YMR227C / TAF7

TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR227C / TAF7

Click on Significant Values for Screen Details ID:SGTC_114|Compound:0364-0001|FD-Score:3.29|P-value:7.94E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.64|P-value:4.19E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.63|P-value:2.50E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:5.13|P-value:4.30E-7 ID:SGTC_401|Compound:neomycin|FD-Score:4.54|P-value:6.54E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.38|P-value:5.51E-4 ID:SGTC_490|Compound:phenamil|FD-Score:3.87|P-value:1.03E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.27|P-value:8.57E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.30|P-value:7.92E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.48|P-value:8.58E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.36|P-value:5.88E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-4.31|P-value:1.59E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.21|P-value:9.49E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.68|P-value:2.07E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.61|P-value:2.73E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.91|P-value:1.23E-6 ID:SGTC_1097|Compound:itavastatin|FD-Score:6.12|P-value:2.13E-9 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.68|P-value:2.06E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:4.84|P-value:1.67E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.36|P-value:6.39E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.53|P-value:6.87E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.49|P-value:3.78E-4 ID:SGTC_1563|Compound:conessine|FD-Score:-3.32|P-value:6.59E-4 ID:SGTC_1567|Compound:st069303|FD-Score:5.01|P-value:7.75E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:4.53|P-value:6.99E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.37|P-value:1.35E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:6.93|P-value:1.40E-11 ID:SGTC_1613|Compound:st002381|FD-Score:3.32|P-value:7.34E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.35|P-value:6.69E-4 ID:SGTC_1629|Compound:st005085|FD-Score:5.30|P-value:1.80E-7 ID:SGTC_1658|Compound:st012944|FD-Score:-3.72|P-value:1.62E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.40|P-value:5.08E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.42|P-value:5.18E-4 ID:SGTC_1781|Compound:st038725|FD-Score:6.80|P-value:3.19E-11 ID:SGTC_1810|Compound:st050138|FD-Score:-3.41|P-value:4.89E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.58|P-value:5.41E-6 ID:SGTC_2014|Compound:4013930|FD-Score:-3.25|P-value:8.37E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.98|P-value:6.73E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.39|P-value:5.78E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.82|P-value:1.83E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-3.26|P-value:8.26E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.24|P-value:9.40E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.77|P-value:2.30E-6 ID:SGTC_2243|Compound:6634756|FD-Score:-3.88|P-value:8.96E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.32|P-value:7.32E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.44|P-value:8.90E-8 ID:SGTC_2315|Compound:7733312|FD-Score:4.14|P-value:3.61E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.23|P-value:9.65E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.69|P-value:1.99E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:5.33|P-value:1.56E-7 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.51|P-value:3.87E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.36|P-value:1.42E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.73|P-value:1.57E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.35|P-value:6.66E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:6.16|P-value:1.67E-9 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.83|P-value:1.79E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:4.06|P-value:4.89E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.42|P-value:5.15E-4 ID:SGTC_2938|Compound:9059746|FD-Score:6.14|P-value:1.80E-9 ID:SGTC_2985|Compound:9022375|FD-Score:4.31|P-value:1.75E-5 ID:SGTC_3141|Compound:9094609|FD-Score:-3.56|P-value:2.89E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.74|P-value:1.48E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.29|P-value:7.94E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.64|P-value:4.19E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.63|P-value:2.50E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:5.13|P-value:4.30E-7 ID:SGTC_401|Compound:neomycin|FD-Score:4.54|P-value:6.54E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.38|P-value:5.51E-4 ID:SGTC_490|Compound:phenamil|FD-Score:3.87|P-value:1.03E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.27|P-value:8.57E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.30|P-value:7.92E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.48|P-value:8.58E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.36|P-value:5.88E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-4.31|P-value:1.59E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.21|P-value:9.49E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.68|P-value:2.07E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.61|P-value:2.73E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.91|P-value:1.23E-6 ID:SGTC_1097|Compound:itavastatin|FD-Score:6.12|P-value:2.13E-9 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.68|P-value:2.06E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:4.84|P-value:1.67E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.36|P-value:6.39E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.53|P-value:6.87E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.49|P-value:3.78E-4 ID:SGTC_1563|Compound:conessine|FD-Score:-3.32|P-value:6.59E-4 ID:SGTC_1567|Compound:st069303|FD-Score:5.01|P-value:7.75E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:4.53|P-value:6.99E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.37|P-value:1.35E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:6.93|P-value:1.40E-11 ID:SGTC_1613|Compound:st002381|FD-Score:3.32|P-value:7.34E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.35|P-value:6.69E-4 ID:SGTC_1629|Compound:st005085|FD-Score:5.30|P-value:1.80E-7 ID:SGTC_1658|Compound:st012944|FD-Score:-3.72|P-value:1.62E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.40|P-value:5.08E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.42|P-value:5.18E-4 ID:SGTC_1781|Compound:st038725|FD-Score:6.80|P-value:3.19E-11 ID:SGTC_1810|Compound:st050138|FD-Score:-3.41|P-value:4.89E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.58|P-value:5.41E-6 ID:SGTC_2014|Compound:4013930|FD-Score:-3.25|P-value:8.37E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.98|P-value:6.73E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.39|P-value:5.78E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.82|P-value:1.83E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-3.26|P-value:8.26E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.24|P-value:9.40E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.77|P-value:2.30E-6 ID:SGTC_2243|Compound:6634756|FD-Score:-3.88|P-value:8.96E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.32|P-value:7.32E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.44|P-value:8.90E-8 ID:SGTC_2315|Compound:7733312|FD-Score:4.14|P-value:3.61E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.23|P-value:9.65E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.69|P-value:1.99E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:5.33|P-value:1.56E-7 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.51|P-value:3.87E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.36|P-value:1.42E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.73|P-value:1.57E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.35|P-value:6.66E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:6.16|P-value:1.67E-9 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.83|P-value:1.79E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:4.06|P-value:4.89E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.42|P-value:5.15E-4 ID:SGTC_2938|Compound:9059746|FD-Score:6.14|P-value:1.80E-9 ID:SGTC_2985|Compound:9022375|FD-Score:4.31|P-value:1.75E-5 ID:SGTC_3141|Compound:9094609|FD-Score:-3.56|P-value:2.89E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.74|P-value:1.48E-4

Top fitness defect scores for YMR227C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1576 erythromycin ethylsuccinate 6.93 23.2 µM 1.40E-11 1 2.11E-12 1.69
2 SGTC_1781 st038725 6.80 66.3 µM 3.19E-11 NEO1 3 5.15E-12 0.43
3 SGTC_2730 imipramine 6.16 71.3 µM 1.67E-9 2 3.69E-10 0.91
4 SGTC_2938 9059746 6.14 27.3 µM 1.80E-9 fatty acid desaturase (OLE1) 5 4.01E-10 0.80
5 SGTC_1097 itavastatin 6.12 7.2 µM 2.13E-9 azole & statin 3 4.80E-10 0.73
6 SGTC_2307 7538926 5.44 6.3 µM 8.90E-8 8 2.70E-8 0.01
7 SGTC_2515 chrysin 5.33 20.8 µM 1.56E-7 RPP1 & pyrimidine depletion 2 4.93E-8 0.96
8 SGTC_1629 st005085 5.30 44.9 µM 1.80E-7 RPP1 & pyrimidine depletion 8 5.76E-8 0.20
9 SGTC_350 k064-0020 5.13 19.8 µM 4.30E-7 heme requiring 5 1.48E-7 1.36
10 SGTC_1567 st069303 5.01 68.4 µM 7.75E-7 mitochondrial processes 6 2.79E-7 0.15
11 SGTC_1037 k284-1091 4.91 78.7 µM 1.23E-6 3 4.61E-7 0.91
12 SGTC_1293 1000-1278 4.84 195.0 µM 1.67E-6 2 6.39E-7 0.47
13 SGTC_2737 bleomycin 4.83 30.5 nM 1.79E-6 Golgi 3 6.90E-7 0.76
14 SGTC_2052 5265182 4.82 7.1 µM 1.83E-6 4 7.06E-7 0.50
15 SGTC_2104 5389443 4.77 200.0 µM 2.30E-6 1 9.02E-7 0.46
16 SGTC_173 1273-0061 4.64 2.7 µM 4.19E-6 mitochondrial stress 15 1.72E-6 0.05
17 SGTC_1953 st076800 4.58 12.1 µM 5.41E-6 7 2.27E-6 0.05
18 SGTC_401 neomycin 4.54 50.0 µM 6.54E-6 1 2.79E-6 0.52
19 SGTC_1514 1189-1591 4.53 158.0 µM 6.87E-6 3 2.94E-6 0.37
20 SGTC_1568 digitonin 4.53 820.0 nM 6.99E-6 sphingolipid biosynthesis & PDR1 10 3.00E-6 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.32E-13 YBR198C TAF5 het Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
0.121 1.79E-12 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.111 1.29E-10 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.106 7.75E-10 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.100 7.09E-9 YJL075C_d APQ13_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
0.091 1.34E-7 YOR211C MGM1 hom Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy
0.086 5.43E-7 YBR039W ATP3 hom Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.086 5.71E-7 YMR311C GLC8 hom Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress
0.084 1.04E-6 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.083 1.32E-6 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.083 1.35E-6 YPR032W SRO7 hom Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
0.078 6.30E-6 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.078 6.65E-6 YBR043C QDR3 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin
0.074 1.58E-5 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.073 2.38E-5 YDR541C_p YDR541C_p hom Putative dihydrokaempferol 4-reductase