YMR233W / TRI1

Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR233W / TRI1

Click on Significant Values for Screen Details ID:SGTC_174|Compound:3553-0389|FD-Score:3.96|P-value:8.13E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:-11.00|P-value:4.74E-26 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.67|P-value:2.12E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:5.34|P-value:1.79E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.74|P-value:1.62E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:5.44|P-value:1.10E-7 ID:SGTC_389|Compound:tpck|FD-Score:-3.26|P-value:8.55E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.86|P-value:1.17E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.61|P-value:2.94E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.58|P-value:3.22E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.80|P-value:1.51E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.25|P-value:8.85E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.66|P-value:4.58E-6 ID:SGTC_901|Compound:1112-0062|FD-Score:3.75|P-value:1.77E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.19|P-value:3.25E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.77|P-value:1.65E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.81|P-value:1.41E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.46|P-value:4.88E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.93|P-value:9.26E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.53|P-value:3.91E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.39|P-value:1.44E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.94|P-value:8.86E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.88|P-value:1.64E-6 ID:SGTC_1581|Compound:himbacine|FD-Score:3.41|P-value:5.91E-4 ID:SGTC_1708|Compound:st033234|FD-Score:4.33|P-value:1.87E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.23|P-value:9.43E-4 ID:SGTC_1735|Compound:st034310|FD-Score:5.92|P-value:8.42E-9 ID:SGTC_1763|Compound:st044482|FD-Score:4.06|P-value:5.59E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.37|P-value:6.72E-4 ID:SGTC_1915|Compound:st067105|FD-Score:5.17|P-value:4.23E-7 ID:SGTC_1974|Compound:st069448|FD-Score:3.61|P-value:2.97E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.82|P-value:1.39E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.75|P-value:1.76E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.70|P-value:3.78E-6 ID:SGTC_2292|Compound:7671323|FD-Score:-4.09|P-value:4.36E-5 ID:SGTC_2297|Compound:7971671|FD-Score:-4.35|P-value:1.51E-5 ID:SGTC_2345|Compound:9052315|FD-Score:3.48|P-value:4.68E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-4.38|P-value:1.32E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.29|P-value:8.84E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.44|P-value:5.31E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.82|P-value:1.36E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.11|P-value:4.57E-5 ID:SGTC_2473|Compound:5854593|FD-Score:4.22|P-value:2.97E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.38|P-value:6.46E-4 ID:SGTC_2486|Compound:5283202|FD-Score:4.58|P-value:6.45E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.76|P-value:1.72E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.84|P-value:1.29E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.01|P-value:6.67E-5 ID:SGTC_2719|Compound:novobiocin|FD-Score:4.72|P-value:3.39E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.46|P-value:9.84E-8 ID:SGTC_2848|Compound:9016370|FD-Score:3.45|P-value:5.17E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.46|P-value:1.06E-5 ID:SGTC_2977|Compound:9011197|FD-Score:3.82|P-value:1.40E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.86|P-value:1.84E-6 ID:SGTC_3129|Compound:9127257|FD-Score:4.28|P-value:2.30E-5 ID:SGTC_3352|Compound:9151559|FD-Score:4.01|P-value:6.70E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:3.96|P-value:8.13E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:-11.00|P-value:4.74E-26 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.67|P-value:2.12E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:5.34|P-value:1.79E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.74|P-value:1.62E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:5.44|P-value:1.10E-7 ID:SGTC_389|Compound:tpck|FD-Score:-3.26|P-value:8.55E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.86|P-value:1.17E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.61|P-value:2.94E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.58|P-value:3.22E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.80|P-value:1.51E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.25|P-value:8.85E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.66|P-value:4.58E-6 ID:SGTC_901|Compound:1112-0062|FD-Score:3.75|P-value:1.77E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.19|P-value:3.25E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.77|P-value:1.65E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.81|P-value:1.41E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.46|P-value:4.88E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.93|P-value:9.26E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.53|P-value:3.91E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.39|P-value:1.44E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.94|P-value:8.86E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.88|P-value:1.64E-6 ID:SGTC_1581|Compound:himbacine|FD-Score:3.41|P-value:5.91E-4 ID:SGTC_1708|Compound:st033234|FD-Score:4.33|P-value:1.87E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.23|P-value:9.43E-4 ID:SGTC_1735|Compound:st034310|FD-Score:5.92|P-value:8.42E-9 ID:SGTC_1763|Compound:st044482|FD-Score:4.06|P-value:5.59E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.37|P-value:6.72E-4 ID:SGTC_1915|Compound:st067105|FD-Score:5.17|P-value:4.23E-7 ID:SGTC_1974|Compound:st069448|FD-Score:3.61|P-value:2.97E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.82|P-value:1.39E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.75|P-value:1.76E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.70|P-value:3.78E-6 ID:SGTC_2292|Compound:7671323|FD-Score:-4.09|P-value:4.36E-5 ID:SGTC_2297|Compound:7971671|FD-Score:-4.35|P-value:1.51E-5 ID:SGTC_2345|Compound:9052315|FD-Score:3.48|P-value:4.68E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-4.38|P-value:1.32E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.29|P-value:8.84E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.44|P-value:5.31E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.82|P-value:1.36E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.11|P-value:4.57E-5 ID:SGTC_2473|Compound:5854593|FD-Score:4.22|P-value:2.97E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.38|P-value:6.46E-4 ID:SGTC_2486|Compound:5283202|FD-Score:4.58|P-value:6.45E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.76|P-value:1.72E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.84|P-value:1.29E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.01|P-value:6.67E-5 ID:SGTC_2719|Compound:novobiocin|FD-Score:4.72|P-value:3.39E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.46|P-value:9.84E-8 ID:SGTC_2848|Compound:9016370|FD-Score:3.45|P-value:5.17E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.46|P-value:1.06E-5 ID:SGTC_2977|Compound:9011197|FD-Score:3.82|P-value:1.40E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.86|P-value:1.84E-6 ID:SGTC_3129|Compound:9127257|FD-Score:4.28|P-value:2.30E-5 ID:SGTC_3352|Compound:9151559|FD-Score:4.01|P-value:6.70E-5

Top fitness defect scores for YMR233W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1735 st034310 5.92 56.8 µM 8.42E-9 Golgi 4 1.65E-9
2 SGTC_2779 methotrexate 5.46 400.0 µM 9.84E-8 15 2.42E-8
3 SGTC_364 0083-0097 5.44 67.7 µM 1.10E-7 9 2.73E-8
4 SGTC_258 haloperidol 5.34 50.8 µM 1.79E-7 fatty acid desaturase (OLE1) 11 4.66E-8
5 SGTC_1915 st067105 5.17 30.6 µM 4.23E-7 RNA pol III & RNase P/MRP 15 1.20E-7
6 SGTC_1576 erythromycin ethylsuccinate 4.88 23.2 µM 1.64E-6 10 5.25E-7
7 SGTC_2980 9014342 4.86 25.3 µM 1.84E-6 18 5.96E-7
8 SGTC_2719 novobiocin 4.72 32.6 µM 3.39E-6 1 1.16E-6
9 SGTC_2274 7947094 4.70 46.1 µM 3.78E-6 12 1.31E-6
10 SGTC_887 0885-0007 4.66 9.6 µM 4.58E-6 endomembrane recycling 24 1.62E-6
11 SGTC_2486 5283202 4.58 22.4 µM 6.45E-6 27 2.35E-6
12 SGTC_2905 7799065 4.46 20.1 µM 1.06E-5 8 4.06E-6
13 SGTC_1480 1070-0044 4.39 41.2 µM 1.44E-5 12 5.66E-6
14 SGTC_1708 st033234 4.33 31.8 µM 1.87E-5 9 7.53E-6
15 SGTC_3129 9127257 4.28 49.5 µM 2.30E-5 15 9.42E-6
16 SGTC_2473 5854593 4.22 8.9 µM 2.97E-5 6 1.25E-5
17 SGTC_972 1319-0219 4.19 195.0 µM 3.25E-5 19 1.38E-5
18 SGTC_2431 5490079 4.11 200.0 µM 4.57E-5 29 2.00E-5
19 SGTC_1763 st044482 4.06 94.5 µM 5.59E-5 copper-dependent oxidative stress 19 2.49E-5
20 SGTC_2660 2',4'-dihydroxychalcone 4.01 17.1 µM 6.67E-5 17 3.02E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 8.68E-15 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.089 2.17E-7 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.076 1.19E-5 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.074 1.70E-5 YGR280C PXR1 het Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
0.074 1.83E-5 YOL110W SHR5 hom Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization
0.072 2.70E-5 YPL216W_p YPL216W_p hom Putative protein of unknown function; YPL216W is not an essential gene
0.071 4.19E-5 YDR129C SAC6 hom Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.069 5.65E-5 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.068 7.99E-5 YIL013C PDR11 hom ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth
0.068 8.35E-5 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.067 1.03E-4 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.067 1.11E-4 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.067 1.13E-4 YOR156C NFI1 hom SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length
0.067 1.15E-4 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.066 1.16E-4 YOR298W MUM3 hom Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases