YMR230W / RPS10B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR230W / RPS10B

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.70|P-value:2.58E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:3.31|P-value:6.64E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.53|P-value:2.67E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.40|P-value:4.24E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.72|P-value:1.57E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.32|P-value:6.48E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.39|P-value:4.35E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.45|P-value:4.12E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.36|P-value:5.76E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.20|P-value:9.65E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.62|P-value:2.27E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.28|P-value:6.44E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.23|P-value:8.75E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.47|P-value:3.93E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.67|P-value:1.61E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.64|P-value:2.08E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-3.40|P-value:4.19E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:7.07|P-value:3.23E-12 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.67|P-value:1.85E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-4.18|P-value:2.07E-5 ID:SGTC_1781|Compound:st038725|FD-Score:4.18|P-value:2.51E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.36|P-value:5.67E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.84|P-value:9.87E-5 ID:SGTC_2320|Compound:7373003|FD-Score:4.68|P-value:2.82E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.26|P-value:7.96E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.51|P-value:5.96E-6 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.98|P-value:4.81E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-5.14|P-value:2.36E-7 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.54|P-value:2.52E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.07|P-value:1.81E-9 ID:SGTC_2829|Compound:7992743|FD-Score:-3.51|P-value:2.83E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.38|P-value:4.55E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.33|P-value:6.22E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.26|P-value:7.89E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.70|P-value:2.58E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:3.31|P-value:6.64E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.53|P-value:2.67E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.40|P-value:4.24E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.72|P-value:1.57E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.32|P-value:6.48E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.39|P-value:4.35E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.45|P-value:4.12E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.36|P-value:5.76E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.20|P-value:9.65E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.62|P-value:2.27E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.28|P-value:6.44E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.23|P-value:8.75E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.47|P-value:3.93E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.67|P-value:1.61E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.64|P-value:2.08E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-3.40|P-value:4.19E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:7.07|P-value:3.23E-12 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.67|P-value:1.85E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-4.18|P-value:2.07E-5 ID:SGTC_1781|Compound:st038725|FD-Score:4.18|P-value:2.51E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.36|P-value:5.67E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.84|P-value:9.87E-5 ID:SGTC_2320|Compound:7373003|FD-Score:4.68|P-value:2.82E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.26|P-value:7.96E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.51|P-value:5.96E-6 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.98|P-value:4.81E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-5.14|P-value:2.36E-7 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.54|P-value:2.52E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.07|P-value:1.81E-9 ID:SGTC_2829|Compound:7992743|FD-Score:-3.51|P-value:2.83E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.38|P-value:4.55E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.33|P-value:6.22E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.26|P-value:7.89E-4

Top fitness defect scores for YMR230W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1255 0566-0045 7.07 221.0 µM 3.23E-12 excess fatty acid 5 7.99E-13
2 SGTC_2688 kanamycin b 6.07 96.7 µM 1.81E-9 calcium & mitochondrial duress 155 6.31E-10
3 SGTC_118 0083-0097 4.70 135.3 µM 2.58E-6 translation 75 1.33E-6
4 SGTC_2320 7373003 4.68 200.0 µM 2.82E-6 8 1.46E-6
5 SGTC_2503 beta-caryophyllene alcohol 4.51 24.7 µM 5.96E-6 6 3.20E-6
6 SGTC_1781 st038725 4.18 66.3 µM 2.51E-5 NEO1 91 1.46E-5
7 SGTC_1893 st059353 3.84 36.1 µM 9.87E-5 29 6.17E-5
8 SGTC_380 3970-0968 3.72 6.0 µM 1.57E-4 18 1.01E-4
9 SGTC_1596 piperlongumine 3.67 63.0 µM 1.85E-4 23 1.20E-4
10 SGTC_1149 3909-7961 3.64 23.3 µM 2.08E-4 30 1.35E-4
11 SGTC_606 k015-0008 3.62 38.6 µM 2.27E-4 24 1.48E-4
12 SGTC_958 1222-0007 3.47 33.0 µM 3.93E-4 44 2.65E-4
13 SGTC_538 2922-0838 3.45 53.3 µM 4.12E-4 Golgi 49 2.78E-4
14 SGTC_1886 st057356 3.36 49.9 µM 5.67E-4 60S ribosome export 34 3.90E-4
15 SGTC_573 3702-0553 3.36 84.7 µM 5.76E-4 26 3.96E-4
16 SGTC_2975 9084847 3.33 53.7 µM 6.22E-4 51 4.30E-4
17 SGTC_462 ag-879 3.32 158.0 µM 6.48E-4 52 4.49E-4
18 SGTC_129 0088-0017 3.31 176.6 µM 6.64E-4 92 4.60E-4
19 SGTC_3276 9139060 3.26 49.5 µM 7.89E-4 60S ribosome export 17 5.52E-4
20 SGTC_2502 avocadyne acetate 3.26 18.6 µM 7.96E-4 58 5.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.18E-21 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.138 1.24E-15 YLR388W RPS29A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication
0.137 1.89E-15 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.131 3.25E-14 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.130 3.55E-14 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.130 4.98E-14 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.120 2.84E-12 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.115 2.51E-11 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.112 8.03E-11 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.111 9.79E-11 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.110 1.76E-10 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.110 1.91E-10 YGL127C SOH1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
0.109 2.37E-10 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.109 2.83E-10 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.108 3.12E-10 YMR236W TAF9 het Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3