RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress
Zygosity: Heterozygous strain
fixedexpanded
![]() ![]() Click on Significant Values for Screen Details |
Top fitness defect scores for YMR229C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.212 | 2.58E-35 | YJL153C | INO1 | hom | Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element |
0.195 | 5.00E-30 | YOL053W | AIM39 | hom | Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss |
0.134 | 5.74E-15 | YKR032W_d | YKR032W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.111 | 1.36E-10 | YOR329C | SCD5 | het | Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency |
0.107 | 4.81E-10 | YOR291W | YPK9 | hom | Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome |
0.106 | 8.79E-10 | YBR083W | TEC1 | hom | Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member |
0.104 | 1.83E-9 | YOR275C | RIM20 | hom | Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation |
0.102 | 3.61E-9 | YGR100W | MDR1 | hom | Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function |
0.101 | 4.77E-9 | YDL205C | HEM3 | het | Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme |
0.101 | 4.82E-9 | YPL019C | VTC3 | hom | Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion |
0.100 | 6.06E-9 | YPL064C | CWC27 | hom | Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress |
0.097 | 2.05E-8 | YGR174W-A_p | YGR174W-A_p | hom | Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis |
0.094 | 4.26E-8 | YJR115W_p | YJR115W_p | hom | Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication |
0.092 | 8.00E-8 | YJR017C | ESS1 | het | Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3 |
0.091 | 1.18E-7 | YLR307C-A_p | YLR307C-A_p | hom | Putative protein of unknown function |