YMR222C / FSH2

Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR222C / FSH2

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.94|P-value:1.59E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.26|P-value:2.90E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-4.00|P-value:1.00E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:3.63|P-value:6.22E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.93|P-value:1.67E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:14.40|P-value:3.23E-53 ID:SGTC_512|Compound:prima-1|FD-Score:3.30|P-value:2.53E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.45|P-value:1.17E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.56|P-value:8.59E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:-4.57|P-value:5.58E-7 ID:SGTC_598|Compound:3937-0236|FD-Score:3.33|P-value:2.17E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-2.98|P-value:7.38E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.45|P-value:1.16E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.90|P-value:1.90E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.12|P-value:4.95E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.69|P-value:3.60E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:3.05|P-value:6.56E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.41|P-value:1.58E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.27|P-value:2.47E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.29|P-value:2.97E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.37|P-value:1.84E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.06|P-value:6.25E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.95|P-value:8.56E-8 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.19|P-value:3.83E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.74|P-value:2.71E-7 ID:SGTC_1701|Compound:st028638|FD-Score:-3.06|P-value:5.50E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.77|P-value:3.43E-5 ID:SGTC_1781|Compound:st038725|FD-Score:-3.43|P-value:1.29E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-3.54|P-value:7.84E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.84|P-value:2.50E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.86|P-value:2.28E-5 ID:SGTC_1989|Compound:st071868|FD-Score:3.62|P-value:6.53E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-2.98|P-value:7.45E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.22|P-value:2.99E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.19|P-value:3.80E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-2.94|P-value:8.39E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-3.53|P-value:8.40E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.04|P-value:6.78E-4 ID:SGTC_2480|Compound:5767542|FD-Score:4.38|P-value:1.82E-6 ID:SGTC_2482|Compound:5981709|FD-Score:3.44|P-value:1.43E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:4.12|P-value:6.68E-6 ID:SGTC_2624|Compound:nerol|FD-Score:3.00|P-value:7.74E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.40|P-value:1.44E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.06|P-value:6.27E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-2.96|P-value:7.89E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.91|P-value:1.80E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:4.29|P-value:2.95E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-4.22|P-value:3.49E-6 ID:SGTC_2794|Compound:7785382|FD-Score:5.03|P-value:5.22E-8 ID:SGTC_2797|Compound:7859098|FD-Score:-3.08|P-value:5.12E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.42|P-value:1.56E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.84|P-value:2.46E-5 ID:SGTC_3067|Compound:9117431|FD-Score:-3.02|P-value:6.38E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.94|P-value:1.59E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.26|P-value:2.90E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-4.00|P-value:1.00E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:3.63|P-value:6.22E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.93|P-value:1.67E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:14.40|P-value:3.23E-53 ID:SGTC_512|Compound:prima-1|FD-Score:3.30|P-value:2.53E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.45|P-value:1.17E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.56|P-value:8.59E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:-4.57|P-value:5.58E-7 ID:SGTC_598|Compound:3937-0236|FD-Score:3.33|P-value:2.17E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-2.98|P-value:7.38E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.45|P-value:1.16E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.90|P-value:1.90E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.12|P-value:4.95E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.69|P-value:3.60E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:3.05|P-value:6.56E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.41|P-value:1.58E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.27|P-value:2.47E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.29|P-value:2.97E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.37|P-value:1.84E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.06|P-value:6.25E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.95|P-value:8.56E-8 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.19|P-value:3.83E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.74|P-value:2.71E-7 ID:SGTC_1701|Compound:st028638|FD-Score:-3.06|P-value:5.50E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.77|P-value:3.43E-5 ID:SGTC_1781|Compound:st038725|FD-Score:-3.43|P-value:1.29E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-3.54|P-value:7.84E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.84|P-value:2.50E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.86|P-value:2.28E-5 ID:SGTC_1989|Compound:st071868|FD-Score:3.62|P-value:6.53E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-2.98|P-value:7.45E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.22|P-value:2.99E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.19|P-value:3.80E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-2.94|P-value:8.39E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-3.53|P-value:8.40E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.04|P-value:6.78E-4 ID:SGTC_2480|Compound:5767542|FD-Score:4.38|P-value:1.82E-6 ID:SGTC_2482|Compound:5981709|FD-Score:3.44|P-value:1.43E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:4.12|P-value:6.68E-6 ID:SGTC_2624|Compound:nerol|FD-Score:3.00|P-value:7.74E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.40|P-value:1.44E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.06|P-value:6.27E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-2.96|P-value:7.89E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.91|P-value:1.80E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:4.29|P-value:2.95E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-4.22|P-value:3.49E-6 ID:SGTC_2794|Compound:7785382|FD-Score:5.03|P-value:5.22E-8 ID:SGTC_2797|Compound:7859098|FD-Score:-3.08|P-value:5.12E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.42|P-value:1.56E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.84|P-value:2.46E-5 ID:SGTC_3067|Compound:9117431|FD-Score:-3.02|P-value:6.38E-4

Top fitness defect scores for YMR222C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_226 1,3-diallylurea 14.40 8.3 mM 3.23E-53 2 1.29E-47
2 SGTC_2794 7785382 5.03 27.3 µM 5.22E-8 8 2.44E-7
3 SGTC_1365 1672-3266 4.95 55.4 µM 8.56E-8 4 3.80E-7
4 SGTC_1525 8-methoxypsoralen 4.74 92.5 µM 2.71E-7 DNA damage response 16 1.07E-6
5 SGTC_637 1181-0519 4.69 7.3 µM 3.60E-7 fatty acid desaturase (OLE1) 76 1.37E-6
6 SGTC_2480 5767542 4.38 37.2 µM 1.82E-6 7 5.88E-6
7 SGTC_2736 butenafine 4.29 14.7 µM 2.95E-6 22 9.05E-6
8 SGTC_1331 1472-0049 4.29 76.2 µM 2.97E-6 12 9.10E-6
9 SGTC_2618 avocadyne 4.12 43.4 µM 6.68E-6 29 1.88E-5
10 SGTC_21 0849-0113 3.94 23.0 µM 1.59E-5 30 4.09E-5
11 SGTC_208 k072-0098 3.93 12.4 µM 1.67E-5 heme biosynthesis & mitochondrial translocase 43 4.28E-5
12 SGTC_2729 fluphenazine 3.91 10.7 µM 1.80E-5 14 4.58E-5
13 SGTC_634 1611-4317 3.90 11.2 µM 1.90E-5 ERG2 16 4.81E-5
14 SGTC_1846 st056244 3.86 14.8 µM 2.28E-5 28 5.65E-5
15 SGTC_2963 9082507 3.84 9.0 µM 2.46E-5 28 6.06E-5
16 SGTC_1845 st056753 3.84 3.0 µM 2.50E-5 TSC3-RPN4 39 6.15E-5
17 SGTC_1736 st036774 3.77 51.0 µM 3.43E-5 39 8.17E-5
18 SGTC_198 3454-2873 3.63 16.2 µM 6.22E-5 60S ribosome export 21 1.39E-4
19 SGTC_1989 st071868 3.62 50.2 µM 6.53E-5 19 1.45E-4
20 SGTC_541 4513-1321 3.56 94.0 µM 8.59E-5 32 1.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.338 1.55E-90 YKL182W FAS1 het Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
0.190 1.62E-28 YDR123C INO2 hom Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion
0.162 3.24E-21 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.107 5.61E-10 YCL028W RNQ1 hom [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate
0.102 2.98E-9 YCL069W VBA3 hom Permease of basic amino acids in the vacuolar membrane
0.096 2.35E-8 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.095 3.57E-8 YBR159W IFA38 hom Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
0.092 1.05E-7 YIL109C SEC24 het Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
0.091 1.10E-7 YOR249C APC5 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
0.089 2.53E-7 YIL041W GVP36 hom BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
0.088 3.73E-7 YGR145W ENP2 het Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
0.087 4.69E-7 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.084 9.96E-7 YPL203W TPK2 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase
0.083 1.36E-6 YDL009C_p YDL009C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene
0.083 1.51E-6 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus