HIPHOP chemogenomics database

YMR216C / SKY1

SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR216C / SKY1

Click on Significant Values for Screen Details

Top fitness defect scores for YMR216C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_453	enantio-paf c16	10.80	10.0 µM	1.68E-17		4	1.38E-27
2	SGTC_2741	miltefosine	9.41	3.0 µM	1.15E-13		6	2.37E-21
3	SGTC_1012	4112-3522	9.20	18.0 µM	3.94E-13		1	1.75E-20
4	SGTC_2932	9016711	8.23	44.5 µM	7.88E-11		8	9.56E-17
5	SGTC_2041	5107442	8.02	45.3 µM	2.26E-10	RSC complex & mRNA processing	7	5.29E-16
6	SGTC_602	3130-1533	7.96	38.1 µM	3.06E-10		1	8.65E-16
7	SGTC_1013	4112-3890	7.66	241.0 µM	1.33E-9	TSC3-RPN4	5	9.36E-15
8	SGTC_2845	9003024	7.30	43.0 µM	7.30E-9	amide catabolism	8	1.49E-13
9	SGTC_2248	tofa	7.10	1.1 µM	1.78E-8	sphingolipid biosynthesis & PDR1	14	6.33E-13
10	SGTC_163	1327-0036	6.92	7.5 µM	3.83E-8		31	2.19E-12
11	SGTC_2760	etidronate	6.72	98.0 µM	9.34E-8		1	9.27E-12
12	SGTC_2013	4024628	6.52	200.0 µM	2.09E-7		13	3.42E-11
13	SGTC_179	1273-0063	6.49	6.8 µM	2.40E-7		7	4.27E-11
14	SGTC_455	paf C-16	6.21	10.0 µM	7.39E-7		7	2.64E-10
15	SGTC_1087	pterostilbene	6.12	9.1 µM	1.05E-6		4	4.68E-10
16	SGTC_914	3820-6779	6.11	408.0 µM	1.11E-6		3	5.12E-10
17	SGTC_3211	9128781	6.06	49.5 µM	1.35E-6		18	6.99E-10
18	SGTC_2645	abamectin	5.99	100.0 µM	1.73E-6	heme requiring	8	1.05E-9
19	SGTC_2651	1327-0036	5.83	5.0 µM	3.10E-6		79	2.69E-9
20	SGTC_173	1273-0061	5.78	2.7 µM	3.83E-6	mitochondrial stress	114	3.79E-9

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.233	9.86E-43	YJR059W	PTK2	hom	Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.171	2.43E-23	YJL005W	CYR1	het	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.157	5.69E-20	YOR290C	SNF2	hom	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
0.144	6.43E-17	YIR008C	PRI1	het	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.137	1.27E-15	YGL008C	PMA1	het	Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.133	1.26E-14	YML122C_d	YML122C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.132	1.98E-14	YIR012W	SQT1	het	Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.131	2.20E-14	YHR155W	YSP1	hom	Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.131	2.95E-14	YGL025C	PGD1	hom	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.131	3.05E-14	YGR063C	SPT4	hom	Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.129	6.25E-14	YDR207C	UME6	hom	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
0.129	7.45E-14	YDL173W	PAR32	hom	Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
0.128	1.11E-13	YML101C-A_d	YML101C-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126	2.36E-13	YDR392W	SPT3	hom	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.123	7.13E-13	YMR214W	SCJ1	hom	One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins