HIPHOP chemogenomics database

YMR230W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR230W-A / YMR230W-A

Click on Significant Values for Screen Details

Top fitness defect scores for YMR230W-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2991	9074669	9.04	71.4 µM	6.52E-20	azole & statin	9	7.63E-20
2	SGTC_2688	kanamycin b	7.20	96.7 µM	2.79E-13	calcium & mitochondrial duress	99	3.11E-13
3	SGTC_1390	3413-2614	5.87	145.0 µM	1.96E-9	fatty acid desaturase (OLE1)	4	2.12E-9
4	SGTC_2021	4019055	5.86	173.0 µM	2.14E-9	endomembrane recycling	41	2.32E-9
5	SGTC_1687	st020778	5.85	55.4 µM	2.22E-9		112	2.40E-9
6	SGTC_528	3492-0019	5.67	172.0 µM	6.64E-9	calcium & mitochondrial duress	132	7.15E-9
7	SGTC_841	0251-0215	5.45	91.2 µM	2.34E-8		46	2.51E-8
8	SGTC_650	1328-0195	5.08	38.0 µM	1.80E-7		5	1.91E-7
9	SGTC_363	0455-0021	4.91	3.1 µM	4.31E-7	azole & statin	42	4.57E-7
10	SGTC_951	1171-0579	4.52	82.7 µM	2.87E-6	cell wall	55	3.03E-6
11	SGTC_2046	4110841	4.35	106.0 µM	6.45E-6	iron homeostasis	20	6.78E-6
12	SGTC_390	dec-rvkr-cmk	4.32	16.7 µM	7.43E-6	calcium & mitochondrial duress	15	7.81E-6
13	SGTC_1750	st081859	4.27	2.4 µM	9.44E-6	endomembrane recycling	165	9.91E-6
14	SGTC_807	1315-0151	4.14	48.0 µM	1.66E-5		21	1.74E-5
15	SGTC_1212	0520-0165	4.08	585.0 µM	2.17E-5		27	2.27E-5
16	SGTC_391	gliotoxin	3.95	8.3 µM	3.75E-5		60	3.92E-5
17	SGTC_649	1123-0311	3.94	367.0 µM	3.96E-5	endomembrane recycling	70	4.13E-5
18	SGTC_431	k089-0097	3.90	107.0 µM	4.70E-5	iron homeostasis	47	4.91E-5
19	SGTC_488	nitrendipine	3.88	139.0 µM	4.97E-5		52	5.19E-5
20	SGTC_1161	k007-0610	3.87	110.0 µM	5.22E-5	ERAD & cell cycle	125	5.45E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.250	4.85E-49	YDR080W	VPS41	hom	Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.243	1.85E-46	YJL024C	APS3	hom	Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.231	7.94E-42	YGL212W	VAM7	hom	Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.226	3.34E-40	YGR261C	APL6	hom	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.219	1.06E-37	YML001W	YPT7	hom	Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.209	2.36E-34	YDL192W	ARF1	hom	ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.201	5.17E-32	YBR288C	APM3	hom	Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.201	5.30E-32	YJR040W	GEF1	hom	Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.199	2.47E-31	YDR467C_d	YDR467C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.198	6.03E-31	YGL079W_p	KXD1_p	hom	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.197	1.34E-30	YJR033C	RAV1	hom	Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.184	4.63E-27	YDR475C	JIP4	hom	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.183	1.47E-26	YDL077C	VAM6	hom	Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.183	1.50E-26	YLR408C_p	BLS1_p	hom	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.182	2.14E-26	YML007C-A_p	YML007C-A_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria