:3.86E-5 ID:SGTC_2248|Compound:tofa|FD-Score:7.10|P-value:1.78E-8 ID:SGTC_2300|Compound:7976697|FD-Score:-6.54|P-value:1.04E-7 ID:SGTC_2302|Compound:7771753|FD-Score:5.55|P-value:8.63E-6 ID:SGTC_2391|Compound:6285546|FD-Score:4.14|P-value:7.09E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.10|P-value:4.01E-5 ID:SGTC_2416|Compound:tofa|FD-Score:5.67|P-value:5.66E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.20|P-value:6.11E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.89|P-value:9.26E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.28|P-value:4.87E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.05|P-value:9.15E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.03|P-value:9.53E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:5.99|P-value:1.73E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.83|P-value:3.10E-6 ID:SGTC_2740|Compound:felodipine|FD-Score:4.71|P-value:1.37E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:9.41|P-value:1.15E-13 ID:SGTC_2747|Compound:doxorubicin|FD-Score:4.74|P-value:1.24E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:6.72|P-value:9.34E-8 ID:SGTC_2790|Compound:5423970|FD-Score:4.59|P-value:1.96E-4 ID:SGTC_2845|Compound:9003024|FD-Score:7.30|P-value:7.30E-9 ID:SGTC_2858|Compound:9025781|FD-Score:5.20|P-value:2.86E-5 ID:SGTC_2907|Compound:7721985|FD-Score:4.54|P-value:2.30E-4 ID:SGTC_2932|Compound:9016711|FD-Score:8.23|P-value:7.88E-11 ID:SGTC_2940|Compound:9060638|FD-Score:4.13|P-value:7.41E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.24|P-value:3.52E-4 ID:SGTC_2997|Compound:9067075|FD-Score:5.74|P-value:4.35E-6 ID:SGTC_3038|Compound:9091290|FD-Score:4.26|P-value:5.08E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.47|P-value:2.86E-4 ID:SGTC_3211|Compound:9128781|FD-Score:6.06|P-value:1.35E-6 ID:SGTC_3231|Compound:9132313|FD-Score:4.04|P-value:9.23E-4 ID:SGTC_3253|Compound:9135987|FD-Score:5.44|P-value:1.29E-5 ID:SGTC_3294|Compound:9122953|FD-Score:-4.48|P-value:1.74E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.10|P-value:7.95E-4

Top fitness defect scores for YMR216C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_453 enantio-paf c16 10.80 10.0 µM 1.68E-17 4 1.38E-27
2 SGTC_2741 miltefosine 9.41 3.0 µM 1.15E-13 6 2.37E-21
3 SGTC_1012 4112-3522 9.20 18.0 µM 3.94E-13 1 1.75E-20
4 SGTC_2932 9016711 8.23 44.5 µM 7.88E-11 8 9.56E-17
5 SGTC_2041 5107442 8.02 45.3 µM 2.26E-10 RSC complex & mRNA processing 7 5.29E-16
6 SGTC_602 3130-1533 7.96 38.1 µM 3.06E-10 1 8.65E-16
7 SGTC_1013 4112-3890 7.66 241.0 µM 1.33E-9 TSC3-RPN4 5 9.36E-15
8 SGTC_2845 9003024 7.30 43.0 µM 7.30E-9 amide catabolism 8 1.49E-13
9 SGTC_2248 tofa 7.10 1.1 µM 1.78E-8 sphingolipid biosynthesis & PDR1 14 6.33E-13
10 SGTC_163 1327-0036 6.92 7.5 µM 3.83E-8 31 2.19E-12
11 SGTC_2760 etidronate 6.72 98.0 µM 9.34E-8 1 9.27E-12
12 SGTC_2013 4024628 6.52 200.0 µM 2.09E-7 13 3.42E-11
13 SGTC_179 1273-0063 6.49 6.8 µM 2.40E-7 7 4.27E-11
14 SGTC_455 paf C-16 6.21 10.0 µM 7.39E-7 7 2.64E-10
15 SGTC_1087 pterostilbene 6.12 9.1 µM 1.05E-6 4 4.68E-10
16 SGTC_914 3820-6779 6.11 408.0 µM 1.11E-6 3 5.12E-10
17 SGTC_3211 9128781 6.06 49.5 µM 1.35E-6 18 6.99E-10
18 SGTC_2645 abamectin 5.99 100.0 µM 1.73E-6 heme requiring 8 1.05E-9
19 SGTC_2651 1327-0036 5.83 5.0 µM 3.10E-6 79 2.69E-9
20 SGTC_173 1273-0061 5.78 2.7 µM 3.83E-6 mitochondrial stress 114 3.79E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.233 9.86E-43 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.171 2.43E-23 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.157 5.69E-20 YOR290C SNF2 hom Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
0.144 6.43E-17 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.137 1.27E-15 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.133 1.26E-14 YML122C_d YML122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.132 1.98E-14 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.131 2.20E-14 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.131 2.95E-14 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.131 3.05E-14 YGR063C SPT4 hom Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.129 6.25E-14 YDR207C UME6 hom Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
0.129 7.45E-14 YDL173W PAR32 hom Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
0.128 1.11E-13 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.36E-13 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.123 7.13E-13 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins