YMR230W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR230W-A / YMR230W-A

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:-3.40|P-value:3.38E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.16|P-value:7.64E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.66|P-value:1.21E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.91|P-value:4.31E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.32|P-value:7.43E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.95|P-value:3.75E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:3.23|P-value:5.96E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.90|P-value:4.70E-5 ID:SGTC_470|Compound:aa-861|FD-Score:-5.19|P-value:1.03E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.88|P-value:4.97E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.67|P-value:6.64E-9 ID:SGTC_562|Compound:3772-2733|FD-Score:3.51|P-value:2.19E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.94|P-value:3.96E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:5.08|P-value:1.80E-7 ID:SGTC_807|Compound:1315-0151|FD-Score:4.14|P-value:1.66E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:5.45|P-value:2.34E-8 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.60|P-value:1.59E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.52|P-value:2.87E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.09|P-value:1.79E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.87|P-value:5.22E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.08|P-value:2.17E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.39|P-value:3.38E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.58|P-value:1.65E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-5.20|P-value:9.69E-8 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.87|P-value:1.96E-9 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.88|P-value:5.31E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.35|P-value:3.91E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.12|P-value:8.89E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.85|P-value:2.22E-9 ID:SGTC_1744|Compound:st037937|FD-Score:3.76|P-value:8.32E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.27|P-value:9.44E-6 ID:SGTC_1886|Compound:st057356|FD-Score:-3.75|P-value:9.03E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-4.69|P-value:1.36E-6 ID:SGTC_2021|Compound:4019055|FD-Score:5.86|P-value:2.14E-9 ID:SGTC_2046|Compound:4110841|FD-Score:4.35|P-value:6.45E-6 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.24|P-value:5.82E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.25|P-value:5.49E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.31|P-value:4.67E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-4.29|P-value:8.83E-6 ID:SGTC_2390|Compound:9097792|FD-Score:3.87|P-value:5.25E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-3.67|P-value:1.21E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.48|P-value:2.55E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.85|P-value:5.57E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.57|P-value:1.80E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.20|P-value:2.79E-13 ID:SGTC_2991|Compound:9074669|FD-Score:9.04|P-value:6.52E-20 ID:SGTC_2992|Compound:9074591|FD-Score:-3.97|P-value:3.60E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-7.30|P-value:1.38E-13 ID:SGTC_3074|Compound:9116018|FD-Score:-3.53|P-value:2.06E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.46|P-value:2.76E-4 ID:SGTC_3183|Compound:9108214|FD-Score:3.62|P-value:1.43E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.40|P-value:3.21E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.40|P-value:3.38E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.16|P-value:7.64E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.66|P-value:1.21E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.91|P-value:4.31E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.32|P-value:7.43E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.95|P-value:3.75E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:3.23|P-value:5.96E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.90|P-value:4.70E-5 ID:SGTC_470|Compound:aa-861|FD-Score:-5.19|P-value:1.03E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.88|P-value:4.97E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.67|P-value:6.64E-9 ID:SGTC_562|Compound:3772-2733|FD-Score:3.51|P-value:2.19E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.94|P-value:3.96E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:5.08|P-value:1.80E-7 ID:SGTC_807|Compound:1315-0151|FD-Score:4.14|P-value:1.66E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:5.45|P-value:2.34E-8 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.60|P-value:1.59E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.52|P-value:2.87E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.09|P-value:1.79E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.87|P-value:5.22E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.08|P-value:2.17E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.39|P-value:3.38E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.58|P-value:1.65E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-5.20|P-value:9.69E-8 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.87|P-value:1.96E-9 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.88|P-value:5.31E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.35|P-value:3.91E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.12|P-value:8.89E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.85|P-value:2.22E-9 ID:SGTC_1744|Compound:st037937|FD-Score:3.76|P-value:8.32E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.27|P-value:9.44E-6 ID:SGTC_1886|Compound:st057356|FD-Score:-3.75|P-value:9.03E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-4.69|P-value:1.36E-6 ID:SGTC_2021|Compound:4019055|FD-Score:5.86|P-value:2.14E-9 ID:SGTC_2046|Compound:4110841|FD-Score:4.35|P-value:6.45E-6 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.24|P-value:5.82E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.25|P-value:5.49E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.31|P-value:4.67E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-4.29|P-value:8.83E-6 ID:SGTC_2390|Compound:9097792|FD-Score:3.87|P-value:5.25E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-3.67|P-value:1.21E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.48|P-value:2.55E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.85|P-value:5.57E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.57|P-value:1.80E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.20|P-value:2.79E-13 ID:SGTC_2991|Compound:9074669|FD-Score:9.04|P-value:6.52E-20 ID:SGTC_2992|Compound:9074591|FD-Score:-3.97|P-value:3.60E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-7.30|P-value:1.38E-13 ID:SGTC_3074|Compound:9116018|FD-Score:-3.53|P-value:2.06E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.46|P-value:2.76E-4 ID:SGTC_3183|Compound:9108214|FD-Score:3.62|P-value:1.43E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.40|P-value:3.21E-4

Top fitness defect scores for YMR230W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2991 9074669 9.04 71.4 µM 6.52E-20 azole & statin 9 7.63E-20
2 SGTC_2688 kanamycin b 7.20 96.7 µM 2.79E-13 calcium & mitochondrial duress 99 3.11E-13
3 SGTC_1390 3413-2614 5.87 145.0 µM 1.96E-9 fatty acid desaturase (OLE1) 4 2.12E-9
4 SGTC_2021 4019055 5.86 173.0 µM 2.14E-9 endomembrane recycling 41 2.32E-9
5 SGTC_1687 st020778 5.85 55.4 µM 2.22E-9 112 2.40E-9
6 SGTC_528 3492-0019 5.67 172.0 µM 6.64E-9 calcium & mitochondrial duress 132 7.15E-9
7 SGTC_841 0251-0215 5.45 91.2 µM 2.34E-8 46 2.51E-8
8 SGTC_650 1328-0195 5.08 38.0 µM 1.80E-7 5 1.91E-7
9 SGTC_363 0455-0021 4.91 3.1 µM 4.31E-7 azole & statin 42 4.57E-7
10 SGTC_951 1171-0579 4.52 82.7 µM 2.87E-6 cell wall 55 3.03E-6
11 SGTC_2046 4110841 4.35 106.0 µM 6.45E-6 iron homeostasis 20 6.78E-6
12 SGTC_390 dec-rvkr-cmk 4.32 16.7 µM 7.43E-6 calcium & mitochondrial duress 15 7.81E-6
13 SGTC_1750 st081859 4.27 2.4 µM 9.44E-6 endomembrane recycling 165 9.91E-6
14 SGTC_807 1315-0151 4.14 48.0 µM 1.66E-5 21 1.74E-5
15 SGTC_1212 0520-0165 4.08 585.0 µM 2.17E-5 27 2.27E-5
16 SGTC_391 gliotoxin 3.95 8.3 µM 3.75E-5 60 3.92E-5
17 SGTC_649 1123-0311 3.94 367.0 µM 3.96E-5 endomembrane recycling 70 4.13E-5
18 SGTC_431 k089-0097 3.90 107.0 µM 4.70E-5 iron homeostasis 47 4.91E-5
19 SGTC_488 nitrendipine 3.88 139.0 µM 4.97E-5 52 5.19E-5
20 SGTC_1161 k007-0610 3.87 110.0 µM 5.22E-5 ERAD & cell cycle 125 5.45E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.250 4.85E-49 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.243 1.85E-46 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.231 7.94E-42 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.226 3.34E-40 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.219 1.06E-37 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.209 2.36E-34 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.201 5.17E-32 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.201 5.30E-32 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.199 2.47E-31 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.198 6.03E-31 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.197 1.34E-30 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.184 4.63E-27 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.183 1.47E-26 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.183 1.50E-26 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.182 2.14E-26 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria