YMR224C / MRE11

Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR224C / MRE11

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:-3.62|P-value:1.83E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:6.59|P-value:6.39E-11 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.81|P-value:8.96E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.97|P-value:5.42E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:3.37|P-value:5.13E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.77|P-value:1.68E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:3.44|P-value:4.04E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.19|P-value:9.57E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.29|P-value:1.26E-7 ID:SGTC_456|Compound:gingerol|FD-Score:3.37|P-value:5.23E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.40|P-value:4.69E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.95|P-value:5.81E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.34|P-value:5.74E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.48|P-value:3.53E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.16|P-value:9.38E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.71|P-value:2.15E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:6.59|P-value:6.22E-11 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.31|P-value:6.37E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.02|P-value:4.39E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.87|P-value:8.21E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.27|P-value:7.21E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.33|P-value:1.20E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.39|P-value:4.75E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:5.07|P-value:3.83E-7 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.21|P-value:9.03E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.21|P-value:8.84E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.93|P-value:7.47E-7 ID:SGTC_1954|Compound:st077032|FD-Score:4.58|P-value:4.00E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.87|P-value:8.12E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.18|P-value:9.82E-4 ID:SGTC_2040|Compound:5100729|FD-Score:5.19|P-value:2.05E-7 ID:SGTC_2061|Compound:5245884|FD-Score:4.24|P-value:1.81E-5 ID:SGTC_2063|Compound:5246145|FD-Score:-3.77|P-value:1.06E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.67|P-value:1.72E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.20|P-value:9.22E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.66|P-value:1.80E-4 ID:SGTC_2387|Compound:9077560|FD-Score:4.79|P-value:1.50E-6 ID:SGTC_2400|Compound:5203494|FD-Score:5.25|P-value:1.48E-7 ID:SGTC_2477|Compound:5967686|FD-Score:5.57|P-value:2.71E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.18|P-value:9.76E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.39|P-value:4.82E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.45|P-value:3.91E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.67|P-value:1.74E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.13|P-value:2.43E-5 ID:SGTC_3213|Compound:9129884|FD-Score:6.39|P-value:2.17E-10 ID:SGTC_3247|Compound:9135149|FD-Score:4.39|P-value:9.42E-6 ID:SGTC_3269|Compound:9137823|FD-Score:3.60|P-value:2.25E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.71|P-value:2.16E-6 ID:SGTC_3288|Compound:9119690|FD-Score:5.62|P-value:2.11E-8 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.62|P-value:1.83E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:6.59|P-value:6.39E-11 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.81|P-value:8.96E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.97|P-value:5.42E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:3.37|P-value:5.13E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.77|P-value:1.68E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:3.44|P-value:4.04E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.19|P-value:9.57E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.29|P-value:1.26E-7 ID:SGTC_456|Compound:gingerol|FD-Score:3.37|P-value:5.23E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.40|P-value:4.69E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.95|P-value:5.81E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.34|P-value:5.74E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.48|P-value:3.53E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.16|P-value:9.38E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.71|P-value:2.15E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:6.59|P-value:6.22E-11 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.31|P-value:6.37E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.02|P-value:4.39E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.87|P-value:8.21E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.27|P-value:7.21E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.33|P-value:1.20E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.39|P-value:4.75E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:5.07|P-value:3.83E-7 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.21|P-value:9.03E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.21|P-value:8.84E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.93|P-value:7.47E-7 ID:SGTC_1954|Compound:st077032|FD-Score:4.58|P-value:4.00E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.87|P-value:8.12E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.18|P-value:9.82E-4 ID:SGTC_2040|Compound:5100729|FD-Score:5.19|P-value:2.05E-7 ID:SGTC_2061|Compound:5245884|FD-Score:4.24|P-value:1.81E-5 ID:SGTC_2063|Compound:5246145|FD-Score:-3.77|P-value:1.06E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.67|P-value:1.72E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.20|P-value:9.22E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.66|P-value:1.80E-4 ID:SGTC_2387|Compound:9077560|FD-Score:4.79|P-value:1.50E-6 ID:SGTC_2400|Compound:5203494|FD-Score:5.25|P-value:1.48E-7 ID:SGTC_2477|Compound:5967686|FD-Score:5.57|P-value:2.71E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.18|P-value:9.76E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.39|P-value:4.82E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.45|P-value:3.91E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.67|P-value:1.74E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.13|P-value:2.43E-5 ID:SGTC_3213|Compound:9129884|FD-Score:6.39|P-value:2.17E-10 ID:SGTC_3247|Compound:9135149|FD-Score:4.39|P-value:9.42E-6 ID:SGTC_3269|Compound:9137823|FD-Score:3.60|P-value:2.25E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.71|P-value:2.16E-6 ID:SGTC_3288|Compound:9119690|FD-Score:5.62|P-value:2.11E-8

Top fitness defect scores for YMR224C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1017 4239-0030 6.59 168.0 µM 6.22E-11 2 2.19E-11
2 SGTC_93 0109-0045 6.59 59.2 µM 6.39E-11 DNA damage response 7 2.25E-11
3 SGTC_3213 9129884 6.39 49.5 µM 2.17E-10 3 8.10E-11
4 SGTC_3288 9119690 5.62 36.2 µM 2.11E-8 11 9.66E-9
5 SGTC_2477 5967686 5.57 25.2 µM 2.71E-8 9 1.26E-8
6 SGTC_422 cantharidin 5.29 155.0 µM 1.26E-7 cell wall signaling 28 6.27E-8
7 SGTC_2400 5203494 5.25 178.7 µM 1.48E-7 RSC complex & mRNA processing 9 7.45E-8
8 SGTC_2040 5100729 5.19 123.0 µM 2.05E-7 17 1.04E-7
9 SGTC_1575 cyproterone acetate 5.07 48.0 µM 3.83E-7 7 2.01E-7
10 SGTC_1617 st002906 4.93 78.0 µM 7.47E-7 13 4.04E-7
11 SGTC_2387 9077560 4.79 195.1 µM 1.50E-6 8 8.38E-7
12 SGTC_219 mitoxanthrone 4.77 164.4 µM 1.68E-6 DNA intercalators 33 9.42E-7
13 SGTC_1008 4106-0037 4.71 6.0 µM 2.15E-6 PDR1 9 1.22E-6
14 SGTC_3286 9117135 4.71 37.2 µM 2.16E-6 4 1.23E-6
15 SGTC_1954 st077032 4.58 68.9 µM 4.00E-6 10 2.33E-6
16 SGTC_3247 9135149 4.39 49.5 µM 9.42E-6 DNA damage response 18 5.72E-6
17 SGTC_1503 4585-0012 4.33 61.3 µM 1.20E-5 7 7.33E-6
18 SGTC_2061 5245884 4.24 81.0 µM 1.81E-5 tubulin folding & SWR complex 16 1.13E-5
19 SGTC_1292 0kpi-0043 4.02 232.0 µM 4.39E-5 12 2.85E-5
20 SGTC_138 0850-0259 3.97 40.9 µM 5.42E-5 cell wall 198 3.56E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.69E-10 YKL084W HOT13 hom Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc
0.103 1.83E-9 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.094 4.41E-8 YHR031C RRM3 hom DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
0.093 6.43E-8 YPL017C IRC15 hom Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.092 1.07E-7 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.088 3.76E-7 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.087 4.92E-7 YAL044W-A_p YAL044W-A_p hom Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
0.085 9.28E-7 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.084 1.14E-6 YDR439W LRS4 hom Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.082 2.26E-6 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.081 2.44E-6 YPL089C RLM1 hom MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication
0.081 2.97E-6 YER110C KAP123 hom Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
0.080 3.84E-6 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.079 4.26E-6 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.079 4.28E-6 YHR104W GRE3 hom Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress