YMR234W / RNH1

Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR234W / RNH1

Click on Significant Values for Screen Details ID:SGTC_269|Compound:exalamide|FD-Score:5.24|P-value:7.48E-8 ID:SGTC_319|Compound:1348-1596|FD-Score:-3.30|P-value:5.76E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.70|P-value:1.23E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.22|P-value:8.41E-8 ID:SGTC_554|Compound:4483-2211|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.53|P-value:1.91E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.27|P-value:4.94E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.31|P-value:4.39E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.62|P-value:1.75E-11 ID:SGTC_850|Compound:0388-0143|FD-Score:3.18|P-value:6.77E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.69|P-value:1.80E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:-4.95|P-value:4.87E-7 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.71|P-value:9.74E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:5.49|P-value:1.95E-8 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.96|P-value:3.36E-7 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.48|P-value:2.32E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.70|P-value:1.01E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.20|P-value:6.41E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:5.98|P-value:1.06E-9 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.36|P-value:6.20E-6 ID:SGTC_1740|Compound:st038286|FD-Score:3.40|P-value:3.18E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.77|P-value:8.63E-7 ID:SGTC_1799|Compound:st045822|FD-Score:3.80|P-value:6.69E-5 ID:SGTC_1809|Compound:st050081|FD-Score:3.57|P-value:1.68E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.11|P-value:1.87E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.74|P-value:8.51E-5 ID:SGTC_1933|Compound:st074711|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_1934|Compound:st074720|FD-Score:9.12|P-value:3.77E-20 ID:SGTC_1935|Compound:st074532|FD-Score:4.91|P-value:4.22E-7 ID:SGTC_1953|Compound:st076800|FD-Score:3.25|P-value:5.36E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.13|P-value:1.70E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.41|P-value:2.99E-4 ID:SGTC_2116|Compound:5511452|FD-Score:7.02|P-value:1.07E-12 ID:SGTC_2123|Compound:5259487|FD-Score:5.04|P-value:2.16E-7 ID:SGTC_2133|Compound:5320837|FD-Score:4.18|P-value:1.35E-5 ID:SGTC_2135|Compound:5326629|FD-Score:4.06|P-value:2.26E-5 ID:SGTC_2213|Compound:7173844|FD-Score:3.56|P-value:1.70E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.65|P-value:1.21E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.89|P-value:4.63E-5 ID:SGTC_2427|Compound:5545055|FD-Score:4.80|P-value:7.48E-7 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.10|P-value:9.18E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.81|P-value:6.55E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.46|P-value:2.56E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.50|P-value:3.12E-6 ID:SGTC_2808|Compound:7946468|FD-Score:5.50|P-value:1.83E-8 ID:SGTC_2929|Compound:9013348|FD-Score:4.77|P-value:8.76E-7 ID:SGTC_2992|Compound:9074591|FD-Score:5.38|P-value:3.45E-8 ID:SGTC_3140|Compound:9094243|FD-Score:4.89|P-value:4.81E-7 ID:SGTC_3196|Compound:9111891|FD-Score:3.74|P-value:8.54E-5 ID:SGTC_3345|Compound:9148410|FD-Score:3.47|P-value:2.42E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.08|P-value:9.53E-4 ID:SGTC_269|Compound:exalamide|FD-Score:5.24|P-value:7.48E-8 ID:SGTC_319|Compound:1348-1596|FD-Score:-3.30|P-value:5.76E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.70|P-value:1.23E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.22|P-value:8.41E-8 ID:SGTC_554|Compound:4483-2211|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.53|P-value:1.91E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.27|P-value:4.94E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.31|P-value:4.39E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.62|P-value:1.75E-11 ID:SGTC_850|Compound:0388-0143|FD-Score:3.18|P-value:6.77E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.69|P-value:1.80E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:-4.95|P-value:4.87E-7 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.71|P-value:9.74E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:5.49|P-value:1.95E-8 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.96|P-value:3.36E-7 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.48|P-value:2.32E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.70|P-value:1.01E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.20|P-value:6.41E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:5.98|P-value:1.06E-9 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.36|P-value:6.20E-6 ID:SGTC_1740|Compound:st038286|FD-Score:3.40|P-value:3.18E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.77|P-value:8.63E-7 ID:SGTC_1799|Compound:st045822|FD-Score:3.80|P-value:6.69E-5 ID:SGTC_1809|Compound:st050081|FD-Score:3.57|P-value:1.68E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.11|P-value:1.87E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.74|P-value:8.51E-5 ID:SGTC_1933|Compound:st074711|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_1934|Compound:st074720|FD-Score:9.12|P-value:3.77E-20 ID:SGTC_1935|Compound:st074532|FD-Score:4.91|P-value:4.22E-7 ID:SGTC_1953|Compound:st076800|FD-Score:3.25|P-value:5.36E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.13|P-value:1.70E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.41|P-value:2.99E-4 ID:SGTC_2116|Compound:5511452|FD-Score:7.02|P-value:1.07E-12 ID:SGTC_2123|Compound:5259487|FD-Score:5.04|P-value:2.16E-7 ID:SGTC_2133|Compound:5320837|FD-Score:4.18|P-value:1.35E-5 ID:SGTC_2135|Compound:5326629|FD-Score:4.06|P-value:2.26E-5 ID:SGTC_2213|Compound:7173844|FD-Score:3.56|P-value:1.70E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.65|P-value:1.21E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.89|P-value:4.63E-5 ID:SGTC_2427|Compound:5545055|FD-Score:4.80|P-value:7.48E-7 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.10|P-value:9.18E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.81|P-value:6.55E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.46|P-value:2.56E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.50|P-value:3.12E-6 ID:SGTC_2808|Compound:7946468|FD-Score:5.50|P-value:1.83E-8 ID:SGTC_2929|Compound:9013348|FD-Score:4.77|P-value:8.76E-7 ID:SGTC_2992|Compound:9074591|FD-Score:5.38|P-value:3.45E-8 ID:SGTC_3140|Compound:9094243|FD-Score:4.89|P-value:4.81E-7 ID:SGTC_3196|Compound:9111891|FD-Score:3.74|P-value:8.54E-5 ID:SGTC_3345|Compound:9148410|FD-Score:3.47|P-value:2.42E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.08|P-value:9.53E-4

Top fitness defect scores for YMR234W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1934 st074720 9.12 32.6 µM 3.77E-20 5 3.60E-20
2 SGTC_2116 5511452 7.02 16.9 µM 1.07E-12 1 1.10E-12
3 SGTC_794 k038-0031 6.62 316.0 µM 1.75E-11 ubiquinone biosynthesis & proteasome 45 1.82E-11
4 SGTC_1387 3342-1166 5.98 1.8 µM 1.06E-9 mitochondrial processes 1 1.11E-9
5 SGTC_2808 7946468 5.50 45.5 µM 1.83E-8 9 1.94E-8
6 SGTC_1181 1222-0449 5.49 220.0 µM 1.95E-8 9 2.07E-8
7 SGTC_2992 9074591 5.38 71.4 µM 3.45E-8 5 3.65E-8
8 SGTC_269 exalamide 5.24 29.0 µM 7.48E-8 ergosterol biosynthesis 5 7.94E-8
9 SGTC_451 chloral hydrate 5.22 100.0 µM 8.41E-8 22 8.94E-8
10 SGTC_2123 5259487 5.04 200.0 µM 2.16E-7 7 2.30E-7
11 SGTC_1212 0520-0165 4.96 585.0 µM 3.36E-7 9 3.58E-7
12 SGTC_1935 st074532 4.91 41.6 µM 4.22E-7 11 4.50E-7
13 SGTC_3140 9094243 4.89 49.5 µM 4.81E-7 17 5.13E-7
14 SGTC_2427 5545055 4.80 42.8 µM 7.48E-7 6 7.98E-7
15 SGTC_1773 st048542 4.77 73.6 µM 8.63E-7 29 9.21E-7
16 SGTC_2929 9013348 4.77 24.6 µM 8.76E-7 9 9.35E-7
17 SGTC_429 1112-0049 4.70 25.5 µM 1.23E-6 DNA damage response 24 1.32E-6
18 SGTC_2782 7736369 4.50 71.4 µM 3.12E-6 22 3.33E-6
19 SGTC_1396 3511-0007 4.36 98.6 µM 6.20E-6 mitochondrial processes 10 6.63E-6
20 SGTC_2133 5320837 4.18 200.0 µM 1.35E-5 ERG2 20 1.45E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 8.89E-10 YFL028C CAF16 hom Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
0.095 3.06E-8 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.094 4.33E-8 YBL091C MAP2 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p
0.089 2.09E-7 YOR229W WTM2 hom Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats
0.087 4.10E-7 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.087 4.74E-7 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.080 3.79E-6 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.078 5.45E-6 YGR178C PBP1 hom Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.076 9.21E-6 YIL017C VID28 hom GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
0.076 9.81E-6 YOR009W TIR4 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock
0.075 1.34E-5 YPL206C PGC1 hom Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs
0.074 1.69E-5 YJR015W_p YJR015W_p hom Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene
0.073 2.37E-5 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.072 2.67E-5 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.072 2.79E-5 YPL247C_p YPL247C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest