YMR236W / TAF9

Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR236W / TAF9

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.04|P-value:7.66E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.61|P-value:8.17E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.30|P-value:2.83E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.11|P-value:8.99E-6 ID:SGTC_303|Compound:1348-1668|FD-Score:3.22|P-value:3.86E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.06|P-value:7.01E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.66|P-value:6.61E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.53|P-value:1.14E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.31|P-value:2.75E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:2.98|P-value:9.55E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.03|P-value:7.98E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.40|P-value:1.93E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.31|P-value:2.74E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.31|P-value:2.83E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.60|P-value:8.48E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.65|P-value:7.11E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.37|P-value:2.56E-6 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.31|P-value:2.75E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.09|P-value:6.32E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.55|P-value:1.06E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.24|P-value:3.56E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.27|P-value:3.26E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:4.17|P-value:6.76E-6 ID:SGTC_1635|Compound:st007035|FD-Score:4.31|P-value:3.47E-6 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.44|P-value:1.68E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.58|P-value:9.23E-5 ID:SGTC_1735|Compound:st034310|FD-Score:3.75|P-value:4.63E-5 ID:SGTC_1820|Compound:st053765|FD-Score:5.60|P-value:2.54E-9 ID:SGTC_1893|Compound:st059353|FD-Score:3.80|P-value:3.73E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.41|P-value:1.90E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.11|P-value:5.96E-4 ID:SGTC_1973|Compound:st070275|FD-Score:-3.23|P-value:3.64E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.62|P-value:7.87E-5 ID:SGTC_2080|Compound:5212524|FD-Score:-3.40|P-value:1.94E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.82|P-value:2.43E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.11|P-value:5.82E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.44|P-value:1.84E-6 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:-3.01|P-value:8.22E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-2.96|P-value:9.75E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.33|P-value:2.62E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.37|P-value:2.19E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.13|P-value:8.41E-6 ID:SGTC_3074|Compound:9116018|FD-Score:4.34|P-value:3.06E-6 ID:SGTC_3133|Compound:9127736|FD-Score:-3.22|P-value:3.85E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.00|P-value:8.58E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.61|P-value:8.19E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.04|P-value:7.66E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.61|P-value:8.17E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.30|P-value:2.83E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.11|P-value:8.99E-6 ID:SGTC_303|Compound:1348-1668|FD-Score:3.22|P-value:3.86E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.06|P-value:7.01E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.66|P-value:6.61E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.53|P-value:1.14E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.31|P-value:2.75E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:2.98|P-value:9.55E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.03|P-value:7.98E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.40|P-value:1.93E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.31|P-value:2.74E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.31|P-value:2.83E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.60|P-value:8.48E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.65|P-value:7.11E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.37|P-value:2.56E-6 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.31|P-value:2.75E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.09|P-value:6.32E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.55|P-value:1.06E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.24|P-value:3.56E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.27|P-value:3.26E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:4.17|P-value:6.76E-6 ID:SGTC_1635|Compound:st007035|FD-Score:4.31|P-value:3.47E-6 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.44|P-value:1.68E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.58|P-value:9.23E-5 ID:SGTC_1735|Compound:st034310|FD-Score:3.75|P-value:4.63E-5 ID:SGTC_1820|Compound:st053765|FD-Score:5.60|P-value:2.54E-9 ID:SGTC_1893|Compound:st059353|FD-Score:3.80|P-value:3.73E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.41|P-value:1.90E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.11|P-value:5.96E-4 ID:SGTC_1973|Compound:st070275|FD-Score:-3.23|P-value:3.64E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.62|P-value:7.87E-5 ID:SGTC_2080|Compound:5212524|FD-Score:-3.40|P-value:1.94E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.82|P-value:2.43E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.11|P-value:5.82E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.44|P-value:1.84E-6 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:-3.01|P-value:8.22E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-2.96|P-value:9.75E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.33|P-value:2.62E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.37|P-value:2.19E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.13|P-value:8.41E-6 ID:SGTC_3074|Compound:9116018|FD-Score:4.34|P-value:3.06E-6 ID:SGTC_3133|Compound:9127736|FD-Score:-3.22|P-value:3.85E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.00|P-value:8.58E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.61|P-value:8.19E-5

Top fitness defect scores for YMR236W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1820 st053765 5.60 18.6 µM 2.54E-9 RPP1 & pyrimidine depletion 3 1.06E-8 0.07
2 SGTC_2316 5844804 4.82 197.4 µM 2.43E-7 8 7.06E-7 0.05
3 SGTC_2540 epiandrosterone 4.44 100.0 µM 1.84E-6 2 4.56E-6 0.66
4 SGTC_1255 0566-0045 4.37 221.0 µM 2.56E-6 excess fatty acid 12 6.18E-6 0.27
5 SGTC_3074 9116018 4.34 49.5 µM 3.06E-6 RNA processing & uracil transport 5 7.26E-6 1.03
6 SGTC_1635 st007035 4.31 42.4 µM 3.47E-6 16 8.17E-6 0.11
7 SGTC_1578 josamycin 4.17 24.2 µM 6.76E-6 4 1.51E-5 0.43
8 SGTC_3067 9117431 4.13 49.5 µM 8.41E-6 6 1.85E-5 0.09
9 SGTC_120 rhodamine 6G 4.11 52.3 µM 8.99E-6 mitochondrial processes 16 1.97E-5 0.10
10 SGTC_1893 st059353 3.80 36.1 µM 3.73E-5 3 7.30E-5 0.02
11 SGTC_1735 st034310 3.75 56.8 µM 4.63E-5 Golgi 12 8.91E-5 0.03
12 SGTC_1174 0739-0097 3.65 51.1 µM 7.11E-5 redox potentiating 5 1.32E-4 0.17
13 SGTC_2062 5245942 3.62 200.0 µM 7.87E-5 1 1.45E-4 0.23
14 SGTC_26 0302-0163 3.61 425.2 µM 8.17E-5 heme biosynthesis & mitochondrial translocase 13 1.51E-4 0.04
15 SGTC_1365 1672-3266 3.55 55.4 µM 1.06E-4 11 1.90E-4 0.02
16 SGTC_547 1120-0019 3.53 610.0 nM 1.14E-4 azole & statin 10 2.05E-4 0.09
17 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 3.44 61.8 µM 1.68E-4 ergosterol biosynthesis 5 2.92E-4 0.06
18 SGTC_1944 st076371 3.41 56.9 µM 1.90E-4 6 3.28E-4 0.00
19 SGTC_856 0433-0016 3.40 11.3 µM 1.93E-4 7 3.33E-4 0.05
20 SGTC_2566 crystal violet carbinol 3.33 226.0 nM 2.62E-4 31 4.41E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 1.97E-18 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.137 1.83E-15 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.135 4.44E-15 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.114 4.01E-11 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.108 3.12E-10 YMR230W RPS10B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.105 1.21E-9 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.104 1.82E-9 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.103 2.08E-9 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.097 1.53E-8 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.095 3.92E-8 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
0.095 3.94E-8 YOR043W WHI2 hom Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
0.092 9.10E-8 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.092 1.09E-7 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.091 1.33E-7 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.090 1.64E-7 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes