YMR239C / RNT1

Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR239C / RNT1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.03|P-value:9.74E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.27|P-value:4.01E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.33|P-value:3.02E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.44|P-value:2.13E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.91|P-value:2.82E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.44|P-value:2.00E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.33|P-value:3.27E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.21|P-value:4.65E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.41|P-value:2.35E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.84|P-value:4.10E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.02|P-value:1.86E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:4.08|P-value:1.48E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:3.64|P-value:9.75E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:4.48|P-value:2.21E-6 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.13|P-value:6.15E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.07|P-value:7.67E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.73|P-value:6.16E-7 ID:SGTC_876|Compound:0720-0963|FD-Score:4.12|P-value:1.19E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.61|P-value:1.00E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.38|P-value:2.73E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.91|P-value:3.10E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.59|P-value:1.11E-6 ID:SGTC_1952|Compound:st077036|FD-Score:3.34|P-value:3.07E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.25|P-value:4.35E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-5.17|P-value:5.03E-8 ID:SGTC_2273|Compound:7815444|FD-Score:3.06|P-value:8.69E-4 ID:SGTC_2291|Compound:7917025|FD-Score:5.54|P-value:6.46E-9 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.88|P-value:3.43E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.52|P-value:1.41E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.28|P-value:3.97E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-4.17|P-value:8.78E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.60|P-value:1.02E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.49|P-value:1.76E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.16|P-value:5.56E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.20|P-value:4.86E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.18|P-value:5.61E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.02|P-value:9.40E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.05|P-value:8.83E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.32|P-value:3.12E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.52|P-value:1.53E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.03|P-value:9.74E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.27|P-value:4.01E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.33|P-value:3.02E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.44|P-value:2.13E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.91|P-value:2.82E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.44|P-value:2.00E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.33|P-value:3.27E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.21|P-value:4.65E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.41|P-value:2.35E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.84|P-value:4.10E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.02|P-value:1.86E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:4.08|P-value:1.48E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:3.64|P-value:9.75E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:4.48|P-value:2.21E-6 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.13|P-value:6.15E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.07|P-value:7.67E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.73|P-value:6.16E-7 ID:SGTC_876|Compound:0720-0963|FD-Score:4.12|P-value:1.19E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.61|P-value:1.00E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.38|P-value:2.73E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.91|P-value:3.10E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.59|P-value:1.11E-6 ID:SGTC_1952|Compound:st077036|FD-Score:3.34|P-value:3.07E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.25|P-value:4.35E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-5.17|P-value:5.03E-8 ID:SGTC_2273|Compound:7815444|FD-Score:3.06|P-value:8.69E-4 ID:SGTC_2291|Compound:7917025|FD-Score:5.54|P-value:6.46E-9 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.88|P-value:3.43E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.52|P-value:1.41E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.28|P-value:3.97E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-4.17|P-value:8.78E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.60|P-value:1.02E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.49|P-value:1.76E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.16|P-value:5.56E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.20|P-value:4.86E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.18|P-value:5.61E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.02|P-value:9.40E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.05|P-value:8.83E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.32|P-value:3.12E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.52|P-value:1.53E-4

Top fitness defect scores for YMR239C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2291 7917025 5.54 104.3 µM 6.46E-9 iron homeostasis 3 1.47E-8 0.42
2 SGTC_873 0591-4978 4.73 488.0 µM 6.16E-7 3 1.12E-6 0.84
3 SGTC_787 4152-0075 4.48 138.0 µM 2.21E-6 2 3.78E-6 0.04
4 SGTC_876 0720-0963 4.12 56.8 µM 1.19E-5 4 1.87E-5 0.07
5 SGTC_752 1896-0090 4.08 130.0 µM 1.48E-5 TSC3-RPN4 3 2.30E-5 0.10
6 SGTC_545 4218-0007 4.02 221.0 µM 1.86E-5 7 2.86E-5 0.13
7 SGTC_1620 st003704 3.91 16.5 µM 3.10E-5 4 4.65E-5 0.51
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.88 3.7 µM 3.43E-5 14 5.12E-5 0.12
9 SGTC_523 1934-0222 3.84 13.7 µM 4.10E-5 5 6.08E-5 0.19
10 SGTC_777 1315-0167 3.64 517.0 µM 9.75E-5 Golgi 5 1.39E-4 0.39
11 SGTC_3295 9122362 3.52 53.6 µM 1.53E-4 8 2.13E-4 0.07
12 SGTC_2813 7971799 3.49 71.4 µM 1.76E-4 13 2.43E-4 0.05
13 SGTC_341 1486-1430 3.44 230.0 µM 2.13E-4 30 2.91E-4 0.03
14 SGTC_511 blebbistatin 3.41 171.0 µM 2.35E-4 DNA intercalators 9 3.20E-4 0.04
15 SGTC_1170 0310-0127 3.38 64.8 µM 2.73E-4 18 3.69E-4 0.05
16 SGTC_1952 st077036 3.34 64.1 µM 3.07E-4 17 4.14E-4 0.21
17 SGTC_449 xestospongin c 3.33 11.2 µM 3.27E-4 NEO1-PIK1 6 4.38E-4 0.27
18 SGTC_2587 piperic acid 3.28 92.2 µM 3.97E-4 12 5.27E-4 0.00
19 SGTC_86 0417-1630 3.27 471.9 µM 4.01E-4 ubiquinone biosynthesis & proteasome 42 5.33E-4 9.92E-4
20 SGTC_1956 st077085 3.25 54.0 µM 4.35E-4 7 5.76E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 7.47E-28 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.132 1.91E-14 YDR242W AMD2 hom Putative amidase
0.130 4.79E-14 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.124 5.60E-13 YGR251W NOP19 het Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.122 1.49E-12 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.116 1.93E-11 YHR130C_d YHR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115 2.76E-11 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.114 3.75E-11 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
0.111 1.13E-10 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.107 5.03E-10 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.104 1.40E-9 YML100W TSL1 hom Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
0.104 1.38E-9 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.104 1.53E-9 YNL188W KAR1 het Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
0.098 1.11E-8 YFL028C CAF16 hom Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
0.097 1.58E-8 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W