YMR220W / ERG8

Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR220W / ERG8

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.10|P-value:1.57E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.10|P-value:8.83E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.80|P-value:5.76E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.64|P-value:1.10E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.58|P-value:1.53E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.12|P-value:7.60E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.24|P-value:5.43E-8 ID:SGTC_462|Compound:ag-879|FD-Score:3.17|P-value:6.44E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.38|P-value:2.99E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.59|P-value:1.46E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.06|P-value:9.39E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:4.23|P-value:8.70E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:3.48|P-value:2.08E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.54|P-value:1.84E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.30|P-value:4.00E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.39|P-value:4.85E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:3.27|P-value:4.47E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.46|P-value:3.48E-6 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.69|P-value:9.11E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.06|P-value:4.10E-10 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.83|P-value:4.97E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.17|P-value:1.14E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:5.20|P-value:6.59E-8 ID:SGTC_1210|Compound:3013-0140|FD-Score:-4.33|P-value:6.19E-6 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.44|P-value:2.61E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.13|P-value:7.45E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:4.09|P-value:1.70E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:4.71|P-value:8.97E-7 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.23|P-value:5.71E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.68|P-value:9.37E-5 ID:SGTC_1735|Compound:st034310|FD-Score:3.39|P-value:2.90E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-4.09|P-value:1.86E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.44|P-value:2.39E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.24|P-value:5.04E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.11|P-value:8.70E-4 ID:SGTC_2160|Compound:5660466|FD-Score:4.30|P-value:6.58E-6 ID:SGTC_2274|Compound:7947094|FD-Score:-3.81|P-value:6.21E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.43|P-value:2.77E-4 ID:SGTC_2319|Compound:6033012|FD-Score:4.50|P-value:2.53E-6 ID:SGTC_2321|Compound:7390090|FD-Score:4.00|P-value:2.42E-5 ID:SGTC_2323|Compound:6148992|FD-Score:3.28|P-value:4.32E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.08|P-value:9.62E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.33|P-value:3.59E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.31|P-value:3.92E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.92|P-value:3.84E-5 ID:SGTC_2441|Compound:5730946|FD-Score:-3.16|P-value:7.37E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.20|P-value:5.82E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.07|P-value:9.83E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.50|P-value:1.89E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.36|P-value:3.27E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.56|P-value:1.68E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.55|P-value:1.74E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.84|P-value:4.70E-7 ID:SGTC_2715|Compound:st079500|FD-Score:4.63|P-value:1.33E-6 ID:SGTC_2925|Compound:9010536|FD-Score:3.16|P-value:6.58E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.20|P-value:6.39E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.23|P-value:8.72E-6 ID:SGTC_2940|Compound:9060638|FD-Score:4.66|P-value:1.15E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-3.89|P-value:4.45E-5 ID:SGTC_2958|Compound:9077254|FD-Score:5.03|P-value:1.70E-7 ID:SGTC_2960|Compound:9079389|FD-Score:-6.03|P-value:5.82E-10 ID:SGTC_3175|Compound:9106517|FD-Score:3.04|P-value:9.93E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.76|P-value:6.86E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:4.10|P-value:1.57E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.10|P-value:8.83E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.80|P-value:5.76E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.64|P-value:1.10E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.58|P-value:1.53E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.12|P-value:7.60E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.24|P-value:5.43E-8 ID:SGTC_462|Compound:ag-879|FD-Score:3.17|P-value:6.44E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.38|P-value:2.99E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.59|P-value:1.46E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.06|P-value:9.39E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:4.23|P-value:8.70E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:3.48|P-value:2.08E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.54|P-value:1.84E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.30|P-value:4.00E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.39|P-value:4.85E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:3.27|P-value:4.47E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.46|P-value:3.48E-6 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.69|P-value:9.11E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.06|P-value:4.10E-10 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.83|P-value:4.97E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.17|P-value:1.14E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:5.20|P-value:6.59E-8 ID:SGTC_1210|Compound:3013-0140|FD-Score:-4.33|P-value:6.19E-6 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.44|P-value:2.61E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.13|P-value:7.45E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:4.09|P-value:1.70E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:4.71|P-value:8.97E-7 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.23|P-value:5.71E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.68|P-value:9.37E-5 ID:SGTC_1735|Compound:st034310|FD-Score:3.39|P-value:2.90E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-4.09|P-value:1.86E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.44|P-value:2.39E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.24|P-value:5.04E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.11|P-value:8.70E-4 ID:SGTC_2160|Compound:5660466|FD-Score:4.30|P-value:6.58E-6 ID:SGTC_2274|Compound:7947094|FD-Score:-3.81|P-value:6.21E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.43|P-value:2.77E-4 ID:SGTC_2319|Compound:6033012|FD-Score:4.50|P-value:2.53E-6 ID:SGTC_2321|Compound:7390090|FD-Score:4.00|P-value:2.42E-5 ID:SGTC_2323|Compound:6148992|FD-Score:3.28|P-value:4.32E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.08|P-value:9.62E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.33|P-value:3.59E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.31|P-value:3.92E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.92|P-value:3.84E-5 ID:SGTC_2441|Compound:5730946|FD-Score:-3.16|P-value:7.37E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.20|P-value:5.82E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.07|P-value:9.83E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.50|P-value:1.89E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.36|P-value:3.27E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.56|P-value:1.68E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.55|P-value:1.74E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.84|P-value:4.70E-7 ID:SGTC_2715|Compound:st079500|FD-Score:4.63|P-value:1.33E-6 ID:SGTC_2925|Compound:9010536|FD-Score:3.16|P-value:6.58E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.20|P-value:6.39E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.23|P-value:8.72E-6 ID:SGTC_2940|Compound:9060638|FD-Score:4.66|P-value:1.15E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-3.89|P-value:4.45E-5 ID:SGTC_2958|Compound:9077254|FD-Score:5.03|P-value:1.70E-7 ID:SGTC_2960|Compound:9079389|FD-Score:-6.03|P-value:5.82E-10 ID:SGTC_3175|Compound:9106517|FD-Score:3.04|P-value:9.93E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.76|P-value:6.86E-5

Top fitness defect scores for YMR220W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1188 1403-0014 6.06 4.6 µM 4.10E-10 mitochondrial stress 5 6.88E-10 0.04
2 SGTC_432 NS 1619 5.24 61.3 µM 5.43E-8 3 8.09E-8 0.44
3 SGTC_1197 1601-0112 5.20 267.0 µM 6.59E-8 2 9.78E-8 0.26
4 SGTC_2958 9077254 5.03 16.7 µM 1.70E-7 2 2.47E-7 0.55
5 SGTC_2621 lithochol-11-enic acid 4.84 100.0 µM 4.70E-7 4 6.65E-7 0.33
6 SGTC_1528 arabinosylhypoxanthine 4.71 74.6 µM 8.97E-7 1 1.25E-6 0.70
7 SGTC_2940 9060638 4.66 45.9 µM 1.15E-6 amide catabolism 4 1.60E-6 0.37
8 SGTC_2715 st079500 4.63 56.4 µM 1.33E-6 2 1.84E-6 0.11
9 SGTC_2319 6033012 4.50 152.6 µM 2.53E-6 tubulin folding & SWR complex 3 3.43E-6 0.25
10 SGTC_2160 5660466 4.30 132.9 µM 6.58E-6 60S ribosome export 12 8.73E-6 0.00
11 SGTC_542 3381-0244 4.23 89.3 µM 8.70E-6 7 1.15E-5 0.43
12 SGTC_2939 9044578 4.23 71.4 µM 8.72E-6 3 1.15E-5 0.00
13 SGTC_1191 1487-1166 4.17 10.6 µM 1.14E-5 azole & statin 3 1.49E-5 0.45
14 SGTC_6 0844-0013 4.10 19.8 µM 1.57E-5 4 2.04E-5 0.16
15 SGTC_1507 4075-3230 4.09 155.0 µM 1.70E-5 2 2.20E-5 0.45
16 SGTC_2321 7390090 4.00 138.8 µM 2.42E-5 6 3.11E-5 0.37
17 SGTC_1190 1486-1332 3.83 13.0 µM 4.97E-5 4 6.28E-5 0.01
18 SGTC_230 MPP+ 3.80 141.7 µM 5.76E-5 7 7.25E-5 0.15
19 SGTC_3208 9114115 3.76 49.5 µM 6.86E-5 16 8.60E-5 0.03
20 SGTC_1149 3909-7961 3.69 23.3 µM 9.11E-5 6 1.13E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.57E-9 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.102 3.24E-9 YMR019W STB4 hom Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;
0.097 1.90E-8 YLR403W SFP1 hom Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion
0.092 8.04E-8 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.091 1.11E-7 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.091 1.12E-7 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.086 5.92E-7 YHL026C_p YHL026C_p hom Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
0.082 1.76E-6 YIL131C FKH1 hom Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication
0.081 2.41E-6 YNL338W_d YNL338W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
0.081 2.95E-6 YMR131C RRB1 het Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
0.076 1.11E-5 YKR062W TFA2 het TFIIE small subunit, involved in RNA polymerase II transcription initiation
0.073 2.53E-5 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.072 3.09E-5 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.072 3.13E-5 YLR250W SSP120 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.071 3.51E-5 YAL055W PEX22 hom Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation