YMR242C / RPL20A

Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR242C / RPL20A

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.25|P-value:9.66E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.85|P-value:1.28E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:8.52|P-value:5.51E-16 ID:SGTC_157|Compound:1348-1695|FD-Score:3.89|P-value:1.11E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.68|P-value:2.31E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:3.79|P-value:1.55E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.33|P-value:7.40E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.54|P-value:3.73E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.38|P-value:1.66E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:3.95|P-value:8.70E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:7.25|P-value:4.14E-12 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.67|P-value:2.41E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.45|P-value:1.14E-12 ID:SGTC_521|Compound:r062-0005|FD-Score:4.47|P-value:1.13E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:3.99|P-value:7.52E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.40|P-value:1.54E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.27|P-value:8.97E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.82|P-value:2.38E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:6.37|P-value:9.51E-10 ID:SGTC_722|Compound:3534-0461|FD-Score:4.20|P-value:3.41E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.82|P-value:1.41E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:4.73|P-value:3.81E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:4.39|P-value:1.56E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.64|P-value:5.55E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:3.37|P-value:6.57E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.30|P-value:8.35E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.92|P-value:9.66E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:5.58|P-value:6.82E-8 ID:SGTC_951|Compound:1171-0579|FD-Score:10.90|P-value:9.67E-25 ID:SGTC_956|Compound:1185-0240|FD-Score:5.67|P-value:4.20E-8 ID:SGTC_960|Compound:1222-0186|FD-Score:4.51|P-value:9.62E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:3.69|P-value:2.20E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:8.49|P-value:7.08E-16 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.91|P-value:1.01E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.08|P-value:5.30E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.12|P-value:4.58E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.30|P-value:2.24E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.27|P-value:2.54E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.47|P-value:7.82E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.39|P-value:8.54E-10 ID:SGTC_1171|Compound:0368-0077|FD-Score:6.72|P-value:1.19E-10 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.17|P-value:3.77E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:5.89|P-value:1.33E-8 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.75|P-value:1.83E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.26|P-value:9.30E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.27|P-value:9.13E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.58|P-value:5.40E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.77|P-value:1.66E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.43|P-value:1.34E-5 ID:SGTC_1687|Compound:st020778|FD-Score:4.91|P-value:1.65E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.77|P-value:1.70E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.62|P-value:2.84E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.43|P-value:1.32E-5 ID:SGTC_1830|Compound:st055982|FD-Score:-3.78|P-value:2.78E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.34|P-value:7.18E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.82|P-value:1.41E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.78|P-value:1.62E-4 ID:SGTC_2111|Compound:5486399|FD-Score:8.19|P-value:6.59E-15 ID:SGTC_2179|Compound:6298986|FD-Score:3.34|P-value:7.17E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.14|P-value:5.71E-7 ID:SGTC_2240|Compound:6690706|FD-Score:3.92|P-value:9.75E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.29|P-value:8.46E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.59|P-value:3.12E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.35|P-value:6.93E-4 ID:SGTC_2671|Compound:danthron|FD-Score:6.25|P-value:1.83E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.71|P-value:3.49E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.42|P-value:5.61E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.79|P-value:1.56E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.51|P-value:9.76E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.70|P-value:2.14E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.55|P-value:8.12E-6 ID:SGTC_2845|Compound:9003024|FD-Score:4.04|P-value:6.15E-5 ID:SGTC_2882|Compound:9058044|FD-Score:3.28|P-value:8.70E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.32|P-value:7.85E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.14|P-value:4.29E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.75|P-value:1.78E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.45|P-value:8.21E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.39|P-value:6.11E-4 ID:SGTC_3090|Compound:9117696|FD-Score:6.96|P-value:2.65E-11 ID:SGTC_3112|Compound:9123419|FD-Score:3.89|P-value:1.08E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.65|P-value:2.53E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.67|P-value:2.40E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.97|P-value:1.28E-6 ID:SGTC_3266|Compound:9136860|FD-Score:5.39|P-value:1.72E-7 ID:SGTC_3306|Compound:9127676|FD-Score:4.59|P-value:6.89E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.56|P-value:7.31E-8 ID:SGTC_3321|Compound:9137793|FD-Score:4.05|P-value:5.97E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.90|P-value:1.04E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.89|P-value:1.08E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.25|P-value:9.66E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.85|P-value:1.28E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:8.52|P-value:5.51E-16 ID:SGTC_157|Compound:1348-1695|FD-Score:3.89|P-value:1.11E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.68|P-value:2.31E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:3.79|P-value:1.55E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.33|P-value:7.40E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.54|P-value:3.73E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.38|P-value:1.66E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:3.95|P-value:8.70E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:7.25|P-value:4.14E-12 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.67|P-value:2.41E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.45|P-value:1.14E-12 ID:SGTC_521|Compound:r062-0005|FD-Score:4.47|P-value:1.13E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:3.99|P-value:7.52E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.40|P-value:1.54E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.27|P-value:8.97E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.82|P-value:2.38E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:6.37|P-value:9.51E-10 ID:SGTC_722|Compound:3534-0461|FD-Score:4.20|P-value:3.41E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.82|P-value:1.41E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:4.73|P-value:3.81E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:4.39|P-value:1.56E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.64|P-value:5.55E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:3.37|P-value:6.57E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.30|P-value:8.35E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.92|P-value:9.66E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:5.58|P-value:6.82E-8 ID:SGTC_951|Compound:1171-0579|FD-Score:10.90|P-value:9.67E-25 ID:SGTC_956|Compound:1185-0240|FD-Score:5.67|P-value:4.20E-8 ID:SGTC_960|Compound:1222-0186|FD-Score:4.51|P-value:9.62E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:3.69|P-value:2.20E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:8.49|P-value:7.08E-16 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.91|P-value:1.01E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.08|P-value:5.30E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.12|P-value:4.58E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.30|P-value:2.24E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.27|P-value:2.54E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.47|P-value:7.82E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.39|P-value:8.54E-10 ID:SGTC_1171|Compound:0368-0077|FD-Score:6.72|P-value:1.19E-10 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.17|P-value:3.77E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:5.89|P-value:1.33E-8 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.75|P-value:1.83E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.26|P-value:9.30E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.27|P-value:9.13E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.58|P-value:5.40E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.77|P-value:1.66E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.43|P-value:1.34E-5 ID:SGTC_1687|Compound:st020778|FD-Score:4.91|P-value:1.65E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.77|P-value:1.70E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.62|P-value:2.84E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.43|P-value:1.32E-5 ID:SGTC_1830|Compound:st055982|FD-Score:-3.78|P-value:2.78E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.34|P-value:7.18E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.82|P-value:1.41E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.78|P-value:1.62E-4 ID:SGTC_2111|Compound:5486399|FD-Score:8.19|P-value:6.59E-15 ID:SGTC_2179|Compound:6298986|FD-Score:3.34|P-value:7.17E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.14|P-value:5.71E-7 ID:SGTC_2240|Compound:6690706|FD-Score:3.92|P-value:9.75E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.29|P-value:8.46E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.59|P-value:3.12E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.35|P-value:6.93E-4 ID:SGTC_2671|Compound:danthron|FD-Score:6.25|P-value:1.83E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.71|P-value:3.49E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.42|P-value:5.61E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.79|P-value:1.56E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.51|P-value:9.76E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.70|P-value:2.14E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.55|P-value:8.12E-6 ID:SGTC_2845|Compound:9003024|FD-Score:4.04|P-value:6.15E-5 ID:SGTC_2882|Compound:9058044|FD-Score:3.28|P-value:8.70E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.32|P-value:7.85E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.14|P-value:4.29E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.75|P-value:1.78E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.45|P-value:8.21E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.39|P-value:6.11E-4 ID:SGTC_3090|Compound:9117696|FD-Score:6.96|P-value:2.65E-11 ID:SGTC_3112|Compound:9123419|FD-Score:3.89|P-value:1.08E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.65|P-value:2.53E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.67|P-value:2.40E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.97|P-value:1.28E-6 ID:SGTC_3266|Compound:9136860|FD-Score:5.39|P-value:1.72E-7 ID:SGTC_3306|Compound:9127676|FD-Score:4.59|P-value:6.89E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.56|P-value:7.31E-8 ID:SGTC_3321|Compound:9137793|FD-Score:4.05|P-value:5.97E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.90|P-value:1.04E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.89|P-value:1.08E-4

Top fitness defect scores for YMR242C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_951 1171-0579 10.90 82.7 µM 9.67E-25 cell wall 8 8.17E-28
2 SGTC_138 0850-0259 8.52 40.9 µM 5.51E-16 cell wall 57 7.86E-18
3 SGTC_994 3910-0338 8.49 138.0 µM 7.08E-16 calcium & mitochondrial duress 6 1.05E-17
4 SGTC_2111 5486399 8.19 200.0 µM 6.59E-15 3 1.32E-16
5 SGTC_514 4466-0038 7.45 2.6 nM 1.14E-12 cell wall 50 4.65E-14
6 SGTC_351 caspofungin 7.25 25.0 nM 4.14E-12 cell wall 23 2.01E-13
7 SGTC_3090 9117696 6.96 49.5 µM 2.65E-11 3 1.66E-12
8 SGTC_1171 0368-0077 6.72 21.4 µM 1.19E-10 3 9.11E-12
9 SGTC_1133 3473-0247 6.39 50.0 µM 8.54E-10 RSC complex & mRNA processing 7 8.54E-11
10 SGTC_709 3807-1509 6.37 243.0 µM 9.51E-10 RSC complex & mRNA processing 3 9.65E-11
11 SGTC_2671 danthron 6.25 100.0 µM 1.83E-9 DNA damage response 11 2.03E-10
12 SGTC_1202 1988-0068 5.89 29.6 µM 1.33E-8 RNA processing & uracil transport 7 1.92E-9
13 SGTC_956 1185-0240 5.67 191.0 µM 4.20E-8 9 7.05E-9
14 SGTC_928 2764-0428 5.58 58.7 µM 6.82E-8 cell wall 20 1.22E-8
15 SGTC_3311 9131146 5.56 2.9 µM 7.31E-8 cell wall 67 1.32E-8
16 SGTC_3266 9136860 5.39 49.5 µM 1.72E-7 cell wall 22 3.47E-8
17 SGTC_2186 6124449 5.14 200.0 µM 5.71E-7 RSC complex & mRNA processing 8 1.35E-7
18 SGTC_3210 9128157 4.97 49.5 µM 1.28E-6 23 3.34E-7
19 SGTC_1687 st020778 4.91 55.4 µM 1.65E-6 136 4.47E-7
20 SGTC_802 4112-3352 4.73 742.0 µM 3.81E-6 11 1.15E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.311 2.41E-76 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.257 8.34E-52 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.254 2.23E-50 YKL114C APN1 hom Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
0.253 3.69E-50 YML128C MSC1 hom Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
0.242 5.27E-46 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.229 4.98E-41 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.228 6.65E-41 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.224 2.88E-39 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.211 5.22E-35 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.204 6.06E-33 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.204 6.19E-33 YOR258W HNT3 hom DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress
0.201 6.55E-32 YDR253C MET32 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication
0.200 1.09E-31 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.199 2.73E-31 YEL044W IES6 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
0.197 1.13E-30 YMR032W HOF1 hom Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p