YMR241W / YHM2

Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR241W / YHM2

Click on Significant Values for Screen Details ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.90|P-value:6.69E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:4.91|P-value:6.46E-7 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.36|P-value:4.63E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.71|P-value:1.26E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.29|P-value:5.95E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.48|P-value:3.04E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.21|P-value:7.67E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.13|P-value:9.44E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.93|P-value:4.81E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:5.80|P-value:5.18E-9 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.25|P-value:6.86E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.05|P-value:3.24E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.61|P-value:1.83E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.31|P-value:1.06E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.75|P-value:1.08E-4 ID:SGTC_1738|Compound:st035555|FD-Score:7.29|P-value:3.06E-13 ID:SGTC_1749|Compound:st037932|FD-Score:6.13|P-value:7.31E-10 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.68|P-value:1.44E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.46|P-value:3.20E-4 ID:SGTC_1863|Compound:st057641|FD-Score:4.19|P-value:1.76E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.26|P-value:6.52E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.58|P-value:2.12E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.31|P-value:5.56E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.29|P-value:5.84E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.58|P-value:3.16E-6 ID:SGTC_2059|Compound:5238311|FD-Score:3.38|P-value:4.25E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.15|P-value:9.56E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.28|P-value:6.11E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.36|P-value:4.23E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.71|P-value:1.25E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.34|P-value:5.01E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.83|P-value:8.08E-5 ID:SGTC_2924|Compound:9010168|FD-Score:3.44|P-value:3.43E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.49|P-value:4.80E-6 ID:SGTC_3258|Compound:9138477|FD-Score:5.05|P-value:3.15E-7 ID:SGTC_3301|Compound:9125354|FD-Score:3.19|P-value:8.38E-4 ID:SGTC_3317|Compound:9138495|FD-Score:5.27|P-value:1.00E-7 ID:SGTC_3320|Compound:9137005|FD-Score:4.07|P-value:2.98E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.90|P-value:6.69E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:4.91|P-value:6.46E-7 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.36|P-value:4.63E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.71|P-value:1.26E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.29|P-value:5.95E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.48|P-value:3.04E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.21|P-value:7.67E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.13|P-value:9.44E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.93|P-value:4.81E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:5.80|P-value:5.18E-9 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.25|P-value:6.86E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.05|P-value:3.24E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.61|P-value:1.83E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.31|P-value:1.06E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.75|P-value:1.08E-4 ID:SGTC_1738|Compound:st035555|FD-Score:7.29|P-value:3.06E-13 ID:SGTC_1749|Compound:st037932|FD-Score:6.13|P-value:7.31E-10 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.68|P-value:1.44E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.46|P-value:3.20E-4 ID:SGTC_1863|Compound:st057641|FD-Score:4.19|P-value:1.76E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.26|P-value:6.52E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.58|P-value:2.12E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.31|P-value:5.56E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.29|P-value:5.84E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.58|P-value:3.16E-6 ID:SGTC_2059|Compound:5238311|FD-Score:3.38|P-value:4.25E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.15|P-value:9.56E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.28|P-value:6.11E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.36|P-value:4.23E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.71|P-value:1.25E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.34|P-value:5.01E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.83|P-value:8.08E-5 ID:SGTC_2924|Compound:9010168|FD-Score:3.44|P-value:3.43E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.49|P-value:4.80E-6 ID:SGTC_3258|Compound:9138477|FD-Score:5.05|P-value:3.15E-7 ID:SGTC_3301|Compound:9125354|FD-Score:3.19|P-value:8.38E-4 ID:SGTC_3317|Compound:9138495|FD-Score:5.27|P-value:1.00E-7 ID:SGTC_3320|Compound:9137005|FD-Score:4.07|P-value:2.98E-5

Top fitness defect scores for YMR241W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1738 st035555 7.29 74.0 µM 3.06E-13 TSC3-RPN4 5 1.56E-13
2 SGTC_1749 st037932 6.13 54.2 µM 7.31E-10 8 4.49E-10
3 SGTC_852 0418-0143 5.80 439.0 µM 5.18E-9 calcium & mitochondrial duress 31 3.33E-9
4 SGTC_3317 9138495 5.27 8.8 µM 1.00E-7 17 6.92E-8
5 SGTC_3258 9138477 5.05 49.5 µM 3.15E-7 1 2.23E-7
6 SGTC_154 3389-1638 4.91 511.1 µM 6.46E-7 10 4.65E-7
7 SGTC_120 rhodamine 6G 4.90 52.3 µM 6.69E-7 mitochondrial processes 14 4.82E-7
8 SGTC_2056 5235370 4.58 200.0 µM 3.16E-6 29 2.36E-6
9 SGTC_2992 9074591 4.49 71.4 µM 4.80E-6 10 3.62E-6
10 SGTC_1597 7-benzyloxygramine 4.31 47.5 µM 1.06E-5 calcium & mitochondrial duress 98 8.13E-6
11 SGTC_1863 st057641 4.19 20.1 µM 1.76E-5 10 1.37E-5
12 SGTC_3320 9137005 4.07 35.1 µM 2.98E-5 endomembrane recycling 14 2.35E-5
13 SGTC_1203 3992-3522 4.05 103.0 µM 3.24E-5 25 2.56E-5
14 SGTC_2569 tetrandrine 3.83 100.0 µM 8.08E-5 24 6.52E-5
15 SGTC_1683 st010134 3.75 710.0 nM 1.08E-4 37 8.80E-5
16 SGTC_2528 xanthyletin 3.71 44.8 µM 1.25E-4 28 1.02E-4
17 SGTC_449 xestospongin c 3.71 11.2 µM 1.26E-4 NEO1-PIK1 80 1.03E-4
18 SGTC_1785 bathophenanthroline 3.68 24.0 µM 1.44E-4 heme requiring 63 1.18E-4
19 SGTC_1565 sinapyl alcohol 3.66 95.1 µM 1.53E-4 40 1.25E-4
20 SGTC_1353 1498-1206 3.61 8.1 µM 1.83E-4 mitochondrial response to ROS 66 1.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.72E-12 YIL085C KTR7 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication
0.104 1.48E-9 YIR042C_p YIR042C_p hom Putative protein of unknown function; YIR042C is a non-essential gene
0.099 1.01E-8 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.097 1.73E-8 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.096 2.38E-8 YGR263C SAY1 hom Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.096 2.62E-8 YKR006C MRPL13 hom Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.089 2.58E-7 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.088 3.26E-7 YER146W LSM5 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.087 4.12E-7 YCL011C GBP2 hom Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication
0.087 4.50E-7 YGL068W MNP1 het Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
0.083 1.33E-6 YJL160C_p YJL160C_p hom Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication
0.081 2.51E-6 YNR054C ESF2 het Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
0.079 5.18E-6 YMR003W AIM34 hom Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss
0.078 6.61E-6 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.077 7.21E-6 YIL006W YIA6 hom Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs