YMR219W / ESC1

Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR219W / ESC1

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:3.72|P-value:1.67E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.84|P-value:1.05E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.16|P-value:9.57E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.25|P-value:8.77E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.94|P-value:7.26E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.16|P-value:9.75E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.25|P-value:8.70E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.51|P-value:3.67E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.56|P-value:2.99E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.50|P-value:2.98E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.82|P-value:1.66E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:3.65|P-value:2.15E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:5.52|P-value:4.88E-8 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.26|P-value:6.99E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.89|P-value:8.87E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:-5.50|P-value:3.78E-8 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.89|P-value:8.84E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.34|P-value:5.24E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.21|P-value:8.28E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-6.43|P-value:1.71E-10 ID:SGTC_1623|Compound:st003709|FD-Score:4.34|P-value:1.43E-5 ID:SGTC_1624|Compound:st003710|FD-Score:10.70|P-value:1.05E-25 ID:SGTC_1954|Compound:st077032|FD-Score:-3.67|P-value:1.62E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.77|P-value:2.97E-11 ID:SGTC_2304|Compound:7443016|FD-Score:3.42|P-value:4.99E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.52|P-value:3.51E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.10|P-value:3.83E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.67|P-value:1.62E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.62|P-value:2.46E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.20|P-value:8.40E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.57|P-value:2.87E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.64|P-value:3.71E-6 ID:SGTC_3258|Compound:9138477|FD-Score:3.25|P-value:8.83E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.72|P-value:1.67E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.84|P-value:1.05E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.16|P-value:9.57E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.25|P-value:8.77E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.94|P-value:7.26E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.16|P-value:9.75E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.25|P-value:8.70E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.51|P-value:3.67E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.56|P-value:2.99E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.50|P-value:2.98E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.82|P-value:1.66E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:3.65|P-value:2.15E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:5.52|P-value:4.88E-8 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.26|P-value:6.99E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.89|P-value:8.87E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:-5.50|P-value:3.78E-8 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.89|P-value:8.84E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.34|P-value:5.24E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.21|P-value:8.28E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-6.43|P-value:1.71E-10 ID:SGTC_1623|Compound:st003709|FD-Score:4.34|P-value:1.43E-5 ID:SGTC_1624|Compound:st003710|FD-Score:10.70|P-value:1.05E-25 ID:SGTC_1954|Compound:st077032|FD-Score:-3.67|P-value:1.62E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.77|P-value:2.97E-11 ID:SGTC_2304|Compound:7443016|FD-Score:3.42|P-value:4.99E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.52|P-value:3.51E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.10|P-value:3.83E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.67|P-value:1.62E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.62|P-value:2.46E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.20|P-value:8.40E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.57|P-value:2.87E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.64|P-value:3.71E-6 ID:SGTC_3258|Compound:9138477|FD-Score:3.25|P-value:8.83E-4

Top fitness defect scores for YMR219W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1624 st003710 10.70 6.2 µM 1.05E-25 calcium & mitochondrial duress 2 3.01E-27
2 SGTC_2302 7771753 6.77 200.0 µM 2.97E-11 6 6.63E-12
3 SGTC_747 3448-8087 5.52 38.7 µM 4.88E-8 6 1.73E-8
4 SGTC_655 k060-0012 4.82 42.0 µM 1.66E-6 3 7.36E-7
5 SGTC_2981 9013952 4.64 39.0 µM 3.71E-6 26 1.72E-6
6 SGTC_1623 st003709 4.34 20.3 µM 1.43E-5 calcium & mitochondrial duress 52 7.26E-6
7 SGTC_2565 isoliquiritigenin 4.10 100.0 µM 3.83E-5 33 2.07E-5
8 SGTC_371 0195-0006 3.94 7.4 µM 7.26E-5 21 4.07E-5
9 SGTC_1274 0865-0114 3.89 173.0 µM 8.84E-5 20 5.02E-5
10 SGTC_1150 3909-7983 3.89 10.9 µM 8.87E-5 26 5.04E-5
11 SGTC_287 k060-0039 3.84 29.6 µM 1.05E-4 14 6.05E-5
12 SGTC_66 0109-0187 3.72 42.4 µM 1.67E-4 46 9.90E-5
13 SGTC_657 3534-0529 3.65 86.7 µM 2.15E-4 22 1.29E-4
14 SGTC_2793 7325131 3.62 81.8 µM 2.46E-4 21 1.49E-4
15 SGTC_2850 9015429 3.57 58.4 µM 2.87E-4 21 1.76E-4
16 SGTC_578 3460-0051 3.56 92.0 µM 2.99E-4 18 1.83E-4
17 SGTC_2558 carylophyllene oxide 3.52 100.0 µM 3.51E-4 25 2.18E-4
18 SGTC_575 k072-0246 3.51 11.9 µM 3.67E-4 32 2.28E-4
19 SGTC_2304 7443016 3.42 91.4 µM 4.99E-4 33 3.16E-4
20 SGTC_514 4466-0038 3.25 2.6 nM 8.70E-4 cell wall 208 5.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.83E-17 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.117 8.66E-12 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 4.13E-8 YBR282W MRPL27 hom Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP
0.093 7.33E-8 YNR060W FRE4 hom Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
0.090 1.51E-7 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.090 2.07E-7 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.086 5.92E-7 YPL029W SUV3 hom ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron
0.086 6.08E-7 YLR404W FLD1 hom Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
0.085 7.64E-7 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.084 9.90E-7 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.083 1.31E-6 YOR105W_p YOR105W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.081 2.99E-6 YER122C GLO3 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
0.080 3.80E-6 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.077 7.84E-6 YDR058C TGL2 hom Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli
0.077 8.97E-6 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication