YMR237W / BCH1

Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR237W / BCH1

Click on Significant Values for Screen Details ID:SGTC_79|Compound:0052-0007|FD-Score:4.80|P-value:1.85E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:6.01|P-value:3.46E-9 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:6.07|P-value:2.45E-9 ID:SGTC_280|Compound:3448-3607|FD-Score:4.19|P-value:2.70E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:3.43|P-value:4.74E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.79|P-value:1.92E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.86|P-value:9.99E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.26|P-value:8.37E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.45|P-value:8.94E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:3.27|P-value:8.11E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:5.01|P-value:6.85E-7 ID:SGTC_650|Compound:1328-0195|FD-Score:4.06|P-value:4.55E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.28|P-value:7.91E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.33|P-value:6.64E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:5.26|P-value:1.93E-7 ID:SGTC_891|Compound:0929-0073|FD-Score:3.98|P-value:6.32E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:11.20|P-value:1.68E-27 ID:SGTC_950|Compound:1165-0508|FD-Score:5.95|P-value:4.94E-9 ID:SGTC_973|Compound:1325-0077|FD-Score:3.60|P-value:2.63E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.24|P-value:8.89E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.40|P-value:1.08E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.49|P-value:3.88E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.03|P-value:5.05E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.32|P-value:6.75E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.85|P-value:1.03E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.74|P-value:2.40E-6 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:6.45|P-value:2.49E-10 ID:SGTC_1712|Compound:st032288|FD-Score:3.69|P-value:1.87E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.58|P-value:2.78E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.65|P-value:2.16E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.51|P-value:3.61E-4 ID:SGTC_1737|Compound:st035557|FD-Score:5.03|P-value:6.11E-7 ID:SGTC_1864|Compound:st057645|FD-Score:3.25|P-value:8.75E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.26|P-value:8.46E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.56|P-value:5.54E-6 ID:SGTC_2005|Compound:4024620|FD-Score:3.21|P-value:9.78E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.89|P-value:8.95E-5 ID:SGTC_2089|Compound:5281248|FD-Score:3.39|P-value:5.39E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.23|P-value:9.20E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.95|P-value:7.13E-5 ID:SGTC_2196|Compound:6573537|FD-Score:3.52|P-value:3.43E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.86|P-value:1.01E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.27|P-value:8.17E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.12|P-value:3.55E-5 ID:SGTC_2315|Compound:7733312|FD-Score:4.65|P-value:3.67E-6 ID:SGTC_2322|Compound:7413319|FD-Score:5.29|P-value:1.71E-7 ID:SGTC_2324|Compound:6149169|FD-Score:4.78|P-value:2.01E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.50|P-value:3.67E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.86|P-value:9.76E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.93|P-value:7.68E-5 ID:SGTC_2476|Compound:5806916|FD-Score:5.62|P-value:2.94E-8 ID:SGTC_2478|Compound:5763493|FD-Score:-4.44|P-value:9.10E-6 ID:SGTC_2479|Compound:5617353|FD-Score:5.60|P-value:3.26E-8 ID:SGTC_2484|Compound:5809818|FD-Score:3.96|P-value:6.73E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.61|P-value:2.55E-4 ID:SGTC_2887|Compound:9044784|FD-Score:4.06|P-value:4.56E-5 ID:SGTC_3171|Compound:9103192|FD-Score:3.84|P-value:1.06E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.66|P-value:2.11E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.80|P-value:1.85E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:6.01|P-value:3.46E-9 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:6.07|P-value:2.45E-9 ID:SGTC_280|Compound:3448-3607|FD-Score:4.19|P-value:2.70E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:3.43|P-value:4.74E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.79|P-value:1.92E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.86|P-value:9.99E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.26|P-value:8.37E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.45|P-value:8.94E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:3.27|P-value:8.11E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:5.01|P-value:6.85E-7 ID:SGTC_650|Compound:1328-0195|FD-Score:4.06|P-value:4.55E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.28|P-value:7.91E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.33|P-value:6.64E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:5.26|P-value:1.93E-7 ID:SGTC_891|Compound:0929-0073|FD-Score:3.98|P-value:6.32E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:11.20|P-value:1.68E-27 ID:SGTC_950|Compound:1165-0508|FD-Score:5.95|P-value:4.94E-9 ID:SGTC_973|Compound:1325-0077|FD-Score:3.60|P-value:2.63E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.24|P-value:8.89E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.40|P-value:1.08E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.49|P-value:3.88E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.03|P-value:5.05E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.32|P-value:6.75E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.85|P-value:1.03E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.74|P-value:2.40E-6 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:6.45|P-value:2.49E-10 ID:SGTC_1712|Compound:st032288|FD-Score:3.69|P-value:1.87E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.58|P-value:2.78E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.65|P-value:2.16E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.51|P-value:3.61E-4 ID:SGTC_1737|Compound:st035557|FD-Score:5.03|P-value:6.11E-7 ID:SGTC_1864|Compound:st057645|FD-Score:3.25|P-value:8.75E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.26|P-value:8.46E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.56|P-value:5.54E-6 ID:SGTC_2005|Compound:4024620|FD-Score:3.21|P-value:9.78E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.89|P-value:8.95E-5 ID:SGTC_2089|Compound:5281248|FD-Score:3.39|P-value:5.39E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.23|P-value:9.20E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.95|P-value:7.13E-5 ID:SGTC_2196|Compound:6573537|FD-Score:3.52|P-value:3.43E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.86|P-value:1.01E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.27|P-value:8.17E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.12|P-value:3.55E-5 ID:SGTC_2315|Compound:7733312|FD-Score:4.65|P-value:3.67E-6 ID:SGTC_2322|Compound:7413319|FD-Score:5.29|P-value:1.71E-7 ID:SGTC_2324|Compound:6149169|FD-Score:4.78|P-value:2.01E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.50|P-value:3.67E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.86|P-value:9.76E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.93|P-value:7.68E-5 ID:SGTC_2476|Compound:5806916|FD-Score:5.62|P-value:2.94E-8 ID:SGTC_2478|Compound:5763493|FD-Score:-4.44|P-value:9.10E-6 ID:SGTC_2479|Compound:5617353|FD-Score:5.60|P-value:3.26E-8 ID:SGTC_2484|Compound:5809818|FD-Score:3.96|P-value:6.73E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.61|P-value:2.55E-4 ID:SGTC_2887|Compound:9044784|FD-Score:4.06|P-value:4.56E-5 ID:SGTC_3171|Compound:9103192|FD-Score:3.84|P-value:1.06E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.66|P-value:2.11E-4

Top fitness defect scores for YMR237W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_949 1165-0505 11.20 146.0 µM 1.68E-27 1 1.97E-29
2 SGTC_1532 4',5'-dihydroxyflavone 6.45 78.7 µM 2.49E-10 Golgi 7 5.57E-11
3 SGTC_243 5hr heat shock (37°C) + splitomicin 6.07 1.0 µM 2.45E-9 heat shock/prefoldin 14 6.47E-10
4 SGTC_163 1327-0036 6.01 7.5 µM 3.46E-9 49 9.37E-10
5 SGTC_950 1165-0508 5.95 94.1 µM 4.94E-9 4 1.38E-9
6 SGTC_2476 5806916 5.62 10.5 µM 2.94E-8 1 9.33E-9
7 SGTC_2479 5617353 5.60 43.9 µM 3.26E-8 9 1.04E-8
8 SGTC_2322 7413319 5.29 38.2 µM 1.71E-7 ERAD & cell cycle 84 6.18E-8
9 SGTC_881 0833-0569 5.26 170.0 µM 1.93E-7 3 7.03E-8
10 SGTC_1737 st035557 5.03 69.7 µM 6.11E-7 7 2.42E-7
11 SGTC_619 1652-1634 5.01 108.0 µM 6.85E-7 PDR1 7 2.74E-7
12 SGTC_79 0052-0007 4.80 94.1 µM 1.85E-6 22 7.93E-7
13 SGTC_299 1273-0059 4.79 1.4 µM 1.92E-6 18 8.26E-7
14 SGTC_2324 6149169 4.78 200.0 µM 2.01E-6 10 8.68E-7
15 SGTC_1527 coumarin 4.74 137.0 µM 2.40E-6 6 1.05E-6
16 SGTC_2315 7733312 4.65 200.0 µM 3.67E-6 13 1.65E-6
17 SGTC_1965 Pectolinarigenin 4.56 58.4 µM 5.54E-6 RPP1 & pyrimidine depletion 9 2.58E-6
18 SGTC_594 1487-1584 4.45 10.8 µM 8.94E-6 17 4.30E-6
19 SGTC_982 1491-0518 4.40 27.5 µM 1.08E-5 8 5.30E-6
20 SGTC_280 3448-3607 4.19 3.0 µM 2.70E-5 60S ribosome export 5 1.41E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.05E-11 YPL049C DIG1 hom MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
0.111 1.12E-10 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.098 1.12E-8 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.095 3.01E-8 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.094 4.62E-8 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.090 2.01E-7 YBL012C_d YBL012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.089 2.49E-7 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.083 1.41E-6 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.083 1.70E-6 YGR118W RPS23A hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.082 2.28E-6 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.081 3.03E-6 YKL027W YKL027W hom Protein of unknown function, localized to the mitochondrial outer membrane
0.075 1.21E-5 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.075 1.24E-5 YLR458W_d YLR458W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
0.075 1.27E-5 YER137C_p YER137C_p hom Putative protein of unknown function
0.075 1.28E-5 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus