YMR232W / FUS2

Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR232W / FUS2

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:2.83|P-value:8.22E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:2.97|P-value:4.77E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.81|P-value:1.34E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.34|P-value:1.08E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.85|P-value:1.08E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.53|P-value:4.85E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.44|P-value:7.25E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:3.32|P-value:1.20E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.25|P-value:1.57E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.18|P-value:2.14E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:2.80|P-value:9.07E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:4.66|P-value:1.63E-7 ID:SGTC_656|Compound:4090-1979|FD-Score:3.00|P-value:4.26E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:2.88|P-value:6.65E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.28|P-value:1.40E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:5.14|P-value:9.30E-9 ID:SGTC_767|Compound:0929-0023|FD-Score:3.83|P-value:1.23E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:3.41|P-value:8.15E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.46|P-value:6.45E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:2.86|P-value:7.25E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.90|P-value:6.19E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.23|P-value:1.68E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.36|P-value:1.01E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.18|P-value:2.07E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.28|P-value:1.37E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:2.88|P-value:6.61E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.43|P-value:7.35E-5 ID:SGTC_1523|Compound:st012844|FD-Score:4.03|P-value:4.66E-6 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.78|P-value:1.55E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.48|P-value:6.09E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.71|P-value:2.08E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.13|P-value:2.60E-4 ID:SGTC_1616|Compound:st002734|FD-Score:2.90|P-value:6.27E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.04|P-value:3.69E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.72|P-value:2.00E-5 ID:SGTC_1709|Compound:st033179|FD-Score:2.99|P-value:4.38E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.02|P-value:3.93E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.33|P-value:1.12E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.04|P-value:8.87E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-4.23|P-value:5.49E-6 ID:SGTC_1977|Compound:st070720|FD-Score:3.32|P-value:1.21E-4 ID:SGTC_2061|Compound:5245884|FD-Score:4.88|P-value:4.57E-8 ID:SGTC_2065|Compound:5221596|FD-Score:4.60|P-value:2.22E-7 ID:SGTC_2086|Compound:5274770|FD-Score:3.79|P-value:1.45E-5 ID:SGTC_2189|Compound:6047310|FD-Score:3.38|P-value:9.00E-5 ID:SGTC_2192|Compound:5915882|FD-Score:4.30|P-value:1.13E-6 ID:SGTC_2204|Compound:7233102|FD-Score:4.10|P-value:3.19E-6 ID:SGTC_2208|Compound:7283366|FD-Score:5.27|P-value:4.13E-9 ID:SGTC_2222|Compound:6885208|FD-Score:-3.08|P-value:7.66E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.64|P-value:2.93E-5 ID:SGTC_2469|Compound:5655019|FD-Score:3.39|P-value:8.73E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.63|P-value:8.73E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-4.34|P-value:3.06E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.50|P-value:5.45E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.61|P-value:3.39E-5 ID:SGTC_2919|Compound:7978188|FD-Score:4.31|P-value:1.07E-6 ID:SGTC_2958|Compound:9077254|FD-Score:2.99|P-value:4.47E-4 ID:SGTC_2987|Compound:9018338|FD-Score:4.15|P-value:2.45E-6 ID:SGTC_2993|Compound:9054257|FD-Score:2.86|P-value:7.13E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.07|P-value:3.22E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.59|P-value:2.43E-7 ID:SGTC_3175|Compound:9106517|FD-Score:3.26|P-value:1.54E-4 ID:SGTC_3178|Compound:9107506|FD-Score:4.55|P-value:3.04E-7 ID:SGTC_3184|Compound:9108758|FD-Score:4.09|P-value:3.42E-6 ID:SGTC_3209|Compound:9113616|FD-Score:-3.05|P-value:8.42E-4 ID:SGTC_3225|Compound:9130819|FD-Score:2.89|P-value:6.58E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.73|P-value:1.90E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:2.83|P-value:8.22E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:2.97|P-value:4.77E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.81|P-value:1.34E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.34|P-value:1.08E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.85|P-value:1.08E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.53|P-value:4.85E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.44|P-value:7.25E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:3.32|P-value:1.20E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.25|P-value:1.57E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.18|P-value:2.14E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:2.80|P-value:9.07E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:4.66|P-value:1.63E-7 ID:SGTC_656|Compound:4090-1979|FD-Score:3.00|P-value:4.26E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:2.88|P-value:6.65E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.28|P-value:1.40E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:5.14|P-value:9.30E-9 ID:SGTC_767|Compound:0929-0023|FD-Score:3.83|P-value:1.23E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:3.41|P-value:8.15E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.46|P-value:6.45E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:2.86|P-value:7.25E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.90|P-value:6.19E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.23|P-value:1.68E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.36|P-value:1.01E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.18|P-value:2.07E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.28|P-value:1.37E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:2.88|P-value:6.61E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.43|P-value:7.35E-5 ID:SGTC_1523|Compound:st012844|FD-Score:4.03|P-value:4.66E-6 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.78|P-value:1.55E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.48|P-value:6.09E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.71|P-value:2.08E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.13|P-value:2.60E-4 ID:SGTC_1616|Compound:st002734|FD-Score:2.90|P-value:6.27E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.04|P-value:3.69E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.72|P-value:2.00E-5 ID:SGTC_1709|Compound:st033179|FD-Score:2.99|P-value:4.38E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.02|P-value:3.93E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.33|P-value:1.12E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.04|P-value:8.87E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-4.23|P-value:5.49E-6 ID:SGTC_1977|Compound:st070720|FD-Score:3.32|P-value:1.21E-4 ID:SGTC_2061|Compound:5245884|FD-Score:4.88|P-value:4.57E-8 ID:SGTC_2065|Compound:5221596|FD-Score:4.60|P-value:2.22E-7 ID:SGTC_2086|Compound:5274770|FD-Score:3.79|P-value:1.45E-5 ID:SGTC_2189|Compound:6047310|FD-Score:3.38|P-value:9.00E-5 ID:SGTC_2192|Compound:5915882|FD-Score:4.30|P-value:1.13E-6 ID:SGTC_2204|Compound:7233102|FD-Score:4.10|P-value:3.19E-6 ID:SGTC_2208|Compound:7283366|FD-Score:5.27|P-value:4.13E-9 ID:SGTC_2222|Compound:6885208|FD-Score:-3.08|P-value:7.66E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.64|P-value:2.93E-5 ID:SGTC_2469|Compound:5655019|FD-Score:3.39|P-value:8.73E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.63|P-value:8.73E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-4.34|P-value:3.06E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.50|P-value:5.45E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.61|P-value:3.39E-5 ID:SGTC_2919|Compound:7978188|FD-Score:4.31|P-value:1.07E-6 ID:SGTC_2958|Compound:9077254|FD-Score:2.99|P-value:4.47E-4 ID:SGTC_2987|Compound:9018338|FD-Score:4.15|P-value:2.45E-6 ID:SGTC_2993|Compound:9054257|FD-Score:2.86|P-value:7.13E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.07|P-value:3.22E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.59|P-value:2.43E-7 ID:SGTC_3175|Compound:9106517|FD-Score:3.26|P-value:1.54E-4 ID:SGTC_3178|Compound:9107506|FD-Score:4.55|P-value:3.04E-7 ID:SGTC_3184|Compound:9108758|FD-Score:4.09|P-value:3.42E-6 ID:SGTC_3209|Compound:9113616|FD-Score:-3.05|P-value:8.42E-4 ID:SGTC_3225|Compound:9130819|FD-Score:2.89|P-value:6.58E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.73|P-value:1.90E-5

Top fitness defect scores for YMR232W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2208 7283366 5.27 200.0 µM 4.13E-9 3 6.81E-8
2 SGTC_667 1498-1044 5.14 59.0 µM 9.30E-9 RPP1 & pyrimidine depletion 4 1.37E-7
3 SGTC_2061 5245884 4.88 81.0 µM 4.57E-8 tubulin folding & SWR complex 12 5.36E-7
4 SGTC_598 3937-0236 4.66 20.2 µM 1.63E-7 ERG2 14 1.60E-6
5 SGTC_2065 5221596 4.60 34.3 µM 2.22E-7 8 2.08E-6
6 SGTC_3174 9107204 4.59 49.5 µM 2.43E-7 ERG2 19 2.25E-6
7 SGTC_3178 9107506 4.55 49.5 µM 3.04E-7 5 2.72E-6
8 SGTC_2919 7978188 4.31 46.4 µM 1.07E-6 14 8.00E-6
9 SGTC_2192 5915882 4.30 198.5 µM 1.13E-6 RNA processing & uracil transport 23 8.40E-6
10 SGTC_2987 9018338 4.15 71.4 µM 2.45E-6 RPP1 & pyrimidine depletion 11 1.63E-5
11 SGTC_2204 7233102 4.10 200.0 µM 3.19E-6 60S ribosome export 2 2.05E-5
12 SGTC_3184 9108758 4.09 49.5 µM 3.42E-6 4 2.17E-5
13 SGTC_1523 st012844 4.03 44.7 µM 4.66E-6 60S ribosome export 18 2.83E-5
14 SGTC_273 hydroxyurea 3.85 18.1 mM 1.08E-5 heme biosynthesis & mitochondrial translocase 40 5.80E-5
15 SGTC_767 0929-0023 3.83 86.0 µM 1.23E-5 TRP & mitochondrial translation 83 6.52E-5
16 SGTC_229 benomyl 3.81 22.9 µM 1.34E-5 tubulin folding & SWR complex 32 6.97E-5
17 SGTC_2086 5274770 3.79 176.6 µM 1.45E-5 26 7.50E-5
18 SGTC_1535 tetrahydropapaveroline hydrobromide 3.78 54.3 µM 1.55E-5 RPP1 & pyrimidine depletion 14 7.91E-5
19 SGTC_3294 9122953 3.73 26.3 µM 1.90E-5 tubulin folding & SWR complex 32 9.44E-5
20 SGTC_1681 tripelennamine 3.72 100.0 µM 2.00E-5 27 9.86E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.31E-10 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.085 7.86E-7 YDL156W CMR1 hom DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS
0.081 2.87E-6 YPL265W DIP5 hom Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress
0.079 4.39E-6 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.076 1.01E-5 YCR086W CSM1 hom Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.072 2.86E-5 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.070 4.70E-5 YOR175C ALE1 hom Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
0.070 4.86E-5 YLR098C CHA4 hom DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
0.070 5.10E-5 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.069 6.08E-5 YCL011C GBP2 hom Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication
0.067 1.11E-4 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.065 1.50E-4 YMR013C SEC59 het Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
0.065 1.64E-4 YLR340W RPP0 het Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10
0.064 1.96E-4 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.063 2.80E-4 YGR284C ERV29 hom Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress