YMR226C

NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR226C / YMR226C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.62|P-value:7.80E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.38|P-value:2.11E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.47|P-value:1.44E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.12|P-value:5.41E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.99|P-value:8.49E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.05|P-value:7.41E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.05|P-value:7.41E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:5.94|P-value:2.81E-10 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.42|P-value:1.99E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.51|P-value:1.18E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.51|P-value:1.26E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:2.97|P-value:9.74E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.22|P-value:5.27E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.13|P-value:5.52E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.01|P-value:8.38E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.93|P-value:1.28E-7 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.04|P-value:7.53E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:7.23|P-value:2.16E-14 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.26|P-value:3.38E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.03|P-value:1.27E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.90|P-value:2.38E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.13|P-value:5.55E-4 ID:SGTC_1775|Compound:st081588|FD-Score:4.08|P-value:1.01E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.35|P-value:2.36E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.52|P-value:1.21E-4 ID:SGTC_2044|Compound:5102272|FD-Score:2.96|P-value:9.97E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.32|P-value:2.70E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.26|P-value:4.25E-6 ID:SGTC_2343|Compound:7990716|FD-Score:3.52|P-value:1.20E-4 ID:SGTC_2421|Compound:5690543|FD-Score:4.04|P-value:1.24E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.82|P-value:3.11E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.37|P-value:2.14E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.12|P-value:5.74E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.70|P-value:5.56E-5 ID:SGTC_2889|Compound:9059656|FD-Score:4.40|P-value:2.14E-6 ID:SGTC_2944|Compound:9067346|FD-Score:-6.22|P-value:3.56E-11 ID:SGTC_2947|Compound:9072639|FD-Score:3.14|P-value:5.25E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.31|P-value:2.76E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.41|P-value:1.84E-4 ID:SGTC_3121|Compound:9125696|FD-Score:3.16|P-value:4.85E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.21|P-value:3.97E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.62|P-value:7.80E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.38|P-value:2.11E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.47|P-value:1.44E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.12|P-value:5.41E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.99|P-value:8.49E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.05|P-value:7.41E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.05|P-value:7.41E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:5.94|P-value:2.81E-10 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.42|P-value:1.99E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.51|P-value:1.18E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.51|P-value:1.26E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:2.97|P-value:9.74E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.22|P-value:5.27E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.13|P-value:5.52E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.01|P-value:8.38E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.93|P-value:1.28E-7 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.04|P-value:7.53E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:7.23|P-value:2.16E-14 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.26|P-value:3.38E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.03|P-value:1.27E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.90|P-value:2.38E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.13|P-value:5.55E-4 ID:SGTC_1775|Compound:st081588|FD-Score:4.08|P-value:1.01E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.35|P-value:2.36E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.52|P-value:1.21E-4 ID:SGTC_2044|Compound:5102272|FD-Score:2.96|P-value:9.97E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.32|P-value:2.70E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.26|P-value:4.25E-6 ID:SGTC_2343|Compound:7990716|FD-Score:3.52|P-value:1.20E-4 ID:SGTC_2421|Compound:5690543|FD-Score:4.04|P-value:1.24E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.82|P-value:3.11E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.37|P-value:2.14E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.12|P-value:5.74E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.70|P-value:5.56E-5 ID:SGTC_2889|Compound:9059656|FD-Score:4.40|P-value:2.14E-6 ID:SGTC_2944|Compound:9067346|FD-Score:-6.22|P-value:3.56E-11 ID:SGTC_2947|Compound:9072639|FD-Score:3.14|P-value:5.25E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.31|P-value:2.76E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.41|P-value:1.84E-4 ID:SGTC_3121|Compound:9125696|FD-Score:3.16|P-value:4.85E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.21|P-value:3.97E-4

Top fitness defect scores for YMR226C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1449 4112-4002 7.23 201.0 µM 2.16E-14 RPP1 & pyrimidine depletion 2 2.47E-13
2 SGTC_1097 itavastatin 5.94 7.2 µM 2.81E-10 azole & statin 7 1.46E-9
3 SGTC_1342 1486-1464 4.93 234.0 µM 1.28E-7 3 4.02E-7
4 SGTC_1104 tacrolimus 4.42 29.8 µM 1.99E-6 25 4.99E-6
5 SGTC_2889 9059656 4.40 52.0 µM 2.14E-6 4 5.35E-6
6 SGTC_2166 5933061 4.26 31.5 µM 4.25E-6 tubulin folding & SWR complex 28 1.00E-5
7 SGTC_1163 k060-0048 4.22 49.9 µM 5.27E-6 17 1.22E-5
8 SGTC_1775 st081588 4.08 35.2 µM 1.01E-5 60S ribosome export 22 2.22E-5
9 SGTC_2421 5690543 4.04 90.7 µM 1.24E-5 16 2.69E-5
10 SGTC_1460 k062-0059 4.03 9.2 µM 1.27E-5 Golgi 11 2.75E-5
11 SGTC_1463 k081-0032 3.90 34.1 µM 2.38E-5 6 4.90E-5
12 SGTC_2760 etidronate 3.70 98.0 µM 5.56E-5 34 1.07E-4
13 SGTC_6 0844-0013 3.62 19.8 µM 7.80E-5 123 1.46E-4
14 SGTC_2343 7990716 3.52 14.8 µM 1.20E-4 29 2.17E-4
15 SGTC_2012 4023501 3.52 200.0 µM 1.21E-4 50 2.18E-4
16 SGTC_1110 3-hydroxy-3'-methoxyflavone 3.51 1.2 µM 1.26E-4 iron homeostasis 64 2.26E-4
17 SGTC_300 r073-0011 3.47 5.0 µM 1.44E-4 38 2.57E-4
18 SGTC_3108 9121785 3.41 49.5 µM 1.84E-4 31 3.21E-4
19 SGTC_95 0471-0001 3.38 561.1 µM 2.11E-4 45 3.64E-4
20 SGTC_2596 sinensetin 3.37 100.0 µM 2.14E-4 55 3.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 4.18E-11 YMR145C NDE1 hom Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
0.111 1.02E-10 YKL127W PGM1 hom Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
0.111 1.03E-10 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.108 4.20E-10 YLR029C RPL15A het Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
0.105 1.13E-9 YNL201C PSY2 hom Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3
0.096 2.55E-8 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication
0.096 2.74E-8 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.092 1.08E-7 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.087 3.90E-7 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.086 6.75E-7 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.085 7.85E-7 YLL034C RIX7 het Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
0.084 1.07E-6 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
0.082 1.80E-6 YLR283W_p YLR283W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
0.082 1.85E-6 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.082 1.96E-6 YMR065W KAR5 hom Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone